Perspectives On Biologically Based Cancer Risk Assessment

Author : Vincent James Cogliano,E. Georg Luebeck,Giovanni A. Zapponi
Publisher : Springer Science & Business Media
Page : 329 pages
File Size : 42,5 Mb
Release : 2012-12-06
Category : Technology & Engineering
ISBN : 9781461547419

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Perspectives on Biologically Based Cancer Risk Assessment by Vincent James Cogliano,E. Georg Luebeck,Giovanni A. Zapponi Pdf

The first meeting of the NATO/CCMS Pilot Study "Dose-Response Analysis and Biologically-Based Risk assessment for Initiator and Promoter Carcinogens" was held in Rome, Italy, in the spring of 1991, and was followed by annual or bi-annual meetings held in Germany, Greece, Netherlands, Portugal, USA, up to the end of 1995; in large part supported by NATO/CCMS grants or fellowships, and organized by Pilot Study participants. The Pilot Study activity has been characterized by a higly collaborative atmosphere, which was essential for a deep and detailed analysis of a problem on which different points of view, methodological approaches and regulations exist in the various member countries. The Pilot Study was aimed at proposing a carcinogenic risk assessment procedure which is based on a detailed analysis of the relevant biological processes, and may also consent the verification of hypotheses. The specific form of theoretical and mathe matical models is identified by considering and using the whole set of objective data available. The multidisciplinary approach of the pilot study is reflected by the struc ture of this book. Each chapter is the result of the cooperation of several authors from to produce a comprehensive manual that includes different countries; its objective was both theoretical and practical information.

Author : Curtis Travis
Publisher : Springer
Page : 355 pages
File Size : 51,7 Mb
Release : 2013-06-26
Category : Medical
ISBN : 1468456261

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Biologically Based Methods for Cancer Risk Assessment by Curtis Travis Pdf

"Biologically Based Methods for Cancer Risk Assessment", an Advanced Research Workshop, (ARW) sponsored by the North Atlantic Treaty Organization (NATO) was held in Corfu, Greece in June, 1989. The intent of the workshop was to survey available pharmacokinetic and pharmacodynamic methods in cancer risk assessment and identify methodological gaps and research needs for biologically based methods in cancer risk assessment. Incorporation of such methods represents one of the most challenging areas for risk assessment. The workshop included an international group of invited experts in the field and provided for a dynamic exchange of ideas and accomplishments. Some of the major topics discussed were: * Inventory of available pharmacokinetic and pharmacodynamic methods for cancer risk assessment. * Identification of methodology gaps and research needs in biologically based methods in cancer risk assessment. * Development of a general framework to guide future cancer risk assessment research. This book is a compilation of the papers presented at the workshop and is intended to provide guidance for future research to reduce uncertainties in the cancer risk assessment process. The primary sponsorship of this ARW by NATO and the advice and cooperation of Dr. C. Sinclair of the Scientific affairs Division are gratefully acknowledged. Acknowledgement is also given to the National Science Foundation for its support. The organization of the ARW and the preparation of this book have required considerable help from many other sources.

Author : Tainya C. Clarke
Publisher : Unknown
Page : 20 pages
File Size : 43,7 Mb
Release : 2015
Category : Alternative medicine
ISBN : UCR:31210024293464

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Trends in the Use of Complementary Health Approaches Among Adults by Tainya C. Clarke Pdf

Author : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation,National Research Council
Publisher : National Academies Press
Page : 422 pages
File Size : 47,9 Mb
Release : 2006-03-23
Category : Science
ISBN : 9780309133340

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Health Risks from Exposure to Low Levels of Ionizing Radiation by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation,National Research Council Pdf

This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.

Author : Lech Chyczewski,Jacek Niklinski,Eric Pluygers
Publisher : IOS Press
Page : 380 pages
File Size : 48,7 Mb
Release : 2002
Category : Medical
ISBN : 1586032186

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Endocrine Disrupters and Carcinogenic Risk Assessment by Lech Chyczewski,Jacek Niklinski,Eric Pluygers Pdf

This work is devoted to the study of the endocrine-related effects on human health with special reference to carcinogenesis, and to the assessment of carcinogenic risk. After providing basic information at the general, cellular and molecular levels, the contents focus on the paradigm of biologically-based risk assessment, as developed form physiologically-based toxicokinetic models. The analysis of this material is proposed as the novel parameters for developing biologically-based models of carcinogenesis, considered to be more relevant to risk assessment than traditional approaches.

Author : Lutz Edler,Christos Kitsos
Publisher : John Wiley & Sons
Page : 510 pages
File Size : 40,7 Mb
Release : 2005-05-27
Category : Mathematics
ISBN : 0470857560

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Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment by Lutz Edler,Christos Kitsos Pdf

Human health risk assessment involves the measuring of risk of exposure to disease, with a view to improving disease prevention. Mathematical, biological, statistical, and computational methods play a key role in exposure assessment, hazard assessment and identification, and dose-response modelling. Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment is a comprehensive text that accounts for the wealth of new biological data as well as new biological, toxicological, and medical approaches adopted in risk assessment. It provides an authoritative compendium of state-of-the-art methods proposed and used, featuring contributions from eminent authors with varied experience from academia, government, and industry. Provides a comprehensive summary of currently available quantitative methods for risk assessment of both cancer and non-cancer problems. Describes the applications and the limitations of current mathematical modelling and statistical analysis methods (classical and Bayesian). Includes an extensive introduction and discussion to each chapter. Features detailed studies of risk assessments using biologically-based modelling approaches. Discusses the varying computational aspects of the methods proposed. Provides a global perspective on human health risk assessment by featuring case studies from a wide range of countries. Features an extensive bibliography with links to relevant background information within each chapter. Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment will appeal to researchers and practitioners in public health & epidemiology, and postgraduate students alike. It will also be of interest to professionals working in risk assessment agencies.

Author : Christos P. Kitsos,Teresa A. Oliveira,Francesca Pierri,Marialuisa Restaino
Publisher : Springer Nature
Page : 230 pages
File Size : 43,6 Mb
Release : 2024-01-13
Category : Mathematics
ISBN : 9783031398643

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Statistical Modelling and Risk Analysis by Christos P. Kitsos,Teresa A. Oliveira,Francesca Pierri,Marialuisa Restaino Pdf

This volume covers the latest results on novel methods in Risk Analysis and assessment, with applications in Biostatistics (which is providing food for thought since the first ICRAs, covering traditional areas of RA, until now), Engineering Reliability, the Environmental Sciences and Economics. The contributions, based on lectures given at the 9th International Conference on Risk Analysis (ICRA 9), at Perugia, Italy, May 2022, detail a wide variety of daily risks, building on ideas presented at previous ICRA conferences. Working within a strong theoretical framework, supporting applications, the material describes a modern extension of the traditional research of the 1980s. This book is intended for graduate students in Mathematics, Statistics, Biology, Toxicology, Medicine, Management, and Economics, as well as quantitative researchers in Risk Analysis.

Author : Helmut Greim,Robert Snyder
Publisher : John Wiley & Sons
Page : 840 pages
File Size : 45,6 Mb
Release : 2018-08-22
Category : Science
ISBN : 9781119135937

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Toxicology and Risk Assessment by Helmut Greim,Robert Snyder Pdf

Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.

Author : Dennis J. Paustenbach
Publisher : John Wiley & Sons
Page : 1592 pages
File Size : 53,7 Mb
Release : 2017-05-22
Category : Science
ISBN : 9781119441335

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Human and Ecological Risk Assessment by Dennis J. Paustenbach Pdf

Human and Ecological Risk Assessment: Theory and Practice assembles the expertise of more than fifty authorities from fifteen different fields, forming a comprehensive reference and textbook on risk assessment. Containing two dozen case studies of environmental or human health risk assessments, the text not only presents the theoretical underpinnings of the discipline, but also serves as a complete handbook and "how-to" guide for individuals conducting or interpreting risk assessments. In addition, more than 4,000 published papers and books in the field are cited. Editor Dennis Paustenbach has assembled chapters that present the most current methods for conducting hazard identification, dose-response and exposure assessment, and risk characterization components for risk assessments of any chemical hazard to humans or wildlife (fish, birds, and terrestrials). Topics addressed include hazards posed by: Air emissions Radiological hazards Contaminated soil and foods Agricultural hazards Occupational hazards Consumer products and water Hazardous waste sites Contaminated air and water The bringing together of so many of the world's authorities on these topics, plus the comprehensive nature of the text, promises to make Human and Ecological Risk Assessment the text against which others will be measured in the coming years.

Author : Jürgen Pilz,Teresa A. Oliveira,Karl Moder,Christos P. Kitsos
Publisher : Springer Nature
Page : 166 pages
File Size : 49,5 Mb
Release : 2022-05-20
Category : Mathematics
ISBN : 9783031066856

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Mindful Topics on Risk Analysis and Design of Experiments by Jürgen Pilz,Teresa A. Oliveira,Karl Moder,Christos P. Kitsos Pdf

This book provides an overview of the role of statistics in Risk Analysis, by addressing theory, methodology and applications covering the broad scope of risk assessment in life sciences and public health, environmental science as well as in economics and finance. Experimental Design plays a key role in many of these areas, therefore there is special attention paid to joining Risk Analysis and Experimental Design topics. The contributions of this volume originate from the 8th International Conference on Risk Analysis (23-26 April, 2019, Vienna). The conference brought together researchers and practitioners working in the field of Risk Analysis. The most important contributions at the conference have been refereed and developed into chapters to show the latest developments in the field.

Author : Larry W. Robertson, Larry G. Hansen
Publisher : University Press of Kentucky
Page : 506 pages
File Size : 42,9 Mb
Release : 2001
Category : Medical
ISBN : 0813130549

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PCBs: Recent Advances in Environmental Toxicology and Health Effects by Larry W. Robertson, Larry G. Hansen Pdf

In April 2000 researchers from around the world met in Lexington, Kentucky to bring together the very latest information on the chemistry and biological effects of the environmental pollutants known as Polychlorinated Biphenyls (PCBs). The result is a comprehensive and extensive treatment of the very latest findings on all significant subjects relating to PCBs and their health risks. The thorough introduction and sixty-two scientific papers presented here represent the most up-to-date research by scientists in government, private industry, and academia.

Author : Atanu Biswas,Sujay Datta,Jason P. Fine,Mark R. Segal
Publisher : John Wiley & Sons
Page : 623 pages
File Size : 43,5 Mb
Release : 2007-12-14
Category : Mathematics
ISBN : 9780470181195

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Statistical Advances in the Biomedical Sciences by Atanu Biswas,Sujay Datta,Jason P. Fine,Mark R. Segal Pdf

The Most Comprehensive and Cutting-Edge Guide to Statistical Applications in Biomedical Research With the increasing use of biotechnology in medical research and the sophisticated advances in computing, it has become essential for practitioners in the biomedical sciences to be fully educated on the role statistics plays in ensuring the accurate analysis of research findings. Statistical Advances in the Biomedical Sciences explores the growing value of statistical knowledge in the management and comprehension of medical research and, more specifically, provides an accessible introduction to the contemporary methodologies used to understand complex problems in the four major areas of modern-day biomedical science: clinical trials, epidemiology, survival analysis, and bioinformatics. Composed of contributions from eminent researchers in the field, this volume discusses the application of statistical techniques to various aspects of modern medical research and illustrates how these methods ultimately prove to be an indispensable part of proper data collection and analysis. A structural uniformity is maintained across all chapters, each beginning with an introduction that discusses general concepts and the biomedical problem under focus and is followed by specific details on the associated methods, algorithms, and applications. In addition, each chapter provides a summary of the main ideas and offers a concluding remarks section that presents novel ideas, approaches, and challenges for future research. Complete with detailed references and insight on the future directions of biomedical research, Statistical Advances in the Biomedical Sciences provides vital statistical guidance to practitioners in the biomedical sciences while also introducing statisticians to new, multidisciplinary frontiers of application. This text is an excellent reference for graduate- and PhD-level courses in various areas of biostatistics and the medical sciences and also serves as a valuable tool for medical researchers, statisticians, public health professionals, and biostatisticians.

Author : Anonim
Publisher : Unknown
Page : 570 pages
File Size : 47,6 Mb
Release : 1993
Category : Cancer cells
ISBN : UIUC:30112009349694

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Environmental Health Perspectives by Anonim Pdf

Author : S.H. Moolgavkar
Publisher : Springer Science & Business Media
Page : 312 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468492187

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Scientific Issues in Quantitative Cancer Risk Assessment by S.H. Moolgavkar Pdf

In 1974, the Societal Institute of the Mathematical Sciences (SIMS) initiated.a series of five-day Research Application Conferences (RAC's) at Alta, Utah, for the purpose of probing in depth societal fields in light of their receptivity to mathematical and statistical analysis. The first 10 conferences addressed ecosys tems, epidemiology, energy, environmental health, time series and ecological processes, energy and health, energy conversion and fluid mechanics, environ mental epidemiology: risk assessment, atomic bomb survivor data: utilization and analysis, and modem statistical methods in chronic disease epidemiology. These Proceedings are a result of the eleventh conference of Scientific Issues in Quantitative Cancer Risk Assessment, which was held in 1989 at Snowbird, Utah. For five days, 45 speakers and observers contributed their expertise in the relevant biology and statistics. The presentations were timely and the discussion was both enlightening and at times spirited. This volume hopefully presents a record that will be useful both now and in the future. Suresh H. Moolgavkar of the Fred Hutchinson Cancer Research Center (Seattle, WA) and the University of Washington (Seattle) chaired the Conference. The Conference was supported by the following organizations: The Dow Chemical Company Haskell Laboratory, E.1. duPont Health and Welfare Canada International Life Sciences Institute Monsanto Company National Cancer Institute Procter & Gamble Shell Oil Company U. S. Department of Energy U.S. Environmental Protection Agency U.S. Food and Drug Administration SIMS is grateful to the above organizations for their support of this Conference. D.L. Thomsen, Jr.

Author : Suzanne H. Reuben
Publisher : DIANE Publishing
Page : 240 pages
File Size : 40,8 Mb
Release : 2010-10
Category : Health & Fitness
ISBN : 9781437934212

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Reducing Environmental Cancer Risk by Suzanne H. Reuben Pdf

Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.