Precision Medicine In Gastrointestinal Cancers

Author : Afsaneh Barzi,Norfilza M. Mokhtar,Raja Affendi Raja Ali
Publisher : Frontiers Media SA
Page : 293 pages
File Size : 45,8 Mb
Release : 2023-09-01
Category : Medical
ISBN : 9782832532904

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Precision Medicine in Gastrointestinal Cancers by Afsaneh Barzi,Norfilza M. Mokhtar,Raja Affendi Raja Ali Pdf

Precision medicine is the main emphasis in healthcare after recognizing the importance to integrate the clinical data with the molecular data of a specific disease. The term was first introduced in 2015 in which the Precision Medicine Initiative was initiated with the final aim to provide targeted therapy with high efficacy and less toxicity. Precision medicine plays an increasingly important in gastrointestinal cancers. Gastrointestinal cancers are divided into the upper (esophagus, stomach) and lower part (hepatobiliary and colon) of the gastrointestinal system. We would like to explore the latest era of integrative therapeutic target in gastrointestinal cancers taking into consideration of various aetiologies including genetic and exposome (dietary factors, microbial, hormonal, environmental insults) and their interactions with the host microenvironment.

Author : Vincenzo Canzonieri,Antonio Giordano
Publisher : Springer
Page : 256 pages
File Size : 42,8 Mb
Release : 2019-05-02
Category : Medical
ISBN : 9783030048617

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Gastric Cancer In The Precision Medicine Era by Vincenzo Canzonieri,Antonio Giordano Pdf

Gastric cancer is one of the most common and potentially lethal gastrointestinal malignancy, but it is now at the forefront of modern oncology due to new discoveries. In recent years, the field of gastric cancer has been transformed by many notable developments in both the diagnostic area and the therapeutic strategies. The main aim of the text is to propose a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for oncologists, pathologists, surgeons and researchers with an interest in gastric cancer. The first chapters will review the interplay between pathogens and especially H. pylori, inflammation, genomic instability, and tumorigenesis. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspectives will be illustrated. Two specific chapters will deal with tissue and serum biomarkers with an important role in diagnosis as well as prognostic and predictive markers of response to specific therapy. A central section of the book will focus on treatment options available today for patients. Surgery is the cornerstone of treatment for gastric cancer; however, the prognosis of patients with locally advanced disease is still poor even after curative resection. Therefore, in order to improve the prognosis of patients, especially with advanced stage, a multimodal strategy is advisable and is thoroughly addressed in the appropriate section. With the advent of next-generation sequencing and new preclinical model technologies, the genomic landscape of gastric cancer has been delineated and molecular characterizations finalized to novel therapeutic targets of each molecular subtype have been identified. These advances are making it feasible to integrate clinical and phenotype-based diagnostic and therapeutic methods and are described in a dedicated section. The text will conclude with chapters focusing on the future direction of gastric cancer research in the precision medicine era: an in-depth analysis of non-coding RNAs and their role in gastric cancer, the impact of immunomodulation/immunotherapy and the perspectives of nano-medicine will be finally proposed to the audience. A brief review of the existing literature addressing the above mentioned topics will be present in each chapter. This text will serve as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Author : Enrico Mini,Stefania Nobili
Publisher : Mdpi AG
Page : 136 pages
File Size : 48,9 Mb
Release : 2022-04-12
Category : Medical
ISBN : 3036538089

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Gastrointestinal Cancers and Personalized Medicine by Enrico Mini,Stefania Nobili Pdf

Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50\% will develop recurrent disease despite aggressive treatments. A number of biomarkers currently guide treatment decisions for patients with gastrointestinal neoplasms. Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, furthering oncology along the path to "personalized cancer medicine". Future research efforts will focus on the identification of new biomarkers, moving existing biomarkers into earlier lines of therapy and evaluating new combinations of existing biomarkers and therapies. The aim of this Special Issue is to provide an overview of exciting new research in the area of gastrointestinal tumors that may establish innovative personalized management and precision medicine modalities for individualized care.

Author : Aslam Ejaz,Timothy M. Pawlik
Publisher : Academic Press
Page : 328 pages
File Size : 48,7 Mb
Release : 2022-06-23
Category : Computers
ISBN : 9780323985680

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SPEC - Contemporary Management of Metastatic Colorectal Cancer by Aslam Ejaz,Timothy M. Pawlik Pdf

Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach summarizes current knowledge and provides evidenced-based practice recommendations on how to treat patients with metastatic colorectal cancer. The book presents topics such as pre-operating imaging, the use of molecular markers in treatment decisions, neoadjuvant therapy, synchronous colorectal liver metastasis, and minimally invasive approaches. In addition, it discusses immunotherapy, targeted therapies and survivorship. This is a valuable resource for practitioners, cancer researchers, oncologists, graduate students and members of biomedical research who need to understand more about novel treatments for colorectal cancer metastasis. Summarizes contemporary data in the workup and treatment of patients with metastatic colorectal cancer Discusses novel patient-centric personalized approaches surrounding the management of such cancer types Presents evidenced-based recommendations for precision care among patients with metastatic colorectal cancer

Author : Jia Wei,Baorui Liu
Publisher : Unknown
Page : 227 pages
File Size : 51,9 Mb
Release : 2017
Category : Stomach
ISBN : 9811039798

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Personalized Management of Gastric Cancer by Jia Wei,Baorui Liu Pdf

This book offers essential information on basic and translational research in gastric cancer, while also illustrating potential opportunities for its application in clinical practice. Gastric cancer is the fourth-most-common cancer globally and the second-leading cause of cancer deaths. It is known to be a heterogeneous disease with varied responses to "one-size-fits-all" treatments. Expanding our knowledge of cancer cell genetics may help us to explore more effective treatments in gastric cancer. The research on molecular mechanisms and its clinical applications, both presented here, will help readers gain an in-depth understanding of gastric cancer and its effective treatment. The book's four sections cover personalized medicine, precise regional therapy, immunotherapy and nanomedicine in gastric cancer. Each part presents the state of art, recent advances and the authors' experiences. Moreover, several interesting cases are described to demonstrate how gastric cancer patients benefit from translational research. This informative and attractively presented book on precision treatment in gastric cancer, including experimental findings and clinical treatment options, offers a valuable resource for oncologists and graduate students working in the field of gastric cancer. Jia Wei, MD, PhD, is an associate professor at Nanjing University and the vice director of Clinical Cancer Institute of Nanjing University. She is now working as an oncologist in the Comprehensive Cancer Center, Affiliated Drum Tower Hospital to Medical School of Nanjing University. Baorui Liu, MD, PhD, is a professor at Nanjing University and director of the Clinical Cancer Institute of Nanjing University. He is also the director of the Comprehensive Cancer Center of Drum Tower Hospital.

Author : Brendan Jenkins
Publisher : Academic Press
Page : 372 pages
File Size : 48,6 Mb
Release : 2021-07-17
Category : Science
ISBN : 9780323885546

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Research and Clinical Applications of Targeting Gastric Neoplasms by Brendan Jenkins Pdf

Research and Clinical Applications of Targeting Gastric Neoplasms provides a comprehensive overview of gastrointestinal cancers, covering preclinical research and clinical findings related to risk factors, current treatment regimens (including immunotherapy), screening/detection methods, etiology of disease, precision medicine and future perspectives. Gastrointestinal cancers rank among the most lethal and common worldwide, and as such, there is intense research into their diverse causes and treatment options. This reference provides a consolidation of the research, making it a perfect resource for basic science and clinical researchers as well as oncologists who work in gastroenterology and GI tract cancer fields. Provides comprehensive coverage of preclinical research and the clinical aspects of gastric cancer Presents future perspectives from leading researchers in the field who provide the potential for furthering research topics Combines the expertise of researchers in GI tracts, cancer, immunity, immunology, infectious disease and microbiology for an interdisciplinary approach

Author : Lin Chen,Seon-Young Kim,Haruhiko Sugimura
Publisher : Unknown
Page : 295 pages
File Size : 47,9 Mb
Release : 2017
Category : Stomach
ISBN : 9887784117

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Gastric Cancer Precision Medicine by Lin Chen,Seon-Young Kim,Haruhiko Sugimura Pdf

Author : Zsolt Kovacs,Simona Gurzu,Raluca Ioana Stefan-van Staden,Cornelia Braicu
Publisher : Frontiers Media SA
Page : 682 pages
File Size : 43,9 Mb
Release : 2023-06-05
Category : Medical
ISBN : 9782832526378

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Advanced Molecular Targets in the Diagnosis and Treatment of Gastrointestinal Cancers by Zsolt Kovacs,Simona Gurzu,Raluca Ioana Stefan-van Staden,Cornelia Braicu Pdf

Gastrointestinal cancers are among the most common cancer types, based on the Cancer Genome Atlas. GI cancers are within the most frequent malignancy, with almost 150.000 new cases in 2020. On one hand a big number of researches are focused on the diagnosis, new diagnostic approaches in upper and lower gastrointestinal tract cancers. On the other hand in the last 10 years several papers had been published about the possible therapeutic targets, pointing to precision and personalized medicine.

Author : Franco Dammacco,Franco Silvestris
Publisher : Academic Press
Page : 718 pages
File Size : 51,5 Mb
Release : 2018-10-30
Category : Medical
ISBN : 9780128117866

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Oncogenomics by Franco Dammacco,Franco Silvestris Pdf

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies. Provides clinical oncologists, human geneticists, physicians, and students with a thorough understanding of current diagnostic and prognostic applications of genomic methods and technologies to a variety of solid malignancies Employs current knowledge in oncogenomics towards developing therapeutic interventions for various cancer types Features a team of internationally recognized researchers and physicians in clinical oncology, oncogenomics and precision medicine

Author : Peter Selby
Publisher : EBN Health, an imprint of Evidence-based Networks Ltd
Page : 256 pages
File Size : 41,7 Mb
Release : 2016-11-07
Category : Medical
ISBN : 9781846926532

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Problem Solving through Precision Oncology by Peter Selby Pdf

Winner of the BMA Oncology Book of the Year Award. This practical learning and reference handbook provides an overview of the latest progress in the developing field of precision oncology, plus a ground breaking collection of case studies ("Problems") showing precision oncology in practice. The book includes a clear, readable summary of developments, alongside real-life case studies, providing a valuable update for all involved in the oncology community. The editors lead research and clinical teams at four UK centres of excellence in the field.

Author : Rama Rao Malla,Ganji Purnachandra Nagaraju
Publisher : Academic Press
Page : 320 pages
File Size : 47,5 Mb
Release : 2020-11-06
Category : Science
ISBN : 9780128226926

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A Theranostic and Precision Medicine Approach for Female-Specific Cancers by Rama Rao Malla,Ganji Purnachandra Nagaraju Pdf

A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

Author : Jaffer A. Ajani,Steven A. Curley,Nora A. Janjan,Patrick M. Lynch
Publisher : Springer
Page : 400 pages
File Size : 48,6 Mb
Release : 2007-12-31
Category : Medical
ISBN : 9780387272856

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Gastrointestinal Cancer by Jaffer A. Ajani,Steven A. Curley,Nora A. Janjan,Patrick M. Lynch Pdf

- This clinical guidebook allows for quick, authoritative access to the latest and best multimodality therapies - Includes AJCC staging of gastrointestinal malignancies - Each chapter ends with an up-to-date list of suggested readings and 'key practice points' making it a usefuly at-a-glance reference - Text includes 80 illustrations

Author : Janusz Jankowski,Richard Sampliner,David J. Kerr,Yuman Fong
Publisher : John Wiley & Sons
Page : 752 pages
File Size : 50,8 Mb
Release : 2009-01-26
Category : Medical
ISBN : 9781444300154

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Gastrointestinal Oncology by Janusz Jankowski,Richard Sampliner,David J. Kerr,Yuman Fong Pdf

Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach is the first evidence-based reference text designed for the multidisciplinary team of medical professionals involved in the investigation, diagnosis, and management of patients with gastrointestinal cancer. Written and edited by leading international experts in the field it sets the standard in clinical practice for dealing with esophageal, gastric, intestinal, colonic, hepatobiliary, pancreatic, and other GI tumors. The book is divided into twenty-five clinical chapters each addressing the specific cancers affecting the gastrointestinal tract. Each chapter is written by a team of authors, with each contributor specially chosen to represent a different role in the MDT. This multidisciplinary team approach reflects the current care of GI cancer patients and enables clinical decision making and patient management. All the chapters have been tried and tested in MDT meetings in leading cancer centers around the world. Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach provides in-depth evidence-based knowledge and is well illustrated throughout with color photographs, line drawings, and diagrams. This authoritative and practical resource is an essential reference for the entire MDT including gastroenterologists, hepatologists, GI surgeons, medical oncologists, radiation therapists, interventional radiologists, pathologists, specialist nurses, and clinical scientists.

Author : Sherry X. Yang,Janet E. Dancey
Publisher : CRC Press
Page : 678 pages
File Size : 50,5 Mb
Release : 2021-02-01
Category : Medical
ISBN : 9781000367515

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Handbook of Therapeutic Biomarkers in Cancer by Sherry X. Yang,Janet E. Dancey Pdf

This book provides a comprehensive overview of the fast-evolving subject of clinical application of cancer therapeutic biomarkers. The second edition captures significant progress of cancer immunotherapy and emphasizes the genetic basis for selective cancer treatment. It covers an in-depth insight on biomarkers across a broad area of cancer research and oncology with a wealth of integrated genetic and molecular information about specific therapies by a multidisciplinary team of internationally recognized experts. Each chapter focuses on a class of targeted, immunologic, or chemotherapy agents and their companion biomarkers that predict response, benefit or resistance, and severe adverse event. The book will serve as a handbook for health professionals and scientists on the current applicable biomarkers in the management of cancer. The vision into the systemic classification and statistical consideration of therapeutic biomarkers summarized by the book editors and chapter authors will help advance precision medicine—a precisely tailored cancer treatment strategy for cancer patient care.

Author : James L. Abbruzzese,Douglas B. Evans,Christopher G. Willett,Cecilia Fenoglio-Preiser
Publisher : Oxford University Press
Page : 948 pages
File Size : 42,5 Mb
Release : 2003-10-23
Category : Medical
ISBN : 0199747865

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Gastrointestinal Oncology by James L. Abbruzzese,Douglas B. Evans,Christopher G. Willett,Cecilia Fenoglio-Preiser Pdf

In 74 chapters, Gastrointestinal Oncology brings together a diverse group of specialists to provide the most authoritative, up-to-date and encyclopedic volume currently available on the subject. The first part of this text introduces a series of concepts and topics taht are important to gastrointestinal malignancies in general. These topics include epidemiologic principles, prevention, screening, familial GI cancers, developmental and molecular biology, pathobiology, general therapeutic principles, emerging therapies, and palliative care. The second part of the book covers each of the specific cancers affecting the human gastrointestinal tract. These chapters are introduced by state of the art discussions outlining our current understanding of the pathobiology and molecular biology relevant to each cancer. Subsequent sections describe the multidisciplinary management of specific clinical situations. By organizing the treatment-related chapters around clinical scenarios, the reader will readily find the information necessary to effectively manage the complex clinical situations encountered by patients with gastrointestinal malignancies.