Pharmaceutical Process Chemistry For Synthesis

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Pharmaceutical Process Chemistry for Synthesis

Peter J. Harrington
Pharmaceutical Process Chemistry for Synthesis Book PDF

Author : Peter J. Harrington
Publisher : John Wiley & Sons
Page : 815 pages
File Size : 43,5 Mb
Release : 2011-02-23
Category : Science
ISBN : 9780470922866

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Pharmaceutical Process Chemistry for Synthesis by Peter J. Harrington Pdf

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Process Chemistry in the Pharmaceutical Industry

Kumar Gadamasetti
Process Chemistry in the Pharmaceutical Industry Book PDF

Author : Kumar Gadamasetti
Publisher : CRC Press
Page : 514 pages
File Size : 51,8 Mb
Release : 1999-05-06
Category : Medical
ISBN : 0824719816

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Process Chemistry in the Pharmaceutical Industry by Kumar Gadamasetti Pdf

Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers—offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs. Featuring over 1000 references, tables, and illustrations, Process Chemistry in the Pharmaceutical Industry is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines.

Pharmaceutical Process Chemistry

Takayuki Shioiri,Kunisuke Izawa,Toshiro Konoike
Pharmaceutical Process Chemistry Book PDF

Author : Takayuki Shioiri,Kunisuke Izawa,Toshiro Konoike
Publisher : John Wiley & Sons
Page : 544 pages
File Size : 55,9 Mb
Release : 2010-12-09
Category : Technology & Engineering
ISBN : 9783527633692

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Pharmaceutical Process Chemistry by Takayuki Shioiri,Kunisuke Izawa,Toshiro Konoike Pdf

Covering the whole area of process chemistry in the pharmaceutical industry, this monograph provides the essential knowledge on the basic chemistry needed for future development and key industrial techniques, as well as morphology, engineering and regulatory compliances. Application-oriented and well structured, the authors include recent examples of excellent industrial production of active pharmaceutical ingredients.

Process Chemistry in the Pharmaceutical Industry, Volume 2

Kumar Gadamasetti,Tamim Braish
Process Chemistry in the Pharmaceutical Industry Volume 2 Book PDF

Author : Kumar Gadamasetti,Tamim Braish
Publisher : CRC Press
Page : 534 pages
File Size : 47,6 Mb
Release : 2007-12-10
Category : Science
ISBN : 9781420008357

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Process Chemistry in the Pharmaceutical Industry, Volume 2 by Kumar Gadamasetti,Tamim Braish Pdf

As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work, Process Chemistry in the Pharmaceutical Industry, Vol. 2: Challenges in an Ever Changing Climate explor

Pharmaceutical Process Development

John Blacker,Michael T Williams
Pharmaceutical Process Development Book PDF

Author : John Blacker,Michael T Williams
Publisher : Royal Society of Chemistry
Page : 374 pages
File Size : 40,5 Mb
Release : 2011-08-17
Category : Science
ISBN : 9781849733076

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Pharmaceutical Process Development by John Blacker,Michael T Williams Pdf

Pharmaceutical process research and development is an exacting, multidisciplinary effort but a somewhat neglected discipline in the chemical curriculum. This book presents an overview of the many facets of process development and how recent advances in synthetic organic chemistry, process technology and chemical engineering have impacted on the manufacture of pharmaceuticals. In 15 concise chapters the book covers such diverse subjects as route selection and economics, the interface with medicinal chemistry, the impact of green chemistry, safety, the crucial role of physical organic measurements in gaining a deeper understanding of chemical behaviour, the role of the analyst, new tools and innovations in reactor design, purification and separation, solid state chemistry and its role in formulation. The book ends with an assessment of future trends and challenges. The book provides a valuable overview of: both early and late stage chemical development, how safe and scaleable synthetic routes are designed, selected and developed, the importance of the chemical engineering, analytical and manufacturing interfaces, the key enabling technologies, including catalysis and biocatalysis, the importance of the green chemical perspective and solid form issues. The book, written and edited by experts in the field, is a contemporary, holistic treatise, with a logical sequence for process development and mini-case histories within the chapters to bring alive different aspects of the process. It is completely pharmaceutical themed, encompassing all essential aspects, from route and reagent selection to manufacture of the active compound. The book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry. It informs them about the breadth of the work carried out in chemical research and development departments, and gives them a feel for the challenges involved in the job. The book is also of value to academics who often understand the drug discovery arena, but have far less appreciation of the drug development area, and are thus unable to advise their students about the relative merits of careers in chemical development versus discovery.

Pharmaceutical Process Development

A. John Blacker,Mike T. Williams,Michael T. Williams,Royal Society of Chemistry (Great Britain)
Pharmaceutical Process Development Book PDF

Author : A. John Blacker,Mike T. Williams,Michael T. Williams,Royal Society of Chemistry (Great Britain)
Publisher : Royal Society of Chemistry
Page : 375 pages
File Size : 50,5 Mb
Release : 2011
Category : Medical
ISBN : 9781849731461

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Pharmaceutical Process Development by A. John Blacker,Mike T. Williams,Michael T. Williams,Royal Society of Chemistry (Great Britain) Pdf

'Pharmaceutical Process Development' is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry and informs them about the breadth of the work carried out in chemical research and development departments.

Process Chemistry in the Pharmaceutical Industry, Volume 2

Kumar Gadamasetti,Tamim Braish
Process Chemistry in the Pharmaceutical Industry Volume 2 Book PDF

Author : Kumar Gadamasetti,Tamim Braish
Publisher : CRC Press
Page : 0 pages
File Size : 47,5 Mb
Release : 2007-12-10
Category : Science
ISBN : 0849390516

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Process Chemistry in the Pharmaceutical Industry, Volume 2 by Kumar Gadamasetti,Tamim Braish Pdf

As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work, Process Chemistry in the Pharmaceutical Industry, Vol. 2: Challenges in an Ever Changing Climate explores novel applications of synthetic, physical, and analytical chemistry in drug discovery and development. It offers an accurate depiction of the most up-to-date process research and development methods applied to synthesis, clinical trials, and commercializing drug candidates. The second installment in this progressive series, this volumereviews the latest breakthroughs to advance process chemistry, including asymmetric synthesis, crystallization, morphology, enzymatic intervention, green chemistry, macromolecules (monoclonal antibodies, biological molecules, polymers), enantioselectivity, organometallic chemistry, process analytical tools, chemical engineering controls, regulatory compliance, and outsourcing/globalization. It explores new approaches to synthetic processes, examines the latest safety methods and experiment design, and suggests realistic solutions to problems encountered in manufacturing and process development. Significant topics include atom economy, ease of synthesis, instrumentation, automization, quality control, cost considerations, green practices, and future trends. Jointly edited by the founder/president of Delphian Pharmaceuticals and the director of Chemical R&D at Pfizer, this book brings together contributions byreputed scientists, technologists, engineers, and professors from leading academic institutions, such as the Imperial College, UK, the University of Tokyo, ETH, Switzerland, the International University at Bermen, Germany, and the University of Connecticut, USA, and from principal pharmaceutical companies that include Merck, Bristol Myers Squibb, Pfizer, Novartis, Eli Lilly, Astrazeneca and DSM.

Active Pharmaceutical Ingredients in Synthesis

Anthony J. Burke,Carolina Silva Marques,Nicholas J. Turner,Gesine J. Hermann
Active Pharmaceutical Ingredients in Synthesis Book PDF

Author : Anthony J. Burke,Carolina Silva Marques,Nicholas J. Turner,Gesine J. Hermann
Publisher : John Wiley & Sons
Page : 450 pages
File Size : 52,5 Mb
Release : 2018-11-28
Category : Science
ISBN : 9783527342419

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Active Pharmaceutical Ingredients in Synthesis by Anthony J. Burke,Carolina Silva Marques,Nicholas J. Turner,Gesine J. Hermann Pdf

Presents the most effective catalytic reactions in use today, with a special focus on process intensification, sustainability, waste reduction, and innovative methods This book demonstrates the importance of efficient catalytic transformations for producing pharmaceutically active molecules. It presents the key catalytic reactions and the most efficient catalytic processes, including their significant advantages over compared previous methods. It also places a strong emphasis on asymmetric catalytic reactions, process intensification (PI), sustainability and waste mitigation, continuous manufacturing processes as enshrined by continuous flow catalysis, and supported catalysis. Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development offers chapters covering: Catalysis and Prerequisites for the Modern Pharmaceutial Industry Landscape; Catalytic Process Design - The Industrial Perspective; Hydrogenation, Hydroformylation and Other Reductions; Oxidation; ; Catalytic Addition Reactions; Catalytic Cross-Coupling Reactions; Catalytic Metathesis Reactions; Catalytic Cycloaddition Reactions: Coming Full-Circle; Catalytic Cyclopropanation Reactions; Catalytic C-H insertion Reactions; Phase Transfer Catalysis; and Biocatalysis. -Provides the reader with an updated clear view of the current state of the challenging field of catalysis for API production -Focuses on the application of catalytic methods for the synthesis of known APIs -Presents every key reaction, including Diels-Alder, CH Insertions, Metal-catalytic coupling-reactions, and many more -Includes recent patent literature for completeness Covering a topic of great interest for synthetic chemists and R&D researchers in the pharmaceutical industry, Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development is a must-read for every synthetic chemist working with APIs.

Green Chemistry in the Pharmaceutical Industry

Peter J. Dunn,Andrew Wells,Michael T. Williams
Green Chemistry in the Pharmaceutical Industry Book PDF

Author : Peter J. Dunn,Andrew Wells,Michael T. Williams
Publisher : John Wiley & Sons
Page : 388 pages
File Size : 41,6 Mb
Release : 2010-02-02
Category : Science
ISBN : 3527629696

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Green Chemistry in the Pharmaceutical Industry by Peter J. Dunn,Andrew Wells,Michael T. Williams Pdf

Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

Principles of Process Research and Chemical Development in the Pharmaceutical Industry

Oljan Repic
Principles of Process Research and Chemical Development in the Pharmaceutical Industry Book PDF

Author : Oljan Repic
Publisher : Wiley-Interscience
Page : 248 pages
File Size : 50,8 Mb
Release : 1998
Category : Medical
ISBN : UOM:39015045683698

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Principles of Process Research and Chemical Development in the Pharmaceutical Industry by Oljan Repic Pdf

This text discusses the functions of Process R&D (research and development), which involves the method of transforming a research synthetic procedure into a plant process and the key aspects of a synthesis that must be considered when scaling up a process. Topics consist of: basic principles of chemical development; techniques for the minimization of by-product impurities; criteria for cost-effective synthesis of enantiopure compounds by resolutions; asymmetric synthesis, and "chiral pool" strategy; synthesis for labeling substances with hydrogen or carbon isotopes; and last, licensing.

The Art of Drug Synthesis

Douglas S. Johnson,Jie Jack Li
The Art of Drug Synthesis Book PDF

Author : Douglas S. Johnson,Jie Jack Li
Publisher : John Wiley & Sons
Page : 295 pages
File Size : 52,9 Mb
Release : 2013-02-26
Category : Science
ISBN : 9781118678466

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The Art of Drug Synthesis by Douglas S. Johnson,Jie Jack Li Pdf

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

The Management of Chemical Process Development in the Pharmaceutical Industry

Derek Walker
The Management of Chemical Process Development in the Pharmaceutical Industry Book PDF

Author : Derek Walker
Publisher : John Wiley & Sons
Page : 424 pages
File Size : 44,6 Mb
Release : 2008-03-03
Category : Medical
ISBN : 9780470259504

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The Management of Chemical Process Development in the Pharmaceutical Industry by Derek Walker Pdf

Here is a practical guide that not only presents insights into the organization and management of the disciplines involved in chemical process development but also provides basic knowledge of these disciplines, enabling process development practitioners to recognize and assimilate them in their work. This book illustrates practical considerations through many examples of the successful direction and integration of the activities of chemists, analysts, chemical engineers, and biologists, as well as safety, regulatory, and environmental professionals in productive teams. Moreover, this reference provides guidance on: Directing and carrying out specific tasks and courses of action Making and communicating clear and achievable decisions Solving problems on the spot Managing the administrative aspects of chemical process development The author, Dr. Derek Walker, has directed chemical process development work for four decades, combining firsthand chemical synthesis experience with many other disciplines needed to create chemical processes. You will benefit from his advice and unique insights into: Understanding the workings of matrix organizations Defining missions and creating action plans Developing interdisciplinary approaches to problem solving Holding review meetings, revising goals, and motivating staff Prioritizing programs and responses to emergencies In addition, you'll learn how successful chemists, in collaboration with other disciplines, define the best (green) chemistry for process scale-up, including accommodating FDA requirements in the last process steps and addressing safety and environmental matters early in their work. Case studies provide incisive perspective on these issues. A chapter on recognizing and patenting intellectual property emphasizes the importance of comprehensive literature surveys and understanding invention. A chapter on the future challenges you to think beyond narrow constraints and explore new horizons.

An Introduction to Drug Synthesis

Graham L. Patrick
An Introduction to Drug Synthesis Book PDF

Author : Graham L. Patrick
Publisher : Oxford University Press, USA
Page : 587 pages
File Size : 44,5 Mb
Release : 2015
Category : Science
ISBN : 9780198708438

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An Introduction to Drug Synthesis by Graham L. Patrick Pdf

'Introduction to Drug Synthesis' explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

Beyond the Molecular Frontier

National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Committee on Challenges for the Chemical Sciences in the 21st Century
Beyond the Molecular Frontier Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Committee on Challenges for the Chemical Sciences in the 21st Century
Publisher : National Academies Press
Page : 238 pages
File Size : 45,6 Mb
Release : 2003-03-19
Category : Science
ISBN : 9780309168397

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Beyond the Molecular Frontier by National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Committee on Challenges for the Chemical Sciences in the 21st Century Pdf

Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.

Organometallics in Process Chemistry

Ahmed F. Abdel-Magid
Organometallics in Process Chemistry Book PDF

Author : Ahmed F. Abdel-Magid
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 47,8 Mb
Release : 2004-06-15
Category : Science
ISBN : 3540016031

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Organometallics in Process Chemistry by Ahmed F. Abdel-Magid Pdf

The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.