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Author : O. Van Bekkum,H. De Vries
Publisher : Academic Press
Page : 128 pages
File Size : 42,5 Mb
Release : 1967-01-01
Category : Electronic
ISBN : 0127103503
Author : M. S. Silverman
Publisher : Unknown
Page : 32 pages
File Size : 43,6 Mb
Release : 1961
Category : Radiation
ISBN : UOM:39015095219039
The immunological status of lethally irradiated mice protected against the acute effects of irradiation by the transfusion of rat or allelogenic, parental or isogenic bone marrow was studied using the reaction against skin grafts as the indicator system. The data indicated that the radiation chimeras were immunologically unresponsive animals and were, therefore, able temporarily to accept skin grafts from donors foreign to both the irradiated host and the marrow donor. It was concluded that the ultimate rejection of the skin grafts was the result of the recovery of the host's immune response rather than the result of any contribution of donor marrow cells to the immune system. If the animal survives, a specific tolerance towards the bone marrow donor's skin may develop. A possible alternative hypothesis to explain the persistence of the foreign skin grafts despite deaths from "secondary disease" is discussed.
Author : Anonim
Publisher : Unknown
Page : 14 pages
File Size : 51,5 Mb
Release : 1964
Category : Electronic
ISBN : UOM:39015087105048
Author : W. E. Davis (Jr.),M. L. Tyan,L. J. Cole
Publisher : Unknown
Page : 34 pages
File Size : 42,5 Mb
Release : 1963
Category : Immunology
ISBN : UOM:39015095208727
Author : L. J. Cole,W. E. Davis
Publisher : Unknown
Page : 26 pages
File Size : 42,5 Mb
Release : 1962
Category : Bone marrow
ISBN : UOM:39015095208701
The present experiments are concerned with the attempt to prevent or ameliorate the occurrence of secondary disease deaths in irradiated mice bearing foreign bone marrow grafts; in addition, certain aspects of graft-to-host tolerance in early radiation chimeras have been investigated. It is concluded that specific graft-to-host tolerance may develop relatively early in radiation chimeras, that it is possible to prevent or eliminate secondary disease in homologous radiation chimeras by suitable preirradiation of the marrow donors, and by injection into the chimeras of specific isoantiserum directed against the marrow donor. (Author).
Author : W. E. Davis,L. J. Cole,W. A. Foley,V. J. Rosen
Publisher : Unknown
Page : 34 pages
File Size : 50,7 Mb
Release : 1962
Category : Leukemia
ISBN : UOM:39015095219252
In studies on lymphoid cell chimerism and homograft tolerance in long-lived homologous radiation chimeras, data were collected on life span, and on leukemia and other lesions. The chimeras were hybrid mice (10 - 12 weeks old) exposed to 880 rad of X radiation and injected with bone marrow cells from C3H donors. Out of 119 mice, 65% were dead by age 32 weeks, with symptoms of second ry disease evident in the great majority. Relatively few deaths occurred between 32 and 75 weeks, and the maximum life span was 105 weeks. Histopathological data were obtained from many of these long-lived chimeras. There was an 80% incidence of glomerulosclerosis of moderate to severe degree, and a 20% incidence of arteriolarsclerosis in t e kidney and spleen. Leukemias were observed in 5 out of 54 homologous chimeras. Also, two leukemias occurred in 13 chimeras (15%) which had been injected with lymphoid cells obtained from other long-lived homologous chimeras. The possibility of a causal relationship between s condary disease and the increased incidence of leukemia is briefly discussed. (Author).
Author : Charles M. Pierce,U.S. Atomic Energy Commission
Publisher : Unknown
Page : 356 pages
File Size : 40,5 Mb
Release : 1963
Category : Plants
ISBN : UOM:39015095048958
Author : Anonim
Publisher : Unknown
Page : 356 pages
File Size : 48,5 Mb
Release : 1963
Category : Radiobiology
ISBN : UIUC:30112018846839
Author : Rėm Viktorovich Petrov,I︠U︡lii︠a︡ Mikhaĭlovna Zaret︠s︡kai︠a︡,I͡Ulii͡a Mikhaĭlovna Zaret͡skai͡a
Publisher : Unknown
Page : 212 pages
File Size : 45,5 Mb
Release : 1967
Category : Bone marrow
ISBN : UOM:39015022048683
Author : Anonim
Publisher : Unknown
Page : 676 pages
File Size : 48,7 Mb
Release : 1978
Category : Electronic
ISBN : CORNELL:31924105637056
Author : Anonim
Publisher : Unknown
Page : 852 pages
File Size : 45,7 Mb
Release : 1974
Category : Nuclear energy
ISBN : UOM:39015023546214
Author : Maurice Errera,Arne Forssberg
Publisher : Elsevier
Page : 410 pages
File Size : 46,5 Mb
Release : 2013-09-03
Category : Science
ISBN : 9781483266329
Mechanisms in Radiobiology, Volume II: Multicellular Organisms presents the development of radiobiology, which has run parallel with the advancement of biology. This book discusses the fundamental aspects of radiobiology in connection with the therapeutic use of X-rays in medicine. Organized into five chapters, this book begins with an overview of radiation effects on embryonic and adult organisms, particularly in mammals. This text then discusses the immunological processes in irradiated organisms. Other chapters consider the mechanisms of action of protective and sensitizing agents and examine the primary or secondary effects of the irradiation on the various organs. This book discusses as well the experimental possibilities of improving the recovery of irradiated mammals. The final chapter deals with the reactions of living organisms after a damaging dose of ionizing radiation, which is determined by a variety of biological and physical factors. This book is a valuable resource for radiobiologists, pathologists, scientists, physicists, clinicians, and research workers.
Author : Anonim
Publisher : Unknown
Page : 1440 pages
File Size : 55,6 Mb
Release : 1990
Category : Medicine
ISBN : OSU:32436011073523
Author : S. Thierfelder,H. Rodt,H. J. Kolb
Publisher : Springer Science & Business Media
Page : 418 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642673191
Bone marrow transplantation, the goal which integrates hemato logists, immunologists, geneticists, oncologists and specialists of several other fields, has overcome its state of stagnation in recent years. Clinically as well as experimentally new approaches to old problems and new conclusions from recent findings proliferate: bone marrow transplantation in leukemic remission, bone marrow growth in cell culture, bone marrow manipulation with antisera, bone marrow differentiation in histoincompatible hosts, immuno suppression with partial body irradiation to cite just a few. These and other new developments were discussed by experts from 12 countries in and outside the European Community during an international seminar held on March 8-10, 1979 by the "Institut fur Hamatologie, GSF", under the auspices of the European Communities. The editors thank both the contributors to this symposium, who made it a successful meeting and submitted their manuscripts punctually, and the publishers, who have provided a volume of high quality in good time. They are also grateful for the valuable cooperation from numerous colleagues at the Institut fur Hamato logie.
Author : Anonim
Publisher : Unknown
Page : 500 pages
File Size : 53,8 Mb
Release : 1965
Category : Hematology
ISBN : UOM:39015076969867