Pharmacokinetics Of Drugs

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Holland-Frei Cancer Medicine

Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Holland Frei Cancer Medicine Book PDF

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 54,8 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Drug Metabolism and Pharmacokinetics Quick Guide

Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Drug Metabolism and Pharmacokinetics Quick Guide Book PDF

Author : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 46,8 Mb
Release : 2011-04-07
Category : Medical
ISBN : 9781441956293

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Drug Metabolism and Pharmacokinetics Quick Guide by Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop Pdf

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Pharmacokinetics and Pharmacodynamics of Biotech Drugs

Bernd Meibohm
Pharmacokinetics and Pharmacodynamics of Biotech Drugs Book PDF

Author : Bernd Meibohm
Publisher : John Wiley & Sons
Page : 426 pages
File Size : 48,7 Mb
Release : 2006-12-13
Category : Science
ISBN : 9783527609529

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Pharmacokinetics and Pharmacodynamics of Biotech Drugs by Bernd Meibohm Pdf

This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides, monoclonal antibodies, antisense oligonucleotides, as well as viral and non-viral gene delivery vectors. The second section discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. The final section considers the integration of PK and PD concepts into the biotech drug development plan, taking as case studies the preclinical and clinical drug development of tasidotin, as well as the examples of cetuximab and pegfilgrastim. The result is vital reading for all pharmaceutical researchers.

Drug Disposition and Pharmacokinetics

Stephen H. Curry,Robin Whelpton
Drug Disposition and Pharmacokinetics Book PDF

Author : Stephen H. Curry,Robin Whelpton
Publisher : Wiley
Page : 388 pages
File Size : 50,5 Mb
Release : 2010-12-01
Category : Science
ISBN : 0470684461

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Drug Disposition and Pharmacokinetics by Stephen H. Curry,Robin Whelpton Pdf

This is an authoritative, comprehensive book on the fate of drug molecules in the body, including implications for pharmacological and clinical effects. The text provides a unique, balanced approach, examining the specific physical and biological factors affecting the absorption, distribution, metabolism and excretion of drugs, together with mathematical assessment of the concentrations in plasma and body fluids. Understanding the equations requires little more than a basic knowledge of algebra, laws of indices and logarithms, and very simple calculus. A companion web site contains additional illustrations, further equations and numerous worked examples. Whilst this book has its roots in the highly acclaimed book of the same name, written by Stephen Curry nearly thirty years ago, it is essentially a new book having been restructured and largely rewritten. This readable and informative book is an invaluable resource for professionals and students needing to develop a rational approach to the investigation and application of drugs.

Oral Drug Absorption

Jennifer B. Dressman,Christos Reppas
Oral Drug Absorption Book PDF

Author : Jennifer B. Dressman,Christos Reppas
Publisher : CRC Press
Page : 432 pages
File Size : 44,5 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420077346

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Oral Drug Absorption by Jennifer B. Dressman,Christos Reppas Pdf

Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an

Pharmacokinetics of Drugs

Peter G. Welling,Luc P. Balant
Pharmacokinetics of Drugs Book PDF

Author : Peter G. Welling,Luc P. Balant
Publisher : Springer Science & Business Media
Page : 546 pages
File Size : 43,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642786808

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Pharmacokinetics of Drugs by Peter G. Welling,Luc P. Balant Pdf

A compilation of researchers' experience in the areas of bioanalysis, pharmacokinetics, and drug metabolism, to present an up-to-date and comprehensive treatise on the application of these and related technologies in drug discovery, development, and clinical use. Contents cover descriptions of analytical methods, in vitro metabolism technology and membrane transport, reappraisal of classical pharmacokinetic problems, and the time course of drug action. The book concludes with a description of PET and imaging methods in pharmacokinetics and an appendix containing a critical appraisal of computer methods and pharmacokinetic software available for PCs.

Pharmacokinetics in Drug Development

Peter L. Bonate
Pharmacokinetics in Drug Development Book PDF

Author : Peter L. Bonate
Publisher : Springer Science & Business Media
Page : 648 pages
File Size : 51,8 Mb
Release : 2005-12-05
Category : Medical
ISBN : 0971176744

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Pharmacokinetics in Drug Development by Peter L. Bonate Pdf

These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. They fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.

Pharmacokinetics and Metabolism in Drug Design

Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
Pharmacokinetics and Metabolism in Drug Design Book PDF

Author : Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
Publisher : John Wiley & Sons
Page : 207 pages
File Size : 44,7 Mb
Release : 2006-08-21
Category : Medical
ISBN : 9783527608287

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Pharmacokinetics and Metabolism in Drug Design by Dennis A. Smith,Han van de Waterbeemd,Don K. Walker Pdf

In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

Drug Metabolism, Pharmacokinetics and Bioanalysis

Hye Suk Lee,Kwang-Hyeon Liu
Drug Metabolism Pharmacokinetics and Bioanalysis Book PDF

Author : Hye Suk Lee,Kwang-Hyeon Liu
Publisher : MDPI
Page : 230 pages
File Size : 52,8 Mb
Release : 2019-06-12
Category : Medical
ISBN : 9783038979166

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Drug Metabolism, Pharmacokinetics and Bioanalysis by Hye Suk Lee,Kwang-Hyeon Liu Pdf

Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.

Pharmacokinetics in Drug Discovery and Development

Ronald D. Schoenwald
Pharmacokinetics in Drug Discovery and Development Book PDF

Author : Ronald D. Schoenwald
Publisher : CRC Press
Page : 430 pages
File Size : 48,6 Mb
Release : 2002-03-06
Category : Medical
ISBN : 9781420010084

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Pharmacokinetics in Drug Discovery and Development by Ronald D. Schoenwald Pdf

Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existi

Pharmacokinetics in Drug Development

Peter L. Bonate,Danny R. Howard
Pharmacokinetics in Drug Development Book PDF

Author : Peter L. Bonate,Danny R. Howard
Publisher : Springer
Page : 330 pages
File Size : 44,5 Mb
Release : 2016-10-06
Category : Medical
ISBN : 9783319390536

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Pharmacokinetics in Drug Development by Peter L. Bonate,Danny R. Howard Pdf

In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies. This book delivers, with an emphasis on the oncology therapeutic area, the goals set in the first three volumes: namely – to provide clinical pharmacologists practical insights for the application of pharmacology, pharmacokinetics and pharmacodynamics for new drug development strategies. Pharmacokinetic-pharmacodynamic concepts for tyrosine kinases, the evaluation of cardiac repolarization prolongation through QTc interval effects, efficacy- and safety-response analyses to support new drug approvals, clinical and preclinical tumor growth modeling, and flat- vs weight-based dose selection are showcased from an oncology clinical pharmacologist’s point-of-view. Oncology development strategies are surveyed for new FDA-approvals to identify patterns in expectations at time of first approval. The special considerations necessary to address combination drug development, metronomics, biosimilars and breakthrough therapies are also presented.

Pharmacokinetics: Basics to Applications

Biswajit Mukherjee
Pharmacokinetics Basics to Applications Book PDF

Author : Biswajit Mukherjee
Publisher : Springer Nature
Page : 354 pages
File Size : 46,5 Mb
Release : 2022-03-17
Category : Medical
ISBN : 9789811689505

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Pharmacokinetics: Basics to Applications by Biswajit Mukherjee Pdf

This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.

Pharmacokinetics and Metabolism in Drug Design

Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker
Pharmacokinetics and Metabolism in Drug Design Book PDF

Author : Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker
Publisher : John Wiley & Sons
Page : 269 pages
File Size : 42,7 Mb
Release : 2012-05-14
Category : Medical
ISBN : 9783527329540

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Pharmacokinetics and Metabolism in Drug Design by Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker Pdf

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

Introduction to Pharmacokinetics and Pharmacodynamics

Thomas N. Tozer,Malcolm Rowland
Introduction to Pharmacokinetics and Pharmacodynamics Book PDF

Author : Thomas N. Tozer,Malcolm Rowland
Publisher : Lippincott Williams & Wilkins
Page : 342 pages
File Size : 55,6 Mb
Release : 2006
Category : Medical
ISBN : 0781751497

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Introduction to Pharmacokinetics and Pharmacodynamics by Thomas N. Tozer,Malcolm Rowland Pdf

This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.

Casebook in Clinical Pharmacokinetics and Drug Dosing

Henry Cohen
Casebook in Clinical Pharmacokinetics and Drug Dosing Book PDF

Author : Henry Cohen
Publisher : McGraw Hill Professional
Page : 300 pages
File Size : 44,5 Mb
Release : 2014-10-06
Category : Medical
ISBN : 9780071832762

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Casebook in Clinical Pharmacokinetics and Drug Dosing by Henry Cohen Pdf

A STEP-BY-STEP APPROACH TO DESIGNING ACCURATE DOSING REGIMENS Casebook in Pharmacokinetics and Drug Dosing uses real-life cases to teach pharmacy students, pharmacists, and clinical pharmacists how to apply pharmacokinetics to formulate proper dosing regimens. In order to be as clinically relevant as possible, the book not only discusses drugs with readily available therapeutic serum levels, but places equal emphasis on high-alert agents with narrow therapeutic indexes. Each drug chapter is written by clinical pharmacists who have hands-on experience in drug dosing and includes an overview of the drug’s pharmacology, including: Indications Mec hanisms of action Toxicities Pharmacokinetics There is comprehensive review and discussion of each drug's bioavailability, volume of distribution, clearance, half-life, therapeutic drug level monitoring, drug interactions, dosing, and availability. Each chapter is enhanced by numerous patient cases with clear step-by-step answers and explanations. Calculations, equations, and dosing recommendations are provided for each case.