Primer Of Genetic Analysis

Author : James N. Thompson, Jr,Jenna J. Hellack,Gerald Braver,David S. Durica
Publisher : Cambridge University Press
Page : 488 pages
File Size : 54,7 Mb
Release : 2007-10-01
Category : Science
ISBN : 9781139465649

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Primer of Genetic Analysis by James N. Thompson, Jr,Jenna J. Hellack,Gerald Braver,David S. Durica Pdf

An invaluable student-tested study aid, this primer, first published in 2007, provides guided instruction for the analysis and interpretation of genetic principles and practice in problem solving. Each section is introduced with a summary of useful hints for problem solving and an overview of the topic with key terms. A series of problems, generally progressing from simple to more complex, then allows students to test their understanding of the material. Each question and answer is accompanied by detailed explanation. This third edition includes additional problems in basic areas that often challenge students, extended coverage in molecular biology and development, an expanded glossary of terms, and updated historical landmarks. Students at all levels, from beginning biologists and premedical students to graduates seeking a review of basic genetics, will find this book a valuable aid. It will complement the formal presentation in any genetics textbook or stand alone as a self-paced review manual.

Author : Thompson James N.,Hellack Jenna J.,Braver Gerald,Durica David S.
Publisher : Unknown
Page : 312 pages
File Size : 46,6 Mb
Release : 2003
Category : Electronic
ISBN : OCLC:772507900

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Primer of Genetic Analysis by Thompson James N.,Hellack Jenna J.,Braver Gerald,Durica David S. Pdf

Author : J. N. Thompson
Publisher : Unknown
Page : 128 pages
File Size : 50,8 Mb
Release : 1987
Category : Electronic
ISBN : OCLC:721609149

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Primer of Genetic Analysis: A Problems Approach by J. N. Thompson Pdf

Author : James N. Thompson
Publisher : Cambridge University Press
Page : 292 pages
File Size : 48,6 Mb
Release : 1997
Category : Science
ISBN : 052147891X

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Primer of Genetic Analysis by James N. Thompson Pdf

A student-tested study aid, this primer provides guided instruction to the analysis and interpretation of genetic principles and problem solving.

Author : Jenna J. Hellack,James N. Thompson, Jr,Gerald Braver
Publisher : Cambridge University Press
Page : 188 pages
File Size : 41,5 Mb
Release : 1987-03-27
Category : Science
ISBN : 0521331781

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Primer of Genetic Analysis by Jenna J. Hellack,James N. Thompson, Jr,Gerald Braver Pdf

"An invaluable student-tested study aid, this primer provides guided instruction for the analysis and interpretation of genetic principles and practice in problem solving. Each section is introduced with a summary of useful hints for problem solving and an overview of the topic with key terms. A series of problems, generally progressing from simple to more complex, then allows students to test their understanding of the material. Each question and answer pair is provided with a detailed explanation." "This new edition includes additional problems in basic areas that often challenge students, extended coverage in molecular biology and development, an expanded glossary of terms, and updated historical landmarks." "Students at all levels, from beginning biologists and premedical students to graduates seeking a review of basic genetics, will find this book to be a valuable aid. It will complement the formal presentation in any genetics textbook or can stand alone as a self-paced review manual."--BOOK JACKET.

Author : Michael R. Barnes
Publisher : John Wiley & Sons
Page : 576 pages
File Size : 42,8 Mb
Release : 2007-03-13
Category : Science
ISBN : 9780470059173

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Bioinformatics for Geneticists by Michael R. Barnes Pdf

Praise from the reviews: "Without reservation, I endorse this text as the best resource I've encountered that neatly introduces and summarizes many points I've learned through years of experience. The gems of truth found in this book will serve well those who wish to apply bioinformatics in their daily work, as well as help them advise others in this capacity." CIRCGENETICS "This book may really help to get geneticists and bioinformaticians on 'speaking-terms'... contains some essential reading for almost any person working in the field of molecular genetics." EUROPEAN JOURNAL OF HUMAN GENETICS "... an excellent resource... this book should ensure that any researcher's skill base is maintained." GENETICAL RESEARCH “... one of the best available and most accessible texts on bioinformatics and genetics in the postgenome age... The writing is clear, with succinct subsections within each chapter....Without reservation, I endorse this text as the best resource I’ve encountered that neatly introduces and summarizes many points I’ve learned through years of experience. The gems of truth found in this book will serve well those who wish to apply bioinformatics in their daily work, as well as help them advise others in this capacity.” CIRCULATION: CARDIOVASCULAR GENETICS A fully revised version of the successful First Edition, this one-stop reference book enables all geneticists to improve the efficiency of their research. The study of human genetics is moving into a challenging new era. New technologies and data resources such as the HapMap are enabling genome-wide studies, which could potentially identify most common genetic determinants of human health, disease and drug response. With these tremendous new data resources at hand, more than ever care is required in their use. Faced with the sheer volume of genetics and genomic data, bioinformatics is essential to avoid drowning true signal in noise. Considering these challenges, Bioinformatics for Geneticists, Second Edition works at multiple levels: firstly, for the occasional user who simply wants to extract or analyse specific data; secondly, at the level of the advanced user providing explanations of how and why a tool works and how it can be used to greatest effect. Finally experts from fields allied to genetics give insight into the best genomics tools and data to enhance a genetic experiment. Hallmark Features of the Second Edition: Illustrates the value of bioinformatics as a constantly evolving avenue into novel approaches to study genetics The only book specifically addressing the bioinformatics needs of geneticists More than 50% of chapters are completely new contributions Dramatically revised content in core areas of gene and genomic characterisation, pathway analysis, SNP functional analysis and statistical genetics Focused on freely available tools and web-based approaches to bioinformatics analysis, suitable for novices and experienced researchers alike Bioinformatics for Geneticists, Second Edition describes the key bioinformatics and genetic analysis processes that are needed to identify human genetic determinants. The book is based upon the combined practical experience of domain experts from academic and industrial research environments and is of interest to a broad audience, including students, researchers and clinicians working in the human genetics domain.

Author : Michael R. Barnes,Ian C. Gray
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 42,6 Mb
Release : 2003-07-01
Category : Science
ISBN : 9780470862193

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Bioinformatics for Geneticists by Michael R. Barnes,Ian C. Gray Pdf

This timely book illustrates the value of bioinformatics, not simply as a set of tools but rather as a science increasingly essential to navigate and manage the host of information generated by genomics and the availability of completely sequenced genomes. Bioinformatics can be used at all stages of genetics research: to improve study design, to assist in candidate gene identification, to aid data interpretation and management and to shed light on the molecular pathology of disease-causing mutations. Written specifically for geneticists, this book explains the relevance of bioinformatics showing how it may be used to enhance genetic data mining and markedly improve genetic analysis.

Author : Asher D. Cutter
Publisher : Oxford University Press, USA
Page : 266 pages
File Size : 52,5 Mb
Release : 2019
Category : Science
ISBN : 9780198838944

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A Primer of Molecular Population Genetics by Asher D. Cutter Pdf

What are the genomic signatures of adaptations in DNA? How often does natural selection dictate changes to DNA? How does the ebb and flow in the abundance of individuals over time get marked onto chromosomes to record genetic history? Molecular population genetics seeks to answer such questions by explaining genetic variation and molecular evolution from micro-evolutionary principles. It provides a way to learn about how evolution works and how it shapes species by incorporating molecular details of DNA as the heritable material. It enables us to understand the logic of how mutations originate, change in abundance in populations, and become fixed as DNA sequence divergence between species. With the revolutionary advances in genomic data acquisition, understanding molecular population genetics is now a fundamental requirement for today's life scientists. These concepts apply in analysis of personal genomics, genome-wide association studies, landscape and conservation genetics, forensics, molecular anthropology, and selection scans. This book introduces, in an accessible way, the bare essentials of the theory and practice of molecular population genetics.

Author : Melinda C. Mills,Nicola Barban,Felix C. Tropf
Publisher : MIT Press
Page : 433 pages
File Size : 48,5 Mb
Release : 2020-02-18
Category : Science
ISBN : 9780262357449

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An Introduction to Statistical Genetic Data Analysis by Melinda C. Mills,Nicola Barban,Felix C. Tropf Pdf

A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.

Author : Cedric Gondro
Publisher : Springer
Page : 270 pages
File Size : 49,9 Mb
Release : 2015-05-18
Category : Medical
ISBN : 9783319144757

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Primer to Analysis of Genomic Data Using R by Cedric Gondro Pdf

Through this book, researchers and students will learn to use R for analysis of large-scale genomic data and how to create routines to automate analytical steps. The philosophy behind the book is to start with real world raw datasets and perform all the analytical steps needed to reach final results. Though theory plays an important role, this is a practical book for graduate and undergraduate courses in bioinformatics and genomic analysis or for use in lab sessions. How to handle and manage high-throughput genomic data, create automated workflows and speed up analyses in R is also taught. A wide range of R packages useful for working with genomic data are illustrated with practical examples. The key topics covered are association studies, genomic prediction, estimation of population genetic parameters and diversity, gene expression analysis, functional annotation of results using publically available databases and how to work efficiently in R with large genomic datasets. Important principles are demonstrated and illustrated through engaging examples which invite the reader to work with the provided datasets. Some methods that are discussed in this volume include: signatures of selection, population parameters (LD, FST, FIS, etc); use of a genomic relationship matrix for population diversity studies; use of SNP data for parentage testing; snpBLUP and gBLUP for genomic prediction. Step-by-step, all the R code required for a genome-wide association study is shown: starting from raw SNP data, how to build databases to handle and manage the data, quality control and filtering measures, association testing and evaluation of results, through to identification and functional annotation of candidate genes. Similarly, gene expression analyses are shown using microarray and RNAseq data. At a time when genomic data is decidedly big, the skills from this book are critical. In recent years R has become the de facto tool for analysis of gene expression data, in addition to its prominent role in analysis of genomic data. Benefits to using R include the integrated development environment for analysis, flexibility and control of the analytic workflow. Included topics are core components of advanced undergraduate and graduate classes in bioinformatics, genomics and statistical genetics. This book is also designed to be used by students in computer science and statistics who want to learn the practical aspects of genomic analysis without delving into algorithmic details. The datasets used throughout the book may be downloaded from the publisher’s website.

Author : Jeffrey K. Conner,Daniel L. Hartl
Publisher : Sinauer Associates Incorporated
Page : 304 pages
File Size : 46,9 Mb
Release : 2004-01
Category : Science
ISBN : 087893202X

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A Primer of Ecological Genetics by Jeffrey K. Conner,Daniel L. Hartl Pdf

This book covers basic concepts in population and quantitative genetics, including measuring selection on phenotypic traits. The emphasis is on material applicable to field studies of evolution focusing on ecologically important traits. Topics addressed are critical for training students in ecology, evolution, conservation biology, agriculture, forestry, and wildlife management. Many texts in this field are too complex and mathematical to allow the average beginning student to readily grasp the key concepts. A Primer of Ecological Genetics, in contrast, employs mathematics and statistics-fully explained, but at a less advanced level-as tools to improve understanding of biological principles. The main goal is to enable students to understand the concepts well enough that they can gain entry into the primary literature. Integration of the different chapters of the book shows students how diverse concepts relate to each other.

Author : Greg Gibson
Publisher : Sinauer
Page : 0 pages
File Size : 48,8 Mb
Release : 2015-04-27
Category : Medical
ISBN : 1605353132

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A Primer of Human Genetics by Greg Gibson Pdf

A Primer of Human Genetics is an introductory textbook designed to give students the foundation they need to understand and appreciate the extraordinary shifts in human genetics that have accompanied the arrival of genomics. The book lays out the key concepts of human evolution, quantitative genetics, and personalized medicine before describing the tools that are missing from most contemporary textbooks: genome-wide association studies, whole-genome resequencing, gene expression and epigenome profiling, and integrative genomics. The final section provides an up-to-date survey of specific findings in six major domains of human disease: immunological, metabolic, cardiovascular, cancer, neuropsychological, and aging disorders. After reading this textbook, not only will students be better equipped to read current literature, they will gain a sense of the impact that the revolution in genomics has had for our understanding of the human condition, as well as of the major trends in human genetics research. Students are assumed to have a core understanding of genetics such as would be obtained in a general genetics class. Each chapter is approximately 20 pages long, and organized under up to ten sub-headings, most of which incorporate an illustrative figure. Chapter summary points recap the key messages, and references point students to key reviews and contemporary highlights. Several of the chapters contain a single box, which provides extra material on topics such as 'Consent and Responsible Conduct of Research' and 'Methylation Analysis in Biology.'

Author : Daniel L. Hartl
Publisher : Sinauer Associates, Incorporated
Page : 326 pages
File Size : 48,9 Mb
Release : 1988
Category : Science
ISBN : 0878933018

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A Primer of Population Genetics by Daniel L. Hartl Pdf

The use of molecular methods to study genetic polymorphisms has made a familiarity with population genetics essential for any biologist whose work is at the population level. A Primer of Population Genetics, Third Edition provides a concise but comprehensive introduction to population genetics. The four chapters of the book address genetic variation, the causes of evolution, molecular population genetics, and the genetic architecture of complex traits. Chapter-end problems reinforce ideas and, while there are some equations, the emphasis is on explanation rather than derivation.

Author : A. R. Hoelzel
Publisher : Oxford University Press
Page : 468 pages
File Size : 45,9 Mb
Release : 1998-03-19
Category : Science
ISBN : 9780191565601

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Molecular Genetic Analysis of Populations by A. R. Hoelzel Pdf

Methods enabling the direct study of genetic variation in natural populations have improved considerably. The new edition explores these updated techniques in DNA analysis and provides a revised and refined laboratory guide to investigating variation in DNA molecules.

Author : Richard Frankham,Jonathan D. Ballou,David A. Briscoe
Publisher : Cambridge University Press
Page : 244 pages
File Size : 44,5 Mb
Release : 2004-02-12
Category : Nature
ISBN : 0521538270

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A Primer of Conservation Genetics by Richard Frankham,Jonathan D. Ballou,David A. Briscoe Pdf

This concise, entry level text provides an introduction to the importance of genetic studies in conservation and presents the essentials of the discipline in an easy-to-follow format, with main points and terms clearly highlighted. The authors assume only a basic knowledge of Mendelian genetics and simple statistics, making the book accessible to those with a limited background in these areas. Connections between conservation genetics and the wider field of conservation biology are interwoven throughout the book. Worked examples are provided throughout to help illustrate key equations and glossary and suggestions for further reading provide additional support for the reader. Many beautiful pen and ink portraits of endangered species are included to enhance the text. Written for short, introductory level courses in genetics, conservation genetics and conservation biology, this book will also be suitable for practising conservation biologists, zoo biologists and wildlife managers.