Protein Protein Interactions Ppis

Author : Siddhartha Roy,Haian Fu
Publisher : Royal Society of Chemistry
Page : 399 pages
File Size : 53,8 Mb
Release : 2020-12-15
Category : Science
ISBN : 9781788011877

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Protein–Protein Interaction Regulators by Siddhartha Roy,Haian Fu Pdf

New genomic information has revealed the crucial role that protein-protein interactions (PPIs) play in regulating numerous cellular functions. Aberrant forms of these interactions are common in numerous diseases and thus PPIs have emerged as a vast class of critical drug targets. Despite the importance of PPIs in biology, it has been extremely challenging to convert targets into therapeutics and targeting PPIs had long been considered a very difficult task. However, over the past decade the field has advanced with increasing growth in the number of successful PPI regulators. Protein-Protein Interaction Regulators surveys the latest advances in the structural understanding of PPIs as well as recent developments in modulator discovery.

Author : Ali Tavassoli
Publisher : Royal Society of Chemistry
Page : 357 pages
File Size : 40,7 Mb
Release : 2020-12-07
Category : Science
ISBN : 9781788015691

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Inhibitors of Protein–Protein Interactions by Ali Tavassoli Pdf

Protein-protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.

Author : Clyde R. Montgomery
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 40,5 Mb
Release : 2017
Category : Protein-protein interactions
ISBN : 1634859707

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Protein-protein Interactions (PPIs) by Clyde R. Montgomery Pdf

Protein-protein interactions (PPIs) play an important role in vital biological processes such as metabolic and signaling pathways, cell cycle control, and DNA replication and transcription. This book discusses types, methods for detection and the analysis of PPIs. Chapter One describes two key nuclear magnetic resonance (NMR) methods for the investigation of protein-protein interactions, chemical shift perturbation, and residual dipolar coupling, with practical tips on the preparation of samples, NMR measurement, and analysis. Chapter Two describes the basic principles and provides a practical description of the recent technological developments in solution NMR spectroscopy for examining protein-protein interactions. Chapter Three focuses on identifying PPIs via many learning methods based on protein sequence information. Chapter Four examines the thermodynamics of PPIs by isothermal titration calorimetry. Chapter Five describes the general microscopic features of amyloid fibril structures and then discusses the macroscopic properties of protein aggregate with conformations such as packing, hydration, and enthalpy using thermodynamic variables in combination with densitometry and isothermal titration calorimetry. Chapter Six reviews the special case of protein self-association as a modulator of protein function.

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
Page : 1367 pages
File Size : 44,5 Mb
Release : 2020-01-09
Category : Medical
ISBN : 9781118900505

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Structural Biology in Drug Discovery by Jean-Paul Renaud Pdf

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Author : Krishna Mohan Poluri,Khushboo Gulati,Sharanya Sarkar
Publisher : Springer Nature
Page : 346 pages
File Size : 45,5 Mb
Release : 2021-05-19
Category : Science
ISBN : 9789811615948

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Protein-Protein Interactions by Krishna Mohan Poluri,Khushboo Gulati,Sharanya Sarkar Pdf

This book provides a comprehensive overview of the fundamental aspects of protein-protein interactions (PPI), including a detailed account of the energetics and thermodynamics involved in these interactions. It also discusses a number of computational and experimental approaches for the prediction of PPI interactions and reviews their principles, advantages, drawbacks, and the recent developments. Further, it offers structural and mechanistic insights into the formation of protein-protein complexes and maps different PPIs into networks to delineate various pathways that operate at the cellular level. Lastly, it describes computational protein-protein docking techniques and discusses their implications for further experimental research. Given its scope, this book is a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 45,6 Mb
Release : 2016-12-01
Category : Electronic
ISBN : 1634859855

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Protein-Protein Interactions (Ppis) by Anonim Pdf

Author : Mahmood-Ur-Rahman Ansari
Publisher : BoD – Books on Demand
Page : 91 pages
File Size : 50,7 Mb
Release : 2018-07-18
Category : Science
ISBN : 9781789233902

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Protein-Protein Interaction Assays by Mahmood-Ur-Rahman Ansari Pdf

The chapters in this book are written by a team of well-reputed international researchers. The objective is to provide advanced and updated information related to protein-protein interactions. I hope the methods, resources and approaches described here will enhance the available knowledge of the reader significantly.

Author : Jurriaan Huskens,Leonard J. Prins,Rainer Haag,Bart Jan Ravoo
Publisher : John Wiley & Sons
Page : 434 pages
File Size : 49,7 Mb
Release : 2018-02-05
Category : Science
ISBN : 9781119143468

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Multivalency by Jurriaan Huskens,Leonard J. Prins,Rainer Haag,Bart Jan Ravoo Pdf

Connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field. Multivalency: Concepts, Research & Applications is divided into three parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their study. Fundamental aspects such as thermodynamics, kinetics and the principle of effective molarity are described, and characterisation methods, experimental methodologies and data treatment methods are also discussed. Parts two and three provide an overview of current systems in which multivalency plays an important role in chemistry and biology, with a focus on the design rules, underlying chemistry and the fundamental principles of multivalency. The systems covered range from chemical/materials-based ones such as dendrimers and sensors, to biological systems including cell recognition and protein binding. Examples and case studies from biochemistry/bioorganic chemistry as well as synthetic systems feature throughout the book. Introduces students and young scientists to the field of multivalent interactions and assists experienced researchers utilising the methodologies in their work Features examples and case studies from biochemistry/bioorganic chemistry, as well as synthetic systems throughout the book Edited by leading experts in the field with contributions from established scientists Multivalency: Concepts, Research & Applications is recommended for graduate students and junior scientists in supramolecular chemistry and related fields, looking for an introduction to multivalent interactions. It is also highly useful to experienced academics and scientists in industry working on research relating to multivalent and cooperative systems in supramolecular chemistry, organic chemistry, pharmaceutical chemistry, chemical biology, biochemistry, materials science and nanotechnology.

Author : Pandjassarame Kangueane,Christina Nilofer
Publisher : Springer
Page : 207 pages
File Size : 41,9 Mb
Release : 2018-02-16
Category : Medical
ISBN : 9789811073472

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Protein-Protein and Domain-Domain Interactions by Pandjassarame Kangueane,Christina Nilofer Pdf

This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins.

Author : Stefan Canzar,Francisca Rojas Ringeling
Publisher : Humana
Page : 286 pages
File Size : 45,7 Mb
Release : 2020-10-18
Category : Science
ISBN : 1493998757

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Protein-Protein Interaction Networks by Stefan Canzar,Francisca Rojas Ringeling Pdf

This volume explores techniques that study interactions between proteins in different species, and combines them with context-specific data, analysis of omics datasets, and assembles individual interactions into higher-order semantic units, i.e., protein complexes and functional modules. The chapters in this book cover computational methods that solve diverse tasks such as the prediction of functional protein-protein interactions; the alignment-based comparison of interaction networks by SANA; using the RaptorX-ComplexContact webserver to predict inter-protein residue-residue contacts; the docking of alternative confirmations of proteins participating in binary interactions and the visually-guided selection of a docking model using COZOID; the detection of novel functional units by KeyPathwayMiner and how PathClass can use such de novo pathways to classify breast cancer subtypes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary hardware- and software, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Protein-Protein Interaction Networks: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.

Author : Weibo Cai,Hao Hong
Publisher : BoD – Books on Demand
Page : 488 pages
File Size : 48,8 Mb
Release : 2012-03-30
Category : Science
ISBN : 9789535103974

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Protein-Protein Interactions by Weibo Cai,Hao Hong Pdf

Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.

Author : Krishna Mohan Poluri,Khushboo Gulati,Sharanya Sarkar
Publisher : Unknown
Page : 0 pages
File Size : 52,7 Mb
Release : 2021
Category : Electronic
ISBN : 9811615950

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Protein-Protein Interactions by Krishna Mohan Poluri,Khushboo Gulati,Sharanya Sarkar Pdf

This book provides a comprehensive overview of the fundamental aspects of protein-protein interactions (PPI), including a detailed account of the energetics and thermodynamics involved in these interactions. It also discusses a number of computational and experimental approaches for the prediction of PPI interactions and reviews their principles, advantages, drawbacks, and the recent developments. Further, it offers structural and mechanistic insights into the formation of protein-protein complexes and maps different PPIs into networks to delineate various pathways that operate at the cellular level. Lastly, it describes computational protein-protein docking techniques and discusses their implications for further experimental research. Given its scope, this book is a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.

Author : Jian Zhang,Ruth Nussinov
Publisher : Springer Nature
Page : 384 pages
File Size : 55,8 Mb
Release : 2019-11-09
Category : Medical
ISBN : 9789811387197

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Protein Allostery in Drug Discovery by Jian Zhang,Ruth Nussinov Pdf

The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.

Author : Gorka Lasso Cabrera,Pablo Guardado-Calvo,Rohit K. Jangra,Eva Mittler,Mercè Llabrés
Publisher : Frontiers Media SA
Page : 121 pages
File Size : 48,6 Mb
Release : 2022-08-02
Category : Science
ISBN : 9782889766147

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Influence of Protein-Protein Interactions (PPIs) on the Outcome of Viral Infections by Gorka Lasso Cabrera,Pablo Guardado-Calvo,Rohit K. Jangra,Eva Mittler,Mercè Llabrés Pdf

Author : Noel R. Rose,Ian R. Mackay
Publisher : Unknown
Page : 928 pages
File Size : 46,6 Mb
Release : 1998
Category : Medical
ISBN : UOM:39015045615823

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The Autoimmune Diseases by Noel R. Rose,Ian R. Mackay Pdf

The Autoimmune Diseases comprehensively describes the clinical expressions of all known autoimmune diseases, as well as the experimental bases of autoimmunity and failure of tolerance. The scientific chapters include mechanisms of natural tolerance, the genetic basis of autoimmunity, the significance of apoptosis, the influence of cytokines, environmental influences, and experimental models. The clinical chapters cover autoimmune endocrine deficiencies, insulin-dependent diabetes, rheumatic disorders, neurological diseases, and diseases of the blood, skin, eye, kidney, and liver.