Physiological Pharmaceutics

Author : Neena Washington,Clive Washington,Clive Wilson
Publisher : CRC Press
Page : 336 pages
File Size : 48,5 Mb
Release : 2000-12-21
Category : Medical
ISBN : 0748405623

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Physiological Pharmaceutics by Neena Washington,Clive Washington,Clive Wilson Pdf

In recent years, the emphasis in drug development has been the design of new delivery systems rather than new drugs. It is the aim of innovative pharmaceutical scientists to design the new dosage forms to overcome the body's barrier mechanisms which have specifically evolved to exclude foreign material. This book provides an integrated approach to the study of drug formulation in the body with the emphasis on the formulation variables rather than the drugs. The link between physiology and pharmaceutics is presented to give an essential background of biological principles for the pharmacy student, pharmaceutical formulator and healthcare professional. Complex mathematical aspects of physical chemistry have been avoided to facilitate understanding, enabling the reader to concentrate on how the biological environment affects the performance of the drugs and dosage forms. As the majority of drugs are administered via the oral route a large proportion of the book is devoted to the gastrointestinal tract and the variation in the capacity for drug absorption which occurs along its length. Transdermal, ocular, pulmonary and nasal drug delivery are discussed in detail. New chapters in the book include 'Vaginal drug delivery', the 'Blood brain barrier' and 'Parenteral drug delivery'.

Author : Clive George Wilson,Neena Washington
Publisher : Unknown
Page : 196 pages
File Size : 53,6 Mb
Release : 1989
Category : Absorption (Physiology).
ISBN : UOM:39015039110013

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Physiological Pharmaceutics by Clive George Wilson,Neena Washington Pdf

Author : Neena Washington
Publisher : CRC Press
Page : 329 pages
File Size : 42,6 Mb
Release : 2000-12-21
Category : Medical
ISBN : 9780203483701

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Physiological Pharmaceutics by Neena Washington Pdf

In recent years, the emphasis in drug development has been the design of new delivery systems rather than new drugs. It is the aim of innovative pharmaceutical scientists to design the new dosage forms to overcome the body's barrier mechanisms which have specifically evolved to exclude foreign material. This book provides an integrated appro

Author : Todd Wilson
Publisher : Unknown
Page : 128 pages
File Size : 51,8 Mb
Release : 2024-06-30
Category : Electronic
ISBN : 0131248014

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Physiological Pharmaceutics by Todd Wilson Pdf

Author : Elsie E. Gaskell,Elsie Gaskell,Chris Rostron
Publisher : Oxford University Press
Page : 228 pages
File Size : 47,6 Mb
Release : 2013-02-14
Category : Medical
ISBN : 9780199655298

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Therapeutics and Human Physiology by Elsie E. Gaskell,Elsie Gaskell,Chris Rostron Pdf

The Integrated Foundations of Pharmacy series is for those at the start of their journey to become a pharmacist. It helps students understand how a drug molecule is made and then turned into a medicine; the role they will have when dispensing; and how the medicine works in the body. Most importantly, it shows how all of these aspects come together.

Author : Elizabeth C.M. de Lange,Margareta Hammarlund-Udenaes,Robert G. Thorne
Publisher : Springer Nature
Page : 810 pages
File Size : 40,7 Mb
Release : 2022-05-24
Category : Science
ISBN : 9783030887735

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Drug Delivery to the Brain by Elizabeth C.M. de Lange,Margareta Hammarlund-Udenaes,Robert G. Thorne Pdf

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood–brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.

Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
Publisher : Springer Science & Business Media
Page : 737 pages
File Size : 54,8 Mb
Release : 2013-12-03
Category : Medical
ISBN : 9781461491057

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Drug Delivery to the Brain by Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne Pdf

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. ​

Author : Hugh C. Hemmings,Talmage D. Egan
Publisher : Elsevier Health Sciences
Page : 986 pages
File Size : 49,8 Mb
Release : 2018-10-19
Category : Medical
ISBN : 9780323568869

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Pharmacology and Physiology for Anesthesia E-Book by Hugh C. Hemmings,Talmage D. Egan Pdf

Pharmacology and physiology are the foundation of every anesthesia provider’s training and clinical competency. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application, 2nd Edition, delivers the information you need in pharmacology, physiology, and molecular-cellular biology, keeping you current with contemporary training and practice. This thoroughly updated edition is your one-stop, comprehensive overview of physiology, and rational anesthetic drug selection and administration, perfect for study, review, and successful practice. Contains new chapters on Special Populations (anesthetic pharmacology in obesity, geriatrics, and pediatrics), Oral and Non-IV Opioids, Thermoregulation, Physiology and Pharmacology of Obstetric Anesthesia, Chemotherapeutic and Immunosuppresive Drugs, and Surgical Infection and Antimicrobial Drugs. Incorporates entirely new sections on Physics, Anatomy, and Imaging. Includes new information on consciousness and cognition, pharmacodynamics, the immune system, and anti-inflammatory drugs. Features user-friendly tables, figures, and algorithms (including 100 new illustrations), all presented in full color and designed to help explain complex concepts. Helps you understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these areas.

Author : Elka Touitou,Brian W. Barry
Publisher : CRC Press
Page : 656 pages
File Size : 45,7 Mb
Release : 2006-11-27
Category : Medical
ISBN : 9781420004816

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Enhancement in Drug Delivery by Elka Touitou,Brian W. Barry Pdf

Providing a significant cross-fertilization of ideas across several disciplines, Enhancement in Drug Delivery offers a unique comprehensive review of both theoretical and practical aspects of enhancement agents and techniques used for problematic administration routes. It presents an integrated evaluation of absorption enhancers and modes fo

Author : M S 1868-1934 Pembrey,Charles Douglas Ferguson Phillips
Publisher : Palala Press
Page : 122 pages
File Size : 48,7 Mb
Release : 2016-05-11
Category : Electronic
ISBN : 135634514X

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The Physiological Action of Drugs, an Introduction to Practical Pharmacology by M S 1868-1934 Pembrey,Charles Douglas Ferguson Phillips Pdf

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Author : M. S. (Marcus Seymour) Pembrey,Charles D. F. (Charles Douglas Phillips
Publisher : Unknown
Page : 116 pages
File Size : 54,6 Mb
Release : 2016-08-29
Category : History
ISBN : 1373472200

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PHYSIOLOGICAL ACTION OF DRUGS by M. S. (Marcus Seymour) Pembrey,Charles D. F. (Charles Douglas Phillips Pdf

Author : Marcus Seymour Pembrey,Charles Douglas Fergusson Phillips
Publisher : Palala Press
Page : 116 pages
File Size : 51,7 Mb
Release : 2018-02-24
Category : Literary Collections
ISBN : 1378585542

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The Physiological Action of Drugs: An Introduction to Practical Pharmacology by Marcus Seymour Pembrey,Charles Douglas Fergusson Phillips Pdf

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Author : Laurie Kelly McCorry
Publisher : CRC Press
Page : 520 pages
File Size : 41,7 Mb
Release : 2008-07-25
Category : Medical
ISBN : 9781420043914

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Essentials of Human Physiology for Pharmacy by Laurie Kelly McCorry Pdf

A firm grasp of the functions of living organisms is one of the most important prerequisites to pharmacy study. The long-awaited second edition of Essentials of Human Physiology presents concepts in physiology in a way that prepares students for their subsequent study of pathophysiology, pharmacology, and pharmacotherapeutics. Thoroughly

Author : Sheila Annie Peters
Publisher : John Wiley & Sons
Page : 399 pages
File Size : 47,6 Mb
Release : 2012-02-17
Category : Medical
ISBN : 9781118140307

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Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations by Sheila Annie Peters Pdf

The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the information researchers need to learn these new techniques, its applications are severely limited. Describing the principles, methods, and applications of PBPK modeling as used in pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations fills this void. Connecting theory with practice, the book explores the incredible potential of PBPK modeling for improving drug discovery and development. Comprised of two parts, the book first provides a detailed and systematic treatment of the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics. The second part looks in greater detail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for a brief overview of the field as well as those who need more detail, the book includes a range of important learning aids. Featuring end-of-chapter keywords for easy reference a valuable asset for general or novice readers without a PBPK background along with an extensive bibliography for those looking for further information, Physiologically- Based Pharmacokinetic (PBPK) Modeling and Simulations is the essential single-volume text on one of the hottest topics in the pharmaceutical sciences today.

Author : Shelley Chambers Fox
Publisher : Pharmaceutical Press
Page : 561 pages
File Size : 44,7 Mb
Release : 2014-06-25
Category : Medical
ISBN : 9780857110701

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Remington Education Pharmaceutics by Shelley Chambers Fox Pdf

Remington Education: Pharmaceutics covers the basic principles of pharmaceutics, from dosage forms to drug delivery and targeting. It addresses all the principles covered in an introductory pharmacy course. As well as offering a summary of key information in pharmaceutics, it offers numerous case studies and MCQs for self assessment.