Preserving The Promise

Author : Scott Dessain,Scott E. Fishman
Publisher : Academic Press
Page : 276 pages
File Size : 54,9 Mb
Release : 2016-10-05
Category : Medical
ISBN : 9780128092095

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Preserving the Promise by Scott Dessain,Scott E. Fishman Pdf

Preserving the Promise: Improving the Culture of Biotech Investment critically examines why most biotech startups fail, as they emerge from universities into an ecosystem that inhibits rather than encourages innovation. This "Valley of Death" squanders our public investments in medical research and with them, the promise of longer and healthier lives. The authors explicate the Translation Gap faced by early stage biotech companies, the result of problematic technology transfer and investment practices, and provide specific prescriptions for improving translation of important discoveries into safe and effective therapies. In Preserving the Promise, Dessain and Fishman build on their collective experience as company founders, healthcare investor (Fishman) and physician/scientist (Dessain). The book offers a forward-looking, critical analysis of "conventional wisdom" that encumbers commercialization practices. It exposes the self-defeating habits of drug development in the Valley of Death, that waste money and extinguish innovative technologies through distorted financial incentives. Explains why translation of biotech discovery into medicine succeeds so infrequently that it’s been dubbed the Valley of Death Uncovers specific decision-making strategies that more effectively align incentives, improving clinical and financial outcomes for investors, inventor/entrepreneurs, and patients Examines the critical, early stages of commercialization, where technology transfer offices and Angels act as gatekeepers to development, and where tension between short-term financial and long-term clinical aspirations sinks important technologies Deconstructs the forces driving biotech, recasts them in a proven conceptual framework, and offers practical guidance for making the system better

Author : United States. Congress. Senate. Special Committee on Aging
Publisher : Unknown
Page : 64 pages
File Size : 40,8 Mb
Release : 2011
Category : Medical
ISBN : UCSD:31822038350245

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Protecting the Promise to Our Seniors by United States. Congress. Senate. Special Committee on Aging Pdf

Author : Christopher McKnight Nichols
Publisher : Harvard University Press
Page : 463 pages
File Size : 53,9 Mb
Release : 2011-08-11
Category : History
ISBN : 9780674061187

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Promise and Peril by Christopher McKnight Nichols Pdf

Spreading democracy abroad or protecting business at home: this book offers a new look at the history of the contest between isolationalism and internationalism that is as current as the wars in Iraq and Afghanistan and as old as America itself, with profiles of the people, policies, and events that shaped the debate.

Author : Douglas W. Portmore
Publisher : Oxford University Press
Page : 656 pages
File Size : 48,7 Mb
Release : 2020-09-17
Category : Philosophy
ISBN : 9780190905330

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The Oxford Handbook of Consequentialism by Douglas W. Portmore Pdf

Consequentialism is a major moral theory in contemporary philosophy: it is the view that the only thing that matters when making moral decisions is the outcome of those decisions. Consequentialists hold that to morally assess an act, we must first evaluate and rank the various ways that things could turn out depending on whether it or some alternative act is performed. Whether we should perform that act thus depends on how its outcome ranks relative to those of its alternatives. Consequentialism rivals deontology, contractualism, and virtue ethics, but, more importantly, it has influenced contemporary moral philosophy such that the consequentialist/non-consequentialist distinction is one of the most central in normative ethics. After all, every plausible moral theory must concede that the goodness of an act's consequences is something that matters, even if it's not the only thing that matters. Thus, all plausible moral theories will accept that both 1) an act's producing good consequences constitutes a moral reason to perform it, and 2) the better its consequences, the more of a moral reason there is to perform it. In this way, much of consequentialist ethical theory is important for normative ethics in general. This Oxford Handbook contains thirty-two previously unpublished contributions by top moral philosophers examining the current state of play in consequentialism and pointing to new directions for future research. The volume is organized into four major sections: foundational issues; objections to consequentialism; its forms and limits; and consequentialism's implications for policy, practice, and social reform.

Author : Al Checchi
Publisher : Open Road Media
Page : 324 pages
File Size : 49,5 Mb
Release : 2011-08-30
Category : Business & Economics
ISBN : 9781453221013

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The Change Maker by Al Checchi Pdf

Entertaining, fast-paced, instructional, The Change Maker is not only a memoir, but a blueprint for how we can change our own lives, as well as the world around us, by providing personal lessons in the values of strategic thinking and responsible leadership. Through compelling true stories, both humorous and serious, Al Checchi demonstrates that through experience, vision, and courage, one person can make a difference and lead others to move beyond their comfort zones and transform our institutions. Al Checchi, a remarkable change maker, chronicles how his creativity, strategic thinking, and negotiating skills helped transform three major American institutions—Marriott Corporation, Walt Disney, and Northwest Airlines—and led him to challenge the California political establishment as a candidate for governor. Peppered with excerpts from speeches and articles, The Change Maker offers thoughtful perspective on institutional change in America since the 1960s, and scalding commentary on the current state of our public and private institutions, political parties, the emergent political class, and the economic policies and leadership of today’s administration. The Change Maker challenges us to confront the status quo and demand accountability and a restoration of the fiduciary standards that are so vital to reclaiming and maintaining America's position of economic and political leadership. Readers will finish the book feeling revitalized, hopeful, and armed with new ideas on how change can, and always will, occur.

Author : Ed Schroeder
Publisher : Fortress Press
Page : 230 pages
File Size : 48,7 Mb
Release : 2016-08-01
Category : Religion
ISBN : 9781506410692

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Gift and Promise by Ed Schroeder Pdf

Gift and Promise shows that the theology of the Augsburg Confession is as much a gift to the world today as it was when first presented in 1530. Building on a book started by Ed Schroeder (three chapters are presented in the first part), nine of his students present the theology of the Augsburg Confession in language that makes it accessible to those without a scholarly background, including pastors, students, and lay people interested in Lutheran history and theology. Gift and Promise establishes the theological “hub” of the Augsburg Confession—what the Confession itself calls the “central teaching of the Christian faith” —in the doctrine of justification by faith alone. That hub is traced to its source in Luther’s theology of the cross. Each chapter presents how that central hub is articulated in the articles of faith that comprise the Ausgburg Confession. Lucid, powerful, and insightful, the expositions in this volume are written by expert theologians, historians, and scholars who aim to present the crucial and practical message of the Christian life in the Augsburg Confession for all.

Author : David Pepper,Frank Webster,George Revill
Publisher : Taylor & Francis
Page : 456 pages
File Size : 47,9 Mb
Release : 2003
Category : Nature
ISBN : 0415206235

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Environmentalism by David Pepper,Frank Webster,George Revill Pdf

Author : The Gardeners and Farmers of Centre Terre Vivante
Publisher : Chelsea Green Publishing
Page : 226 pages
File Size : 48,7 Mb
Release : 2007-04-04
Category : Cooking
ISBN : 9781933392592

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Preserving Food Without Freezing Or Canning by The Gardeners and Farmers of Centre Terre Vivante Pdf

Translation of: Conserves naturelles des quatre saisons.

Author : Howard Sutherland
Publisher : Unknown
Page : 36 pages
File Size : 50,5 Mb
Release : 2015-07-01
Category : Self-Help
ISBN : 1330533879

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The Promise of Life (Classic Reprint) by Howard Sutherland Pdf

Excerpt from The Promise of Life These are days of stress and of endeavor, when in the pursuit of the material, one is apt to forget that another life shall follow this as surely as night the day, gentler Spring the stern and uncompromising Winter. Let there be no question in our minds as to this. Let us not permit the metaphysician to cloud the issue, nor the scientist to clothe it with doubt. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

Author : Martin Heidegger
Publisher : John Wiley & Sons
Page : 131 pages
File Size : 50,5 Mb
Release : 2022-11-29
Category : Philosophy
ISBN : 9781509536009

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On the Essence of Language and the Question of Art by Martin Heidegger Pdf

The texts and notes collected in this volume offer unique insight into the development of Heidegger’s thinking on language and art from the late 1930s to the early 1950s – a tumultuous period both for Heidegger personally and for Germany as a whole. Following Germany’s defeat in World War II, Heidegger was banned from teaching at Freiburg University, where he had been a professor since 1928, and his thinking underwent significant changes as he began to cultivate different modes of silence and non-saying in his philosophy of language. This volume illuminates these shifts and charts the evolution of key terms in Heidegger’s philosophy of language during this key period in the development of his thought. The central theme of Heidegger’s reflections on language in this volume is his repeated engagement with the character of the word, silence and the unsaid, and his rejection of the instrumental conception of language, where he instead prioritized conversation as the “homeland of language.” Alongside references to Hölderlin and von Hofmannsthal and shrewd scrutiny of aural phenomena such as silent thought and speechlessness, speech is demonstrated to be intimately connected to the human essence. In a later section, Heidegger examines the place of art, in particular the plastic arts, and the role of the artist in conjunction with the new industrial landscape and architecture of his time, and in juxtaposition with ancient Greek attitudes to space and the polis. This key work by Heidegger, now available in English for the first time, will be of great interest to students and scholars of philosophy and to anyone interested in Heidegger’s thought.

Author : Anonim
Publisher : Unknown
Page : 478 pages
File Size : 40,9 Mb
Release : 1968
Category : Forest products
ISBN : UOM:39015069903766

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U.S.D.A. Forest Service Research Paper FPL. by Anonim Pdf

Author : Herbert Lockyer
Publisher : Zondervan
Page : 356 pages
File Size : 46,7 Mb
Release : 2017-06-06
Category : Religion
ISBN : 9780310537571

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All the Promises of the Bible by Herbert Lockyer Pdf

Promises You Can Stand On Through Thick and Thin The Bible is filled with hundreds of what the apostle Peter called "exceeding great and precious promises": definite, explicit declarations God has made that you can count on. In All the Promises of the Bible, Dr. Herbert Lockyer discusses the nature of God’s promises - their substance, simplicity, surety, source, security, scope. Lockyer’s in-depth look at the scope of God’s promises arranges them in categories that cover the full array of human concerns, from the spiritual to the material and the corporate to the personal. As you come to understand God’s promises and how they apply to every aspect of your life, you’ll gain a trust in God that will sustain you through the worst of times and be your source of rejoicing in the best. X

Author : M. Boyd Gillespie,Rohan R. Walvekar,Barry M. Schaitkin,David W. Eisele
Publisher : Springer
Page : 267 pages
File Size : 41,7 Mb
Release : 2018-02-05
Category : Medical
ISBN : 9783319583358

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Gland-Preserving Salivary Surgery by M. Boyd Gillespie,Rohan R. Walvekar,Barry M. Schaitkin,David W. Eisele Pdf

Salivary Endoscopy is a rapidly emerging field that has revolutionized the management of non-neoplastic diseases of the salivary gland, such as salivary stones, sialadenitis, and salivary duct stenosis. With the emergence of endoscopic access to the salivary ductal system, several procedural and technical innovations have emerged that have now permitted gland preservation surgery for these pathologies. As more centers and physicians are adopting this rapidly emerging and evolving procedure, there is a need for source of literature that provides current concepts and detailed technical descriptions of the procedures that involve gland preservation surgery. This text intends to capture the current concepts among experts and in literature regarding the management of non-neoplastic salivary gland diseases. The book also focuses on steps of surgical management and technical pearls while providing detailed information on the decision-making process when emcompassing the diversity of clinical presentation, intra-operative decision-making and post op care. Gland Preservation Surgery provides high quality illustrations, clinical and operative images, and videos that serve as an online resource to salivary gland surgeons and endoscopists with varying experience and expertise. ​

Author : Vannetta Chapman
Publisher : Harvest House Publishers
Page : 308 pages
File Size : 44,5 Mb
Release : 2012-07-01
Category : Fiction
ISBN : 9780736946131

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A Promise for Miriam by Vannetta Chapman Pdf

A Promise for Miriam, the first book in a brand-new romantic series from popular author Vannetta Chapman, introduces the Amish community of Pebble Creek and some of the kind, caring people there. As they face challenges to their community from the English world, they come together to reach out to their non-Amish neighbors while still preserving their cherished Plain ways. Amish schoolteacher Miriam King loves her students. At 26, most women her age are married with children of their own, but she hasn’t yet met anyone who can convince her to give up the Plain school that sits along the banks of Pebble Creek. Then newcomer Gabriel Miller steps into her life, bringing his daughter, an air of mystery, and challenges Miriam has never faced before. Will Gabe be able to let go of the past that haunts him? He thinks he just wants to be left alone, but the loving and warm community he and his daughter have moved to has other plans for him. After a near tragedy is averted, he hesitantly returns offers of help and friendship, and he discovers he can make a difference to the people of Pebble Creek—and maybe find love again.

Author : Michael Beck
Publisher : Wipf and Stock Publishers
Page : 331 pages
File Size : 42,7 Mb
Release : 2023-02-02
Category : Religion
ISBN : 9781666737578

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Covenant Lord and Cultic Boundary by Michael Beck Pdf

The Reformed Two-Kingdom project has generated a great deal of literature. However, this literature is often characterized by inflamed rhetoric. Further, though it is standard fare to assume that Kline was the architect of the project, in reality, there has been very little scholarly examination of this point. In response, Kline’s system is analyzed through the means of a dialectical discourse with three differing models within the Reformed tradition—the Theonomist, Perspectivalist, and Dooyeweerdian schools. Through this means, the study keeps away from surface-level polemics and instead directs readers to the critically important substructural level of current discussions. While clarifying some of the key differences between Kline and his interlocutors, often-overlooked points of nuance are also highlighted. These points are shown to be important in that they present the potential to lessen frustration and impasse in the ongoing dialogue.