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Author : Francisco Ciruela,Kenneth A. Jacobson
Publisher : Frontiers Media SA
Page : 852 pages
File Size : 43,9 Mb
Release : 2019-08-16
Category : Electronic
ISBN : 9782889459476
Author : Francisco Ciruela,Kenneth. A. Jacobson
Publisher : Frontiers Media SA
Page : 187 pages
File Size : 41,5 Mb
Release : 2023-06-07
Category : Science
ISBN : 9782832525753
Author : Maria P. Abracchio,Michael Williams
Publisher : Springer Science & Business Media
Page : 814 pages
File Size : 55,9 Mb
Release : 2001-02-12
Category : Medical
ISBN : 3540678492
Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Author : Kenneth A Jacobson,Joel Linden
Publisher : Academic Press
Page : 559 pages
File Size : 47,6 Mb
Release : 2011-06
Category : Medical
ISBN : 9780123855268
This is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors. Authors are the leading authorities in their fields Subject matter is important for understanding tissue protection Subject matter is of intense interest for new drug development
Author : Kenneth A. Jacobson,Michael F. Jarvis
Publisher : Wiley-Liss
Page : 0 pages
File Size : 43,8 Mb
Release : 1997-07-15
Category : Medical
ISBN : 0471140716
Edited by Kenneth A. Jacobson and Michael F. Jarvis The roles of extracellular purines and pyrimidines in cellularhomeostasis and disease etiology have come to be understoodgradually over the past 40 years. However, due to the recentcloning and expression of receptors for ATP and adenosine, novelcompounds have been developed with unique therapeutic potential forthe treatment of thrombosis, stroke, epilepsy, chronic pain,immunological disorders, and cancer. As a result, the study ofadenosine- and ATP-mediated responses in cellular regulation isentering a phase of opportunity and development unmatched since thedays of serotonin receptor research in the 1970s. The only definitive book on the topic, Purinergic Approaches inExperimental Therapeutics covers all of the major therapeuticapplications of purinergic receptors and reflects the very latestdevelopments in this new area of therapeutic research. Twenty-eightchapters, authored by an international group of contributors whoare the leading authorities in the field, provide details onmolecular pharmacology; medicinal chemistry; and therapeuticimplications, including cardiology, metabolism, immunology,neurology, and cancer. Among the topics covered: * Purinergic Neurotransmission and Neuromodulation: A HistoricalPerspective * Adenosine Receptor Subtypes: New Insights from Cloning andFunctional Studies * Modulators of Adenosine Uptake, Release, and Inactivation * Cardiac Electrophysiology of Adenosine: Antiarrhythmic andProarrhythmic Actions * Purinergic Modulation of Gastrointestinal Function * The Role of Adenosine in Asthma * ATP in Brain Function * ATP in the Treatment of Cancer For researchers in pharmacology, physiology, molecular biology, andmedicinal chemistry, Purinergic Approaches in ExperimentalTherapeutics heralds an exciting new era in the understanding ofpurinergic neurotransmission and the development of noveltherapeutic modalities.
Author : Yong Tang,Patrizia Rubini,Beata Sperlagh,Henning Ulrich
Publisher : Frontiers Media SA
Page : 139 pages
File Size : 55,6 Mb
Release : 2024-01-26
Category : Science
ISBN : 9782832543566
This Research Topic aims to honour the 80th birthday of Professor Peter Illes, who is a member of the European Academy of Sciences, the founder/first president of the German Purine Club, and Honorary President of the Chinese Purine Club. He established a worldwide co-operation network on purinergic signalling and is an internationally recognized leader in the field. We aim to collect research articles and reviews from friends, colleagues and co-operation partners of Dr. Illes to showcase, build on and develop research being achieved related to the physiological/pathophysiological roles of purines in the central nervous system (CNS). Adenosine Triphosphate (ATP) is an intracellular energy-storing molecule, but may also reach the extracellular space, where it participates in cell-to-cell signalling. For this purpose, ATP utilises a range of purinergic receptors activated either by ATP itself (P2X receptors; seven subtypes) or by ATP/ADP and UTP/UDP (P2Y receptors; 8 subtypes) and finally via its enzymatic degradation product, adenosine (P1/A receptors; 4 subtypes). Purine nucleotides and nucleosides together with the whole plethora of receptors and degrading enzymes constitute the purinome. This fascinating and extensive network exists both in the animal kingdom and in humans and is essential in regulating important physiological functions. Disturbances in the network can lead to a variety of illnesses clinically associated with both neurological or psychiatric traits. In recent years, hope has arisen that pharmacological chemistry together with various newly developed methods, will enable researchers to discover and design efficient drugs for treating these neurodegenerative and affective diseases.
Author : Francesco Caciagli,Francisco Ciruela,Kjell Fuxe,Peter Illes,Henning Ulrich
Publisher : Frontiers Media SA
Page : 287 pages
File Size : 41,5 Mb
Release : 2021-10-29
Category : Science
ISBN : 9782889715701
Author : Rosa Gomez-Villafuertes,Elena Adinolfi
Publisher : Frontiers Media SA
Page : 126 pages
File Size : 55,9 Mb
Release : 2020-08-27
Category : Electronic
ISBN : 9782889639649
Author : Maria P. Abracchio,Michael Williams
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642569210
Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Author : Robson Faria
Publisher : BoD – Books on Demand
Page : 112 pages
File Size : 54,7 Mb
Release : 2020-03-11
Category : Medical
ISBN : 9781789845341
This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.
Author : Ralph W. Straub,Liana Bolis
Publisher : Unknown
Page : 392 pages
File Size : 48,6 Mb
Release : 1978
Category : Medical
ISBN : UOM:39015003242198
Author : James M. Ritter,Rod J. Flower,Graeme Henderson,Yoon Kong Loke,David MacEwan,Humphrey P. Rang
Publisher : Elsevier Health Sciences
Page : 808 pages
File Size : 55,7 Mb
Release : 2018-11-04
Category : Medical
ISBN : 9780702074462
World-renowned coverage of today’s pharmacology at your fingertips Keeps you up-to-date with new information in this fast-changing field, including significantly revised coverage of CNS drugs, cognitive enhancers, anti-infectives, biologicals/biopharmaceuticals, lifestyle drugs, and more. Includes access to unique features, including more than 100 brand new chapter-specific multiple-choice questions and 6 new cases for immediate self-assessment. Features a color-coded layout for faster navigation and cross-referencing. Clarifies complex concepts with Key Points boxes, Clinical Uses boxes and full-color illustrations throughout.
Author : Anonim
Publisher : Unknown
Page : 442 pages
File Size : 41,6 Mb
Release : 2001
Category : Purines
ISBN : LCCN:00048277
Author : James M. Ritter,Rod J. Flower,Graeme Henderson,Yoon Kong Loke,David MacEwan,Emma Robinson,James Fullerton
Publisher : Elsevier Health Sciences
Page : 1001 pages
File Size : 44,5 Mb
Release : 2023-05-13
Category : Medical
ISBN : 9780323873987
Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years. Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required. This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing. Comprehensive information on drug mechanisms, basic physiology and biochemistry, and underlying pathophysiology of disease – suitable for students from many disciplines Clear figures to aid understanding, including data figures as well as mechanistic diagrams, Key points box summaries, clinical boxes and colour-coded chapters help to master difficult concepts Emphasis on therapeutic drugs to help apply theory to practice Over 150 questions and 12 clinical cases to test your knowledge New chapters on drugs and the eye and the pharmacological management of headache Revised information on biopharmaceuticals (including RNA drugs), antivirals (including Covid-19 therapies) as well as general principles of antimicrobial therapy. A completely revised and updated chapter on lifestyle drugs Recent advances in oxygen sensing and response to reduced oxygen tension Expanded chapters on dementia and analgesic drugs
Author : Salvatore Salomone
Publisher : Frontiers Media SA
Page : 266 pages
File Size : 51,5 Mb
Release : 2020-04-14
Category : Electronic
ISBN : 9782889634798
Frontiers in Pharmacology was launched in 2010, with a number of sections which were eventually reorganized. The founding Field Chief Editor was Prof. Théophile Godfraind, an eminent scientist active in cardiovascular pharmacology, who pioneered the discovery of calcium antagonists. At that time he invited me to serve as Chief Editor for a section named “Analytical and Experimental Pharmacology”. Later on, our section enlarged and was re-named as “Experimental Pharmacology and Drug Discovery” to outline the translational potential of fundamental pharmacological research and theoretical analysis to the improvement of human health, through the invention of novel medicinal products. We are now entering the 10th year of editorial activity, which sees the publication of the 1,000th paper in our section. Such an achievement is very rewarding for us and our community, but it is even more remarkable when placed into the timeline of our development. In fact, in a 10-year frame we have significantly grown in quantity and quality, e.g. both in number of published papers and in scientific impact. [From a personal perspective by Salvatore Salomone, Specialty Chief Editor]
