Protein Synthesis And Ribosome Structure

Author : Knud H. Nierhaus,Daniel Wilson
Publisher : John Wiley & Sons
Page : 597 pages
File Size : 52,6 Mb
Release : 2009-07-10
Category : Science
ISBN : 9783527616381

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Protein Synthesis and Ribosome Structure by Knud H. Nierhaus,Daniel Wilson Pdf

Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.

Author : Alexander Spirin
Publisher : Springer Science & Business Media
Page : 417 pages
File Size : 52,5 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781461578178

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Ribosomes by Alexander Spirin Pdf

This book is based on an advanced course of lectures on ribosome structure and protein biosynthesis that I offer at the Moscow State University. These lectures have been part of a general course on molecular biology for almost three decades, and they have undergone considerable evolution as knowledge has been pro gressing in this field. The progress continues, and readers should be prepared that some facts, statements, and ideas included in the book may be incomplete or out of-date. In any case, this is primarily a textbook, but not a comprehensive review. It provides a background of knowledge and current ideas in the field and gives ex amples of observations and their interpretations. I understand that some interpre tations and generalizations may be tentative or disputable, but I hope that this will stimulate thinking and discussing better than if I left white spots. The book has a prototype: it is my monograph "Ribosome Structure and Pro tein Biosynthesis" published by the Benjamin/Cummings Publishing Company, Menlo Park, California, in 1986. Here I have basically kept the former order of pre sentation ofthe topics and the subdivision into chapters. The contents ofthe chap ters, however, have been significantly revised and supplemented. The newly writ ten chapters on translational control in prokaryotes (Chapter 16) and eukaryotes (Chapter 17) are added.

Author : Marina V. Rodnina,Wolfgang Wintermeyer,Rachel Green
Publisher : Springer Science & Business Media
Page : 442 pages
File Size : 50,7 Mb
Release : 2011-12-10
Category : Medical
ISBN : 9783709102152

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Ribosomes Structure, Function, and Dynamics by Marina V. Rodnina,Wolfgang Wintermeyer,Rachel Green Pdf

The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

Author : Walter Ensign Hill,American Society for Microbiology
Publisher : ASM Press
Page : 716 pages
File Size : 49,9 Mb
Release : 1990
Category : Science
ISBN : UOM:39015021883312

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The Ribosome by Walter Ensign Hill,American Society for Microbiology Pdf

This book is recommended as a 'hitchhiker's guide to the ribosome' for everyone with an interest in translation, RNA-protein structures, and macromolecular structure-function relationships Science >.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 48,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Mans Ehrenberg,Anders Liljas
Publisher : World Scientific
Page : 492 pages
File Size : 42,5 Mb
Release : 2013-06-06
Category : Electronic
ISBN : 9789814531801

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Structural Aspects of Protein Synthesis by Mans Ehrenberg,Anders Liljas Pdf

This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases. Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation. There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system.Contents: The Basics of TranslationHistorical MilestonesMethods of Studying StructureThe Message ? mRNAThe Adaptor ? tRNAThe Workbench ? RibosomesThe Structure of the RibosomeRibosomal Sites and Ribosomal StatesThe Catalysts ? Translation FactorsInhibitors of Protein Synthesis ? Antibiotics, ResistanceThe Process ? TranslationProtein Processing, Folding and TargetingEvolution of the Translation Apparatus Readership: Upper level undergraduates and graduate students with an interest in protein synthesis; researchers in cell and molecular biology, biochemistry and biophysics who need to get an overview of translation.

Author : Vijay Kumar
Publisher : Academic Press
Page : 298 pages
File Size : 40,5 Mb
Release : 2021-09-25
Category : Science
ISBN : 9780128167342

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Emerging Concepts in Ribosome Structure, Biogenesis, and Function by Vijay Kumar Pdf

Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research. Provides an overview of ribosome biogenesis and examines its involvement in cell transformation and cancerous growth Covers disorders related to the ribosome (ribosomopathies) and explains the significance of ribosome dysfunction in human diseases Includes commonly used methods to study ribosomes, such as polysome preparation, RNA profiling and proteomics, CryoEM, and Cell-free assays along with proper illustrations

Author : Aleksandr Sergeevich Spirin
Publisher : Benjamin-Cummings Publishing Company
Page : 440 pages
File Size : 53,8 Mb
Release : 1986
Category : Science
ISBN : UOM:39015010660689

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Ribosome Structure and Protein Biosynthesis by Aleksandr Sergeevich Spirin Pdf

Author : Glenn Chambliss
Publisher : Unknown
Page : 1020 pages
File Size : 50,9 Mb
Release : 1980
Category : Science
ISBN : UOM:39015004626522

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Ribosomes, Structure, Function, and Genetics by Glenn Chambliss Pdf

Author : Herbert Weissbach
Publisher : Elsevier
Page : 739 pages
File Size : 45,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323141703

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Molecular Mechanisms of Protein Biosynthesis by Herbert Weissbach Pdf

Molecular Mechanisms of Protein Biosynthesis is a collection of papers dealing with cell-free systems at the molecular level, including transfer RNA; the initiation, elongation, and termination processes; ribosome structure and function; mRNA translation; and DNA-directed in vitro protein synthesis. A couple of papers review tRNA, aminoacyl-tRNA synthetases, and aspects of ribosome structure. One paper discusses affinity labeling in the study of binding and catalytic sites of large complex and heterogeneous systems such as the ribosome. The investigator should be aware of the chemically reactive or photoactivatible analogue reacting specifically with one or more ribosomal components. This reaction should be determined if it is dependent on the correct binding of the affinity label at the functional site. Another paper describes the series of reactions in protein synthesis as the process by which the ribosome moves relative to the messenger RNA. Other papers discuss messenger RNA and its translation, DNA-dependent cell-free protein synthesis, as well as the genetics of the translational apparatus. The collection will benefit microbiologists, biotechnologists, and academicians connected with the biological sciences.

Author : Boyd Hardesty,Gisela Kramer
Publisher : Springer Science & Business Media
Page : 832 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461248842

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Structure, Function, and Genetics of Ribosomes by Boyd Hardesty,Gisela Kramer Pdf

During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was transmitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramati cally different. We have an almost bewildering variety of information de tailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for replicating, distributing, and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids, and smaller mole cules work together to provide the molecular setting of living systems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of mono graphs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field.

Author : Anonim
Publisher : CSHL Press
Page : 660 pages
File Size : 55,9 Mb
Release : 2001
Category : Electronic journals
ISBN : 0879696206

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The Ribosome by Anonim Pdf

Author : Boyd Hardesty,Gisela Kramer
Publisher : Springer
Page : 840 pages
File Size : 45,6 Mb
Release : 1986-10-14
Category : Science
ISBN : UOM:39015004841964

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Structure, Function, and Genetics of Ribosomes by Boyd Hardesty,Gisela Kramer Pdf

During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was transmitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramati cally different. We have an almost bewildering variety of information de tailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for replicating, distributing, and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids, and smaller mole cules work together to provide the molecular setting of living systems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of mono graphs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field.

Author : Roger A. Garrett
Publisher : Amer Society for Microbiology
Page : 565 pages
File Size : 48,8 Mb
Release : 2000
Category : Medical
ISBN : 1555811841

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The Ribosome by Roger A. Garrett Pdf

Complete coverage of the ribosome and mechanisms of protein synthesis. * Examines the structure and function of numerous extra-chromosomal factors. * Offers the first detailed account of crystal structures of the ribosome as well as insights into the mechanisms and action of antibiotics. This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Author : Gary Spedding
Publisher : Oxford University Press, USA
Page : 352 pages
File Size : 52,8 Mb
Release : 1990
Category : Science
ISBN : UOM:39015059001613

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Ribosomes and Protein Synthesis by Gary Spedding Pdf

A practical and self-contained introduction to methods of researching the structure and function of the ribosome in light of the increasing recognition of the potential capability of RNA molecules to act as molecular catalysts. Also describes protein synthesis and cell-free synthesizing systems. Annotation copyrighted by Book News, Inc., Portland, OR