Principles And Applications Of Clinical Mass Spectrometry

Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Andy Hoofnagle
Publisher : Elsevier
Page : 216 pages
File Size : 40,5 Mb
Release : 2018-06-26
Category : Science
ISBN : 9780128160640

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Principles and Applications of Clinical Mass Spectrometry by Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Andy Hoofnagle Pdf

Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well as pathogen identification. A thorough yet succinct guide to using mass spectrometry technology in the clinical laboratory, Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is an essential resource for chemists, pharmaceutical and biotech researchers, certain government agencies, and standardization groups. Provides concrete examples of the main applications of mass spectrometry technology Describes current capabilities of the LC- and MS-based analytical methods Details methods for successful analytical work in the field

Author : Karoly Vekey,Andreas Telekes,Akos Vertes
Publisher : Elsevier
Page : 606 pages
File Size : 41,6 Mb
Release : 2011-08-11
Category : Science
ISBN : 9780080554655

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Medical Applications of Mass Spectrometry by Karoly Vekey,Andreas Telekes,Akos Vertes Pdf

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine. The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry. * Guides the reader from basic principles and methods to cutting edge applications. * There is NO comparable book on the market to fill this fast growing field.

Author : Hari Nair,William Clarke
Publisher : Academic Press
Page : 304 pages
File Size : 52,6 Mb
Release : 2016-11-02
Category : Medical
ISBN : 9780128009925

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Mass Spectrometry for the Clinical Laboratory by Hari Nair,William Clarke Pdf

Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Author : Nigel Clarke,Andrew N. Hoofnagle
Publisher : Elsevier Health Sciences
Page : 104 pages
File Size : 47,5 Mb
Release : 2011-10-03
Category : Medical
ISBN : 9781455712014

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Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book by Nigel Clarke,Andrew N. Hoofnagle Pdf

This issue of Clinics in Laboratory Medicine, Guest Edited by Nigel Clarke, MD, and Andrew Hoofnagle, MD, will focus on Mass Spectrometry, with topics including: Proteins; Peptides; Small Molecules: Toxicology; Small Molecules: Diagnostics; and Regulatory Considerations.

Author : Edmond de Hoffmann,Vincent Stroobant
Publisher : Wiley
Page : 420 pages
File Size : 49,7 Mb
Release : 2001-10-10
Category : Science
ISBN : 0471485659

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Mass Spectrometry by Edmond de Hoffmann,Vincent Stroobant Pdf

Offers a complete overview of the principles, theories and key applications of modern mass spectrometry in this introductory textbook. Following on from the highly successful first edition, this edition is extensively updated including new techniques and applications. All instrumental aspects of mass spectrometry are clearly and concisely described; sources, analysers and detectors. * Revised and updated * Numerous examples and illustrations are combined with a series of exercises to help encourage student understanding * Includes biological applications, which have been significantly expanded and updated * Also includes coverage of ESI and MALDI

Author : Donald H. Chace
Publisher : Unknown
Page : 97 pages
File Size : 49,8 Mb
Release : 2007
Category : Diagnosis, Laboratory
ISBN : 1562386484

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Mass spectrometry in the clinical laboratory : general principles and guidance ; approved guideline by Donald H. Chace Pdf

Author : Yiyang Dong
Publisher : John Wiley & Sons
Page : 370 pages
File Size : 43,6 Mb
Release : 2018-04-09
Category : Science
ISBN : 9783527341849

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Direct Analysis in Real Time Mass Spectrometry by Yiyang Dong Pdf

Clear, comprehensive, and state of the art, the groundbreaking book on the emerging technology of direct analysis in real time mass spectrometry Written by a noted expert in the field, Direct Analysis in Real Time Mass Spectrometry offers a review of the background and the most recent developments in DART-MS. Invented in 2005, DART-MS offers a wide range of applications for solving numerous analytical problems in various environments, including food science, forensics, and clinical analysis. The text presents an introduction to the history of the technology and includes information on the theoretical background, for exampleon the ionization mechanism. Chapters on sampling and coupling to different types of mass spectrometers are followed by a comprehensive discussion of a broad range of applications. Unlike most other ionization methods, DART does not require laborious sample preparation, as ionization takes place directly on the sample surface. This makes the technique especially attractive for applications in forensics and food science. Comprehensive in scope, this vital text: -Sets the standard on an important and emerging ionization technique -Thoroughly discusses all the relevant aspects from instrumentation to applications -Helps in solving numerous analytical problems in various applications, for example food science, forensics, environmental and clinical analysis -Covers mechanisms, coupling to mass spectrometers, and includes information on challenges and disadvantages of the technique Academics, analytical chemists, pharmaceutical chemists, clinical chemists, forensic scientists, and others will find this illuminating text a must-have resource for understanding the most recent developments in the field.

Author : J. Throck Watson,O. David Sparkman
Publisher : John Wiley & Sons
Page : 972 pages
File Size : 43,7 Mb
Release : 2013-07-09
Category : Science
ISBN : 9781118681589

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Introduction to Mass Spectrometry by J. Throck Watson,O. David Sparkman Pdf

Completely revised and updated, this text provides an easy-to-read guide to the concept of mass spectrometry and demonstrates its potential and limitations. Written by internationally recognised experts and utilising "real life" examples of analyses and applications, the book presents real cases of qualitative and quantitative applications of mass spectrometry. Unlike other mass spectrometry texts, this comprehensive reference provides systematic descriptions of the various types of mass analysers and ionisation, along with corresponding strategies for interpretation of data. The book concludes with a comprehensive 3000 references. This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry

Author : Uttam Garg,Catherine A. Hammett-Stabler
Publisher : Humana Press
Page : 0 pages
File Size : 40,9 Mb
Release : 2009-12-14
Category : Science
ISBN : 1607614588

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Clinical Applications of Mass Spectrometry by Uttam Garg,Catherine A. Hammett-Stabler Pdf

As mass spectrometric methods now offer a level of specificity and sensitivity unrealized by spectrophotometric- and immunoassay-based methods, mass spectrometry has entered the clinical laboratory where it is being used for a wide range of applications. In Clinical Applications of Mass Spectrometry: Methods and Protocols, expert researchers provide detailed step-by-step procedures for the analysis of number of analytes of clinical importance. This versatile and expansive volume covers mass spectrometry methods for analytes including a variety of drugs, hormones, and metabolic compounds spanning the disciplines of toxicology, therapeutic drug monitoring, endocrinology, and pediatric metabolism. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to the analytes, lists of the necessary materials and reagents, readily reproducible analytical protocols, and detailed notes on troubleshooting and avoiding known pitfalls. Comprehensive and dependable, Clinical Applications of Mass Spectrometry: Methods and Protocols offers its readers a wide array of valuable methods for experienced mass spectrometric labs that are looking to introduce new analyses as well as for those laboratories currently considering the addition of this resourceful and vital technology.

Author : A. M. Lawson,H. C. Curtius,M. Roth
Publisher : Unknown
Page : 745 pages
File Size : 52,6 Mb
Release : 1989-01-01
Category : Electronic
ISBN : 0899255817

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Clinical Biochemistry: Principles, Methods, Applications by A. M. Lawson,H. C. Curtius,M. Roth Pdf

Author : Salvatore Fanali,Paul R. Haddad,Colin Poole,Marja-Liisa Riekkola
Publisher : Elsevier
Page : 838 pages
File Size : 50,5 Mb
Release : 2017-06-23
Category : Science
ISBN : 9780128093443

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Liquid Chromatography by Salvatore Fanali,Paul R. Haddad,Colin Poole,Marja-Liisa Riekkola Pdf

Liquid Chromatography: Applications, Second Edition,is a single source of authoritative information on all aspects of the practice of modern liquid chromatography. It gives those working in both academia and industry the opportunity to learn, refresh, and deepen their knowledge of the wide variety of applications in the field. In the years since the first edition was published, thousands of papers have been released on new achievements in liquid chromatography, including the development of new stationary phases, improvement of instrumentation, development of theory, and new applications in biomedicine, metabolomics, proteomics, foodomics, pharmaceuticals, and more. This second edition addresses these new developments with updated chapters from the most expert researchers in the field. Emphasizes the integration of chromatographic methods and sample preparation Explains how liquid chromatography is used in different industrial sectors Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical) Includes references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision-making

Author : Uttam Garg
Publisher : Springer Nature
Page : 541 pages
File Size : 43,9 Mb
Release : 2022-09-20
Category : Science
ISBN : 9781071625651

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Clinical Applications of Mass Spectrometry in Biomolecular Analysis by Uttam Garg Pdf

This updated volume provides stepwise instructions for the analysis of numerous clinically important analytes by mass spectrometry. Mass spectrometry offers clinical laboratory scientists a number of advantages including increased sensitivity and specificity, multiple component analysis, and limited need for specialized reagents. These techniques are essential in laboratory fields including endocrinology, biochemical genetics, drug analysis, proteomics, and pathogen identification. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Clinical Applications of Mass Spectrometry in Biomolecular Analysis: Methods and Protocols, Second Edition is an ideal resource for clinical laboratory scientists who are already using or thinking of bringing mass spectrometry to their laboratories.

Author : Dominic M. Desiderio
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 46,5 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781489911735

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Mass Spectrometry by Dominic M. Desiderio Pdf

In response to the growing use of mass spectrometry in the clinical and biomedical fields, this book collects recent research involving electrospray ionization, neuronal systems, and structural modifications of proteins. The significant advances in instrumentation, methodology, experimentation presented herein will serve to expand the current concept of clinical mass spectrometry.

Author : Hans-Joachim Hubschmann
Publisher : John Wiley & Sons
Page : 884 pages
File Size : 47,5 Mb
Release : 2015-07-27
Category : Science
ISBN : 9783527334742

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Handbook of GC-MS by Hans-Joachim Hubschmann Pdf

The only comprehensive reference on this popular and rapidly developing technique provides a detailed overview, ranging from fundamentals to applications, including a section on the evaluation of GC-MS analyses. As such, it covers all aspects, including the theory and principles, as well as a broad range of real-life examples taken from laboratories in environmental, food, pharmaceutical and clinical analysis. It also features a glossary of approximately 300 terms and a substance index that facilitates finding a specific application. The first two editions were very well received, making this handbook a must-have in all analytical laboratories using GC-MS.

Author : Wilfried M.A. Niessen
Publisher : CRC Press
Page : 530 pages
File Size : 52,5 Mb
Release : 2001-04-04
Category : Science
ISBN : 1420029517

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Current Practice of Gas Chromatography-Mass Spectrometry by Wilfried M.A. Niessen Pdf

This volume details the principles and instrumentation of gas chromatography-mass spectrometry (CG-MS), and outlines industrial, environmental, pharmaceutical, clinical, toxicological, forensic and food-related applications, revealing findings from the laboratories of 40 contributing scientists around the world using GC-MS in practice. It describes upstream and downstream applications of GC-MS in the petroleum industry and identifies chlorinated compounds in the environment with quadrupole ion-trap technology and high-resolution sector instruments.