Recent Progress In Hiv Research

Author : Anabella Frost
Publisher : Hayle Medical
Page : 0 pages
File Size : 45,8 Mb
Release : 2023-09-19
Category : Health & Fitness
ISBN : 1646475690

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Recent Progress in HIV Research by Anabella Frost Pdf

HIV is a virus that severely affects the immune system resulting in acquired immunodeficiency syndrome (AIDS). The treatment of HIV involves combination antiretroviral therapy (cART). This therapy suppresses HIV-1 replication, blocks transmission, and improves immune responses. cART is a lifelong treatment, and does not eliminate the virus while also having side effects. The focus in the treatment of HIV is the reactivation of HIV reservoirs for subsequent termination by viral cytopathic effects or host immunity. The most researched HIV reservoir is resting memory CD4+ T cells in peripheral blood and lymphoid tissues. The antiretroviral therapies have expanded significantly in the recent times and comprise five categories of antiretrovirals, including nucleoside reverse transcriptase inhibitors (NRTIs), protease inhibitors, non-nucleoside reverse transcriptase inhibitors (NNRTIs), integrase strand transfer inhibitors (INSTIs) and entry inhibitors. This book unfolds the innovative aspects of HIV research which will be crucial for the progress of this field in the future. For someone with an interest and eye for detail, this book covers the most significant topics on HIV-AIDS and its treatment.

Author : Gualberto Buela-Casal
Publisher : Nova Science Publishers
Page : 358 pages
File Size : 47,6 Mb
Release : 2006
Category : AIDS (Disease)
ISBN : UCSD:31822034771030

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Recent Advances in HIV Infection Research by Gualberto Buela-Casal Pdf

The acquired immunodeficiency syndrome (AIDS) is caused by two retroviruses of the lentivirus subfamily, human immunodeficiency viruses types 1 (HIV-1) and 2 (HIV-2), which derive from cross-species transmissions of viruses naturally infecting two African primate species, the chimpanzee (Pan troglodytes) and the sooty mangabey (Cercocebus atys), respectively. Eleven transmission events of lentiviruses from these primate species to humans have been inferred from phylogenetic sequence analyses, although only four (which originated HIV-1 groups M and O, and HIV-2 groups A and B) have resulted in epidemic spread. One of these transmissions, corresponding to the common ancestor of the HIV-1 group M viruses, whose initial expansion in Central Africa has been dated by molecular clock analyses to around 1930, eventually originated the AIDS pandemic. How humans acquired the ancestors of the AIDS viruses from simians is uncertain, but natural infection of African non-human primates with lentiviruses is common, and contact with blood of these animals, which are frequently hunted in Africa for human consumption, is a plausible mechanism for virus acquisition. Sociodemograhic developments, including rapid urbanisation, large scale migrations, growth of prostitution, wars, and increase in travel, and, possibly, the widespread use of non-sterile injection material, may have promoted the emergence of the AIDS pandemic in Central Africa in the 20th century. Subsequent global propagation of HIV-1 derives from multiple introductions at different time points, often representing phylogenetically identifiable founder events. In areas in which diverse HIV-1 variants are cocirculating, these frequently recombine to generate mosaic forms, some of provided new insights on the origin and spread of AIDS viruses and may contribute to the efforts aimed at containing the pandemic which have propagated extensively. Phylogenetic sequence analyses and molecular epidemiology studies have.

Author : Linqi Zhang,Sharon R. Lewin
Publisher : Springer
Page : 318 pages
File Size : 55,7 Mb
Release : 2018-07-20
Category : Medical
ISBN : 9789811304842

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HIV Vaccines and Cure by Linqi Zhang,Sharon R. Lewin Pdf

This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.

Author : National Research Council,Division of Behavioral and Social Sciences and Education,Commission on Behavioral and Social Sciences and Education,Panel on Monitoring the Social Impact of the AIDS Epidemic
Publisher : National Academies Press
Page : 337 pages
File Size : 46,7 Mb
Release : 1993-02-01
Category : Medical
ISBN : 9780309046282

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The Social Impact of AIDS in the United States by National Research Council,Division of Behavioral and Social Sciences and Education,Commission on Behavioral and Social Sciences and Education,Panel on Monitoring the Social Impact of the AIDS Epidemic Pdf

Europe's "Black Death" contributed to the rise of nation states, mercantile economies, and even the Reformation. Will the AIDS epidemic have similar dramatic effects on the social and political landscape of the twenty-first century? This readable volume looks at the impact of AIDS since its emergence and suggests its effects in the next decade, when a million or more Americans will likely die of the disease. The Social Impact of AIDS in the United States addresses some of the most sensitive and controversial issues in the public debate over AIDS. This landmark book explores how AIDS has affected fundamental policies and practices in our major institutions, examining: How America's major religious organizations have dealt with sometimes conflicting values: the imperative of care for the sick versus traditional views of homosexuality and drug use. Hotly debated public health measures, such as HIV antibody testing and screening, tracing of sexual contacts, and quarantine. The potential risk of HIV infection to and from health care workers. How AIDS activists have brought about major change in the way new drugs are brought to the marketplace. The impact of AIDS on community-based organizations, from volunteers caring for individuals to the highly political ACT-UP organization. Coping with HIV infection in prisons. Two case studies shed light on HIV and the family relationship. One reports on some efforts to gain legal recognition for nonmarital relationships, and the other examines foster care programs for newborns with the HIV virus. A case study of New York City details how selected institutions interact to give what may be a picture of AIDS in the future. This clear and comprehensive presentation will be of interest to anyone concerned about AIDS and its impact on the country: health professionals, sociologists, psychologists, advocates for at-risk populations, and interested individuals.

Author : A. P. Liberman
Publisher : Nova Science Pub Incorporated
Page : 290 pages
File Size : 51,8 Mb
Release : 2005
Category : Medical
ISBN : 1594541817

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Progress in AIDS Research by A. P. Liberman Pdf

AIDS (Acquired ImmunoDeficiency Syndrome) has become a major world-wide epidemic. AIDS is caused by the human immunodeficiency virus (HIV). By killing or damaging cells of the body's immune system, HIV progressively destroys the body's ability to fight infections and certain cancers. People diagnosed with AIDS may get life-threatening diseases called opportunistic infections, which are caused by microbes such as viruses or bacteria that usually do not make healthy people sick. The term AIDS applies to the most advanced stages of HIV infection. During the past 10 years, however, researchers have developed drugs to fight both HIV infection and its associated infections and cancers. The first group of drugs used to treat HIV infection, called nucleoside reverse transcriptase (RT) inhibitors, interrupts an early stage of the virus making copies of itself. A second class of drugs for treating HIV infection is called protease inhibitors, which interrupt virus replication at a later step in its life cycle. Research is extremely active in all areas of HIV infection, including developing and testing preventive HIV vaccines and new treatments for HIV infection and AIDS - associated opportunistic infections. Researchers also are investigating how exactly HIV damages the immune system. This research is identifying new and more effective targets for drugs and vaccines. This new book includes in its scope the prevention, pathogenesis, diagnosis and treatment of this disease.

Author : Institute of Medicine,Board on Global Health,Committee on Envisioning a Strategy to Prepare for the Long-Term Burden of HIV/AIDS: African Needs and U.S. Interests
Publisher : National Academies Press
Page : 228 pages
File Size : 51,7 Mb
Release : 2011-03-28
Category : Medical
ISBN : 9780309212076

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Preparing for the Future of HIV/AIDS in Africa by Institute of Medicine,Board on Global Health,Committee on Envisioning a Strategy to Prepare for the Long-Term Burden of HIV/AIDS: African Needs and U.S. Interests Pdf

HIV/AIDS is a catastrophe globally but nowhere more so than in sub-Saharan Africa, which in 2008 accounted for 67 percent of cases worldwide and 91 percent of new infections. The Institute of Medicine recommends that the United States and African nations move toward a strategy of shared responsibility such that these nations are empowered to take ownership of their HIV/AIDS problem and work to solve it.

Author : Institute of Medicine,Committee to Study HIV Transmission Through Blood and Blood Products
Publisher : National Academies Press
Page : 349 pages
File Size : 40,5 Mb
Release : 1995-10-05
Category : Medical
ISBN : 9780309053297

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HIV and the Blood Supply by Institute of Medicine,Committee to Study HIV Transmission Through Blood and Blood Products Pdf

During the early years of the AIDS epidemic, thousands of Americans became infected with HIV through the nation's blood supply. Because little reliable information existed at the time AIDS first began showing up in hemophiliacs and in others who had received transfusions, experts disagreed about whether blood and blood products could transmit the disease. During this period of great uncertainty, decision-making regarding the blood supply became increasingly difficult and fraught with risk. This volume provides a balanced inquiry into the blood safety controversy, which involves private sexual practices, personal tragedy for the victims of HIV/AIDS, and public confidence in America's blood services system. The book focuses on critical decisions as information about the danger to the blood supply emerged. The committee draws conclusions about what was doneâ€"and recommends what should be done to produce better outcomes in the face of future threats to blood safety. The committee frames its analysis around four critical area: Product treatmentâ€"Could effective methods for inactivating HIV in blood have been introduced sooner? Donor screening and referralâ€"including a review of screening to exlude high-risk individuals. Regulations and recall of contaminated bloodâ€"analyzing decisions by federal agencies and the private sector. Risk communicationâ€"examining whether infections could have been averted by better communication of the risks.

Author : King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Publisher : World Bank Publications
Page : 506 pages
File Size : 54,6 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9781464805257

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Disease Control Priorities, Third Edition (Volume 6) by King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha Pdf

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Author : Dean T. Jamison,Joel G. Breman,Anthony R. Measham,George Alleyne,Mariam Claeson,David B. Evans,Prabhat Jha,Anne Mills,Philip Musgrove
Publisher : World Bank Publications
Page : 1449 pages
File Size : 41,5 Mb
Release : 2006-04-02
Category : Medical
ISBN : 9780821361801

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Disease Control Priorities in Developing Countries by Dean T. Jamison,Joel G. Breman,Anthony R. Measham,George Alleyne,Mariam Claeson,David B. Evans,Prabhat Jha,Anne Mills,Philip Musgrove Pdf

Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries.

Author : Valerie Stone,Bisola Ojikutu,M. Keith Rawlings,Kimberly Y. Smith
Publisher : Springer Science & Business Media
Page : 309 pages
File Size : 55,8 Mb
Release : 2009-05-28
Category : Medical
ISBN : 9780387981529

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HIV/AIDS in U.S. Communities of Color by Valerie Stone,Bisola Ojikutu,M. Keith Rawlings,Kimberly Y. Smith Pdf

More people in communities of color are contracting, living with, and being treated for HIV/AIDS than ever before. In 2005, 71% of new AIDS cases were diagnosed in people of color. The rate of HIV infection in the African-American community alone has increased from 25% of total cases diagnosed in 1985 to 50% in 2005. Latinos similarly comprise a disproportionate segment of the AIDS epidemic: though they make up only 14% of the U.S. population, 20% of AIDS cases diagnosed in 2004 were Latino/a. Though the number of racial and ethnic minority HIV/AIDS cases continues to grow, the health care community has been unable to adequately meet the unique medical needs of these populations. African-American, Latino/Latina, and other patients of color are less likely to seek medical care, have sufficient access to the health care system, or receive the drugs they need for as long as they need them. HIV/AIDS in Minority Communities acknowledges the prevalence of HIV/AIDS within minority communities in the U.S. and strives to educate physicians about the barriers to treatment that exist for minority patients. By analyzing the main causes of treatment failure and promoting respect for individual and cultural values, this book effectively teaches readers to provide responsive, patient-centered care and devise preventive strategies for minority communities. Comprehensive chapters contributed by physicians with extensive experience dealing with HIV/AIDS in minority communities cover issues as far-reaching as: anti-retroviral therapy; dermatologic manifestations and co-morbidities of the disease in patients of color; unique risks to women and MSMs of color; participation of minority cases in HIV research; and substance abuse and mental health issues.

Author : Sarah Schulman
Publisher : Farrar, Straus and Giroux
Page : 736 pages
File Size : 51,7 Mb
Release : 2021-05-18
Category : Biography & Autobiography
ISBN : 9780374719951

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Let the Record Show by Sarah Schulman Pdf

Winner of the 2022 Lambda Literary LGBTQ Nonfiction Award and the 2022 NLGJA Excellence in Book Writing Award. Finalist for the PEN/John Kenneth Galbriath Award for Nonfiction, the Gotham Book Prize, and the ALA Stonewall Israel Fishman Nonfiction Award. A 2021 New York Times Book Review Notable Book and a New York Times Book Review Editors' Choice. Longlisted for the 2021 Brooklyn Public Library Literary Prize. One of NPR, New York, and The Guardian's Best Books of 2021, one of Buzzfeed's Best LGBTQ+ Books of 2021, one of Electric Literature's Favorite Nonfiction Books of 2021, one of NBC's 10 Most Notable LGBTQ Books of 2021, and one of Gay Times' Best LGBTQ Books of 2021. "This is not reverent, definitive history. This is a tactician’s bible." --Parul Sehgal, The New York Times Twenty years in the making, Sarah Schulman's Let the Record Show is the most comprehensive political history ever assembled of ACT UP and American AIDS activism In just six years, ACT UP, New York, a broad and unlikely coalition of activists from all races, genders, sexualities, and backgrounds, changed the world. Armed with rancor, desperation, intelligence, and creativity, it took on the AIDS crisis with an indefatigable, ingenious, and multifaceted attack on the corporations, institutions, governments, and individuals who stood in the way of AIDS treatment for all. They stormed the FDA and NIH in Washington, DC, and started needle exchange programs in New York; they took over Grand Central Terminal and fought to change the legal definition of AIDS to include women; they transformed the American insurance industry, weaponized art and advertising to push their agenda, and battled—and beat—The New York Times, the Catholic Church, and the pharmaceutical industry. Their activism, in its complex and intersectional power, transformed the lives of people with AIDS and the bigoted society that had abandoned them. Based on more than two hundred interviews with ACT UP members and rich with lessons for today’s activists, Let the Record Show is a revelatory exploration—and long-overdue reassessment—of the coalition’s inner workings, conflicts, achievements, and ultimate fracture. Schulman, one of the most revered queer writers and thinkers of her generation, explores the how and the why, examining, with her characteristic rigor and bite, how a group of desperate outcasts changed America forever, and in the process created a livable future for generations of people across the world.

Author : United States. Congress. Senate. Committee on Labor and Human Resources
Publisher : Unknown
Page : 224 pages
File Size : 53,6 Mb
Release : 1998
Category : Medical
ISBN : PSU:000033091587

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HIV/AIDS, Recent Developments and Future Opportunities by United States. Congress. Senate. Committee on Labor and Human Resources Pdf

Author : Keith A. Crandall
Publisher : JHU Press
Page : 524 pages
File Size : 47,9 Mb
Release : 1999-04-26
Category : Medical
ISBN : 0801861519

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The Evolution of HIV by Keith A. Crandall Pdf

Wolinsky.-- "European Molecular Biology Organization Reports"

Author : Ali Al Mazari
Publisher : IGI Global, Medical Information Science Reference
Page : 0 pages
File Size : 46,5 Mb
Release : 2018
Category : Computers
ISBN : 1522532056

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Big Data Analytics in HIV/AIDS Research by Ali Al Mazari Pdf

With the advent of new technologies in big data science, the study of medical problems has made significant progress. Connecting medical studies and computational methods is crucial for the advancement of the medical industry. Big Data Analytics in HIV/AIDS Research provides emerging research on the development and implementation of computational techniques in big data analysis for biological and medical practices. While highlighting topics such as deep learning, management software, and molecular modeling, this publication explores the various applications of data analysis in clinical decision making. This book is a vital resource for medical practitioners, nurses, scientists, researchers, and students seeking current research on the connections between data analytics in the field of medicine.

Author : Max Essex,Souleymane Mboup,Phyllis J. Kanki,Richard G. Marlink,Sheila D. Tlou
Publisher : Springer Science & Business Media
Page : 740 pages
File Size : 49,6 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780306478178

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AIDS in Africa by Max Essex,Souleymane Mboup,Phyllis J. Kanki,Richard G. Marlink,Sheila D. Tlou Pdf

This comprehensive reference book addresses the unique challenges facing many African nations as poor infrastructure and economics continue to obstruct access to advanced treatments and AIDS care training. It takes into account the context of settings with limited resources. Information on how to best utilize existing resources and prioritize scaling-up of infrastructure is a critical aspect of this book for those working in HIV/AIDS-related fields in Africa.