Rational Basis For Clinical Translation In Stroke Therapy

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Rational Basis for Clinical Translation in Stroke Therapy

Giuseppe Micieli,Diana Amantea
Rational Basis for Clinical Translation in Stroke Therapy Book PDF

Author : Giuseppe Micieli,Diana Amantea
Publisher : CRC Press
Page : 542 pages
File Size : 53,8 Mb
Release : 2014-08-27
Category : Medical
ISBN : 9781466594975

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Rational Basis for Clinical Translation in Stroke Therapy by Giuseppe Micieli,Diana Amantea Pdf

Stroke remains one of the major causes of death and long-term disability worldwide. Currently, the only approved therapy for the acute treatment of this disease is thrombolysis, a strategy that can only be applied to a small percentage of patients due to its narrow therapeutic window. Unfortunately, during the last years numerous promising drugs that showed neuroprotection in the experimental setting failed to translate into the clinic because of their toxicity or lack of efficacy. Researchers in the field now face the crucial need to develop effective stroke therapies and successfully translate novel strategies into the clinical setting. Rational Basis for Clinical Translation in Stroke Therapy presents the most recent promising preclinical approaches and the most updated clinical evidence for treating stroke patients. By bringing together the experience of accomplished stroke researchers and clinicians, the book is a useful tool for improving the treatment and management of stroke patients. The book describes current approaches for the management of stroke patients including thrombolysis and mechanical recanalization procedures as well as other clinically relevant topics such as diagnosis, imaging, risk factors, and prevention. Also described are emerging interventions based on the use of stem cells, botulinum toxin, and antidepressants which complement emergency stroke treatment and conventional rehabilitation procedures. Clinical approaches are integrated with the most promising therapeutic opportunities based on targeting the immune system, hypothermia, and postconditioning. The book also covers issues related to the improvement of R&D strategies in stroke therapeutics, aimed at the implementation of preclinical approaches with stroke model guidelines and at the optimization of clinical trial design. This volume is a reference for all those interested in the rational development of novel stroke therapeutics.

Clinical Pathways in Stroke Rehabilitation

Thomas Platz
Clinical Pathways in Stroke Rehabilitation Book PDF

Author : Thomas Platz
Publisher : Springer Nature
Page : 284 pages
File Size : 48,5 Mb
Release : 2021-01-14
Category : Medical
ISBN : 9783030585051

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Clinical Pathways in Stroke Rehabilitation by Thomas Platz Pdf

This open access book focuses on practical clinical problems that are frequently encountered in stroke rehabilitation. Consequences of diseases, e.g. impairments and activity limitations, are addressed in rehabilitation with the overall goal to reduce disability and promote participation. Based on the available best external evidence, clinical pathways are described for stroke rehabilitation bridging the gap between clinical evidence and clinical decision-making. The clinical pathways answer the questions which rehabilitation treatment options are beneficial to overcome specific impairment constellations and activity limitations and are well acceptable to stroke survivors, as well as when and in which settings to provide rehabilitation over the course of recovery post stroke. Each chapter starts with a description of the clinical problem encountered. This is followed by a systematic, but concise review of the evidence (RCTs, systematic reviews and meta-analyses) that is relevant for clinical decision-making, and comments on assessment, therapy (training, technology, medication), and the use of technical aids as appropriate. Based on these summaries, clinical algorithms / pathways are provided and the main clinical-decision situations are portrayed. The book is invaluable for all neurorehabilitation team members, clinicians, nurses, and therapists in neurology, physical medicine and rehabilitation, and related fields. It is a World Federation for NeuroRehabilitation (WFNR) educational initiative, bridging the gap between the rapidly expanding clinical research in stroke rehabilitation and clinical practice across societies and continents. It can be used for both clinical decision-making for individuals and as well as clinical background knowledge for stroke rehabilitation service development initiatives.

Disease Control Priorities, Third Edition (Volume 5)

Dorairaj Prabhakaran,Shuchi Anand,Thomas A. Gaziano,Jean-Claude Mbanya,Rachel Nugent
Disease Control Priorities Third Edition Volume 5 Book PDF

Author : Dorairaj Prabhakaran,Shuchi Anand,Thomas A. Gaziano,Jean-Claude Mbanya,Rachel Nugent
Publisher : World Bank Publications
Page : 466 pages
File Size : 53,7 Mb
Release : 2017-11-17
Category : Medical
ISBN : 9781464805202

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Disease Control Priorities, Third Edition (Volume 5) by Dorairaj Prabhakaran,Shuchi Anand,Thomas A. Gaziano,Jean-Claude Mbanya,Rachel Nugent Pdf

Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.

Improving Healthcare Quality in Europe Characteristics, Effectiveness and Implementation of Different Strategies

OECD,World Health Organization
Improving Healthcare Quality in Europe Characteristics Effectiveness and Implementation of Different Strategies Book PDF

Author : OECD,World Health Organization
Publisher : OECD Publishing
Page : 128 pages
File Size : 53,8 Mb
Release : 2019-10-17
Category : Electronic
ISBN : 9789264805903

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Improving Healthcare Quality in Europe Characteristics, Effectiveness and Implementation of Different Strategies by OECD,World Health Organization Pdf

This volume, developed by the Observatory together with OECD, provides an overall conceptual framework for understanding and applying strategies aimed at improving quality of care. Crucially, it summarizes available evidence on different quality strategies and provides recommendations for their implementation. This book is intended to help policy-makers to understand concepts of quality and to support them to evaluate single strategies and combinations of strategies.

Brain Repair After Stroke

Steven C. Cramer,Randolph J. Nudo
Brain Repair After Stroke Book PDF

Author : Steven C. Cramer,Randolph J. Nudo
Publisher : Cambridge University Press
Page : 307 pages
File Size : 54,8 Mb
Release : 2010-10-28
Category : Medical
ISBN : 9781139490658

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Brain Repair After Stroke by Steven C. Cramer,Randolph J. Nudo Pdf

Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.

Precision Medicine in Stroke

Ana Catarina Fonseca,José M. Ferro
Precision Medicine in Stroke Book PDF

Author : Ana Catarina Fonseca,José M. Ferro
Publisher : Springer Nature
Page : 339 pages
File Size : 53,9 Mb
Release : 2021-05-04
Category : Medical
ISBN : 9783030707613

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Precision Medicine in Stroke by Ana Catarina Fonseca,José M. Ferro Pdf

This book provides a comprehensive coverage of the state of the art in precision medicine in stroke. It starts by explaining and giving general information about precision medicine. Current applications in different strokes types (ischemic, haemorrhagic) are presented from diagnosis to treatment. In addition, ongoing research in the field (early stroke diagnosis and estimation of prognosis) is extensively discussed. The final part provides an in-depth discussion of how different interdisciplinary areas like artificial intelligence, molecular biology and genetics are contributing to this area. Precision Medicine in Stroke provides a practical approach to each chapter, reinforcing clinical applications and presenting clinical cases. This book is intended for all clinicians that interact with stroke patients (neurologists, internal medicine doctors, general practitioners, neurosurgeons), students and basic researchers.

Intracerebral Hemorrhage Research

John Zhang,Austin Colohan
Intracerebral Hemorrhage Research Book PDF

Author : John Zhang,Austin Colohan
Publisher : Springer Science & Business Media
Page : 453 pages
File Size : 41,5 Mb
Release : 2011-07-05
Category : Medical
ISBN : 9783709106938

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Intracerebral Hemorrhage Research by John Zhang,Austin Colohan Pdf

The volume includes 75 papers which were presented at the Third International Conference on Intracerebral Hemorrhage, held in Rancho Mirage, California, in March 2010. The topics treated include animal models, pathophysiology of cerebral hemorrhage, experimental treatment for cerebral hemorrhage, cerebral hemorrhage clinical manifestations, prognosis of cerebral hemorrhage, and clinical management. The articles represent the recent advances in hemorrhagic brain injury research presented by highly respected laboratories around the world.

Oxford Textbook of Stroke and Cerebrovascular Disease

Bo Norrving
Oxford Textbook of Stroke and Cerebrovascular Disease Book PDF

Author : Bo Norrving
Publisher : Oxford Textbooks in Clinical N
Page : 306 pages
File Size : 48,8 Mb
Release : 2014
Category : Medical
ISBN : 9780199641208

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Oxford Textbook of Stroke and Cerebrovascular Disease by Bo Norrving Pdf

This practical volume covers the current pedagogic principles of stroke disease and care, including the acute hospital phase, public health issues, prevention, long-term management, and silent vascular disease.

Advances in Patient Safety

Kerm Henriksen
Advances in Patient Safety Book PDF

Author : Kerm Henriksen
Publisher : Unknown
Page : 526 pages
File Size : 49,6 Mb
Release : 2005
Category : Medical
ISBN : CHI:70548902

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Advances in Patient Safety by Kerm Henriksen Pdf

v. 1. Research findings -- v. 2. Concepts and methodology -- v. 3. Implementation issues -- v. 4. Programs, tools and products.

Neurologic Rehabilitation

Bruce H. Dobkin
Neurologic Rehabilitation Book PDF

Author : Bruce H. Dobkin
Publisher : Oxford University Press, USA
Page : 366 pages
File Size : 53,6 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015037453191

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Neurologic Rehabilitation by Bruce H. Dobkin Pdf

Dobkin (Director, Neurologic Rehabilitation and Research, U. of California Los Angeles School of Medicine) examines clinical disorders that arise during the rehabilitation of diseases of the central and peripheral nervous systems. His findings concentrate on aspects of motor control, muscle plasticity, and cognitive processes as they relate to the rehabilitation teams' role in assessment and practice. He comprehensively discusses specific issues in the areas of stroke, spinal cord injury, traumatic brain injury, Parkinson's Disease, multiple sclerosis, and other neurologic disorders. Annotation copyright by Book News, Inc., Portland, OR

Stroke Medicine

Hugh Markus,Anthony Pereira,Geoffrey Cloud
Stroke Medicine Book PDF

Author : Hugh Markus,Anthony Pereira,Geoffrey Cloud
Publisher : Oxford University Press
Page : 609 pages
File Size : 54,5 Mb
Release : 2017
Category : Medical
ISBN : 9780198737889

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Stroke Medicine by Hugh Markus,Anthony Pereira,Geoffrey Cloud Pdf

A practical handbook written for the practising physician, 'Stroke Medicine' provides an up-to-date, and easily accessible source of information on all aspects of stroke care from acute care, through to rehabilitation and secondary prevention.

Occupational Therapy and Stroke

Judi Edmans
Occupational Therapy and Stroke Book PDF

Author : Judi Edmans
Publisher : John Wiley & Sons
Page : 276 pages
File Size : 54,7 Mb
Release : 2011-06-09
Category : Medical
ISBN : 9781444348088

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Occupational Therapy and Stroke by Judi Edmans Pdf

Occupational Therapy and Stroke guides newly qualified occupational therapists (and those new to the field of stroke management) through the complexities of treating people following stroke. It encourages and assists therapists to use their skills in problem solving, building on techniques taught and observed as an undergraduate. Written and edited by practising occupational therapists, the book acknowledges the variety of techniques that may be used in stroke management and the scope of the occupational therapist's role. Chapters span such key topics as early intervention and the theoretical underpinnings of stroke care, as well as the management of motor, sensory, cognitive and perceptual deficits. They are written in a user-friendly style and presented in a form that enables the therapist to review the subject prior to assessment and treatment planning. Complex problems are grouped together for greater clarity. This second edition has been fully revised and updated in line with the WHO ICF model, National Clinical Guidelines and Occupational Therapy standards. It is produced on behalf of the College of Occupational Therapists Specialist Section - Neurological Practice.

The Persona Lifecycle

John Pruitt,Tamara Adlin
The Persona Lifecycle Book PDF

Author : John Pruitt,Tamara Adlin
Publisher : Elsevier
Page : 744 pages
File Size : 52,9 Mb
Release : 2010-08-04
Category : Computers
ISBN : 0080455735

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The Persona Lifecycle by John Pruitt,Tamara Adlin Pdf

The Persona Lifecycle is a field guide exclusively focused on interaction design's most popular new technique. The Persona Lifecycle addresses the "how" of creating effective personas and using those personas to design products that people love. It doesn’t just describe the value of personas; it offers detailed techniques and tools related to planning, creating, communicating, and using personas to create great product designs. Moreover, it provides rich examples, samples, and illustrations to imitate and model. Perhaps most importantly, it positions personas not as a panacea, but as a method used to complement other user-centered design (UCD) techniques including scenario-based design, cognitive walkthroughs and user testing. The authors developed the Persona Lifecycle model to communicate the value and practical application of personas to product design and development professionals. This book explores the complete lifecycle of personas, to guide the designer at each stage of product development. It includes a running case study with rich examples and samples that demonstrate how personas can be used in building a product end-to-end. It also presents recommended best practices in techniques, tools, and innovative methods and contains hundreds of relevant stories, commentary, opinions, and case studies from user experience professionals across a variety of domains and industries. This book will be a valuable resource for UCD professionals, including usability practitioners, interaction designers, technical writers, and program managers; programmers/developers who act as the interaction designers for software; and those professionals who work with developers and designers. Features * Presentation and discussion of the complete lifecycle of personas, to guide the designer at each stage of product development. * A running case study with rich examples and samples that demonstrate how personas can be used in building a product end-to-end. * Recommended best practices in techniques, tools, and innovative methods. * Hundreds of relevant stories, commentary, opinions, and case studies from user experience professionals across a variety of domains and industries.

Prevention of Stroke

John W. Norris,Vladimir C. Hachinski
Prevention of Stroke Book PDF

Author : John W. Norris,Vladimir C. Hachinski
Publisher : Springer Science & Business Media
Page : 280 pages
File Size : 52,6 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475742268

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Prevention of Stroke by John W. Norris,Vladimir C. Hachinski Pdf

Prevention of Stroke sums up and critically analyzes our present knowledge and understanding of all major aspects of stroke prophylaxis, medical and surgical. The book is intended for not only neurologists and neurosurgeons directly involved with stroke patients, but also vascular surgeons, internists, family physicians, and health planners. Topics explored include the cellular basis of atherosclerosis; stroke risk factors; head and neck bruits in stroke prevention; the present status of anticoagulant prophylaxis; hypertension and stroke prevention; and prevention of cardioembolic stroke, as well as the efficacy of aspirin and of ticlopidine in stroke prevention. Surgical prophylaxis is examined through discussions of carotid endarterectomy, prevention of stroke from cerebral vascular malformations, prevention of aneurysmal subarachnoid hemorrhage, balloon transluminal angioplasty of the carotid artery in the head and neck, and prevention of recurrent stroke.

The Man Who Mistook His Wife for a Hat

Oliver Sacks
The Man Who Mistook His Wife for a Hat Book PDF

Author : Oliver Sacks
Publisher : Knopf Canada
Page : 336 pages
File Size : 51,5 Mb
Release : 2021-09-14
Category : Biography & Autobiography
ISBN : 9781039002494

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The Man Who Mistook His Wife for a Hat by Oliver Sacks Pdf

In his most beloved and extraordinary book, Dr. Sacks recounts the case histories of patients inhabiting the compelling world of neurological disorders. Featuring a preface never before included. Oliver Sacks's The Man Who Mistook His Wife for a Hat tells the stories of individuals afflicted with perceptual and intellectual disorders: patients who have lost their memories and with them the greater part of their pasts; who are no longer able to recognize people and common objects; whose limbs seem alien to them; who lack some skills yet are gifted with uncanny artistic or mathematical talents. In Dr. Sacks's splendid and sympathetic telling, his patients are deeply human, and his tales are studies of struggles against incredible adversity. A great healer, Sacks never loses sight of medicine's ultimate responsibility: "the suffering, afflicted, fighting human subject."