Pharmacoresistance In Epilepsy

Author : Luisa L. Rocha,Alberto Lazarowski,Esper A. Cavalheiro
Publisher : Springer Nature
Page : 598 pages
File Size : 54,7 Mb
Release : 2023-08-29
Category : Medical
ISBN : 9783031365263

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Pharmacoresistance in Epilepsy by Luisa L. Rocha,Alberto Lazarowski,Esper A. Cavalheiro Pdf

This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.

Author : Luisa Rocha,Esper A. Cavalheiro
Publisher : Springer Science & Business Media
Page : 329 pages
File Size : 44,9 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9781461464648

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Pharmacoresistance in Epilepsy by Luisa Rocha,Esper A. Cavalheiro Pdf

Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoesistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they’re studying epilepsy in the lab or treating it in a doctor’s office.”

Author : Philippe Kahane
Publisher : John Libbey Eurotext
Page : 228 pages
File Size : 45,9 Mb
Release : 2008
Category : Electronic
ISBN : 8210379456XXX

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Drug-Resistant Epilepsies by Philippe Kahane Pdf

More than 12 million people with epilepsy have seizures that cannot be controlled by antiepileptic drugs. The term "drug-resistance" is abundantly used in the epilepsy literature but the definitions proposed differ considerably. It is used indifferently in a number of different settings: as a criterion for selection of patients eligible for new antiepileptic drug trials, for the selection of surgical candidates, for the design of epidemiological studies, for the design of studies on quality of life, for the definition of the epileptic encephalopathies (in comparison to more benign epilepsy syndromes), to mention but a few. As a result, available studies are usually not comparable and referral to epilepsy specialists is unacceptably delayed. The present volume of Progress in Epileptic Disorders includes several focused chapters on all issues relating to drug-resistance and offers the basis for a consensus on a clinically meaningful core definition.

Author : Philippe Kahane, Anne Berg, Wolfgang Löscher, Doug Nordli, Emilio Perucca
Publisher : John Libbey Eurotext
Page : 128 pages
File Size : 40,7 Mb
Release : 2013-09-18
Category : Electronic
ISBN : 9782742012176

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Drug-Resistant Epilepsies by Philippe Kahane, Anne Berg, Wolfgang Löscher, Doug Nordli, Emilio Perucca Pdf

Over 12 million people with epilepsy have seizures that cannot be controlled by antiepileptic drugs. The term "drug-resistance" is abundantly used in the epilepsy literature but the definitions proposed differ considerably. It is used indifferently in a number of different settings: as a criterion for selection of patients eligible for new antiepileptic drug trials, for the selection of surgical candidates, for the design of epidemiological studies, for the design of studies on quality of life, for the definition of the epileptic encephalopathies (in comparison to more benign epilepsy syndromes), to mention but a few. As a result, available studies are usually not comparable and referral to epilepsy specialists is unacceptably delayed. The volume includes several focused chapters on all issues relating to drug-resistance and offers the basis for a consensus on a clinically meaningful core definition.

Author : W. McIntyre Burnham,Peter L. Carlen,Paul A. Hwang
Publisher : Springer Science & Business Media
Page : 252 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461513353

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Intractable Seizures by W. McIntyre Burnham,Peter L. Carlen,Paul A. Hwang Pdf

About 20% of people with epilepsy have seizures which are resistant to anticonvulsant medications. These drug-resistant seizures are called `intractable', and the patients who have them - about 1 in 500 of the general population - present a major challenge to neurologists and epilepsy associations. The present volume describes the symptomatology of the major `intractable' syndromes, the most appropriate drugs for each, and the possibilities for surgical control. Research related to the causes and effects of unchecked seizures is presented, and new directions in prevention and therapy are discussed.

Author : Tianfu Li,Xiangping Chu,Jiong Qin
Publisher : Frontiers Media SA
Page : 92 pages
File Size : 43,9 Mb
Release : 2024-03-05
Category : Medical
ISBN : 9782832545584

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Neuromodulation for pharmacoresistant epilepsy: From bench to bed by Tianfu Li,Xiangping Chu,Jiong Qin Pdf

Author : Jeffrey L. Noebels,Massimo Avoli
Publisher : OUP USA
Page : 1258 pages
File Size : 51,9 Mb
Release : 2012-06-29
Category : Medical
ISBN : 9780199746545

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Jasper's Basic Mechanisms of the Epilepsies by Jeffrey L. Noebels,Massimo Avoli Pdf

Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Author : Simon Shorvon,Emilio Perucca,Jerome Engel, Jr.
Publisher : John Wiley & Sons
Page : 1072 pages
File Size : 41,5 Mb
Release : 2015-09-15
Category : Medical
ISBN : 9781118936986

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The Treatment of Epilepsy by Simon Shorvon,Emilio Perucca,Jerome Engel, Jr. Pdf

Highly Commended at the British Medical Association Book Awards 2016 The Treatment of Epilepsy, fourth edition, is a comprehensive reference and clinical guide to the pharmacological, medical and surgical options available in the treatment of epilepsy. The text is compiled by a group of internationally renowned editors and contributors and is now in full color and extensively illustrated The first two sections cover the background to, and principles of, treatment in different clinical situations Section three comprises a series of systematic reviews of contemporary drug therapy, devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects Section four focuses on the surgical options, devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach This 4th edition is extensively revised incorporating the many recent developments in therapy, and comprises 81 chapters from world experts from 18 countries

Author : Simon Shorvon,Emilio Perucca,Jerome Engel, Jr.
Publisher : John Wiley & Sons
Page : 1072 pages
File Size : 42,6 Mb
Release : 2015-09-23
Category : Medical
ISBN : 9781118936993

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The Treatment of Epilepsy by Simon Shorvon,Emilio Perucca,Jerome Engel, Jr. Pdf

Highly Commended at the British Medical Association Book Awards 2016 The Treatment of Epilepsy, fourth edition, is a comprehensive reference and clinical guide to the pharmacological, medical and surgical options available in the treatment of epilepsy. The text is compiled by a group of internationally renowned editors and contributors and is now in full color and extensively illustrated The first two sections cover the background to, and principles of, treatment in different clinical situations Section three comprises a series of systematic reviews of contemporary drug therapy, devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects Section four focuses on the surgical options, devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach This 4th edition is extensively revised incorporating the many recent developments in therapy, and comprises 81 chapters from world experts from 18 countries

Author : Gregory R. Bock,Jamie A. Goode
Publisher : Wiley
Page : 0 pages
File Size : 44,6 Mb
Release : 2002-04-26
Category : Medical
ISBN : 047084146X

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Drug Resistance in Epilepsy by Gregory R. Bock,Jamie A. Goode Pdf

The object of this book is to gather together workers in the fields of epilepsy, those concerned with the basic science of resistance and the blood-brain barrier, and those with clinical experience of drug resistance in cancer, with a view to stimulating further work on drug resistance in epilepsy. Whilst resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken, with some success, resistance in epilepsy has only just begun to be addressed.

Author : Juerg Hodler,Rahel A. Kubik-Huch,Gustav K. von Schulthess
Publisher : Springer Nature
Page : 252 pages
File Size : 53,5 Mb
Release : 2020-02-14
Category : Medical
ISBN : 9783030384906

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Diseases of the Brain, Head and Neck, Spine 2020–2023 by Juerg Hodler,Rahel A. Kubik-Huch,Gustav K. von Schulthess Pdf

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

Author : Hermann Stefan,Elinor Ben-Menachem,Patrick Chauvel,Renzo Guerrini
Publisher : Cambridge University Press
Page : 205 pages
File Size : 53,5 Mb
Release : 2012-11-22
Category : Medical
ISBN : 9780521167123

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Case Studies in Epilepsy by Hermann Stefan,Elinor Ben-Menachem,Patrick Chauvel,Renzo Guerrini Pdf

This selection of epilepsy case studies will inform and challenge clinicians at all stages in their careers. Including both common and uncommon cases, Case Studies in Epilepsy reinforces the diagnostic skills and treatment decision-making processes necessary to treat epilepsy and other seizures confidently in pediatric and adult patients.

Author : S. Andrew Josephson,W. David Freeman,David J. Likosky
Publisher : Cambridge University Press
Page : 128 pages
File Size : 42,8 Mb
Release : 2011-09-29
Category : Medical
ISBN : 9781139501828

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Neurohospitalist Medicine by S. Andrew Josephson,W. David Freeman,David J. Likosky Pdf

Over the past decade, the hospitalist model has become a dominant system for the delivery of inpatient care. Forces such as national mandates to improve safety and quality, and intense pressure to safely reduce length of hospital stays, are now exerting pressure on neurologists. To meet these challenges, a new neurohospitalist model is emerging. This is the first authoritative text to detail the advances and strategies for treating neurologic disease in a hospital setting. It includes chapters on specific acute neurologic diseases including stroke, epilepsy, neuromuscular disease and traumatic brain injury and also addresses common reasons for neurologic consultation in the hospital including encephalopathy, electrolyte disturbances and neurologic complications of pregnancy. Ethical and structural issues commonly encountered in neurologic inpatients are also addressed. This will be a key resource for any clinician or trainee caring for neurologic patients in the hospital including practising neurologists, internists and trainees across multiple subspecialities.

Author : Simon Shorvon,Renzo Guerrini,Eugen Trinka,Steven Schachter
Publisher : Cambridge University Press
Page : 1013 pages
File Size : 40,9 Mb
Release : 2019-05-02
Category : Medical
ISBN : 9781108420754

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The Causes of Epilepsy by Simon Shorvon,Renzo Guerrini,Eugen Trinka,Steven Schachter Pdf

Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.

Author : James E. Barrett,Joseph T. Coyle,Michael Williams
Publisher : Cambridge University Press
Page : 128 pages
File Size : 40,8 Mb
Release : 2012-06-28
Category : Medical
ISBN : 9781139510301

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Translational Neuroscience by James E. Barrett,Joseph T. Coyle,Michael Williams Pdf

Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.