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Author : F. Kasler
Publisher : Unknown
Page : 210 pages
File Size : 47,7 Mb
Release : 1973
Category : Analytical chemistry
ISBN : UCAL:B4477507
Author : Anonim
Publisher : Academic Press
Page : 214 pages
File Size : 48,6 Mb
Release : 2017-01-02
Category : Science
ISBN : 9780128120101
Annual Reports on NMR Spectroscopy provides a thorough and in-depth accounting of progress in nuclear magnetic resonance (NMR) spectroscopy and its many applications. Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained as much significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required, and where the nature of interactions and reactions in solution is being studied. This book has established itself as a premier means for both specialists and non-specialists looking to familiarize themselves with the newest techniques and applications pertaining to NMR spectroscopy. Serves as the premier resource for learning the new techniques and applications of NMR spectroscopy Provides a key reference for chemists and physicists using NMR spectroscopy to study the structure and dynamics of molecules Covers all aspects of molecular science, including MRI (Magnetic Resonance Imaging)
Author : Iwona Wawer,Bernd Diehl
Publisher : Elsevier
Page : 528 pages
File Size : 50,9 Mb
Release : 2008-08-22
Category : Science
ISBN : 9780080558196
For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples. Combines theory, techniques, and concrete applications—all of which closely resemble the laboratory experience Considers international pharmacopoeias, addressing the concern for licensing Features the work of academics and researchers, appealing to a broad readership
Author : Michael Bernstein,Bernd Diehl,Ulrike Holzgrabe,Michael Maiwald,Klas Meyer,Yulia Monakhova,Torsten Schönberger
Publisher : BoD – Books on Demand
Page : 304 pages
File Size : 55,7 Mb
Release : 2024-02-06
Category : Science
ISBN : 9783756878918
Quantitative NMR (qNMR) has been around for a long time, but also has great potential to solve future problems in any quantitative analysis. As a primary method, it differs fundamentally from chromatographic methods: it is better described as a quantum mechanical balance. Successful implementation of qNMR requires certain attention to detail. 'qNMR - the handbook' is intended to be a guide for analysts to help understand the fundamental principles of NMR and the significant points relating to its implementation for quantitation. Regulatory considerations of qNMR adoption are explained. NMR fundamentals are explained to provide understanding. Together with many useful examples, the book is a compelling addition to the laboratory's reference library, providing all the tools that any practitioner should know to successfully implement qNMR. The authors are qNMR pioneers and come from a variety of backgrounds including business, government, and academia.
Author : Iwona Wawer,Bernd Diehl
Publisher : Elsevier
Page : 525 pages
File Size : 40,9 Mb
Release : 2017-07-07
Category : Science
ISBN : 9780080951522
For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples. Combines theory, techniques, and concrete applications—all of which closely resemble the laboratory experience Considers international pharmacopoeias, addressing the concern for licensing Features the work of academics and researchers, appealing to a broad readership
Author : Karol Jackowski,Michał Jaszuński
Publisher : Royal Society of Chemistry
Page : 400 pages
File Size : 54,6 Mb
Release : 2016-02-09
Category : Medical
ISBN : 9781782623816
This book covers the recent NMR studies with the application of gaseous molecules. Among the comprehensively discussed aspects of the area it includes in particular: new multinuclear experiments that deliver spectral parameters of isolated molecules and provide the most accurate values of nuclear magnetic shielding, isotropic spin–spin coupling and relaxation times; advanced, precise and correct theoretical descriptions of spectral parameters of molecules as well as the application of gas-phase NMR measurements to chemical analysis and medicine. The progress of research in these fields is enormous and has rapidly changed our knowledge and understanding of molecular parameters in NMR spectroscopy. For example, accurate studies of the shielding for isolated molecules allow the exact determination of nuclear magnetic dipole moments, the calculated values of spectral parameters can be verified by precise gas-phase NMR measurements, and the application of hyperpolarized noble gases provides excellent MRI pictures of lungs. Aimed at graduates and researchers in spectroscopy, analytical chemistry and those researching the applications of NMR in medicine, this book presents the connections between sophisticated experiments, the theory of magnetic parameters and the exploration of new methods in practice.
Author : Steven M. Colegate,Russell J. Molyneux
Publisher : CRC Press
Page : 624 pages
File Size : 49,9 Mb
Release : 2007-12-14
Category : Medical
ISBN : 9781420006889
Bioactive natural products are proving to be a rich source of novel therapeutics to both protect against and combat diseases, as well as serve as lead compounds in crop protection. Following the successful format of the first edition, this volume brings together collective research from many new contributors and emphasizes the rationale behind the
Author : David A. R. Williams,Norma Chadwick
Publisher : Wiley
Page : 292 pages
File Size : 51,5 Mb
Release : 1986-12-23
Category : Science
ISBN : 0471911771
Provides a very practical introduction to the applications of NMR spectroscopy within analytical chemistry. Introduces the reader, by means of a readable, open lay-out, to both qualitative and quantitative applications, focusing on the practicalities of using each technique. Treats thoroughly the background, theory, and instrumentation of NMR. Makes clear the situations where the technique is best applied and shows how to interpret the resulting spectra. As with all books in the ACOL series, objectives of each section, and of the overall book, are explained fully, and the reader is encouraged to test his knowledge with self-assessment questions, for which detailed solutions are given. The details of supporting practical work and the bibliography lead to further avenues of study.
Author : Atta-ur-Rahman,M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 289 pages
File Size : 47,9 Mb
Release : 2016-11-22
Category : Science
ISBN : 9781681082875
Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture. The fifth volume of the series features several reviews focusing on NMR spectroscopic techniques for identifying natural and synthetic compounds (polymer and peptide characterization, GABA in tinnitus affected mice), medical diagnosis and therapy (gliomas) and food analysis. The spectroscopic methods highlighted in this volume include high resolution proton magnetic resonance spectroscopy and solid state NMR.
Author : Ulrike Holzgrabe,Iwona Wawer,Bernd Diehl
Publisher : John Wiley & Sons
Page : 312 pages
File Size : 47,7 Mb
Release : 2008-07-11
Category : Medical
ISBN : 9783527613656
Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (> 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis. This book illustrates the power and versatility of NMR spectroscopy in the determination of impurities in and the content of drugs, the composition of polymer excipients, the characterization of isomeric drug mixtures, the complexity of drugs with small-size components or ions, and the behavior of drugs in acid and basic solution. In addition, NMR spectroscopy and especially the hyphenated technique with HPLC is shown to be a powerful tool to measure a drug and its metabolites in various body fluids. The solid state NMR technique can give information on the structure, especially the conformation of drugs and excipients in drug formulations. Recently, SAR by NMR, introduced by Fesik, impressively demonstrated the potential of NMR spectroscopy in drug development and in the characterization of the interaction between large molecules and ligands. The complexation between proteins, lipids and cyclodextrins with drugs is described. Finally, NMR imaging (MRI and MRS) can be used to characterize the liberation of drugs from a drug formulation. Furthermore, the distribution of substances in plants, in animals, in tissues and in humans can be visualized by imaging. In short, this book covers all aspects of drug analysis.
Author : F. W. Wehrli,A. P. Marchand,S. Wehrli
Publisher : Unknown
Page : 504 pages
File Size : 55,8 Mb
Release : 1988-06-23
Category : Science
ISBN : UCSD:31822002409050
This is the second edition of a very successful book which provides the conceptual and experimental basis for the interpretation of 13 C NMR spectra.
Author : L. D. Field,S. Sternhell,John R. Kalman
Publisher : John Wiley & Sons
Page : 426 pages
File Size : 48,9 Mb
Release : 2011-09-07
Category : Science
ISBN : 9781119964612
Organic Structures from Spectra, Fourth Edition consists of a carefully selected set of over 300 structural problems involving the use of all the major spectroscopic techniques. The problems are graded to develop and consolidate the student’s understanding of Organic Spectroscopy, with the accompanying text outlining the basic theoretical aspects of major spectroscopic techniques at a level sufficient to tackle the problems. Specific changes for the new edition will include A significantly expanded section on 2D NMR spectroscopy focusing on COSY, NOESY and CH-Correlation Incorporating new material into some tables to provide extra characteristic data for various classes of compounds Additional basic information on how to solve spectroscopic problems Providing new problems within the area of 10 2D NMR spectroscopy More problems at the ‘simpler’ end of the range As with previous editions, this book combines basic theory, practical advice and sensible approaches to solving spectra problems. It will therefore continue to prove invaluable to students studying organic spectroscopy across a range of disciplines.
Author : David S. Hage,James D. Carr
Publisher : Pearson
Page : 0 pages
File Size : 54,9 Mb
Release : 2011
Category : Analytical chemistry
ISBN : 0321596943
Analytical Chemistry and Quantitative Analysis presents concepts and procedures in a manner that reflects the practice and applications of these methods in today's analytical laboratories. These methods are illustrated by using current examples from fields that include forensics, environmental analysis, medicine, biotechnology, food science, pharmaceutical science, materials analysis, and basic research. The fundamental principles of laboratory techniques for chemical analysis are introduced, along with issues to consider in the appropriate selection and use of these methods--including the proper use and maintenance of balances, laboratory glassware, and notebooks, as well as mathematical tools for the evaluation and comparison of experimental results. Basic topics in chemical equilibria are reviewed and used to help demonstrate the principles and proper use of classical methods of analysis like gravimetry and titrations. Common instrumental techniques are also introduced, such as spectroscopy, chromatography and electrochemical methods. Sideboxes discuss other methods, including mass spectrometry and NMR spectroscopy, throughout the text.
Author : Tatsuki Kitayama,Koichi Hatada
Publisher : Springer Science & Business Media
Page : 231 pages
File Size : 41,9 Mb
Release : 2013-03-09
Category : Technology & Engineering
ISBN : 9783662089828
Based on the authors ́ extensive experimental experience, NMR Spectroscopy of Polymers explains the practical use of NMR spectroscopy in polymer chemistry.
Author : L. D. Field,H. L. Li,A. M. Magill
Publisher : John Wiley & Sons
Page : 560 pages
File Size : 50,5 Mb
Release : 2020-04-22
Category : Science
ISBN : 9781119524793
The derivation of structural information from spectroscopic data is now an integral part of organic chemistry courses at all Universities. A critical part of any such course is a suitable set of problems to develop the students’ understanding of how organic structures are determined from spectra. The book builds on the very successful teaching philosophy of learning by hands-on problem solving; carefully graded examples build confidence and develop and consolidate a student’s understanding of organic spectroscopy. Organic Structures from Spectra, 6th Edition is a carefully chosen set of about 250 structural problems employing the major modern spectroscopic techniques, including Mass Spectrometry, 1D and 2D 13C and 1H NMR Spectroscopy and Infrared Spectroscopy. There are 25 problems specifically dealing with the interpretation of spin–spin coupling in proton NMR spectra and 10 problems based on the quantitative analysis of mixtures using proton and carbon NMR spectroscopy. The accompanying text is descriptive and only explains the underlying theory at a level that is sufficient to tackle the problems. The text includes condensed tables of characteristic spectral properties covering the frequently encountered functional groups. The examples themselves have been selected to include all important structural features and to emphasise connectivity arguments and stereochemistry. Many of the compounds were synthesised specifically for this book. In this collection, there are many additional easy problems designed to build confidence and to demonstrate basic principles. The Sixth Edition of this popular textbook: now incorporates many new problems using 2D NMR spectra (C–H Correlation spectroscopy, HMBC, COSY, NOESY and TOCSY); has been expanded and updated to reflect the new developments in NMR spectroscopy; has an additional 40 carefully selected basic problems; provides a set of problems dealing specifically with the quantitative analysis of mixtures using NMR spectroscopy; features proton NMR spectra obtained at 200, 400 and 600 MHz and 13C NMR spectra including routine 2D C–H correlation, HMBC spectra and DEPT spectra; contains a selection of problems in the style of the experimental section of a research paper; includes examples of fully worked solutions in the appendix; has a complete set of solutions available to instructors and teachers from the authors. Organic Structures from Spectra, Sixth Edition will prove invaluable for students of Chemistry, Pharmacy and Biochemistry taking a first course in Organic Chemistry.