Protein Synthesis And Translational Control

Author : John W. B. Hershey,Nahum Sonenberg,Michael Mathews
Publisher : Cold Spring Harbor Perspective
Page : 0 pages
File Size : 51,5 Mb
Release : 2012
Category : Science
ISBN : 1936113465

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Protein Synthesis and Translational Control by John W. B. Hershey,Nahum Sonenberg,Michael Mathews Pdf

The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and genetic disorders including "ribosomopathies." Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of protein synthesis and its control, from the genomic level to single- molecule analysis and single-cell imaging. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high- resolution structures of the translational machinery. They review the targets of translational control (e.g., initiation factors and mRNAs) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs (including microRNAs) are also covered. This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as developmental and neurobiologists, oncologists, virologists, and all those investigating human diseases associated with translation dysfunction.

Author : Michael B. Mathews,Nahum Sonenberg,John W. B. Hershey
Publisher : Unknown
Page : 499 pages
File Size : 52,5 Mb
Release : 2018-09-30
Category : Genetic translation
ISBN : 1621821862

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Translation Mechanisms and Control by Michael B. Mathews,Nahum Sonenberg,John W. B. Hershey Pdf

A subject collection from Cold Spring Harbor Perspectives in Biology.

Author : Michael B. Mathews
Publisher : Unknown
Page : 212 pages
File Size : 47,9 Mb
Release : 1986
Category : Science
ISBN : UOM:39015010141003

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Translational Control by Michael B. Mathews Pdf

Author : Greco Hernández,Rosemary Jagus
Publisher : Springer
Page : 564 pages
File Size : 45,5 Mb
Release : 2016-08-10
Category : Science
ISBN : 9783319394688

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Evolution of the Protein Synthesis Machinery and Its Regulation by Greco Hernández,Rosemary Jagus Pdf

The “omics” era has given a new perspective to the findings on the origin and evolution of the process of translation. This book provides insight into the evolution of the translation process and machinery from a modern perspective. Written by leading experts in molecular biology, this text looks into the origins and evolution of the protein synthetic machinery.

Author : Antonius M. VanDongen
Publisher : CRC Press
Page : 350 pages
File Size : 44,9 Mb
Release : 2008-10-29
Category : Science
ISBN : 142004415X

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Biology of the NMDA Receptor by Antonius M. VanDongen Pdf

The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world’s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field.

Author : Nahum Sonenberg,John W. B. Hershey,Michael B. Mathews
Publisher : CSHL Press
Page : 1034 pages
File Size : 43,5 Mb
Release : 2001
Category : Gene expression
ISBN : 0879696184

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Translational Control of Gene Expression by Nahum Sonenberg,John W. B. Hershey,Michael B. Mathews Pdf

Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translation control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translation machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 44,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Jonathan D. Dinman
Publisher : Springer Science & Business Media
Page : 325 pages
File Size : 52,7 Mb
Release : 2012-09-20
Category : Medical
ISBN : 9781461439912

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Biophysical approaches to translational control of gene expression by Jonathan D. Dinman Pdf

This book provides a premier resource on understanding the ribosome's essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis. As one of the central foundations in our understanding of the biology at the molecular level, this topic appeals to a wide audience, from bench researcher to clinician. With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm.

Author : Michael Mathews,Nahum Sonenberg,John W. B. Hershey
Publisher : CSHL Press
Page : 932 pages
File Size : 45,6 Mb
Release : 2007
Category : Medical
ISBN : 9780879697679

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Translational Control in Biology and Medicine by Michael Mathews,Nahum Sonenberg,John W. B. Hershey Pdf

Updated and broadened 3rd edition. Since the last edition was published, the structures of the bacterial and eukaryotic ribosomes have been published, adding substantially to our knowledge of the basic mechanisms of translation. Understanding of how translation is regulated, by both protein and RNA regulators, has also advanced considerable. In addition, the current manifesttion of this volume has a significant focus on the role of translational control in human development and disease.

Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 41,5 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390

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Systems Biology of Cancer by Sam Thiagalingam Pdf

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Author : Anonim
Publisher : Academic Press
Page : 300 pages
File Size : 44,8 Mb
Release : 2009-10-26
Category : Science
ISBN : 008091196X

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Translational Control in Health and Disease by Anonim Pdf

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology and translational science. It contains contributions from leaders in their fields and abundant references. This volume focuses on translational control in health and disease. * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Author : Eric Jan
Publisher : Biota Publishing
Page : 106 pages
File Size : 53,8 Mb
Release : 2014-05-01
Category : Science
ISBN : 9781615046317

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Protein Translation by Eric Jan Pdf

Protein synthesis is a fundamental aspect of gene expression across kingdoms. The regulation of translation is important for many biological processes including cell fate determination, development, and growth and is especially crucial to maintain cellular homeostasis during cellular stress and virus infection. Misregulation of protein translation can contribute to diseases such as diabetes, cancer, and neurodegenerative diseases. In this chapter, we highlight the basic understanding of eukaryotic translation and the major regulations that control biological events. We focus on signaling pathways that regulate overall protein synthesis and also mechanisms that control translation of specific mRNAs such as cis-acting elements within the 5' and 3 untranslated regions (UTR). Understanding these mechanisms provide insights into the fundamental gene regulations that may provide new targets for combating disease and virus infections.

Author : Wayne S. Sossin
Publisher : Oxford University Press
Page : 512 pages
File Size : 55,8 Mb
Release : 2021-04-15
Category : Science
ISBN : 9780190686321

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The Oxford Handbook of Neuronal Protein Synthesis by Wayne S. Sossin Pdf

Translational control in the nervous system is important. Many physiological processes in the nervous system depend on accurate control of the proteome that is mediated through protein synthetic mechanisms and thus, the nervous system is very sensitive to dysregulation of translational control. The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how important nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. The handbook is comprehensive in its coverage of translational control mechanisms with particular focus on how these general control mechanisms are specifically utilized in the context of the cell biological constraints of the nervous system from both a mechanistic and systems perspective.

Author : Alexander Spirin
Publisher : Springer Science & Business Media
Page : 417 pages
File Size : 41,9 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781461578178

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Ribosomes by Alexander Spirin Pdf

This book is based on an advanced course of lectures on ribosome structure and protein biosynthesis that I offer at the Moscow State University. These lectures have been part of a general course on molecular biology for almost three decades, and they have undergone considerable evolution as knowledge has been pro gressing in this field. The progress continues, and readers should be prepared that some facts, statements, and ideas included in the book may be incomplete or out of-date. In any case, this is primarily a textbook, but not a comprehensive review. It provides a background of knowledge and current ideas in the field and gives ex amples of observations and their interpretations. I understand that some interpre tations and generalizations may be tentative or disputable, but I hope that this will stimulate thinking and discussing better than if I left white spots. The book has a prototype: it is my monograph "Ribosome Structure and Pro tein Biosynthesis" published by the Benjamin/Cummings Publishing Company, Menlo Park, California, in 1986. Here I have basically kept the former order of pre sentation ofthe topics and the subdivision into chapters. The contents ofthe chap ters, however, have been significantly revised and supplemented. The newly writ ten chapters on translational control in prokaryotes (Chapter 16) and eukaryotes (Chapter 17) are added.

Author : Manish Biyani
Publisher : BoD – Books on Demand
Page : 148 pages
File Size : 46,6 Mb
Release : 2012-10-10
Category : Science
ISBN : 9789535108030

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Cell-Free Protein Synthesis by Manish Biyani Pdf

The Nobel Prize in Medicine 1968 for interpretation of the genetic code and its function in protein synthesis and in Chemistry 2009 for studies of the structure and function of the ribosome highlighted the ground-breaking experiment performed on May 15, 1961 by Nirenberg and Matthaei and their principal breakthrough on the creation of "cell-free protein synthesis (CFPS) system". Since then the continuous technical advances have revitalized CFPS system as a simple and powerful technology platform for industrial and high-throughput protein production. CFPS yields exceed grams protein per liter reaction volume and offer several advantages including the ability to easily manipulate the reaction components and conditions to favor protein synthesis, decreased sensitivity to product toxicity, batch reactions last for multiple hours, costs have been reduced orders of magnitude, and suitability for miniaturization and high-throughput applications. With these advantages, there is continuous increasing interest in CFPS system among biotechnologists, molecular biologists and medical or pharmacologists.