Physiology Biochemistry And Pharmacology Of Transporters For Organic Cations

Author : Giuliano Ciarimboli
Publisher : MDPI
Page : 248 pages
File Size : 55,6 Mb
Release : 2021-06-24
Category : Medical
ISBN : 9783036505626

Get Book

Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations by Giuliano Ciarimboli Pdf

Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field.

Author : Giuliano Ciarimboli
Publisher : Unknown
Page : 248 pages
File Size : 42,7 Mb
Release : 2021
Category : Electronic
ISBN : 3036505636

Get Book

Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations by Giuliano Ciarimboli Pdf

Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field.

Author : Giuliano Ciarimboli,Sophie Gautron,Eberhard Schlatter
Publisher : Springer
Page : 264 pages
File Size : 50,7 Mb
Release : 2015-12-17
Category : Medical
ISBN : 9783319237930

Get Book

Organic Cation Transporters by Giuliano Ciarimboli,Sophie Gautron,Eberhard Schlatter Pdf

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

Author : Lynette C. Daws
Publisher : Springer Nature
Page : 333 pages
File Size : 45,7 Mb
Release : 2021-10-27
Category : Medical
ISBN : 9783030829841

Get Book

Organic Cation Transporters in the Central Nervous System by Lynette C. Daws Pdf

Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com

Author : Anonim
Publisher : Springer Science & Business Media
Page : 162 pages
File Size : 49,8 Mb
Release : 2007-05-02
Category : Medical
ISBN : 9783540452072

Get Book

Reviews of Physiology, Biochemistry and Pharmacology by Anonim Pdf

H. Wegele, L. Müller, and J. Buchner: Hsp70 and Hsp90 - A Relay Team for Protein Folding R. Schülein: The Early Stages of the Intracellular Transport of Membrane Proteins: Clinical and Pharmacological Implications L. Schild: The Epithelial Sodium Channel: From Molecule to Disease.

Author : Anonim
Publisher : Springer
Page : 162 pages
File Size : 43,5 Mb
Release : 2014-08-23
Category : Medical
ISBN : 3662310759

Get Book

Reviews of Physiology, Biochemistry and Pharmacology by Anonim Pdf

Author : Ashim Mitra,Chi H. Lee,Kun Cheng
Publisher : John Wiley & Sons
Page : 844 pages
File Size : 40,6 Mb
Release : 2013-08-26
Category : Medical
ISBN : 9781118662847

Get Book

Advanced Drug Delivery by Ashim Mitra,Chi H. Lee,Kun Cheng Pdf

Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

Author : Anonim
Publisher : Academic Press
Page : 512 pages
File Size : 52,7 Mb
Release : 2014-10-21
Category : Medical
ISBN : 9780128003381

Get Book

Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders by Anonim Pdf

This new volume of Advances in Pharmacology presents pharmacology of the blood brain barrier, focusing on targeting CNS disorders. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists

Author : M.A. Jakupec,M. Galanski,B.K. Keppler,H.-G. Koch,M. Moser,M. Müller,B.C. Burckhardt,G. Burckhardt
Publisher : Springer Science & Business Media
Page : 223 pages
File Size : 40,6 Mb
Release : 2003-03-25
Category : Medical
ISBN : 9783540002284

Get Book

Reviews of Physiology, Biochemistry and Pharmacology 146 by M.A. Jakupec,M. Galanski,B.K. Keppler,H.-G. Koch,M. Moser,M. Müller,B.C. Burckhardt,G. Burckhardt Pdf

In this volume of Reviews of Physiology there are three outstanding contributions, the first on Selenium-containing proteins in mammals and other forms of life, and the second on constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0 and the third on Chloroplast quest: a journey from the cytosol into the chloroplast and beyond.

Author : Stephen C. Piscitelli,Keith A. Rodvold,Manjunath P. Pai
Publisher : Springer Science & Business Media
Page : 692 pages
File Size : 55,6 Mb
Release : 2011-09-08
Category : Medical
ISBN : 1617792136

Get Book

Drug Interactions in Infectious Diseases by Stephen C. Piscitelli,Keith A. Rodvold,Manjunath P. Pai Pdf

The revised and up-to-date third edition of Drug Interactions in Infectious Diseases delivers a text that will enhance your clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The third edition features five new chapters that cover material not addressed in previous editions. These new chapters describe interactions with a number of drug classes such as non-HIV antiviral, antimalarial, antiparasitic, antihelmintic, macrolide, azalide and ketolide agents. A novel chapter on probe cocktail studies has been included to highlight an important research tool for drug development. These chapters address material that cannot be retrieved easily in the medical literature. The highly acclaimed food-drug interactions as well as the study design and analysis chapters remain definitive references. The newly written drug-cytokine interaction highlights the need for our improved understanding of the complex interrelationship of acute infection, inflammation, and the risk of drug interactions. Informative tables on specific drug-drug interactions are provided throughout the chapters as a quick clinical resource. The Third Edition of Drug Interactions in Infectious Diseases is a distillation of relevant drug interactions associated with antimicrobials, infection, and inflammation. This concise review of the mechanisms and strategies to manage drug interactions should be valuable to all health care practitioners. Features • Definitive reference source of up-to-date information on antimicrobial drug interactions • Informative tables on the degree of interaction for specific antimicrobial agents • In-depth discussion of mechanisms and potential mechanistic pathways of interaction • New chapters on non-HIV antiviral, antimalarial, antiparasitic, and macrolide, azalide and ketolide agents • New chapter on probe-cocktail studies as a research tool to study drug-drug interactions • Inclusion of new antimicrobial agents and their associated drug interactions • First rate chapters on study design and analysis, and drug-food interactions • A fresh perspective on drug-cytokine interactions • Authoritative chapter on regulatory considerations of drug interactions during drug development

Author : Lee E. Eiden
Publisher : Academic Press
Page : 500 pages
File Size : 54,7 Mb
Release : 2013-09-17
Category : Medical
ISBN : 9780124115392

Get Book

A New Era of Catecholamines in the Laboratory and Clinic by Lee E. Eiden Pdf

This new volume of Advances in Pharmacology presents catecholamine symposium proceedings. Chapters cover such topics as cellular dynamics of catecholamine release and re-uptake, catecholamines in mood regulation and imaging catecholamine transporters. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Presents catecholamine symposium proceedings Chapters cover a variety of topics such as cellular dynamics of catecholamine release and re-uptake, catecholamines in mood regulation and imaging catecholamine transporters With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike

Author : Miles Hacker,William S. Messer,Kenneth A. Bachmann
Publisher : Academic Press
Page : 608 pages
File Size : 49,8 Mb
Release : 2009-06-19
Category : Medical
ISBN : 0080919227

Get Book

Pharmacology by Miles Hacker,William S. Messer,Kenneth A. Bachmann Pdf

Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. Uses individual drugs to explain molecular actions Full color art program explains molecular and chemical concepts graphically Logical structure reflecting the current state of pharmacology and translational research Covers such intricacies as drug resistance and cell death Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

Author : Gordon L. Amidon,Wolfgang Sadée
Publisher : Springer Science & Business Media
Page : 547 pages
File Size : 47,9 Mb
Release : 1999-11-30
Category : Medical
ISBN : 9780306460944

Get Book

Membrane Transporters as Drug Targets by Gordon L. Amidon,Wolfgang Sadée Pdf

Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.

Author : Jerome Casas
Publisher : Academic Press
Page : 192 pages
File Size : 55,7 Mb
Release : 2008-11-21
Category : Science
ISBN : 9780080921761

Get Book

Advances in Insect Physiology by Jerome Casas Pdf

Advances in Insect Physiology publishes eclectic volumes containing important, comprehensive and in-depth reviews on all aspects of insect physiology. It is an essential reference source for invertebrate physiologists and neurobiologists, entomologists, zoologists and insect biochemists. First published in 1963, the serial is now edited by Steve Simpson and Jerome Casas to provide an international perspective. * Contributions from the leading researchers in entomology * Discusses the physiological diversity in insects * Includes in-depth reviews with valuable information for a variety of entomology disciplines

Author : Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lirong Liu,William Porter
Publisher : Academic Press
Page : 978 pages
File Size : 42,8 Mb
Release : 2009-03-10
Category : Medical
ISBN : 008093272X

Get Book

Developing Solid Oral Dosage Forms by Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lirong Liu,William Porter Pdf

Developing Solid Oral Dosage Forms is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. The specific goals are to provide readers with: Basics of modern theories of physical pharmacy, biopharmaceutics and industrial pharmacy and their applications throughout the entire process of research and development of oral dosage forms Tools and approaches of preformulation investigation, formulation/process design, characterization and scale-up in pharmaceutical sciences and technologies New developments, challenges, trends, opportunities, intellectual property issues and regulations in solid product development The first book (ever) that provides comprehensive and in-depth coverage of what's required for developing high quality pharmaceutical products to meet international standards It covers a broad scope of topics that encompass the entire spectrum of solid dosage form development for the global market, including the most updated science and technologies, practice, applications, regulation, intellectual property protection and new development trends with case studies in every chapter A strong team of more than 50 well-established authors/co-authors of diverse background, knowledge, skills and experience from industry, academia and regulatory agencies