Proton Radiotherapy Accelerators

Author : Wioletta Wieszczycka,Waldemar Scharf
Publisher : World Scientific
Page : 354 pages
File Size : 47,7 Mb
Release : 2001
Category : Science
ISBN : 9812811648

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Proton Radiotherapy Accelerators by Wioletta Wieszczycka,Waldemar Scharf Pdf

Hadronic radiotherapy uses particle beams to treat tumors located near critical body structures and tumors that respond poorly to conventional photon and electron beam radiotherapy. Initial research in hadronic radiotherapy was performed using accelerators built for physics research. The good results of the proton and ion therapy programs have enhanced the tendency to use protontherapy as a routine method. There are about 20 working protontherapy facilities (first, second and third generation) and more than 30 centers are planned. This book presents the first comprehensive overview of the field with a discussion on the fundamental basis of particle physics and radiobiology, as well as review of clinical and technical specifications and designs for proton radiotherapy. In particular, the current designs of proton and heavy ion accelerators, beam delivery systems, gantries, beam monitoring and dosimetry systems, control and safety systems, patient positioning and immobilization devices, and ancillary treatment facilities are widely discussed. Contents: Physical and Radiobiological Properties of Hadrons; Status of Clinical Research in Protontherapy; Hadrontherapy Facilities World-Wide; Requirements for Hadrontherapy Centers; Protontherapy Accelerators; Beam Transport and Delivery Systems; Proton Gantries; Radiation Detectors; Treatment Ancillary Facilities; Control System of the Protontherapy Center; Shielding for Proton Facility; Global Costs and Financial Analysis of the Activities of the Proton Center; Proposal of a Dedicated Protontherapy Facility. Readership: Engineers, medical physicists and physicians involved in the design and construction of radiotherapy accelerators, undergraduate and graduate students in high energy accelerator and biomedical physics, radiotherapists.

Author : Santosh Yajnik
Publisher : Springer Science & Business Media
Page : 120 pages
File Size : 42,5 Mb
Release : 2012-10-17
Category : Medical
ISBN : 9781461452980

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Proton Beam Therapy by Santosh Yajnik Pdf

Proton beam therapy is an emerging technology with promise of revolutionizing the treatment of cancer. While nearly half of all patients diagnosed with cancer in the US receive radiation therapy, the majority is delivered via electron accelerators, where photons are used to irradiate cancerous tissue. Because of the physical properties of photon beams, photons may deposit energy along their entire path length through the body. On the other hand, a proton beam directed at a tumor travels in a straight trajectory towards its target, gives off most of its energy at a defined depth called the Bragg peak, and then stops. While photons often deposit more energy within the healthy tissues of the body than within the cancer itself, protons can deposit most of their cancer-killing energy within the area of the tumor. As a result, in the properly selected patients, proton beam therapy has the ability to improve cure rates by increasing the dose delivered to the tumor and simultaneously reduce side-effects by decreasing the dose to surrounding tissue. The benefits of proton beam therapy in delivering a lethal hit to the target while sparing surrounding normal tissues from radiation are becoming applicable to an increasing number of patients and a growing list of conditions. In this book, the author will guide the reader through existing evidence supporting proton beam therapy for pediatric cancer, prostate cancer, lung cancer, brain tumors, spinal tumors, and several other conditions. The book will discuss which conditions are suitable for treatment with proton beam therapy, how the treatment is delivered, and the current data supporting its use.

Author : Harald Paganetti
Publisher : CRC Press
Page : 691 pages
File Size : 49,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439836453

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Proton Therapy Physics by Harald Paganetti Pdf

Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.

Author : Toshiyuki Shirai,Teiji Nishio,Kiyokazu Sato
Publisher : Academic Press
Page : 386 pages
File Size : 46,5 Mb
Release : 2023-05-25
Category : Science
ISBN : 9780323991926

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Advances in Accelerators and Medical Physics by Toshiyuki Shirai,Teiji Nishio,Kiyokazu Sato Pdf

Radiotherapy is now one of the major cancer treatments. The field of accelerator and medical physics is important and growing to support high precision cancer radiotherapy. Advances in Accelerators and Medical Physics provides in-depth and comprehensive coverage of the basic concepts in x-ray therapy, electron beam therapy, particle therapy, boron neutron capture therapy, and molecular imaging and therapy. Novel technologies such as FLASH therapy and laser ion accelerator are also introduced. Each section of the book presents the current state of accelerators, irradiation methods and therapy technologies, as well as future trends in advanced research. This book will serve as a key resource for researchers and students to find all information on latest cancer radiotherapy technologies and methods. Offers a deep dive into fundamental accelerator and medical physics techniques and technologies used in cancer radiotherapy Considers updated status at hospitals and clinical facilities, and future research trends Covers advanced research, development and novel technologies Chapters written by experts from the Particle Accelerator Society of Japan(PASJ) and the Japan Society of Medical Physics (JSMP)

Author : Harald Paganetti
Publisher : CRC Press
Page : 772 pages
File Size : 54,5 Mb
Release : 2018-11-19
Category : Science
ISBN : 9781351855754

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Proton Therapy Physics, Second Edition by Harald Paganetti Pdf

Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective

Author : Damien Weber,Simon Crompton
Publisher : vdf Hochschulverlag AG
Page : 220 pages
File Size : 55,9 Mb
Release : 2023-02-06
Category : Medical
ISBN : 9783728141361

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Physics against cancer by Damien Weber,Simon Crompton Pdf

Cancer Treatment, Radiation Oncology, PSI, Pencil Beam Scanning, History of Medicine Modern proton therapy is saving the lives of more and more children and adults with difficult-to-treat cancers. The spectacular rise of proton therapy might never have happened if it were not for the pioneering work of the Paul Scherrer Institute – a Swiss centre founded to explore physics and the nature of matter, but which turned its understanding of basic science into applications that would benefit mankind. This is the place that pioneered a technique of delivering protons to tumours called pencil beam scanning (also known as spot scanning) – now used in nearly every proton therapy centre in the world. It also developed techniques to more accurately deliver the correct proton dose to every part of a tumour – again, now used globally. This book is for anyone with an interest in scientists’ continual quest to find out more. It tells the remarkable story, spanning half a century, of the men and women at the Paul Scherrer Institute’s Center for Proton Therapy who had the knowledge, imagination and perseverance to bring their ideas to fruition. It demonstrates, perhaps most of all, just what can be achieved from close collaboration between physicians and scientists – bringing all the powers of physics to bear in the fight against cancer. "For a field to grow, and for the community of patients to be best served, it’s necessary to learn, grow, improve and share, the way it has been done at PSI. This book provides a look at that extremely important perspective. I, for one, read it with great pleasure." (Jay Flanz, Project Director and Technical Director of the Burr Proton Therapy Center, Massachusetts General Hospital)

Author : Thomas F. De Laney,Hanne M. Kooy
Publisher : Lippincott Williams & Wilkins
Page : 298 pages
File Size : 46,5 Mb
Release : 2008
Category : Medical
ISBN : 0781765528

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Proton and Charged Particle Radiotherapy by Thomas F. De Laney,Hanne M. Kooy Pdf

This volume is the first comprehensive and practical clinical reference on proton and charged particle radiotherapy. The first half of the book explains the treatment delivery systems used, offers detailed guidance on treatment planning techniques, examines key clinical issues in proton radiotherapy, and reviews recent experience with heavier charged particle radiotherapy. The second half of the book offers "how-to" information on treatment of pediatric tumors, lymphomas, and tumors of the central nervous system, eye, skull base, cervical spine, bone and soft tissue, paranasal sinus, nasal cavity, nasopharynx, oropharynx, oral cavity, salivary glands, prostate, lung, gastrointestinal tract, female reproductive tract, and breast. More than 100 full-color illustrations complement the text.

Author : Alex Chao
Publisher : World Scientific
Page : 321 pages
File Size : 51,9 Mb
Release : 2009
Category : Medical
ISBN : 9789814299350

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Reviews of Accelerator Science and Technology by Alex Chao Pdf

Physical and biological basis of proton and of carbon ion radiation therapy and clinical outcome data / Herman Suit, Thomas F. Delaney and Alexei Trofimov -- The production of radionuclides for radiotracers in nuclear medicine / Thomas J. Ruth -- Proton radiation therapy in the hospital environment : conception, development, and operation of the initial hospital-based facility / James M. Slater, Jerry D. Slater and Andrew J. Wroe -- Microwave electron linacs for oncology / David H. Whittum -- Heavy-particle radiotherapy : system design and application / H. Tsujii, S. Minohara and K. Noda -- High frequency linacs for hadrontherapy / Ugo Amaldi, Saverio Braccini and Paolo Puggioni -- Medical cyclotrons / D.L. Friesel and T.A. Antaya -- Synchrotrons for hadrontherapy / Marco G. Pullia -- Beam delivery systems for particle radiation therapy : current status and recent developments / J.M. Schippers -- Laser acceleration of ions for radiation therapy / Toshiki Tajima, Dietrich Habs and Xueqing Yan -- FFAGs as accelerators and beam delivery devices for ion cancer therapy / Dejan Trbojevic -- The dielectric wall accelerator / George J. Caporaso, Yu-Jiuan Chen and Stephen E. Sampayan -- The supercollider : the Texas days - a personal recollection of its short life and demise / Stanley Wojcicki -- A man for all seasons : Robert R. Wilson / Edwin L. Goldwasser

Author : C-M Charlie Ma,Tony Lomax
Publisher : CRC Press
Page : 258 pages
File Size : 46,7 Mb
Release : 2012-10-09
Category : Science
ISBN : 9781439816073

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Proton and Carbon Ion Therapy by C-M Charlie Ma,Tony Lomax Pdf

Proton and Carbon Ion Therapy is an up-to-date guide to using proton and carbon ion therapy in modern cancer treatment. The book covers the physics and radiobiology basics of proton and ion beams, dosimetry methods and radiation measurements, and treatment delivery systems. It gives practical guidance on patient setup, target localization, and treatment planning for clinical proton and carbon ion therapy. The text also offers detailed reports on the treatment of pediatric cancers, lymphomas, and various other cancers. After an overview, the book focuses on the fundamental aspects of proton and carbon ion therapy equipment, including accelerators, gantries, and delivery systems. It then discusses dosimetry, biology, imaging, and treatment planning basics and provides clinical guidelines on the use of proton and carbon ion therapy for the treatment of specific cancers. Suitable for anyone involved with medical physics and radiation therapy, this book offers a balanced and critical assessment of state-of-the-art technologies, major challenges, and the future outlook of proton and carbon ion therapy. It presents a thorough introduction for those new to the field while providing a helpful, up-to-date reference for readers already using the therapy in clinical settings.

Author : David Greene,P.C Williams
Publisher : CRC Press
Page : 300 pages
File Size : 50,6 Mb
Release : 1997-01-01
Category : Science
ISBN : 0750304766

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Linear Accelerators for Radiation Therapy, Second Edition by David Greene,P.C Williams Pdf

Linear Accelerators for Radiation Therapy, Second Edition focuses on the fundamentals of accelerator systems, explaining the underlying physics and the different features of these systems. This edition includes expanded sections on the treatment head, on x-ray production via multileaf and dynamic collimation for the production of wedged and other intensity modulated beams, on electron scattering systems, and on dosimetry. With high-quality illustrations and practical examples throughout, it contains a detailed description of electron beam optics and linear accelerator components. The final chapter explains how to use other equipment, such as scanners and simulators, in conjunction with linear accelerators for optimum treatment of cancers.

Author : Koji Tsuboi,Takeji Sakae,Ariungerel Gerelchuluun
Publisher : Springer Nature
Page : 232 pages
File Size : 40,9 Mb
Release : 2020-01-24
Category : Medical
ISBN : 9789811374548

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Proton Beam Radiotherapy by Koji Tsuboi,Takeji Sakae,Ariungerel Gerelchuluun Pdf

This book offers a comprehensive, practical guide to understanding the physical and biological characteristics of proton beam radiotherapy. The application of proton beams to the treatment of solid cancers has expanded exponentially over the last decade due to their physical properties, which make it possible to administer higher doses of radiation to lesions with only a minimum dose to the surrounding healthy tissues. Accordingly, understanding the basic aspects of proton beam radiotherapy is a primary concern not only for medical physicists and radiation biologists, but also for all physicians involved in cancer treatment using proton beams. The major aspects discussed include the technique’s development background, the generation and delivery system for proton beams, physical characteristics, biological consequences, dosimetry, and future prospects in both medical physics and radiation biology in terms of effective cancer treatment. Gathering contributions from experts who provide clear and detailed information on the basics of proton beams, the book will greatly benefit not only radiological technicians, medical physicists, and physicians, but also scientists in cancer radiotherapy.

Author : Indra J. Das,Paganetti Harald
Publisher : Unknown
Page : 828 pages
File Size : 43,6 Mb
Release : 2015-06-22
Category : Electronic
ISBN : 1936366436

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Principles and Practice of Proton Bean Therapy, AAPM Monograph by Indra J. Das,Paganetti Harald Pdf

Author : Hans Breuer,Berend J. Smit
Publisher : Springer Science & Business Media
Page : 288 pages
File Size : 46,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662043011

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Proton Therapy and Radiosurgery by Hans Breuer,Berend J. Smit Pdf

The book is divided into two parts: Part I deals with the relevant physics and planning algorithms of protons (H Breuer) and Part II with the radiobiology, radiopathology and clinical outcomes of proton therapy and a comparison of proton therapy versus photon therapy (BJ Smit). Protons can be used for radiosurgery and general radio therapy. Since proton therapy was first proposed in 1946 by Wilson, about sixteen facilities have been built globally. Only a very few of these have isocentric beam delivery systems so that proton therapy is really only now in a position to be compared directly by means of randomised clinical trials, with modern photon radiotherapy therapy sys tems, both for radiosurgery and for general fractionated radiotherapy. Three-dimensional proton planning computer systems with image fusion (image of computerised tomography (CT), magnetic resonance registration) capabilities imaging (MRI), stereotactic angiograms and perhaps positron emission tomography (PET) are essential for accurate proton therapy planning. New planning systems for spot scanning are under development. Many of the older comparisons of the advantageous dose distributions for protons were made with parallel opposing or multiple co-planar field arrangements, which are now largely obsolete. New comparative plans are necessary once more because of the very rapid progress in 3-D conformal planning with photons. New cost-benefit analy ses may be needed. Low energy (about 70 MeV) proton therapy is eminently suitable for the treatment of eye tumours and has firmly established itself as very useful in this regard.

Author : Manjit Dosanjh,Jacques Bernier
Publisher : CRC Press
Page : 370 pages
File Size : 40,6 Mb
Release : 2018-05-11
Category : Science
ISBN : 9781351662338

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Advances in Particle Therapy by Manjit Dosanjh,Jacques Bernier Pdf

Hadron therapy is a groundbreaking new method of treating cancer. Boasting greater precision than other therapies, this therapy is now utilised in many clinical settings and the field is growing. More than 50 medical facilities currently perform (or are planned to perform) this treatment, with this number set to double by 2020. This new text covers the most recent advances in hadron therapy, exploring the physics, technology, biology, diagnosis, clinical applications, and economics behind the therapy. Providing essential and up-to-date information on recent developments in the field, this book will be of interest to current and aspiring specialists from a wide range of backgrounds. Features: Multidisciplinary approach: explores the physics, IT (big data), biology, clinical applications from imaging to treatment, clinical trials, and economics associated with hadron therapy Contains the latest research and developments in this rapidly evolving field, and integrates them into the current global challenges for radiation therapy Edited by recognised leaders in the field, including the co-ordinator of ENLIGHT (the European Network for Light Ion Hadron Therapy), with chapter contributions from international leading experts in the field

Author : Barbara Bridgman Perkins
Publisher : Routledge
Page : 244 pages
File Size : 49,6 Mb
Release : 2017-08-16
Category : History
ISBN : 9781351978125

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Cancer, Radiation Therapy, and the Market by Barbara Bridgman Perkins Pdf

Appraising cancer as a major medical market in the 2010s, Wall Street investors placed their bets on single-technology treatment facilities costing $100-$300 million each. Critics inside medicine called the widely-publicized proton-center boom "crazy medicine and unsustainable public policy." There was no valid evidence, they claimed, that proton beams were more effective than less costly alternatives. But developers expected insurance to cover their centers’ staggeringly high costs and debts. Was speculation like this new to health care? Cancer, Radiation Therapy, and the Market shows how the radiation therapy specialty in the United States (later called radiation oncology) coevolved with its device industry throughout the twentieth-century. Academic engineers and physicians acquired financing to develop increasingly powerful radiation devices, initiated companies to manufacture the devices competitively, and designed hospital and freestanding procedure units to utilize them. In the process, they incorporated market strategies into medical organization and practice. Although palliative benefits and striking tumor reductions fueled hopes of curing cancer, scientific research all too often found serious patient harm and disappointing beneficial impact on cancer survival. This thoroughly documented and provocative inquiry concludes that public health policy needs to re-evaluate market-driven high-tech medicine and build evidence-based health care systems.