Precision Medicine And The Reinvention Of Human Disease

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Precision Medicine and the Reinvention of Human Disease

Jules J. Berman
Precision Medicine and the Reinvention of Human Disease Book PDF

Author : Jules J. Berman
Publisher : Academic Press
Page : 398 pages
File Size : 45,8 Mb
Release : 2018-01-26
Category : Business & Economics
ISBN : 9780128143940

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Precision Medicine and the Reinvention of Human Disease by Jules J. Berman Pdf

Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Toward Precision Medicine

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Toward Precision Medicine Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publisher : National Academies Press
Page : 142 pages
File Size : 51,7 Mb
Release : 2012-01-16
Category : Medical
ISBN : 9780309222228

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Toward Precision Medicine by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease Pdf

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Evolution's Clinical Guidebook

Jules J. Berman
Evolution s Clinical Guidebook Book PDF

Author : Jules J. Berman
Publisher : Academic Press
Page : 357 pages
File Size : 51,7 Mb
Release : 2019-04-25
Category : Science
ISBN : 9780128171271

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Evolution's Clinical Guidebook by Jules J. Berman Pdf

Evolution's Clinical Guidebook: Translating Ancient Genes into Precision Medicine demonstrates, through well-documented examples, how an understanding of the phylogenetic ancestry of humans allows us to make sense out of the flood of genetic data streaming from modern laboratories and how it can lead us to new ways to prevent, diagnose and treat diseases. Topics cover evolution and human genome, meiosis and other recombinants events, embryology, speciation, phylogeny, rare and common diseases, and the evolution of aging. This book is a valuable source for bioinformaticians and those in the biomedical field who need knowledge, down to gene level, to fully comprehend currently available data. Offers an innovative approach, focusing on how disease-associated pathways evolved Explains how the fields of phylogeny and embryology have become closely tied to the fields of genetics and bioinformatics Demonstrates how students and biomedical professionals can apply the knowledge obtained in this book to the theory and practice of precision medicine

Can Precision Medicine Be Personal; Can Personalized Medicine Be Precise?

Yechiel Michael Barilan,Margherita Brusa,Aaron Ciechanover
Can Precision Medicine Be Personal Can Personalized Medicine Be Precise Book PDF

Author : Yechiel Michael Barilan,Margherita Brusa,Aaron Ciechanover
Publisher : Oxford University Press
Page : 353 pages
File Size : 43,6 Mb
Release : 2022
Category : Medical ethics
ISBN : 9780198863465

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Can Precision Medicine Be Personal; Can Personalized Medicine Be Precise? by Yechiel Michael Barilan,Margherita Brusa,Aaron Ciechanover Pdf

The book provides a multidisciplinary and interdisciplinary discussion of the ethos and ethics of precision / personal medicine, involving scientists who have shaped the field, in dialogue with ethicists, social scientists and philosophers of science.

Genomics and Personalized Medicine

Michael Snyder
Genomics and Personalized Medicine Book PDF

Author : Michael Snyder
Publisher : Oxford University Press
Page : 185 pages
File Size : 53,7 Mb
Release : 2016
Category : Health & Fitness
ISBN : 9780190234768

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Genomics and Personalized Medicine by Michael Snyder Pdf

Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. Elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This book offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As consumers are faced with additional options and more complicated decisions regarding their own health care, Snyder unpacks this sometimes-opaque subject matter into clear and actionable prose. -- from back cover.

Precision Medicine and Artificial Intelligence

Michael Mahler
Precision Medicine and Artificial Intelligence Book PDF

Author : Michael Mahler
Publisher : Academic Press
Page : 300 pages
File Size : 41,7 Mb
Release : 2021-03-12
Category : Science
ISBN : 9780323854320

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Precision Medicine and Artificial Intelligence by Michael Mahler Pdf

Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine

Precision Medicine in Cancers and Non-Communicable Diseases

Debmalya Barh
Precision Medicine in Cancers and Non Communicable Diseases Book PDF

Author : Debmalya Barh
Publisher : CRC Press
Page : 563 pages
File Size : 43,7 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9781351650786

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Precision Medicine in Cancers and Non-Communicable Diseases by Debmalya Barh Pdf

The availability of human genome, large amount of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the era of clinical practice of "Precision Medicine". This book aims to provide a readily available resource on all the important developments achieved so far in the field of oncology. All recent developments have been explained along with epidemiology, technologies and approaches to manage the included diseases. Therefore, readers will get the up to date information on the next-generation approach in tackling all kinds of cancer. Key Features • Presents the latest trend of cancer management based on precision/predictive medicine approach • Reviews the latest and up to date literature in the field of Precision Medicine • Highlights the next generation approach in tackling malignant diseases • Discusses how a life-threatening disease like cancer can be managed with the help of Precision Medicine • Encapsulates a global prospective

Precision Medicine in Clinical Practice

Mandana Hasanzad
Precision Medicine in Clinical Practice Book PDF

Author : Mandana Hasanzad
Publisher : Springer Nature
Page : 259 pages
File Size : 45,5 Mb
Release : 2022-09-30
Category : Medical
ISBN : 9789811950827

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Precision Medicine in Clinical Practice by Mandana Hasanzad Pdf

The book provides complete information on the cornerstones of precision medicine through the omics approach. Clinical applications of genomics and precision medicine have progressed from a theoretical wish list to an impactful force in medical practice.Step-by-step descriptions are provided from basics to the future application and its benefit in clinical practice. Precision medicine aims to personalize health care by tailoring decisions and treatments to each individual in every possible way. Precision medicine includes pharmacogenomics. Essential information is provided on the role of precision medicine and pharmacogenomics in the clinical practice of cancer, cardiovascular disease, diabetes, psychiatric disease, and also the importance for healthcare professionals. This book will assist the practitioners how to integrate precision medicine and pharmacogenomics data into their clinical practice. It is hoped that physicians, pharmacists, and scientists with basic scientific knowledge of precision medicine will findthis book useful.

Tyranny of the Gene

James Tabery
Tyranny of the Gene Book PDF

Author : James Tabery
Publisher : Knopf
Page : 337 pages
File Size : 42,5 Mb
Release : 2023-08-15
Category : Social Science
ISBN : 9780525658207

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Tyranny of the Gene by James Tabery Pdf

A revelatory account of how power, politics, and greed have placed the unfulfilled promise of personalized medicine at the center of American medicine The United States is embarking on a medical revolution. Supporters of personalized, or precision, medicine—the tailoring of health care to our genomes—have promised to usher in a new era of miracle cures. Advocates of this gene-guided health-care practice foresee a future where skyrocketing costs can be curbed by customization and unjust disparities are vanquished by biomedical breakthroughs. Progress, however, has come slowly, and with a price too high for the average citizen. In Tyranny of the Gene, James Tabery exposes the origin story of personalized medicine—essentially a marketing idea dreamed up by pharmaceutical executives—and traces its path from the Human Genome Project to the present, revealing how politicians, influential federal scientists, biotech companies, and drug giants all rallied behind the genetic hype. The result is a medical revolution that privileges the few at the expense of health care that benefits us all. Now American health care, driven by the commercialization of biomedical research, is shifting focus away from the study of the social and environmental determinants of health, such as access to fresh and nutritious food, exposure to toxic chemicals, and stress caused by financial insecurity. Instead, it is increasingly investing in “miracle pills” for leukemia that would bankrupt most users, genetic studies of minoritized populations that ignore structural racism and walk dangerously close to eugenic conclusions, and oncology centers that advertise the perfect gene-drug match, igniting a patient’s hope, and often dashing it later.Tyranny of the Gene sounds a warning cry about the current trajectory of health care and charts a path to a more equitable alternative.

The Personalized Medicine Revolution

Pieter Cullis
The Personalized Medicine Revolution Book PDF

Author : Pieter Cullis
Publisher : Greystone Books Ltd
Page : 168 pages
File Size : 50,8 Mb
Release : 2015
Category : Health & Fitness
ISBN : 9781771640381

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The Personalized Medicine Revolution by Pieter Cullis Pdf

Every one of us is unique. With recent advances in technology, we now know that that statement is more true that ever: we are each individuals, right down to a molecular level ? a one-of-a-kind combination of genes, proteins, and metabolism. So why does healthcare still take a one-size-fits-all approach? The same methods are used on everyone to diagnose illness, and the same drugs are used to treat it ? despite the fact that those methods and treatments are not effective for everyone and are even harmful for some. Shouldn't our medicine be tailored to our differences? The Personalized Medicine Revolution explores recent advances in genomics, the study of the human genome ? as well as its cousins proteomics, metabolomics, microbiomics, and the like ? and explains how technology is even now changing the way medicine is delivered. Along the way, it takes the reader through the five critical healthcare areas that will be transformed most radically by personalized medicine ? prediction, prevention, diagnosis, treatment, and monitoring ? and examines the practical and ethical issues involved. Finally, it details how readers can use personalized medicine to take charge of their own health and build a stronger and safer medical system.

Enabling Precision Medicine

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,Forum on Drug Discovery, Development, and Translation
Enabling Precision Medicine Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Page : 145 pages
File Size : 51,6 Mb
Release : 2017-11-17
Category : Medical
ISBN : 9780309462631

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Enabling Precision Medicine by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,Forum on Drug Discovery, Development, and Translation Pdf

Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development. Participants examined successes, challenges, and possible best practices for effectively using genetic information in the design and implementation of clinical trials to support the development of precision medicines, including exploring the potential advantages and disadvantages of such trials across a variety of disease areas. This publication summarizes the presentations and discussions from the workshop.

Genomics and the Reimagining of Personalized Medicine

Richard Tutton
Genomics and the Reimagining of Personalized Medicine Book PDF

Author : Richard Tutton
Publisher : Routledge
Page : 212 pages
File Size : 44,8 Mb
Release : 2016-04-15
Category : Medical
ISBN : 9781317129394

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Genomics and the Reimagining of Personalized Medicine by Richard Tutton Pdf

Drawing on insights from work in medical history and sociology, this book analyzes changing meanings of personalized medicine over time, from the rise of biomedicine in the twentieth century, to the emergence of pharmacogenomics and personal genomics in the 1990s and 2000s. In the past when doctors championed personalization they did so to emphasize that patients had unique biographies and social experiences in the name of caring for their patients as individuals. However, since the middle of the twentieth century, geneticists have successfully promoted the belief that genes are implicated in why some people develop diseases and why some have adverse reactions to drugs when others do not. In doing so, they claim to offer a new way of personalizing the prediction, prevention and treatment of disease. As this book shows, the genomic reimagining of personalized medicine centres on new forms of capitalization and consumption of genetic information. While genomics promises the ultimate individualization of medicine, the author argues that personalized medicine exists in the imaginative gap between the problems and limits of current scientific practices and future prospects to individualize medical interventions. A rigorous, critical examination of the promises of genomics to transform the economics and delivery of medicine, Genomics and the Reimagining of Personalized Medicine examines the consequences of the shift towards personalization for the way we think about and act on health and disease in society. As such, it will be of interest to scholars and students of the sociology of medicine and health, science and technology studies, and health policy.

Precision Medicine

Hans-Peter Deigner,Matthias Kohl
Precision Medicine Book PDF

Author : Hans-Peter Deigner,Matthias Kohl
Publisher : Academic Press
Page : 376 pages
File Size : 51,5 Mb
Release : 2018-02-15
Category : Medical
ISBN : 9780128054338

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Precision Medicine by Hans-Peter Deigner,Matthias Kohl Pdf

Precision Medicine: Tools and Quantitative Approaches discusses precision and personalized medicine, two relevant topics that are revolutionizing diagnostics and treatment, while also providing a shift toward prevention. The book covers the most relevant features and explanations underlying developments in the field. A timely review on prerequisites, causes and consequences is given. Unique to this book is a combined view on technical and data analysis aspects that is mandatory for obtaining and interpreting results. This book is a valuable source for researchers in medical and life sciences, physicians and students with an interest in this emerging field of precision medicine. Provides technological aspects in precision medicine with aspects of modern statistical and bioinformatics models and methods Brings timely reviews on status and chances in precision medicine and associated aspects of data analysis, statistics and data interpretation Encompasses easy access to relevant approaches, interactions and original literature

Precision Medicine Oncology

Lorna Rodriguez-Rodriguez
Precision Medicine Oncology Book PDF

Author : Lorna Rodriguez-Rodriguez
Publisher : Rutgers University Press
Page : 123 pages
File Size : 40,8 Mb
Release : 2019-09-13
Category : Medical
ISBN : 9780813575872

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Precision Medicine Oncology by Lorna Rodriguez-Rodriguez Pdf

Resource added for the Nursing-Associate Degree 105431, Practical Nursing 315431, and Nursing Assistant 305431 programs.

Relevance of Health Literacy to Precision Medicine

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Roundtable on Health Literacy
Relevance of Health Literacy to Precision Medicine Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Roundtable on Health Literacy
Publisher : National Academies Press
Page : 125 pages
File Size : 53,8 Mb
Release : 2016-12-04
Category : Medical
ISBN : 9780309447324

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Relevance of Health Literacy to Precision Medicine by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Roundtable on Health Literacy Pdf

On January 20, 2015, President Obama announced the Precision Medicine Initiative (PMI) in his State of the Union address. The PMI, by developing new approaches for detecting, measuring, and analyzing a wide range of biomedical information including molecular, genomic, cellular, clinical, behavioral, physiological, and environmental parameters, is intended to enable a new era of medicine in which researchers, providers, and patients work together to develop individualized care. Part of this effort included the creation of a national, large-scale research participant group, or cohort. The PMI Cohort Program is aimed at extending precision medicine to many diseases, including both rare and common diseases such as diabetes, heart disease, Alzheimer's disease, obesity, and mental illnesses such as depression, bipolar disorder, and schizophrenia, by building a national research cohort of 1 million or more U.S. participants. An important challenge to assembling the PMI Cohort will be to reach individuals who are socioeconomically disadvantaged. Individuals who are socioeconomically disadvantaged have lower health literacy; often belong to racial, ethnic, and minority communities; and are often less likely to participate in research studies and biorepositories. To explore possible strategies and messaging designs, the Roundtable on Health Literacy formed an ad hoc committee charged with planning and conducting a 1-day public workshop on the intersection of health literacy and precision medicine. The workshop participants discussed a variety of topics including an overview of precision medicine and its potential, the relevance of health literacy to the success of precision medicine efforts, and perspectives and understanding of different groups, such as health care providers, consumers, and insurers. This publication summarizes the presentations and discussions from the workshop.