Pharmacogenetics And Individualized Therapy

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Pharmacogenetics and Individualized Therapy

Anke-Hilse Maitland-van der Zee,Ann K. Daly
Pharmacogenetics and Individualized Therapy Book PDF

Author : Anke-Hilse Maitland-van der Zee,Ann K. Daly
Publisher : John Wiley & Sons
Page : 32 pages
File Size : 52,8 Mb
Release : 2012-04-02
Category : Medical
ISBN : 9781118116487

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Pharmacogenetics and Individualized Therapy by Anke-Hilse Maitland-van der Zee,Ann K. Daly Pdf

This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.

Pharmacogenomics

Yui-Wing Francis Lam,Larisa H. Cavallari
Pharmacogenomics Book PDF

Author : Yui-Wing Francis Lam,Larisa H. Cavallari
Publisher : Academic Press
Page : 515 pages
File Size : 52,7 Mb
Release : 2013-02-12
Category : Science
ISBN : 9780123983039

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Pharmacogenomics by Yui-Wing Francis Lam,Larisa H. Cavallari Pdf

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Pharmacogenomics

Julio Licinio,Ma-Li Wong
Pharmacogenomics Book PDF

Author : Julio Licinio,Ma-Li Wong
Publisher : John Wiley & Sons
Page : 599 pages
File Size : 43,6 Mb
Release : 2009-07-30
Category : Science
ISBN : 9783527616305

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Pharmacogenomics by Julio Licinio,Ma-Li Wong Pdf

This work represents the first comprehensive publication in the innovative field of pharmacogenomics, a field which is set to revolutionize pharmaceutical research. In addition to renowned editors, the list of contributors is a "who-is-who" in the field. Broad coverage of all aspects of pharmacogenomics with a full presentation of applications to disease conditions is featured. Anyone involved in pharmaceutical research and drug development needs this book to keep up with this new and revolutionary approach

Pharmacogenetics of Breast Cancer

Brian Leyland-Jones
Pharmacogenetics of Breast Cancer Book PDF

Author : Brian Leyland-Jones
Publisher : CRC Press
Page : 360 pages
File Size : 54,7 Mb
Release : 2020-04-27
Category : Medical
ISBN : 9780429525681

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Pharmacogenetics of Breast Cancer by Brian Leyland-Jones Pdf

Pharmacogenetics is becoming increasingly relevant in the diagnosis, treatment, and recovery of cancer patients. A major problem facing oncologists is the outstanding varied efficacy of treatment. Promising advances in pharmacogenetics have allowed the development of effective agents which will enable personalized cancer chemotherapy to become rout

Textbook of Personalized Medicine

Kewal K. Jain
Textbook of Personalized Medicine Book PDF

Author : Kewal K. Jain
Publisher : Humana Press
Page : 762 pages
File Size : 50,6 Mb
Release : 2015-03-17
Category : Medical
ISBN : 9781493925537

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Textbook of Personalized Medicine by Kewal K. Jain Pdf

Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Principles of Pharmacogenetics and Pharmacogenomics

Russ B. Altman,Russ Altman,David Flockhart,David B. Goldstein
Principles of Pharmacogenetics and Pharmacogenomics Book PDF

Author : Russ B. Altman,Russ Altman,David Flockhart,David B. Goldstein
Publisher : Cambridge University Press
Page : 283 pages
File Size : 43,6 Mb
Release : 2012-01-23
Category : Medical
ISBN : 9780521885379

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Principles of Pharmacogenetics and Pharmacogenomics by Russ B. Altman,Russ Altman,David Flockhart,David B. Goldstein Pdf

This textbook presents the latest information on pharmacogenetics and pharmacogenomics for students, professionals and researchers.

Pharmacogenetics

Wendell Weber
Pharmacogenetics Book PDF

Author : Wendell Weber
Publisher : Oxford University Press
Page : 448 pages
File Size : 41,5 Mb
Release : 2008-04-02
Category : Medical
ISBN : 0199712166

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Pharmacogenetics by Wendell Weber Pdf

Drugs are administered to patients with the intention of achieving an expected therapeutic response. Yet drug therapy remains a medical art because of the wide variation in individual responses to standard drug doses. Pharmacogenetics emerged as a field aimed at identifying heritable factors that are predictive of individual variations in drug efficacy and toxicity from the dedicated work of a small group of investigators who in the 1950s began to enrich the discipline of pharmacology by integrating it with human genetics. Pharmacogenetics provides the experimental framework to understand variation in human reactions to drugs and other exogenous substances as a function of inborn human genetic variability. Recently, pharmacogenetics has experienced a period of rapid growth and redefinition. The human genome initiative has provided a wealth of primary genetic information and functional genomic data to fuel the understanding of genetic polymorphism and its functional consequences on a genomic scale. Today, the field of pharmacogenetics is a well-integrated, worldwide network engaging a vast community of academic, institutional, and industrial scientists. The second edition of this highly regarded book provides a systematic and comprehensive account of the foundations, fundamentals, and futures of the field of pharmacogenetics and serves as introduction to all facets of pharmacogenetics for physicians, pharmacists, epidemiologists and other professionals in the life sciences. Dr. Wendell Weber has completely revised and updated each chapter in this new edition to reflect the enormous changes in this field.

Preventive and Predictive Genetics: Towards Personalised Medicine

Godfrey Grech,Iris Grossman
Preventive and Predictive Genetics Towards Personalised Medicine Book PDF

Author : Godfrey Grech,Iris Grossman
Publisher : Springer
Page : 378 pages
File Size : 53,9 Mb
Release : 2015-06-24
Category : Science
ISBN : 9783319153445

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Preventive and Predictive Genetics: Towards Personalised Medicine by Godfrey Grech,Iris Grossman Pdf

Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine

David F. Kisor,Professor of Pharmacokinetics Chair Department of Pharmaceutical and Biomedical Sciences Ohio Northern University Raabe College of Pharmacy David F Kisor,Michael D. Kane,Jon E. Sprague,Jeffery N. Talbot
Pharmacogenetics Kinetics and Dynamics for Personalized Medicine Book PDF

Author : David F. Kisor,Professor of Pharmacokinetics Chair Department of Pharmaceutical and Biomedical Sciences Ohio Northern University Raabe College of Pharmacy David F Kisor,Michael D. Kane,Jon E. Sprague,Jeffery N. Talbot
Publisher : Jones & Bartlett Publishers
Page : 225 pages
File Size : 43,9 Mb
Release : 2013-02-19
Category : Medical
ISBN : 9781449633943

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Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine by David F. Kisor,Professor of Pharmacokinetics Chair Department of Pharmaceutical and Biomedical Sciences Ohio Northern University Raabe College of Pharmacy David F Kisor,Michael D. Kane,Jon E. Sprague,Jeffery N. Talbot Pdf

Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine provides a primer to understand pharmacogenetics (the study of genetic factors that influence how a drug works) in the applied context of pharmacokinetics (how the body handles a drug) and pharmacodynamics (the effects of a drug on the body). This valuable foundation illuminates how these principles and scientific advances can create optimal individual patient care, that is, "personalized medicine." Through specific drug examples, this resource explores how the genetic constitution of an individual may lead to the need for an altered dose or in some cases alternative drug therapy. Real-world cases highlight the specific relationships between genetics, drug action, and the body's response as well as adverse drug reactions, altered metabolism, and drug efficacy. Ethical issues concerning pharmacogenomics and study design are also discussed in this concise overview.

Pharmacogenomics and Personalized Medicine

Erika Cecchin,Gabriele Stocco
Pharmacogenomics and Personalized Medicine Book PDF

Author : Erika Cecchin,Gabriele Stocco
Publisher : MDPI
Page : 208 pages
File Size : 53,7 Mb
Release : 2021-01-20
Category : Medical
ISBN : 9783039367306

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Pharmacogenomics and Personalized Medicine by Erika Cecchin,Gabriele Stocco Pdf

Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient’s genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including a study of the pharmacogenomic role of the immune system genetics and of previously neglected rare genetic variants, reported to account for a large part of inter-individual variability in drug metabolism. In this book, we have collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastructures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics.

Pharmacogenetics

Islam A. Khalil
Pharmacogenetics Book PDF

Author : Islam A. Khalil
Publisher : BoD – Books on Demand
Page : 188 pages
File Size : 49,5 Mb
Release : 2021-11-24
Category : Medical
ISBN : 9781839692178

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Pharmacogenetics by Islam A. Khalil Pdf

Pharmacogenetics is the study of the effects of individual genetics on drug responses. This book provides an overview of the current state of the pharmacological genetic aspects of these treatments. It discusses drugs with genetic information to support product labeling, clinical guidelines, or significant mechanical effects. Pharmacogenetic studies have also allowed us to better understand the pharmacology of medications used to treat neurologic and psychiatric disorders. This book also reviews the current state of the science and potential clinical utility of pharmacogenetic markers for these treatments. Furthermore, it highlights the in silico approach as a promising tool for further research on experimental pharmacology.

Concepts in Pharmacogenomics

Martin M. Zdanowicz
Concepts in Pharmacogenomics Book PDF

Author : Martin M. Zdanowicz
Publisher : ASHP
Page : 425 pages
File Size : 51,6 Mb
Release : 2010
Category : Medical
ISBN : 9781585282340

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Concepts in Pharmacogenomics by Martin M. Zdanowicz Pdf

The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time.If you are pharmacist, resident, or student curious about this new field, start withConcepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application and implementation.Features include: case studies in each chapter clinical pearls illustrations of key concepts figures, diagrams, and flow charts for visual learners key points summarized.

Pharmacogenomics in Precision Medicine

Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang
Pharmacogenomics in Precision Medicine Book PDF

Author : Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang
Publisher : Springer Nature
Page : 290 pages
File Size : 47,9 Mb
Release : 2020-06-12
Category : Medical
ISBN : 9789811538957

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Pharmacogenomics in Precision Medicine by Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang Pdf

This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Clinical Applications of Pharmacogenetics

Despina Sanoudou
Clinical Applications of Pharmacogenetics Book PDF

Author : Despina Sanoudou
Publisher : BoD – Books on Demand
Page : 308 pages
File Size : 42,6 Mb
Release : 2012-03-21
Category : Medical
ISBN : 9789535103899

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Clinical Applications of Pharmacogenetics by Despina Sanoudou Pdf

The rapidly evolving field of Pharmacogenetics aims at identifying the genetic factors implicated in the inter-individual variation of drug response. These factors could enable patient sub-classification based on their treatment needs thus expediting drug development and promoting personalized, safer and more effective treatments. This book presents Pharmacogenetic examples from a broad spectrum of different drugs, for different diseases, which are representative of different stages of evaluation or application. It has been designed so as to serve both the unfamiliar reader through explanations of basic Pharmacogenetic concepts, the clinician with presentation of the latest developments and international guidelines, and the research scientist with examples of Pharmacogenetic applications, discussions on the limitations and an outlook on the new scientific trends in this field.

Pharmacogenomics

Federico Innocenti,Ron H.N. Schaik
Pharmacogenomics Book PDF

Author : Federico Innocenti,Ron H.N. Schaik
Publisher : Humana Press
Page : 359 pages
File Size : 41,5 Mb
Release : 2013-07-04
Category : Medical
ISBN : 1627034366

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Pharmacogenomics by Federico Innocenti,Ron H.N. Schaik Pdf

Understanding an individual's genetic makeup is the key to creating personalized drugs with greater efficacy and safety, and pharmacogenomics aims to study the complex genetic basis of inter-patient variability in response to drug therapy. Based upon the success of its first edition, the second edition of Pharmacogenomics: Methods And Protocols aims to continue providing readers with high-quality content on the most innovative and commonly adopted technologies in the field of pharmacogenomics as presented by experts in the field. Broken into several sections, this detailed volume examines techniques for interrogating variation in human genes and genomes, functional assessment of genetic variation, both in vitro and in vivo, as well as tools for translation and implementation of pharmacogenetic markers. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to the respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Comprehensive and thoroughly updated, Pharmacogenomics: Methods And Protocols, Second Edition serves as an essential reference and an invaluable source on the latest information in this field.