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Author : World Health Organization
Publisher : World Health Organization
Page : 34 pages
File Size : 44,6 Mb
Release : 2022-06-30
Category : Medical
ISBN : 9789240053038
Author : World Health Organization
Publisher : Unknown
Page : 429 pages
File Size : 48,8 Mb
Release : 2016
Category : AIDS (Disease)
ISBN : 9241549688
These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care. This edition updates the 2013 consolidated guidelines on the use of antiretroviral drugs following an extensive review of evidence and consultations in mid-2015, shared at the end of 2015, and now published in full in 2016. It is being published in a changing global context for HIV and for health more broadly.
Author : Anonim
Publisher : World Health Organization
Page : 46 pages
File Size : 55,6 Mb
Release : 2021-03-25
Category : Medical
ISBN : 9789240022157
The Paediatric Antituberculosis Drug Optimization (PADO-TB) meetings provide a forum for clinicians, researchers, financial and technical partners and other relevant key stakeholders to work together, to ensure that priority optimal paediatric formulations of TB medicines are investigated, developed and made available to children in a timely manner. After the first meeting (PADO-TB1) in February 2019, WHO hosted an interim review of the PADO-TB1 priorities. The review considered the latest WHO recommendations and other relevant developments since February 2019, such as results of clinical trials, results of pharmacokinetics and pharmacodynamics studies, new formulations available and advancements of key drugs in the TB research and development pipeline. The 4.5-hour virtual review was attended by more than 50 experts including clinicians, researchers, representatives of national TB programmes (NTPs) from high TB burden countries, community representatives, financial and technical partners, members of the Child and Adolescent TB Working Group and representatives from various international agencies, including WHO. This report summarizes the main developments presented for various TB medicines and the decisions taken with regard to the PADO-TB priority list.
Author : World Health Organization
Publisher : World Health Organization
Page : 46 pages
File Size : 46,5 Mb
Release : 2024-03-01
Category : Medical
ISBN : 9789240086319
This brief report summarizes recent information on HIV drug resistance (HIVDR) in the era of integrase-strand transfer inhibitors (INSTI) for HIV prevention and treatment. In this report, WHO documents high levels of HIV viral load suppression (>90%) in populations receiving dolutegravir (DTG)-containing antiretroviral therapy (ART). However, recent observational data reveal that HIVDR to DTG is emerging at levels exceeding those observed in clinical trials. Few countries have reported people not achieving viral suppression while receiving DTG-containing ART. However, amongst the surveys reported, levels of DTG resistance ranged from 3.9% to 8.6%, with levels as high as 19.6% observed among highly treatment-experienced people who transitioned to a DTG-containing ART while having high HIV viral loads. Levels of observed DTG resistance in real world populations receiving ART appear to be higher than anticipated from clinical trials. WHO recommends that countries routinely implement standardised surveillance of HIVDR to follow the prevalence and patterns of resistance among people not achieving suppressed viral load. The use of long acting cabotegravir (CAB-LA) for pre-exposure prophylaxis (PrEP) greatly reduces the risk of acquiring HIV. However, INSTI resistance has been observed in some cases with recent CAB-LA exposure, and delayed detection and confirmation of HIV infection can increase the risk of selection of INSTI drug resistance–associated mutations. Despite the possible risk, the roll-out of CAB-LA for PrEP should not be hindered. Scale-up of PrEP should be accompanied by standardized surveillance of drug resistance among people testing positive for HIV while receiving PrEP.
Author : World Health Organization
Publisher : World Health Organization
Page : 31 pages
File Size : 50,8 Mb
Release : 2024-04-19
Category : Business & Economics
ISBN : 9789240091276
The Paediatric Regulatory Network was initially created as a global paediatric working group in February 2010 in response to a recommendation from the 2008 International Conference on Drug Regulatory Authorities and as part of the World Health Organization (WHO) Better Medicines for Children Project in collaboration with the Bill & Melinda Gates Foundation, to offer a platform for discussion on paediatric regulatory considerations for national regulatory authorities. The Network was reactivated in December 2019 as a global paediatric network supporting the availability of quality-assured medical products for children, by facilitating communication, collaboration, training and regulatory harmonization across the development, registration and pharmacovigilance of paediatric medical products. The Network’s activities contribute efficiently to the implementation of World Health Assembly resolutions WHA60.20 (2007) on better medicines for children, WHA69.20 (2016) on promoting innovation and access to quality, safe, efficacious and affordable medicines for children, WHA67.20 (2014) on regulatory system strengthening for medical products and WHA67.22 (2014) on access to essential medicines.
Author : World Health Organization
Publisher : Unknown
Page : 0 pages
File Size : 53,9 Mb
Release : 2022
Category : Electronic
ISBN : OCLC:1396937430
Author : Gerd Pluschke,Katharina Röltgen
Publisher : Springer
Page : 287 pages
File Size : 49,7 Mb
Release : 2019-04-29
Category : Medical
ISBN : 9783030111144
A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.
Author : AM Kadri
Publisher : Jaypee Brothers Medical Publishers
Page : 1255 pages
File Size : 54,9 Mb
Release : 2019-06-30
Category : Medical
ISBN : 9789352709946
Author : World Health Organization
Publisher : World Health Organization
Page : 592 pages
File Size : 54,8 Mb
Release : 2021-07-16
Category : Medical
ISBN : 9789240031593
These consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring bring together existing and new clinical and programmatic recommendations across different ages, populations and settings, bringing together all relevant WHO guidance on HIV produced since 2016. It serves as an update to the previous edition of the consolidated guidelines on HIV. These guidelines continue to be structured along the continuum of HIV care. Information on new combination prevention approaches, HIV testing, ARV regimens and treatment monitoring are included. There is a new chapter on advanced HIV disease that integrates updated guidance on the management of important HIV comorbidities, including cryptococcal disease, histoplasmosis and tuberculosis. The chapter on general HIV care, contains a new section on palliative care and pain management, and up to date information on treatment of several neglected tropical diseases, such as visceral leishmaniasis and Buruli ulcer. New recommendations for screening and treating of cervical pre-cancer lesions in women living with HIV are also addressed in this chapter. Guidance on service delivery was expanded to help the implementation and strengthening the HIV care cascade. Importantly, this guidance emphasizes the need for differentiated approaches to care for people who are established on ART, such as reduced frequency of clinic visits, use of multi-month drug dispensing and implementation of community ART distribution. The adoption of these efficiencies is essential to improve the quality of care of people receiving treatment and reduce the burden on health facilities, particularly in resource limited settings.
Author : King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Publisher : World Bank Publications
Page : 506 pages
File Size : 55,9 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9781464805257
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Author : Anonim
Publisher : World Health Organization
Page : 73 pages
File Size : 51,8 Mb
Release : 2021-11-10
Category : Medical
ISBN : 9789240008182
Author : World Health Organization
Publisher : World Health Organization
Page : 44 pages
File Size : 49,6 Mb
Release : 2024-05-14
Category : Medical
ISBN : 9789240093386
This report reviews key clinical trials, observational studies, and programmatic data on newer antiretrovirals to inform future updates to global HIV treatment policies. The report also reviewed the latest data on the safety and efficacy of dolutegravir, tenofovir alafenamide, and long-acting ARV-containing regimens in people living with HIV, including pregnant women. Critical gaps in clinical knowledge, research, monitoring, and surveillance on the transition to these new antiretrovirals were discussed, and future research priorities were summarized. The primary audience for this report includes national HIV program managers, clinicians, and healthcare providers. This document will also be of interest to treatment advisory boards, international agencies and organizations that provide technical and financial support to HIV programmes.
Author : World Health Organization
Publisher : World Health Organization
Page : 40 pages
File Size : 48,6 Mb
Release : 2023-05-01
Category : Medical
ISBN : 9789240071087
Author : Anonim
Publisher : World Health Organization
Page : 24 pages
File Size : 40,5 Mb
Release : 2021-11-19
Category : Medical
ISBN : 9789240039520
The aim of this document is to provide guidance on how to undertake a paediatric drug optimization (PADO) exercise and identify key priority products for research and development. This guidance is for all technical units undertaking a PADO exercise, all stakeholders involved in PADO processes as well as interested organizations and experts involved in the research and development of therapeutics in the public and private sectors.
Author : Alan D. Lopez
Publisher : World Bank Publications
Page : 511 pages
File Size : 52,9 Mb
Release : 2006-04-02
Category : Medical
ISBN : 9780821362631
Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.
