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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author : Gary D. Hammer,Stephen J. McPhee Publisher : McGraw Hill Professional Page : 779 pages File Size : 55,9 Mb Release : 2014-03-22 Category : Medical ISBN : 9780071806015
Pathophysiology of Disease: An Introduction to Clinical Medicine 7/E (ENHANCED EBOOK) by Gary D. Hammer,Stephen J. McPhee Pdf
A full-color, case-based review of the essentials of pathophysiology--covering all major organs and systems The goal of this trusted text is to introduce you to clinical medicine by reviewing the pathophysiologic basis of 120 diseases (and associated signs and symptoms) commonly encountered in medical practice. The authors, all experts in their respective fields, have provided a concise review of relevant normal structure and function of each body system, followed by a description of the pathophysiologic mechanisms that underlie several common diseases related to that system. Each chapter of Pathophysiology of Disease concludes with a collection of case studies and questions designed to test your understanding of the pathophysiology of each clinical entity discussed. These case studies allow you to apply your knowledge to specific clinical situations. Detailed answers to each case study question are provided at the end of the book. This unique interweaving of physiological and pathological concepts will put you on the path toward thinking about signs and symptoms in terms of their pathophysiologic basis, giving you an understanding of the "why" behind illness and treatment. Features 120 case studies (9 new) provide an opportunity for you to test your understanding of the pathophysiology of each clinical entity discussed Checkpoint questions provide review and appear in every chapter Updates and revisions throughout this new edition reflect the latest research and developments Numerous tables and diagrams encapsulate important information Updated references for each chapter topic Pathophysiology of Disease is a true must-have resource for medical students preparing for the USMLE Step 1 exam, as well as students engaged in their clerkship studies. House officers, nurses, nurse practitioners, physicians’ assistants, and allied health practitioners will find its concise presentation and broad scope a great help in facilitating their understanding of common disease entities.
How the Immune System Works, Includes Desktop Edition by Lauren Sompayrac Pdf
How the Immune System Works is not a comprehensive textbook. It’s the book thousands of students have used to help them understand what’s in their big, thick, immunology texts. In this book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject. Fifteen easy to follow lectures, featuring the uniquely popular humorous style and engaging analogies developed by Dr Sompayrac, provide an introduction to the ‘bigger picture’, followed by practical discussion on how each of the components interacts with one another. Now featuring full-color diagrams, this book has been rigorously updated for its fourth edition to reflect today’s immunology teaching and includes updated discussion of B and T cell memory, T cell activation, vaccines, immunodeficiency, and cancer. Whether you are completely new to immunology, or require a refresher, How the Immune System Works is an enjoyable way of engaging with the key concepts – you need know nothing of the workings of the immune system to benefit from this book! How the Immune System Works is now accompanied by a FREE enhanced Wiley Desktop Edition - the interactive, digital version of the book - featuring downloadable text and images, highlighting and note taking facilities, book-marking, cross-referencing, in-text searching, and linking to references and glossary terms. It is also available from CourseSmart for instant, online and offline access for studying anytime, anywhere.
Stress Challenges and Immunity in Space by Alexander Choukèr Pdf
This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Immune Function in Sport and Exercise by Michael Gleeson Pdf
This title is directed primarily towards health care professionals outside of the United States. Designed to help readers understand and evaluate the relationship between exercise, immune function and infection risk, this book presents evidence for the "J-shaped" relationship between exercise load and infection risk. It also describes the components of the human immune system and key functions that protect the body from disease, the impact of acute and chronic psychological stress on immune function, and practical guidelines for minimizing the risk of immunodepression and infection in athletes. Further chapters explore different ways of measuring immune function, as well as the effects of heavy training on innate and specific (acquired) immunity, exercise in environmental extremes, and nutrition. Connections between exercise, infection risk, and immune function in special populations (elderly, obese, diabetic and HIV patients) are also addressed. Authored by a team of highly experienced experts. The "J-shaped" relationship between exercise load and infection risk is described, backed by current research and evidence. Components of the immune system and normal immune function are explained in detail, as well as methods for measuring immune function. The impact of acute and chronic psychological stress on immune function is presented, along with suggestions for minimizing the risk of immunodepression and infection in athletes. The effects of heavy training, exercise in environmental extremes, and nutrition are discussed with regard to their impact on innate and specific (acquired) immunity. Immune function in special populations (elderly, obese, diabetic and HIV patients) is also addressed, exploring links between exercise and infection risk in these groups. Evidence-based coverage includes a list of references in each chapter, as well as suggestions for further reading that direct readers to important texts and review articles. Information is presented in an easily accessible format, following a logical progression of material. LEach chapter begins with a list of learning objectives and ends with a list of key points to reinforce learning. A glossary at the end of the book defines all key terms and abbreviations.
Autoimmunity by Antonio Coutinho,Michael D. Kazatchkine Pdf
AUTOIMMUNITY: PHYSIOLOGY AND DISEASE presents a thorough and coherent analysis of all aspects of autoreactivity in normal healthy individuals and in sufferers of autoimmune diseases.
Stress, Immune Function, and Health by Bruce S. Rabin Pdf
Written by a renowned figure in the field of immunology and compiling a wealth of scientific information, Stress, Immune Function, and Health: The Connection looks at the long-term effects of stress on human health from a psychoneuroimmunological approach. The recent changes in dietary modifications, clinical applications, and evolution in the field of immunology have created the need for a book which addresses the growing awareness of health benefits that can be achieved by buffering the effects of stress on the immune system. Emphasizing the importance of the interaction among the mind, the body, and physical health, this reference includes important developmental procedures that can be used to resist stress on the immune system. By examining components of the immune system, along with the effects of psychological stress and the capacity for hormonal response, author Bruce Rabin demonstrates, in a concise, accessible manner, the ability of an individual's immune system to alter susceptibility to immune-mediated diseases. In addition, the book examines several key issues in this rapidly expanding field, including: * Information and examples that illustrate how distinct areas of the brain that perceive the presence of a stressor are able to communicate with the cells of the immune system * The correlation between stress-related changes in health practices and stressor-induced risks of disease development * The effect on the immune system due to stress from an increased concentration of neuropeptides and hormones * Behaviors and beliefs that can reduce the harmful effects of stress on the immune system by interfering with the stress-responsive areas of the brain * The issue of stress during pregnancy and the early period of development on behaviors and immune functions in children An authoritative guide for all researchers and students in the fields of immunology, neuroscience, and psychology, Stress, Immune Function, and Health: The Connection is also an essential reference for physicians and nurses concerned with stress and immune-related diseases.
Immunotoxicity, Immune Dysfunction, and Chronic Disease by Rodney R. Dietert,Robert W. Luebke Pdf
Chronic diseases are the leading cause of deaths worldwide and according to the World Economics Council and the Harvard School of Public Health, the cost of chronic diseases is expected to reach a staggering 48% of global gross domestic product by the year 2030. The urgency of the issue was demonstrated in 2011 when for only the second time in its existence, the U.N. General Assembly brought a health issue to the floor for consideration: chronic diseases. To date, most considerations of the issue have approached the topic from the vantage point that chronic diseases are a myriad of largely unconnected diseases and conditions arising in diverse tissues, organs and physiological systems. This book, Immunotoxicity, Immune Dysfuction, and Chronic Disease, deviates from that prior model. It considers the interconnectivity of chronic diseases with both environmental insult of the immune system and subsequent immune dysfunction and inflammatory dysregulation as the underlying basis for many, if not most, chronic diseases. This change in the perception of environment-immune linkages to chronic disease is significant and has immediate implications both for the prevention of disease as well as for the development of more effective therapeutic approaches. Rather than considering environmental factors and types of reported immune alterations (e.g., depressed humoral immunity) as is common in books involving immunotoxicity, the present book approaches the environment-immune-disease triad from the standpoint of the disease. Each chapter emphasizes one or more specific immune dysfunction-based chronic disease(s) or condition(s) (e.g., asthma, atherosclerosis, multiple sclerosis, lupus) and describes: 1) the suggested environmental risk factors, 2) the underlying immune dysfunction(s) associated with the disease and 3) the overall health consequences of the disease. This book is an early entry for a new Toxicology book series for Springer titled: Molecular and Integrative Toxicology (MaIT). The series will feature detailed research information, but in the context of a more integrative or holistic framework. As part of this framework, the chapters will contain a section on ”Key Points” as well as “Recommendations” where appropriate. The goal is to cover the most timely, state-of-the-art issues in toxicology as well as to ensure that the information is maximally accessible for research scientists, teachers, physicians and students. We are particularly grateful to the numerous chapter authors for providing comprehensive and expert disease-oriented contributions. We are also appreciative of their willingness to consider their material not as disparate pieces of what has become a major health crisis, but rather as key pieces in a network of apparently interconnected health challenges.
Immuno-Psychiatry by Michael Berk,Marion Leboyer,Iris E. Sommer Pdf
This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.
Cooperation of Liver Cells in Health and Disease by Z. Kmiec Pdf
It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
B Cell Receptor Signaling by Tomohiro Kurosaki,Jürgen Wienands Pdf
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Innate Immunity: Resistance and Disease-Promoting Principles by G. Hartmann,H. Wagner Pdf
Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the state of the art in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.
J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Author : J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young Publisher : Unknown Page : 0 pages File Size : 54,6 Mb Release : 2013-04-25 Category : Electronic ISBN : 1947172808
Anatomy and Physiology by J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young Pdf
Handbook of Human Stress and Immunity by Ronald Glaser,Janice K. Kiecolt-Glaser Pdf
In 1964, George Solomon coined the term psychoneuroimmunology. In the intervening 30 years, this term has emerged into a dynamic field of study which investigates the unique interactions between the nervous, endocrine, and immune systems. The Handbook of Human Stress and Immunity is a comprehensive reference for this dynamic new field. Focusing on how stressors impact the central nervous system and the resulting changes in immune responses, the Handbook is the first to describehow stress specifically affects human immune systems. It discusses how stress generally makes people more susceptible to infection, how personal support systems can counteract the physiological effects of stress, and how stress, or lack of stress, affects the aging process. Chapters are authored by the leading names in the field and cover such diseases as autoimmune disease, viral pathogenesis, herpes, HIV, and AIDS.
Randy J. Nelson,Gregory E. Demas,Sabra L. Klein,Lance J. Kriegsfeld
Author : Randy J. Nelson,Gregory E. Demas,Sabra L. Klein,Lance J. Kriegsfeld Publisher : Cambridge University Press Page : 309 pages File Size : 41,5 Mb Release : 2002-03-25 Category : Science ISBN : 9781139431170
Seasonal Patterns of Stress, Immune Function, and Disease by Randy J. Nelson,Gregory E. Demas,Sabra L. Klein,Lance J. Kriegsfeld Pdf
This book presents evidence that infection is cyclical with the seasons, and that this phenomenon is mirrored in cycles of immune function. The book identifies the mechanisms by which immune systems are bolstered to counteract seasonally-recurrent stressors, such as extreme temperature reductions and food shortages. Stress, infectious diseases, autoimmune diseases, and human cancers are examined, and the role of hormones such as melatonin and glucocorticoids is considered. The book begins with an overview of seasonality, biological rhythms and photoperiodism, and basic immunology, and then discusses seasonal fluctuations in disease prevalence, immune function, and energetics and endocrinology as they relate to immune function. The clinical significance of this issue is also addressed, as such seasonal changes may play an important role in the development and treatment of infections. This first monograph to examine seasonal immune function from an interdisciplinary perspective will serve practitioners as well as advanced undergraduates and graduate students in biology, immunology, human and veterinary medicine, neuroscience, endocrinology, and zoology.