Practical Aspects Of Ion Trap Mass Spectrometry

Author : Raymond E. March,John F.J Todd
Publisher : CRC Press
Page : 452 pages
File Size : 52,6 Mb
Release : 1995-09-18
Category : Science
ISBN : 0849344522

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Practical Aspects of Ion Trap Mass Spectrometry by Raymond E. March,John F.J Todd Pdf

Fundamentals of Ion Trap Mass Spectrometry presents an account of the development and theory of the quadrupole ion trap and its utilization as an ion storage device, a reactor for ion/molecular reactions, and a mass spectrometer. It also expands the appreciation of ion traps from that of a unique arrangement of electrodes of hyperbolic form (and having a pure quadrupole field) to a series of ion traps having fields with hexapole and octopole components and introduces the practical ion trapping device in which electrode spacing has been increased. The fundamentals of ion trap are covered in four chapters, beginning with the origin of the ion trap, its development and operating principles, and improvements in performance. The second part focuses on the environment within the ion trap -- the movement of ions within the trap -- and how this movement is modified by repeated collisions of the ions with buffer gas atoms of helium, and on the collisions of ions with molecules that lead to chemical change. The critical role of collisions in focusing the ion cloud for subsequent operations is emphasized. This important reference presents a coherent picture of the present status of research in the ion trapping field to facilitate the entree of potential ion trappers and provide a backdrop for ion trap research and development in the future.

Author : Raymond E. March,John F.J. Todd
Publisher : CRC Press
Page : 950 pages
File Size : 46,5 Mb
Release : 2010-05-25
Category : Science
ISBN : 1420083724

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Practical Aspects of Trapped Ion Mass Spectrometry, Volume IV by Raymond E. March,John F.J. Todd Pdf

Reflecting the substantial increase in popularity of quadrupole ion traps and Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers, Practical Aspects of Trapped Ion Mass Spectrometry, Volume IV: Theory and Instrumentation explores the historical origins of the latest advances in this expanding field. It covers new methods for trapping ions, such as the OrbitrapTM, the digital ion trap (DIT), the rectilinear ion trap (RIT), and the toroidal ion trap; the development and application of the quadrupole ion trap (QIT) and the quadrupole linear ion trap (LIT); and the introduction of high-field asymmetric waveform ion mobility spectrometry (FAIMS). After a combined appreciation and historical survey of mass spectrometry and a discussion of how improved capabilities for microfabrication have led to interest in arrays of ion traps, the book examines the theory and practice of the Orbitrap mass analyzer, the rectangular waveform-driven DIT mass spectrometer, FAIMS, and ion traps with circular geometries. It next discusses ion accumulation for increasing sensitivity in FT-ICR spectrometry, a radio frequency-only-mode event for Penning traps in FT MS, and an FT operating mode applied to a 3D-QIT. The text then presents three behavioral aspects of quadrupole rod sets, before illustrating the development of the 3D-QIT in recent years. The final chapters explore photodissociation in ion traps and the chemical and photochemical studies of metal dication complexes in a 3D-QIT. In this volume that spans twenty-one chapters, a stellar panel of leading experts and up-and-coming researchers presents a cohesive, global, and up-to-date view of the practical aspects of using trapped ion devices. A companion to Volume V: Applications of Ion Trapping Devices, the book authoritatively covers the theory involved as well as the instrumentation currently used in this dynamic field.

Author : Raymond E. March,John F.J Todd
Publisher : CRC Press
Page : 542 pages
File Size : 40,8 Mb
Release : 1995-10-23
Category : Science
ISBN : 0849382513

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Practical Aspects of Ion Trap Mass Spectrometry by Raymond E. March,John F.J Todd Pdf

By delivering concentrated information in three different volumes, the editors of the Practical Aspects of Ion Trap Mass Spectrometry mini-series present in-depth reviews on mainstream developments in each active and popular area. Contributing authors provide concise reports illustrating successful approaches to difficult analytical problems across the basic scientific disciplines. Volume three, Chemical, Environmental, and Biomedical Applications, presents a coherent picture of research and applications in the ion trapping field. It examines tandem mass spectrometry, the principal mode of ion trap operation, where one stage of mass selectivity follows another in the same region of space. This volume discusses the fundamentals of ion trap theory, design, and operation; practical ion trap technology; applications involving small molecules; and the environmental and biomedical applications.

Author : Raymond E. March,John F.J Todd
Publisher : CRC Press
Page : 566 pages
File Size : 50,9 Mb
Release : 2016-04-19
Category : Science
ISBN : 1420083740

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Practical Aspects of Trapped Ion Mass Spectrometry, Volume V by Raymond E. March,John F.J Todd Pdf

Widely used in medical research, pharmaceutical and fine chemicals industries, biological and physical sciences, and security and environmental agencies, mass spectrometry techniques are continually under development. In Practical Aspects of Trapped Ion Mass Spectrometry: Volume V, Applications of Ion Trapping Devices, an international panel of authors presents a world-wide view of the practical aspects of recent progress using trapped ion devices. In contrast to previous texts, which have concentrated generally on a single or limited range of ion trapping techniques, a key feature of this compilation of contributions is its coverage of all the ion trapping techniques currently in use. Spanning sixteen chapters, the text examines: Ion/neutral and ion/ion reactions Structural characterization of proteins and peptides using quadrupole ion trap mass spectrometry, Fourier transform – ion cyclotron resonance (FT-ICR) mass spectrometry, and traveling wave ion mobility mass spectrometry Ion spectroscopy and electron diffraction Conformational analysis of protein isobaric charge states Practical examples of trapped-ion technology that reflect the wide diversity of applications of trapped-ion devices This text is the first detailed account of the application of new and established mass spectrometric techniques utilizing trapped or confined ions for prolonged investigation and increased sensitivity. Each chapter contains complete references and utilizes a consistent format and writing style, with all terms, acronyms, procedures, and equations thoroughly explained. The strong editorial input to the diverse sections enables readers to readily appreciate the commonalities of topics ranging from theory of instrument operation to proteins, flavonoids, atomic clocks, and single ion mass spectrometry.

Author : Raymond E. March,John F.J Todd
Publisher : CRC Press
Page : 348 pages
File Size : 49,9 Mb
Release : 1995-09-25
Category : Science
ISBN : 084938253X

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Practical Aspects of Ion Trap Mass Spectrometry by Raymond E. March,John F.J Todd Pdf

By delivering concentrated information in three different volumes, the editors of the Practical Aspects of Ion Trap Mass Spectrometry mini-series present in-depth reviews on mainstream developments in each active and popular area. Contributing authors provide concise reports illustrating successful approaches to difficult analytical problems across the basic scientific disciplines. Ion Trap Instrumentation, the second volume in the series, conveys an appreciation of the ion trap as a versatile instrument which is used successfully in research and in applications, often in tandem with other instruments or components, such as external ion sources and lasers. The book begins with a discussion of high resolution mass spectrometry and mass measurement accuracy. It then demonstrates that trajectories of high kinetic energy ions can be controlled so that such ions are confined. It provides applications of lasers to the study of trapped ions the laser photodissociation of gaseous ions confined within the ion trap. The book concludes with physics applications of the ion trap, in particular, the Penning trap and the Paul trap.

Author : Raymond E. March,John F. J. Todd
Publisher : Unknown
Page : 128 pages
File Size : 41,6 Mb
Release : 1995
Category : Mass spectrometry
ISBN : OCLC:872455945

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Practical Aspects of Ion Trap Mass Spectrometry by Raymond E. March,John F. J. Todd Pdf

Author : Raymond E. March
Publisher : Unknown
Page : 128 pages
File Size : 55,5 Mb
Release : 2010
Category : Electronic
ISBN : OCLC:1073503567

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Practical Aspects of Trapped Ion Mass Spectrometry by Raymond E. March Pdf

Author : Raymond E. March,John F. Todd
Publisher : John Wiley & Sons
Page : 389 pages
File Size : 45,6 Mb
Release : 2005-09-15
Category : Science
ISBN : 9780471717973

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Quadrupole Ion Trap Mass Spectrometry by Raymond E. March,John F. Todd Pdf

A definitive reference, completely updated Published in 1989, the First Edition of this book, originally entitled Quadrupole Storage Mass Spectrometry, quickly became the definitive reference in analytical laboratories worldwide. Revised to reflect scientific and technological advances and new applications in the field, the Second Edition includes new chapters covering: * New ion trap instruments of high sensitivity * Peptide analysis by liquid chromatography/ion trap tandem mass spectrometry * Analytical aspects of ion trap mass spectrometry combined with gas chromatography * Simulation of ion trajectories in the ion trap One additional chapter discusses the Rosetta mission, a "comet chaser" that was sent on a ten-year journey in 2004 to study the comet Churyumov-Gerasimenko using, among other instruments, a GC/MS system incorporating a specially designed ion trap mass spectrometer. This comprehensive reference also includes discussions of the history of the quadrupole ion trap, the theory of quadrupole mass spectrometry, the dynamics of ion-trapping chemistry in the quadrupole ion trap, the cylindrical ion trap, miniature traps, and linear ion traps. Complete with conclusions and references, this primer effectively encapsulates the body of knowledge on quadrupole ion trap mass spectrometry. With its concise descriptions of the theory of ion motion and the principles of operation, Quadrupole Ion Trap Mass Spectrometry, Second Edition is ideal for new users of quadrupole devices, as well as for scientists, researchers, and graduate and post-doctoral students working in analytical laboratories.

Author : Jürgen H Gross
Publisher : Springer Science & Business Media
Page : 534 pages
File Size : 43,5 Mb
Release : 2006-04-05
Category : Science
ISBN : 9783540407393

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Mass Spectrometry by Jürgen H Gross Pdf

Mass Spectrometry is an ideal textbook for students and professionals as well as newcomers to the field. Starting from the very first principles of gas-phase ion chemistry and isotopic properties, the textbook takes the reader through the design of mass analyzers and ionization methods all the way to mass spectral interpretation and coupling techniques. Step-by-step, the reader learns how mass spectrometry works and what it can do. The book comprises a balanced mixture of practice-oriented information and theoretical background. It features a clear layout and a wealth of high-quality figures. Exercises and solutions are located on the Springer Global Web.

Author : Klaus Wanner,Georg Höfner
Publisher : John Wiley & Sons
Page : 460 pages
File Size : 52,8 Mb
Release : 2007-06-27
Category : Science
ISBN : 9783527610914

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Mass Spectrometry in Medicinal Chemistry by Klaus Wanner,Georg Höfner Pdf

This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.

Author : Peter James
Publisher : Springer Science & Business Media
Page : 306 pages
File Size : 42,7 Mb
Release : 2000-10-26
Category : Science
ISBN : 3540672567

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Proteome Research: Mass Spectrometry by Peter James Pdf

Recent advances in large scale DNA sequencing technology have made it possible to sequence the entire genome of an organism. Attention is now turning to the analysis of the product of the genome, the proteome, which is the set of proteins being expressed by a cell. Mass spectrometry is the method of choice for the rapid large-scale identification of these proteomes and their modifications. This is the first book to extensively cover the applications of mass spectrometry to proteome research.

Author : Jehuda Yinon
Publisher : CRC Press
Page : 300 pages
File Size : 51,5 Mb
Release : 2003-12-29
Category : Law
ISBN : 9780203998281

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Advances in Forensic Applications of Mass Spectrometry by Jehuda Yinon Pdf

Recent developments in analytical instrumentation have had an enormous influence on forensic analysis. The mass spectrometer is now an integral part of every forensic laboratory, resulting in greater analytical accuracy, more reliable identification, and lower detection limits. As the instrumental method of choice among forensic analysts, the mass

Author : Peter H. Dawson
Publisher : Elsevier
Page : 372 pages
File Size : 50,9 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483165042

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Quadrupole Mass Spectrometry and Its Applications by Peter H. Dawson Pdf

Quadrupole Mass Spectrometry and Its Applications provides a comprehensive discussion of quadrupoles and their applications. It proceeds from a general explanation of the action of radiofrequency quadrupole fields to the description of their utilization in mass analyzers—such as the quadrupole mass filter, the monopole, the three-dimensional quadrupole ion trap, and various time-of-flight spectrometers—and finally to the characteristic applications of quadrupoles. A multi-author format has been adopted to provide broader-than-usual viewpoint in the book. The book begins by explaining the principles of operation of quadrupole devices. These include ion trajectories and computer simulations of performance; analytical theory; numerical methods of calculation of performance, including the recently developed application of phase-space dynamics; and fringing fields and other field imperfections. Subsequent chapters provide design and performance evaluations of the mass filter, the monopole, ion traps, and time-of-flight instruments; and describe areas of application where quadrupole devices have made the greatest impact because of their particular advantages and disadvantages.

Author : Julian Whitelegge
Publisher : Elsevier
Page : 552 pages
File Size : 44,9 Mb
Release : 2008-10-09
Category : Science
ISBN : 0080932037

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Protein Mass Spectrometry by Julian Whitelegge Pdf

This book is designed to be a central text for young graduate students interested in mass spectrometry as it relates to the study of protein structure and function as well as proteomics. It is a definite must-have work for: - libraries at academic institutions with Master and Graduate programs in biochemistry, molecular biology, structural biology and proteomics - individual laboratories with interests covering these areas - libraries and individual laboratories in the pharmaceutical and biotechnology industries. *Serves as an essential reference to those working in the field *Incorporates the contributions of prominent experts *Features comprehensive coverage and a logical structure

Author : Jürgen H Gross
Publisher : Springer
Page : 968 pages
File Size : 51,6 Mb
Release : 2017-06-13
Category : Science
ISBN : 9783319543987

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Mass Spectrometry by Jürgen H Gross Pdf

This book offers a balanced mixture of practice-oriented information and theoretical background as well as numerous references, clear illustrations, and useful data tables. Problems and solutions are accessible via a special website. This new edition has been completely revised and extended; it now includes three new chapters on tandem mass spectrometry, interfaces for sampling at atmospheric pressure, and inorganic mass spectrometry.