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Author : International Dietary Energy Consultancy Group
Publisher : Unknown
Page : 452 pages
File Size : 52,8 Mb
Release : 1992
Category : Energy metabolism
ISBN : CORNELL:31924085644874
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 42,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Bodwell
Publisher : CRC Press
Page : 414 pages
File Size : 42,9 Mb
Release : 1988-05-19
Category : Technology & Engineering
ISBN : 0824778685
This book contains the proceedings of the Eleventh Annual Basic Symposium sponsored by the Institute of Food Technologists and the International Union of Food Science and Technology. It discusses nutrition interactions in human and emphasizes research findings from human and animal studies.
Author : Nevin Stewart Scrimshaw,Beat Schurch,International Dietary Energy Consultancy Group
Publisher : Unknown
Page : 437 pages
File Size : 40,7 Mb
Release : 1992
Category : Proteins
ISBN : OCLC:503435077
Author : G. Weber
Publisher : Springer
Page : 312 pages
File Size : 43,5 Mb
Release : 1992-05-31
Category : Medical
ISBN : UOM:39015026879240
A study of the thermodynamics of protein-protein and protein-ligand interactions. The author explains the energetics of protein interactions and gives a thorough account of the complicated biophysics that occur when the effects of multiple, complex molecules are taken into account.
Author : Institute of Medicine,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 448 pages
File Size : 47,9 Mb
Release : 1999-09-15
Category : Technology & Engineering
ISBN : 9780309172813
It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.
Author : Ruth Nussinov,Gideon Schreiber
Publisher : CRC Press
Page : 344 pages
File Size : 45,6 Mb
Release : 2009-06-26
Category : Science
ISBN : 142007007X
Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current research directions, Computational Protein-Protein Interactions examines topics in the prediction of protein-protein interactions, including interference with protein-protein interactions and their design. Explores Computational Approaches to Understanding Protein-Protein Interactions Outlining fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers protein-protein interaction prediction and dynamics, design, drug design for inhibition, and uses for the prediction of function. The text provides general chapters that overview the topic and also includes advanced material. The chapters detail the complexity of protein interaction studies and discuss potential caveats. Addresses the Next Big Problem in Molecular Biology While it is important to predict protein associations, this is a daunting task. Edited by two experts in the field and containing contributions from those at the forefront of research, the book provides a basic outline of major directions in computational protein-protein interactions research at the heart of functional genomics and crucial for drug discovery. It addresses the next big problem in molecular biology: how to create links between all the pieces of the cell jigsaw puzzle.
Author : James W. Oltjen,E. Kebreab,Hélène Lapierre
Publisher : Springer
Page : 537 pages
File Size : 43,9 Mb
Release : 2013-11-04
Category : Science
ISBN : 9789086867813
As world population increases, demand for food and particularly animal products is expected to grow substantially. Because of limited area for expansion of animal agriculture and growing consumer concern for the environmental impact of animal production, gains in animal efficiency will have to be part of the solution. This book addresses key issues of how energy and protein are utilized and interact in farm animals from the molecular to the whole animal and even to the herd or group level of organization. It contains state-of-the-art research and reviews on several topics of nutrient utilization and metabolism from top scientists worldwide. Key issues addressed include energy/protein interactions, methodology such as in vitro and in vivo techniques, regulation including pre-natal programming and endocrine regulation, modeling and systems biology (including a tribute to the late Professor R. Lee Baldwin of the University of California, Davis, a leader in the field), products and health of animals, tissue metabolism, and environmental sustainability in agriculture. This book is a valuable resource for researchers, students, policy makers, producers and industry professionals believing that a better understanding of metabolism and nutrition of farm animals is part of the solution.
Author : International Union of Nutritional Sciences. Workshop
Publisher : Bernan Press(PA)
Page : 386 pages
File Size : 47,9 Mb
Release : 1984
Category : Bioenergetics
ISBN : UIUC:30112017878684
Abstract: A report of a 1981 workshop by the International Union of Nutritional Sciences Committee on Protein-Energy Requirements reviews the current state of world research findings on protein-energy requirements. The 35 technical papers discuss research studies conducted on a variety of sub-populations and ethnic groups. The papers are organized under 6 principal categories: (1) general methodological studies for assessing human protein-energy requirements; (2) studies assessing adult protein requirements using (a) the standard nitrogen balance protocol, (b) long-term studies, and (c) large sample populations; (3) energy expenditure studies; (4) studies on protein-energy interactions; (5) nitrogen balance studies in children; and (6) ancillary studies concerning miscellaneous aspects that influence protein-energy requirements. Two expert reports are appended: (1) a 1977 FAO/WHO report on energy intake and protein requirements, and (2) a 1980 report reviewing collaborative research on protein requirements and energy intake.
Author : Weibo Cai,Hao Hong
Publisher : BoD – Books on Demand
Page : 488 pages
File Size : 43,6 Mb
Release : 2012-03-30
Category : Science
ISBN : 9789535103974
Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.
Author : Shahid Mukhtar
Publisher : Springer Nature
Page : 480 pages
File Size : 55,7 Mb
Release : 2023-07-14
Category : Science
ISBN : 9781071633274
This detailed volume provides a comprehensive collection of classic and cutting-edge methods and techniques in mapping protein-protein interactions. The chapters include a variety of in vitro and in vivo experimental methods covering cell biology, biochemistry, and biophysics. In addition, the book also explores in silico methods including sequence-, structure-, and phylogenetic profile-based approaches as well as gene expression and machine learning methods. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein-Protein Interactions: Methods and Protocols serves as an ideal guide for researchers working in protein science and beyond.
Author : Gabriel Waksman
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 53,8 Mb
Release : 2005-12-21
Category : Medical
ISBN : 0387245316
The rapidly evolving field of protein science has now come to realize the ubiquity and importance of protein-protein interactions. It had been known for some time that proteins may interact with each other to form functional complexes, but it was thought to be the property of only a handful of key proteins. However, with the advent of high throughput proteomics to monitor protein-protein interactions at an organism level, we can now safely state that protein-protein interactions are the norm and not the exception. Thus, protein function must be understood in the larger context of the various binding complexes that each protein may form with interacting partners at a given time in the life cycle of a cell. Proteins are now seen as forming sophisticated interaction networks subject to remarkable regulation. The study of these interaction networks and regulatory mechanism, which I would like to term "systems proteomics," is one of the thriving fields of proteomics. The bird-eye view that systems proteomics offers should not however mask the fact that proteins are each characterized by a unique set of physical and chemical properties. In other words, no protein looks and behaves like another. This complicates enormously the design of high-throughput proteomics methods. Unlike genes, which, by and large, display similar physico-chemical behaviors and thus can be easily used in a high throughput mode, proteins are not easily amenable to the same treatment. It is thus important to remind researchers active in the proteomics field the fundamental basis of protein chemistry. This book attempts to bridge the two extreme ends of protein science: on one end, systems proteomics, which describes, at a system level, the intricate connection network that proteins form in a cell, and on the other end, protein chemistry and biophysics, which describe the molecular properties of individual proteins and the structural and thermodynamic basis of their interactions within the network. Bridging the two ends of the spectrum is bioinformatics and computational chemistry. Large data sets created by systems proteomics need to be mined for meaningful information, methods need to be designed and implemented to improve experimental designs, extract signal over noise, and reject artifacts, and predictive methods need to be worked out and put to the test. Computational chemistry faces similar challenges. The prediction of binding thermodynamics of protein-protein interaction is still in its infancy. Proteins are large objects, and simplifying assumptions and shortcuts still need to be applied to make simulations manageable, and this despite exponential progress in computer technology. Finally, the study of proteins impacts directly on human health. It is an obvious statement to say that, for decades, enzymes, receptors, and key regulator proteins have been targeted for drug discovery. However, a recent and exciting development is the exploitation of our knowledge of protein-protein interaction for the design of new pharmaceuticals. This presents particular challenges because protein-protein interfaces are generally shallow and interactions are weak. However, progress is clearly being made and the book seeks to provide examples of successes in this area.
Author : Krishna Mohan Poluri,Khushboo Gulati,Sharanya Sarkar
Publisher : Springer Nature
Page : 346 pages
File Size : 54,5 Mb
Release : 2021-05-19
Category : Science
ISBN : 9789811615948
This book provides a comprehensive overview of the fundamental aspects of protein-protein interactions (PPI), including a detailed account of the energetics and thermodynamics involved in these interactions. It also discusses a number of computational and experimental approaches for the prediction of PPI interactions and reviews their principles, advantages, drawbacks, and the recent developments. Further, it offers structural and mechanistic insights into the formation of protein-protein complexes and maps different PPIs into networks to delineate various pathways that operate at the cellular level. Lastly, it describes computational protein-protein docking techniques and discusses their implications for further experimental research. Given its scope, this book is a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.
Author : Sebastian Doniach
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 45,8 Mb
Release : 2013-11-22
Category : Science
ISBN : 9781489913494
A number of factors have come together in the last couple of decades to define the emerging interdisciplinary field of structural molecular biology. First, there has been the considerable growth in our ability to obtain atomic-resolution structural data for biological molecules in general, and proteins in particular. This is a result of advances in technique, both in x-ray crystallography, driven by the development of electronic detectors and of synchrotron radiation x-ray sources, and by the development ofNMR techniques which allow for inference of a three-dimensional structure of a protein in solution. Second, there has been the enormous development of techniques in DNA engineering which makes it possible to isolate and clone specific molecules of interest in sufficient quantities to enable structural measurements. In addition, the ability to mutate a given amino acid sequence at will has led to a new branch of biochemistry in which quantitative measurements can be made assessing the influence of a given amino acid on the function of a biological molecule. A third factor, resulting from the exponential increase in computing power available to researchers, has been the emergence of a growing body of people who can take the structural data and use it to build atomic-scale models of biomolecules in order to try and simulate their motions in an aqueous environment, thus helping to provide answers to one of the most basic questions of molecular biology: the relation of structure to function.
Author : M Michael Gromiha
Publisher : World Scientific
Page : 424 pages
File Size : 46,5 Mb
Release : 2020-03-05
Category : Science
ISBN : 9789811211881
This book is indexed in Chemical Abstracts ServiceThe interactions of proteins with other molecules are important in many cellular activities. Investigations have been carried out to understand the recognition mechanism, identify the binding sites, analyze the the binding affinity of complexes, and study the influence of mutations on diseases. Protein interactions are also crucial in structure-based drug design.This book covers computational analysis of protein-protein, protein-nucleic acid and protein-ligand interactions and their applications. It provides up-to-date information and the latest developments from experts in the field, using illustrations to explain the key concepts and applications. This volume can serve as a single source on comparative studies of proteins interacting with proteins/DNAs/RNAs/carbohydrates and small molecules.