Phytochemistry An In Silico And In Vitro Update

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Phytochemistry: An in-silico and in-vitro Update

Author : Shashank Kumar,Chukwuebuka Egbuna
Publisher : Springer
Page : 575 pages
File Size : 51,6 Mb
Release : 2019-06-25
Category : Science
ISBN : 9789811369209

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Phytochemistry: An in-silico and in-vitro Update by Shashank Kumar,Chukwuebuka Egbuna Pdf

Phytochemistry is the branch of science that deals with the study of plant-derived chemicals or compounds, which are also known as phytochemicals or plant-derived secondary metabolites. Plants are known to produce phytochemicals that are essential for their growth and reproduction, as they protect them from insects, pathogens, and herbivores. Some of the major groups of plant-derived secondary metabolites are phenolics, flavonoids, terpenoids, alkaloids, tannin etc. Plant-derived phytochemicals are pharmacologically active and have the potential to cure various human diseases and disorders. Natural plant products have been known for their medicinal properties for untold years, and form the basis of several medicinal systems such as Chinese, Unani, and Ayurvedic Medicine. This book offers an essential introduction to phytochemicals and their synthetic analogues. It discusses various in silico approaches used to identify pharmacologically active phytochemicals and their biological activities, as well as in vitro and in vivo models/assays that have been utilized for the pharmacological profiling of plant-derived products to combat cancer, diabetes, cardiovascular diseases and neurological disorders. The intended audience includes upper-level undergraduate and graduate students; researchers and scientists from the pharmaceutical/food chemistry/nutrition sciences/biochemistry, and clinical biochemistry fields; and medical students. Sharing the latest findings, the book will familiarize these readers with the concepts, chemistry, and tremendous potential of phytochemistry.

Obesity and Cancer

Author : Shashank Kumar,Sanjay Gupta
Publisher : Springer Nature
Page : 363 pages
File Size : 54,7 Mb
Release : 2021-07-18
Category : Medical
ISBN : 9789811618468

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Obesity and Cancer by Shashank Kumar,Sanjay Gupta Pdf

This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry.

Phytochemistry, Computational Tools, and Databases in Drug Discovery

Author : Chukwuebuka Egbuna,Mithun Rudrapal,Habibu Tijjani
Publisher : Elsevier
Page : 494 pages
File Size : 53,7 Mb
Release : 2022-11-30
Category : Science
ISBN : 9780323907163

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Phytochemistry, Computational Tools, and Databases in Drug Discovery by Chukwuebuka Egbuna,Mithun Rudrapal,Habibu Tijjani Pdf

Phytochemistry, Computational Tools and Databases in Drug Discovery presents the state-of-the-art in computational methods and techniques for drug discovery studies from medicinal plants. Various tools and databases for virtual screening and characterization of plant bioactive compounds and their subsequent predictions on biological targets for the discovery of new drugs against specific diseases are presented, along with computational tools for the prediction of the toxic effects of phytochemicals on living systems. The book also provides in-depth insight on the applications of these computational tools as well as the databases that describe the interactions of phytochemicals with diseases along with predictions for druggable bioactive compounds. Useful for drug developers, medicinal chemists, toxicologists, phytochemists, plant biochemists and analytical chemists, this book clearly presents the various computational techniques, tools and databases for phytochemical research. Provides the various databases, methods and procedures for computational drug discovery in plants Includes insights into the predictors for properties of phytochemicals against different diseases Discusses the applications of computational tools and their databases

Phytochemical Drug Discovery for Central Nervous System Disorders

Author : Chukwuebuka Egbuna,Mithun Rudrapal
Publisher : John Wiley & Sons
Page : 468 pages
File Size : 50,7 Mb
Release : 2023-06-23
Category : Medical
ISBN : 9781119794110

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Phytochemical Drug Discovery for Central Nervous System Disorders by Chukwuebuka Egbuna,Mithun Rudrapal Pdf

PHYTOCHEMICAL DRUG DISCOVERY FOR CENTRAL NERVOUS SYSTEM DISORDERS Understand herbal and plant-based treatments for chronic disorders with this groundbreaking work Due in part to the aging of the global population, disorders of the central nervous system have become an increasingly grave public health concern in recent years. Demand for pharmaceutical treatments has been correspondingly high, but there are many barriers to the successful development of effective synthetic drugs. Phytomedicines, or plant-based and herbal medicines, have proven to be an effective alternative, boasting lower toxicity and cost and higher efficacy, and one that demands greater research and broader-based practitioner knowledge. Phytochemical Drug Discovery for Central Nervous System Disorders meets this demand with a timely, clearly-structured guide. It thorough coverage presents a wide range of phytochemicals with potential as candidates for drug discovery, describing their sources, properties, and therapeutic efficacy. The result is a vital contribution to the ongoing fight against central nervous system (CNS) disorders. Phytochemical Drug Discovery for Central Nervous System Disorders readers will also find: Detailed treatment of CNS-active plant products, neuroprotective chemicals, plant-based nutraceutical products, and more Up-to-date information on FDA-approved drugs and existing plant-based products used to treat CNS disorders An authorial team featuring experts from across the globe Phytochemical Drug Discovery for Central Nervous System Disorders is essential for drug discovery scientists, drug developers, medicinal chemists, biochemists, and any researchers and professionals in the health care or pharmaceutical industries.

Computational Phytochemistry

Author : Satyajit Dey Sarker,Lutfun Nahar
Publisher : Elsevier
Page : 532 pages
File Size : 45,8 Mb
Release : 2024-03-15
Category : Science
ISBN : 9780443161032

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Computational Phytochemistry by Satyajit Dey Sarker,Lutfun Nahar Pdf

Computational Phytochemistry, Second Edition, explores how recent advances in computational techniques and methods have been embraced by phytochemical researchers to enhance many of their operations, refocusing and expanding the possibilities of phytochemical studies. By applying computational aids and mathematical models to extraction, isolation, structure determination, and bioactivity testing, researchers can obtain highly detailed information about phytochemicals and optimize working approaches. This book aims to support and encourage researchers currently working with or looking to incorporate computational methods into their phytochemical work. Topics in this book include computational methods for predicting medicinal properties, optimizing extraction, isolating plant secondary metabolites, and building dereplicated phytochemical libraries. The roles of high-throughput screening, spectral data for structural prediction, plant metabolomics, and biosynthesis are all reviewed before the application of computational aids for assessing bioactivities and virtual screening is discussed. Illustrated with detailed figures and supported by practical examples, this book is an indispensable guide for all those involved with the identification, extraction, and application of active agents from natural products. This new edition captures remarkable advancements in mathematical modeling and computational methods that have been incorporated in phytochemical research, addressing, e.g., extraction, isolation, structure determination, and bioactivity testing of phytochemicals. Includes step-by-step protocols for various computational and mathematical approaches applied to phytochemical research Features clearly illustrated chapters contributed by highly reputable researchers Covers all key areas in phytochemical research, including virtual screening and metabolomics

Functional Foods and Nutraceuticals

Author : Chukwuebuka Egbuna,Genevieve Dable Tupas
Publisher : Springer Nature
Page : 644 pages
File Size : 53,7 Mb
Release : 2020-08-24
Category : Technology & Engineering
ISBN : 9783030423193

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Functional Foods and Nutraceuticals by Chukwuebuka Egbuna,Genevieve Dable Tupas Pdf

Functional foods and nutraceuticals are food products that naturally offer or have been modified to offer additional health benefits beyond basic nutrition. As such products have surged in popularity in recent years, it is crucial that researchers and manufacturers understand the concepts underpinning functional foods and the opportunity they represent to improve human health, reduce healthcare costs, and support economic development worldwide. Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations presents a guide to functional foods from experienced professionals in key institutions around the world. The text provides background information on the health benefits, bioavailability, and safety measurements of functional foods and nutraceuticals. Subsequent chapters detail the bioactive components in functional foods responsible for these health benefits, as well as the different formulations of these products and recent innovations spurred by consumer demands. Authors emphasize product development for increased marketability, taking into account safety issues associated with functional food adulteration and solutions to be found in GMP adherence. Various food preservation methods aimed at enhancing the quality and shelf life of functional food are also highlighted. Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations is the first of its kind, designed to be useful to students, teachers, nutritionists, food scientists, food technologists and public health regulators alike.

Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases

Author : Mala Trivedi,Sachidanand Singh,Parul Johri,Pedro Lopez-Sanchez
Publisher : CRC Press
Page : 225 pages
File Size : 54,9 Mb
Release : 2024-06-03
Category : Medical
ISBN : 9781040034354

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Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases by Mala Trivedi,Sachidanand Singh,Parul Johri,Pedro Lopez-Sanchez Pdf

In today's fast-paced and modern world, our lifestyles have undergone a dramatic shift. The conveniences and comforts that accompany our technological advancements have come at a cost – an increased prevalence of lifestyle diseases. Lack of physical activity, stress, sedentary habits, and poor dietary choices have become leading causes of a spurt in varied health complications such as obesity, diabetes, and cardiovascular diseases. Various health awareness programmes organized by central/state governments, private organizations, and NGOs from time to time have generated interest among common people in exploring organic foods that are free from chemicals and full of nutraceuticals. There has been a growing interest in exploring the potential of nutraceuticals to address lifestyle diseases. Recognizing the urgent need to address this global health crisis, this book delves into a realm of science that offers immense potential for improving our health and well-being. Nutraceuticals, which combine "nutrition" with "pharmaceuticals," offer a promising strategy for treating certain conditions caused by a particular way of life. They include a variety of bioactive substances obtained from plants, including fruits, vegetables, herbs, and marine organisms. Certain substances have therapeutic qualities and have shown significant promise in treating and even preventing certain disorders. Features: The chapters in this book have been meticulously curated to provide readers with a diverse range of perspectives. Provides a comprehensive exploration of nutraceuticals and their potential benefits. Examines the impact of specific nutraceuticals on various lifestyle diseases to discuss their synergistic effects and potential adverse reactions. Each chapter offers valuable insights and practical guidance for healthcare professionals, researchers, and individuals seeking to enhance their overall well-being. A systematic overview of the state-of-the-art in nutraceuticals with recent research results. This book will certainly be a valuable resource for researchers engaged in studies on nutraceuticals to develop a depth of understanding of the latest trends and tools in this field. Additionally, it can serve as a comprehensive textbook for graduate-level courses in food and nutrition, biomedical, and health sciences.

Coronavirus Drug Discovery

Author : Chukwuebuka Egbuna
Publisher : Elsevier
Page : 408 pages
File Size : 48,5 Mb
Release : 2022-07-06
Category : Medical
ISBN : 9780323955799

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Coronavirus Drug Discovery by Chukwuebuka Egbuna Pdf

Coronavirus Drug Discovery, Volume Three: Druggable Targets and In Silico Update presents comprehensive information on drug discovery against COVID-19. Chapters in Part One of this volume describe the various druggable targets and associated signaling pathways for effective targeting of SARS-CoV-2. In Part Two, chapters discuss the various computational approaches and in silico studies against SARS-CoV-2. Written by global team of experts, this book is an excellent resource that will be extremely useful to drug developers, medicinal chemists, pharmaceutical companies in R&D, research institutes in both academia and industry, and the National Library of Medicines and Health. In addition, agencies such as the National Institutes of Health, Centers for Disease Control and Prevention, World Health Organization, European Medicines Agency, the US Food and Drug Administration, and all others involved in drug discovery against COVID-19 will find this book useful. Discusses the pathogenic mechanisms of SARS-CoV-2 and druggable targets Reviews the various signaling pathways associated with SAR-CoV-2 as possible druggable targets Presents computational approaches and in silico studies against SARS-CoV-2

Phytochemicals as Lead Compounds for New Drug Discovery

Author : Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal
Publisher : Elsevier
Page : 382 pages
File Size : 55,9 Mb
Release : 2019-09-07
Category : Science
ISBN : 9780128178911

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Phytochemicals as Lead Compounds for New Drug Discovery by Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal Pdf

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Medicinal Plants, Phytomedicines and Traditional Herbal Remedies for Drug Discovery and Development against COVID-19

Author : Mithun Rudrapal,Chukwuebuka Egbuna
Publisher : Bentham Science Publishers
Page : 254 pages
File Size : 46,8 Mb
Release : 2023-11-05
Category : Medical
ISBN : 9789815049527

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Medicinal Plants, Phytomedicines and Traditional Herbal Remedies for Drug Discovery and Development against COVID-19 by Mithun Rudrapal,Chukwuebuka Egbuna Pdf

This comprehensive reference explores medicinal plants, phytomedicines, and traditional herbal remedies as potential sources for the prevention and treatment of COVID-19. It features 9 chapters authored and edited by renowned experts. The book specifically highlights the promising drug discovery opportunities grounded in bioactive compounds from medicinal plants and herbal medicines, offering insights into combatting SARS-CoV-2 infections and respiratory complications. Key Highlights: Drug Discovery Potential: Explores the vast potential of medicinal plants, phytomedicine, and traditional remedies against COVID-19, shedding light on groundbreaking drug discovery avenues. Cutting-Edge Insights: Provides up-to-date insights into the use of medicinal plants, herbal drugs, and traditional medicines in the fight against COVID-19. Natural Immune Boosters: Details the use of indigenous herbs, spices, functional foods, and herbal drugs for boosting immunity and preventing SARS-CoV-2 infections. Drug Repurposing: Highlights innovative drug repurposing strategies using phytomedicine-derived bioactive compounds and phytochemical databases for COVID-19 drug development. Additional features of the book include a reader-friendly introduction to each topic and a list of references for advanced readers. This timely reference is an informative resource for a broad range of readers interested in strategies to control COVID-19, including postgraduate researchers, and pharmaceutical R&D experts. It also serves as a handbook for professionals in clinical and herbal medicine.

Science of Spices and Culinary Herbs: Volume 3

Author : Atta-ur-Rahman,M. Iqbal Choudhary,Sammer Yousuf
Publisher : Bentham Science Publishers
Page : 213 pages
File Size : 55,9 Mb
Release : 2020-11-19
Category : Medical
ISBN : 9789811468346

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Science of Spices and Culinary Herbs: Volume 3 by Atta-ur-Rahman,M. Iqbal Choudhary,Sammer Yousuf Pdf

Many herbs and spices, in addition to their culinary use for taste, contain chemical compounds which have medicinal uses. For this reason, herbs and spices have been used for treating various ailments since ancient times. Modern scientific methods have enabled researchers to isolate bioactive compounds from herbs and spices and perform chemical analyses, which can be used to develop medicines to treat different diseases. This book series is a compilation of current reviews on studies performed on herbs and spices. Science of Spices and Culinary Herbs is essential reading for medicinal chemists, herbalists and biomedical researchers interested in the science of natural herbs and spices that are common part of regional diets and folk medicine. The third volume of this series features the following reviews: 1. Anthelmintic Properties of Cinnamon for the Control of Agricultural and Public Health Pests 2. Nutraceutical Attributes of Tamarindus indica L. - Devils’ Tree with Sour Date 3. An Overview of the Tamarind (Tamarindus indica L.) Fruit: A Potential source of Nutritional and Health promoting Phytoconstituents 4. The Clinical Overview of Turmeric, Turmeric-based Medicines, and Turmeric Isolates 5. Origanum majorana: The Fragrance of Health 6. Black Pepper (Piper nigrum L.): The King of Spices 7. Coriander: A Herb with Multiple Benefits 8. Flax Seed (Linum usitatissimum) a Potential Functional Food Source.

Essentials of Medicinal and Aromatic Crops

Author : Muhammad Zia-Ul-Haq,Arwa Abdulkreem AL-Huqail,Muhammad Riaz,Umar Farooq Gohar
Publisher : Springer Nature
Page : 1216 pages
File Size : 43,9 Mb
Release : 2023-10-09
Category : Technology & Engineering
ISBN : 9783031354038

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Essentials of Medicinal and Aromatic Crops by Muhammad Zia-Ul-Haq,Arwa Abdulkreem AL-Huqail,Muhammad Riaz,Umar Farooq Gohar Pdf

Medicinal and aromatic crops (MACs) are high-value crops since the natural products obtained from them are low-volume high-value commodities that have numerous applications in various sectors such as the food, beverage, food supplement, flavor and fragrance, perfumery and cosmetics, pharmaceutical and aromatherapy industries. In addition, the plant biomass is used in the production of teas and medical applications in traditional and also modern medicines. MACs are important mainly because they contain plant secondary metabolites such as essential oils, alkaloids, glygosides, saponins, tannins, vitamins and other bioactives. Plant secondary metabolites are differentiated from plant primary metabolites of photosynthesis and respiration since they are directly involved in growth and development of plants. Some MACs are used as spices and culinary herbs since they contain mainly essential oils, and are used as tonic to the digestive system, appetite modification and other systems and may facilitate nutrient uptake and utilization from various foods. A significant amount of MACs and their natural products have also demonstrated antimicrobial, antifungal and bactericidal activity and significant antioxidant capacity. In the past, MACs and their natural products have been used as a source for various medicines, in food and beverage production and in aroma products. Essentials of Medicinal and Aromatic Crops summarizes the current knowledge on medicinal and aromatic crops, including the agronomical practices of important MACs and their products, their beneficial effects and utilization of MAP and their products. The chapters provide a comprehensive guide to the most important and used medicinal and aromatic crops and their use in functional foods, nutraceuticals and as bioactives against various ailments, providing researchers, teachers, chemists, food scientists, agronomists and agroecologists in academia, industry and government a fully up to date singular source on this important topic.

Functionalized Nanomaterials for Cancer Research

Author : Hamed Barabadi,Ebrahim Mostafavi,Chaudhery Mustansar Hussain
Publisher : Elsevier
Page : 771 pages
File Size : 48,8 Mb
Release : 2024-03-29
Category : Science
ISBN : 9780443155192

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Functionalized Nanomaterials for Cancer Research by Hamed Barabadi,Ebrahim Mostafavi,Chaudhery Mustansar Hussain Pdf

Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices presents an in-depth and step by step description of knowledge on functionalized nanomaterials for cancer research, including treatment and future developments as well as their impact on patients’ overall outcomes. The book discusses the functionalized nanoplatforms for cancer detection and imaging, interactions between nanomaterials and cancer cells, and drug resistant malignancies. The chapters are organized in a manner that can be readily adopted as sources for new and further studies by highlighting the main in vitro and in vivo nano-therapeutic achievements on cancer. Additionally, current trends on functionalized nanomaterials for cancer research and commercial scale opportunities are discussed. It is a valuable resource for researchers, oncologists, students, and members of the biomedical and medical fields who want to learn more about the potential of nanotechnology in cancer research and treatment. Provides comprehensive coverage on functionalized nanomaterials for cancer therapeutics and future developments Explores current trends on functionalized nanomaterials for cancer research and commercial scale opportunities Discusses real-world case studies on functionalized nanomaterials for cancer therapy and research

Applications of Nanotechnology in Drug Discovery and Delivery

Author : Chukwuebuka Egbuna,Mihnea-Alexandru Găman,Jaison Jeevanandam
Publisher : Elsevier
Page : 449 pages
File Size : 45,6 Mb
Release : 2022-08-17
Category : Science
ISBN : 9780323859318

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Applications of Nanotechnology in Drug Discovery and Delivery by Chukwuebuka Egbuna,Mihnea-Alexandru Găman,Jaison Jeevanandam Pdf

Applications of Nanotechnology in Drug Discovery and Delivery, in the Drug Discovery Update series, presents complete coverage of the application of nanotechnology in the discovery of new drugs and efficient target delivery of drugs. The book highlights recent advances of nanotechnology applications in the biomedical sciences, starting with chapters that provide the basics of nanotechnology, nanoparticles and nanocarriers. Part II deals with the application of nanotechnology in drug discovery, with an emphasis on enhanced delivery of pharmaceutical products, with Part III discussing toxicological and safety issues arising from the use of nanomaterials. This book brings together a global team of experts, making it an essential resource for researchers, drug developers, medicinal chemists, toxicologists and analytical chemists. Serves as a guide to drug developers working in pharma, biotech and academia, bringing together the latest research on the topic Presents recent information on the use of nanomaterials for the development of drugs using engineered nanocarriers to target specific delivery Features a global team of contributing experts who discuss nanotechnology applications in drug discovery as well as safety issues and challenges

Application of Nano/Microencapsulated Ingredients in Food Products

Author : Anonim
Publisher : Academic Press
Page : 548 pages
File Size : 45,9 Mb
Release : 2020-10-17
Category : Technology & Engineering
ISBN : 9780128165195

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Application of Nano/Microencapsulated Ingredients in Food Products by Anonim Pdf

Application of Nano/Microencapsulated Ingredients in Food Products, a volume in the Nanoencapsulation in the Food Industry series, presents applications of nano/micro-encapsulated ingredients such as vitamins, minerals, flavors, colorants, enzymes, probiotics antioxidants and many other bioactive components in different groups of food products. Each chapter explores nano/microencapsulated ingredients in food products, including beverages, cereal flours and bakery products, meat, oils and fats, salt, spices and seasonings, functional supplements, and in chewing gum. In addition, the book explores active food packaging and edible coatings with nano/microencapsulated ingredients. Authored by a team of global experts in the fields of nano and microencapsulation of food, nutraceutical and pharmaceutical ingredients, this title is of great value to those engaged in the various fields of nanoencapsulation. Clarifies which nanoencapsulated ingredients can be applied for different food products Thoroughly explores the influence of nanoencapsulated ingredients on the qualitative properties of different food products