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Author : Travis Thompson,Klaus R. Unna
Publisher : Unknown
Page : 360 pages
File Size : 44,8 Mb
Release : 1977
Category : Medical
ISBN : UOM:39015000865058
Author : Anonim
Publisher : Unknown
Page : 1072 pages
File Size : 43,9 Mb
Release : 1977
Category : Epidemiology
ISBN : UOM:39015007773859
Author : Anonim
Publisher : Unknown
Page : 904 pages
File Size : 52,6 Mb
Release : 1977
Category : Medicine
ISBN : OSU:32436001304516
Author : B. Saletu,P. Berner,L. Hollister
Publisher : Elsevier
Page : 750 pages
File Size : 41,7 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483159775
Neuro-psychopharmacology covers the proceedings of the 11th Congress of the Collegium Internationale Neuro-psychopharmacologicum, held in Vienna on July 9-14, 1978. The book focuses on the processes, methodologies, and approaches in neuropsychopharmacology. The selection first offers information on the long-lasting effects of electroconvulsive therapy (ECT) on monoaminergic mechanisms and enhanced monoamine behavioral responses following repeated electroconvulsive shock to rats and their relevance to ECT. The book also underscores the ECT effects on mineral metabolism and neuroendocrine function. The publication reviews the genetic components in the mechanism of action of lithium; genetics and lithium ion metabolism in affective disorders; and pharmacogenetics and the pharmacologic challenge strategy in clinical research. The text also examines the influence of peptides in affective disorders and HLA antigens in affective disorders and cycloid psychoses. Discussions also focus on the biological and clinical basis of the therapeutic effects of benzodiazepines; effects of benzodiazepines on the electrical activity of the central nervous system; and diazepam metabolism in healthy subjects and patients with heart failure, renal failure, and hepatic cirrhosis. The selection is a dependable reference for readers interested in neuropsychopharmacology.
Author : Michael A. Bozarth
Publisher : Springer Science & Business Media
Page : 658 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461248125
Methods of Assessing the Reinforcing Properties of Abused Drugs presents a synopsis of the preclinical procedures used to assess drug reinforcement. Researchers using one technique are provided with an overview of the other available methods, and clinicians who wish to evaluate drug abuse research reports can gain the necessary background from this volume. Although emphasis is placed on the methodological aspects of assessing drug reinforcement, some of the scientific conclusions derived from using these techniques are also presented. This edited collection offers a lasting framework for interpreting the results of current experimental findings.
Author : Library of Congress. Copyright Office
Publisher : Copyright Office, Library of Congress
Page : 1914 pages
File Size : 53,9 Mb
Release : 1979
Category : Copyright
ISBN : STANFORD:36105119498405
Author : Ali S. Faqi
Publisher : Elsevier
Page : 1074 pages
File Size : 51,5 Mb
Release : 2024-02-11
Category : Medical
ISBN : 9780323984621
A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy Includes the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology
Author : Committee on Problems of Drug Dependence (U.S.). Scientific Meeting
Publisher : Unknown
Page : 570 pages
File Size : 51,6 Mb
Release : 1983
Category : Drug abuse
ISBN : PURD:32754081425948
Author : Anonim
Publisher : Unknown
Page : 804 pages
File Size : 45,6 Mb
Release : 1976
Category : Drug abuse
ISBN : COLUMBIA:HR01828576
Author : Marian W. Fischman,Nancy K. Mello
Publisher : Unknown
Page : 420 pages
File Size : 46,6 Mb
Release : 1989
Category : Drug abuse
ISBN : MINN:31951D00426555C
Representatives from industry, academia and government discuss issues related to testing for drug abuse liability and dependence potential. Contributors critically assess current methods for evaluating drugs in human subjects and describe both the advantages and limitations of each approach. This information permits identification of areas in which further research and development are needed.
Author : Ali S. Faqi
Publisher : Academic Press
Page : 904 pages
File Size : 55,7 Mb
Release : 2012-11-02
Category : Business & Economics
ISBN : 9780123878151
A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics --
Author : Anonim
Publisher : Unknown
Page : 441 pages
File Size : 45,7 Mb
Release : 1981
Category : Drug abuse
ISBN : PURD:32754081640256
Author : Anonim
Publisher : Unknown
Page : 570 pages
File Size : 49,6 Mb
Release : 1981
Category : Drug abuse
ISBN : MINN:31951P01093402I
Author : D.E. Smith,D.R. Wesson
Publisher : Springer Science & Business Media
Page : 303 pages
File Size : 42,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400948860
Author : Carrie Markgraf,Thomas Hudzik,David Compton
Publisher : Academic Press
Page : 320 pages
File Size : 48,8 Mb
Release : 2015-07-14
Category : Medical
ISBN : 9780124202160
Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy