Personalized Immunotherapy For Tumor Diseases And Beyond

Author : Biaoru Li, Alan Larson,Shen Li
Publisher : Bentham Science Publishers
Page : 283 pages
File Size : 42,8 Mb
Release : 2020-11-03
Category : Medical
ISBN : 9789811482731

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Personalized Immunotherapy for Tumor Diseases and Beyond by Biaoru Li, Alan Larson,Shen Li Pdf

This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology. Key Features: - Introduces readers to basic concepts in personalized medicine and immunotherapy - Presents current information about immunological assays used in research - Presents an overview of T cell immunotherapy and cloning techniques - Presents an overview of tumor cell bioinformatics and its role in immunotherapy - Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling) - Includes a section on biobanking - Presents information in an easy-to-read format for a wide range of readers - Brings contributions from experts with over 30 years of experience in personalized immunotherapy Personalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided.

Author : Shen Li,Biaoru Li
Publisher : Unknown
Page : 284 pages
File Size : 55,8 Mb
Release : 2020-11-03
Category : Electronic
ISBN : 9811482748

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Personalized Immunotherapy for Tumor Diseases and Beyond by Shen Li,Biaoru Li Pdf

This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology.Key Features: - Introduces readers to basic concepts in personalized medicine and immunotherapy- Presents current information about immunological assays used in research- Presents an overview of T cell immunotherapy and cloning techniques- Presents an overview of tumor cell bioinformatics and its role in immunotherapy- Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling)- Includes a section on biobanking- Presents information in an easy-to-read format for a wide range of readers- Brings contributions from experts with over 30 years of experience in personalized immunotherapyPersonalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided

Author : Patrick Schmidt,Stefan B. Eichmüller,Yun-Fan Sun,Jonathan Scolnick
Publisher : Frontiers Media SA
Page : 160 pages
File Size : 50,7 Mb
Release : 2024-02-16
Category : Medical
ISBN : 9782832544914

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Personalized Immunotherapy: Advancing processes to extend patient collectives by Patrick Schmidt,Stefan B. Eichmüller,Yun-Fan Sun,Jonathan Scolnick Pdf

Cancer Immunotherapy apart from checkpoint inhibitors is a highly personalized medicine that puts the patient's cells in the focus of drug manufacturing and promises outcomes that rarely have been seen in the history of cancer treatment. CAR-T cells can be mentioned here as the key example that has gained FDA and EMA approvals as the first living drugs for the treatment of leukemias and is now under clinical investigation for application in solid tumors as well. Improvements in cellular engineering in combination with advanced sequencing methods have made it possible to discover tumor-mutation-specific T-cell receptors that can be used to redirect effector cells toward the malignant cell pool with high specificity. This approach opens the opportunity to drug driver mutations that are occurring in a group of patients as well as to design unique patient individual treatment regimens.

Author : Paul D. Rennert
Publisher : Springer
Page : 276 pages
File Size : 49,9 Mb
Release : 2016-05-30
Category : Medical
ISBN : 9783319298276

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Novel Immunotherapeutic Approaches to the Treatment of Cancer by Paul D. Rennert Pdf

Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.

Author : Matthias Theobald
Publisher : Springer
Page : 187 pages
File Size : 54,5 Mb
Release : 2020-09-20
Category : Medical
ISBN : 3030237672

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Current Immunotherapeutic Strategies in Cancer by Matthias Theobald Pdf

This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities. It discusses in detail the successes achieved using monoclonal antibodies (mAbs), including developments with regard to conjugated mAbs and also bispecific mAbs as novel treatment options for leukemia and solid tumors. It also examines the advances toward personalized immunotherapy, focusing on the effectiveness of adoptive cell therapy using genetically engineered T cells with tumor-associated antigen-specific T-cell receptors and chimeric antigen receptors, as well as the role of tailored vaccines based on the patient’s cancer mutanome. Further, it describes the impressive therapeutic results recently achieved with checkpoint inhibitors, and analyzes novel strategies to modulate the immunosuppressive tumor microenvironment. Written by leading international experts and providing up-to-date information on emerging strategies, such as oncolytic virus-based therapy, epigenetic therapy, and combination therapy, the book appeals to all those with an interest in immunotherapy as it comes of age.

Author : Ari VanderWalde
Publisher : Mdpi AG
Page : 190 pages
File Size : 41,9 Mb
Release : 2022-01-25
Category : Electronic
ISBN : 3036528210

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Personalized Medicine in Oncology by Ari VanderWalde Pdf

Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests. The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first "site-agnostic" drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic "signatures" that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.

Author : Aliasghar Tabatabaei Mohammadi,Melika Naderpour,Atiye Rabbani,Roya Firuzi,Leila Moradi Najar,Masoumeh Mahdilou
Publisher : Nobel TM
Page : 14 pages
File Size : 47,5 Mb
Release : 2022-11-16
Category : Medical
ISBN : 8210379456XXX

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Cancer Research and textbook 2 by Aliasghar Tabatabaei Mohammadi,Melika Naderpour,Atiye Rabbani,Roya Firuzi,Leila Moradi Najar,Masoumeh Mahdilou Pdf

What is Cancer? Cancer is a disease caused by the uncontrolled growth and spread of abnormal cells in the body. This abnormal growth of cells can form tumors or invade nearby tissues and organs, leading to serious health problems. Cancer can occur in any part of the body and can be life-threatening if not diagnosed and treated early. This essay aims to provide a comprehensive overview of cancer, including its causes, risk factors, symptoms, diagnosis, and treatment options. Causes of Cancer Cancer is caused by a complex interaction of genetic, environmental, and lifestyle factors that can damage the DNA within cells and trigger uncontrolled growth. Exposure to certain chemicals and radiation, viruses, and chronic inflammation are all potential causes of cancer. Additionally, genetic mutations and inherited gene mutations can increase the risk of developing certain types of cancer. Some lifestyle factors that may increase the risk of cancer include tobacco use, alcohol consumption, poor diet, and lack of physical activity.## Common Types of Cancer There are many different types of cancer that can affect various parts of the body, including but not limited to breast cancer, lung cancer, prostate cancer, colorectal cancer, skin cancer, and leukemia ## Diagnosis and Treatment of Cancer Diagnosis of cancer typically involves a combination of physical examination, medical history review, imaging tests, and laboratory tests. In some cases, a biopsy may be necessary to confirm the diagnosis. Treatment options for cancer may include surgery, radiation therapy, chemotherapy, immunotherapy, targeted therapy or a combination of these approaches The choice of treatment depends on the type and stage of cancer, as well as the patient's overall health and preferences It is important for individuals to have regular screenings and check-ups with their healthcare provider to detect cancer early, when it is most treatable. In conclusion, cancer is a serious disease that can have a significant impact on individuals and society as a whole Prevention and early detection efforts are key in reducing the impact of cancer on individuals and society.

Author : Cathy Waldby,Robert Mitchell
Publisher : Duke University Press
Page : 246 pages
File Size : 50,7 Mb
Release : 2006-03-20
Category : Medical
ISBN : 0822337703

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Tissue Economies by Cathy Waldby,Robert Mitchell Pdf

DIVA cultural studies account of how the "bio-value" of blood, stem cells, organs, and cell lines moves back and forth between 'gift' and 'commodity'./div

Author : Anne Kerr
Publisher : Unknown
Page : 280 pages
File Size : 53,6 Mb
Release : 2021-02-23
Category : Medical
ISBN : 1526141027

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Personalised Cancer Medicine by Anne Kerr Pdf

Author : Bulent Aydogan,James A. Radosevich
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 52,9 Mb
Release : 2020-11-02
Category : Medical
ISBN : 9781119432449

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Precision Medicine in Oncology by Bulent Aydogan,James A. Radosevich Pdf

A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

Author : Dr. Spineanu Eugenia
Publisher : Dr. Spineanu Eugenia
Page : 268 pages
File Size : 46,9 Mb
Release : 2024-02-25
Category : Medical
ISBN : 8210379456XXX

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Skin Cancer Uncovered: A Comprehensive Guide to Melanoma and Beyond by Dr. Spineanu Eugenia Pdf

Explore the intricate world of skin cancer with 'Skin Cancer Uncovered: A Comprehensive Guide to Melanoma and Beyond.' This meticulously crafted treatise delves deep into the realm of dermatology, offering an in-depth understanding of skin neoplasms, risk factors, clinical presentations, and cutting-edge treatments. Whether you're a medical professional seeking to enhance your knowledge or a concerned individual looking to safeguard your skin health, this book is your definitive resource. Discover the latest research on melanoma and other malignant skin neoplasms, their epidemiology, and the crucial risk factors that predispose individuals to these conditions. Unearth the underlying pathogenesis and etiology, unraveling the molecular and genetic intricacies that drive skin cancer's development. With detailed insights into histopathological features, molecular mechanisms, and immune responses, 'Skin Cancer Uncovered' provides a comprehensive view of skin cancer, empowering you to distinguish between various neoplasms and assess their prognosis. Navigate the complexities of diagnosis through clinical evaluation, dermoscopy, and molecular testing. Explore advanced imaging modalities and sentinel lymph node biopsy techniques that aid in precise staging and grading. Stay updated on emerging therapeutic strategies, including immunotherapy and targeted therapies, while also understanding the importance of palliative care in the journey. With a holistic approach, this treatise delves into the psychological, emotional, and social aspects of skin cancer, offering insights into patient support, survivorship care, and end-of-life considerations. Empower yourself with the knowledge of patient rights and advocacy, ensuring compassionate and dignified end-of-life care. 'Skin Cancer Uncovered' is your gateway to comprehensive, up-to-date information on skin cancer, meticulously designed to enrich your understanding, guide your practice, and enhance your skin health. Get ready to embark on a transformative journey through the world of skin neoplasms, armed with knowledge that can make a difference.

Author : Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 42,6 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9781597452229

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Gene Therapy for Cancer by Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher Pdf

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Author : Charles Graeber
Publisher : Twelve
Page : 298 pages
File Size : 47,6 Mb
Release : 2018-11-13
Category : Health & Fitness
ISBN : 9781455568499

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The Breakthrough by Charles Graeber Pdf

Follow along as this New York Times bestselling author details the astonishing scientific discovery of the code to unleashing the human immune system to fight in this "captivating and heartbreaking" book (The Wall Street Journal). For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold? As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses -- tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer's "penicillin moment," a revolutionary discovery in our understanding of cancer and how to beat it. In The Breakthrough, New York Times bestselling author of The Good Nurse Charles Graeber guides readers through the revolutionary scientific research bringing immunotherapy out of the realm of the miraculous and into the forefront of twenty-first-century medical science. As advances in the fields of cancer research and the human immune system continue to fuel a therapeutic arms race among biotech and pharmaceutical research centers around the world, the next step -- harnessing the wealth of new information to create modern and more effective patient therapies -- is unfolding at an unprecedented pace, rapidly redefining our relationship with this all-too-human disease. Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.

Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Page : 213 pages
File Size : 47,7 Mb
Release : 2017-10-20
Category : Medical
ISBN : 9783319605111

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Tumor Organoids by Shay Soker,Aleksander Skardal Pdf

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Author : Siamak Daneshmand,Kevin G. Chan
Publisher : Springer
Page : 308 pages
File Size : 42,8 Mb
Release : 2018-08-31
Category : Medical
ISBN : 9783319933399

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Genitourinary Cancers by Siamak Daneshmand,Kevin G. Chan Pdf

This book addresses the most pressing current questions in the management of urologic malignancies. The rapid advances in imaging and molecular markers are placed into a clinical context, with explanation of their effects on prognosis and treatment planning. Similarly, progress in immunotherapy is carefully examined, focusing in particular on the role of immune checkpoint inhibitors in both early- and late-stage urologic malignancies. Looking beyond the improvements in minimally invasive techniques for urologic cancers, the impacts of care coordination pathways and enhanced recovery after surgery protocols are reviewed. Readers will also find enlightening discussion of the decision algorithm for the treatment of early-stage, high-grade bladder cancer, taking into account evidence on the most advanced treatment options and the circumstances in which surgery may need to be expedited. The penultimate chapter discusses the Cancer Genome Atlas project for bladder cancer, and the book closes by considering contemporary medical and surgical management of testicular cancer.