Receptor And Ion Channel Detection In The Brain

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Receptor and Ion Channel Detection in the Brain

Rafael Luján,Francisco Ciruela

Author : Rafael Luján,Francisco Ciruela
Publisher : Unknown
Page : 128 pages
File Size : 46,7 Mb
Release : 2021
Category : Electronic books
ISBN : 107161522X

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Receptor and Ion Channel Detection in the Brain by Rafael Luján,Francisco Ciruela Pdf

This second edition volume expands on the previous edition with new information on the latest developments in the field, and the most up-to-date representative methodological information on molecular neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters in this book are organized into three parts. Part One discusses molecular immunological and pharmacological aspects related to the detection of receptors and ion channels in the brain. Part Two explores the neuroanatomical techniques devoted to localizing receptors and ion channels within the central nervous system. Part Three looks at functional approaches devoted to ascertaining receptors and ion channels functionality in the brain. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Receptor and Ion Channels Detection in the Brain, Second Edition is a valuable resource that contains detailed molecular, cellular, neuroanatomical, and electrophysiological methods that will help researchers study neurotransmitter receptor and ion channel in any region of neuron of the brain.

Receptor and Ion Channel Detection in the Brain

Rafael Luján,Francisco Ciruela

Author : Rafael Luján,Francisco Ciruela
Publisher : Humana
Page : 0 pages
File Size : 54,7 Mb
Release : 2016-02-02
Category : Medical
ISBN : 149393063X

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Receptor and Ion Channel Detection in the Brain by Rafael Luján,Francisco Ciruela Pdf

Receptor and Ion Channel Detection in the Brain provides state-of-the-art and up-to-date methodological information on molecular, neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters have been contributed by world-wide recognized neuroscientists who explain in an easy and detailed way well established and tested protocols embracing molecular, cellular, subcellular, anatomical and electrophysiological aspects of the brain. This comprehensive and practical manual is presented in a simple, step-by-step manner for laboratory use, and also offers unambiguous detail and key implementation advice that proves essential for successful results and facilitate choosing the best method for the target proteins under study. This work serves as a useful guide for young researchers and students in training as well as for neurologists and established scientists who wish to extend their repertoire of techniques.

Neuroreceptors, Ion Channels, and the Brain

Nobufumi Kawai,Terumi Nakajima,Eric A. Barnard

Author : Nobufumi Kawai,Terumi Nakajima,Eric A. Barnard
Publisher : Unknown
Page : 256 pages
File Size : 50,5 Mb
Release : 1992
Category : Glutamic acid
ISBN : UOM:39015025203038

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Neuroreceptors, Ion Channels, and the Brain by Nobufumi Kawai,Terumi Nakajima,Eric A. Barnard Pdf

Enormous advances have been made in our understanding of the neurotransmitters, receptors and ionic channels of the brain over the past ten years. The use of gene technology has greatly contributed to an improved study of the receptor ion channels and specific neurotoxins affecting the receptors, and by patch clamp recording of channel currents. This volume brings together the latest research and insights of many of the leading workers in these areas. The topics are grouped into three major subjects which overlap significantly. The first chapters provide an overview of the contributions of studies using neurotoxins which act specifically at receptor sites or ion channels. Succeeding chapters are concerned with molecular studies of receptor proteins, including the recent huge strides made by molecular cloning techniques in the isolation of glutamata and IP3 receptors. The final set of chapters describes our current understanding of the function of glutamate receptors. Particular emphasis has been placed on neuronal basis of learning and memory.Neurobiologists and clinicians who wish to increase their knowledge of the neuroreceptors and ion channels of the brain will find this publication a valuable addition to their library.

Nonclassical Ion Channels in the Nervous System

Xu Tian-le,Long-Jun Wu

Author : Xu Tian-le,Long-Jun Wu
Publisher : CRC Press
Page : 341 pages
File Size : 51,5 Mb
Release : 2021-08-05
Category : Science
ISBN : 9781000403749

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Nonclassical Ion Channels in the Nervous System by Xu Tian-le,Long-Jun Wu Pdf

Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.

Receptor and Ion-channel Trafficking

Stephen John Moss,Jeremy Henley

Author : Stephen John Moss,Jeremy Henley
Publisher : Unknown
Page : 250 pages
File Size : 52,6 Mb
Release : 2002
Category : Medical
ISBN : UOM:39015056276416

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Receptor and Ion-channel Trafficking by Stephen John Moss,Jeremy Henley Pdf

A volume in the Molecular and Cellular Neurobiology series. This book reviews the recent advances in our understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting and anchoring of the protein complexes making up the most important ion channels and receptor families, fundamental to synaptic function. Improved understanding of these processes is expected to reveal novel therapeutic targets relevant to a range of disease states. The first section of the book contains three chapters dealing with cation channels and provides an accessible, succinct and comprehensive account of what is known about the structures and the assembly and targeting of these multimeric proteins. The focus of the book then moves on to cover ligand-gated ion channels with two chapters on accetylcholine receptors. The final section of the book contains four chapters covering the excitatory and inhibitory amino acid receptors. Receptor and Ion-Channel Trafficking provides an integrated overview of the significant recent advances in the field of molecular neurobiology and will be essential reading for all researchers in neuroscience, neurobiology, biochemistry, cellular and molecular biology.

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

Wolfgang B. Liedtke, MD, PH.D.

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
Page : 502 pages
File Size : 42,8 Mb
Release : 2006-09-29
Category : Medical
ISBN : 9781420005844

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TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by Wolfgang B. Liedtke, MD, PH.D. Pdf

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

Handbook of Receptors and Channels

R. Alan North

Author : R. Alan North
Publisher : CRC Press
Page : 372 pages
File Size : 55,7 Mb
Release : 1994-10-25
Category : Science
ISBN : 0849383226

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Handbook of Receptors and Channels by R. Alan North Pdf

This authoritative and comprehensive volume presents a perspective in the molecular and cellular diversity of membrane ion channels. Written in an accessible format, it depicts the structure and function of each of the known classes of ion channels. Each chapter provides amino acid sequences, including data base accession numbers; views of secondary, tertiary and quaternary channel structure; and evolutionary relationships among channels.

Ion Channels

T. Narahashi

Author : T. Narahashi
Publisher : Springer Science & Business Media
Page : 361 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461533283

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Ion Channels by T. Narahashi Pdf

In the past few years, the scientific community has witnessed significant progress in the study of ion channels. Technological advancement in biophysics, molecular biology, and immunology has been greatly ac celerated, making it possible to conduct experiments which were deemed very difficult if not impossible in the past. For example, patch-clamp techniques can now be used to measure ionic currents generated by almost every type of cell, thereby allowing us to analyze whole-cell and single channel events. It is now possible to incorporate purified ion channel components into lipid bilayers to reconstitute an "excitable membrane." Gene cloning and monoclonal antibody techniques provide us with new approaches to the study of the molecular structure of ion channels. A variety of chemicals have now been found to interact with ion channels. One of the classical examples is represented by tetrodotoxin, a puffer fish poison, which was shown in the early 1960s to block the voltage-activated sodium channel in a highly specific and potent manner.

The truth in complexes: why unraveling ion channel multi-protein signaling nexuses is critical for understanding the function of the nervous system

Leigh Anne Swayne,Christophe Altier, Gerald W. Zamponi

Author : Leigh Anne Swayne,Christophe Altier, Gerald W. Zamponi
Publisher : Frontiers Media SA
Page : 161 pages
File Size : 53,6 Mb
Release : 2015-04-15
Category : Ion channels
ISBN : 9782889194452

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The truth in complexes: why unraveling ion channel multi-protein signaling nexuses is critical for understanding the function of the nervous system by Leigh Anne Swayne,Christophe Altier, Gerald W. Zamponi Pdf

In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.

Ion Channels

James N. C. Kew,Ceri H. Davies

Author : James N. C. Kew,Ceri H. Davies
Publisher : Unknown
Page : 586 pages
File Size : 41,9 Mb
Release : 2010
Category : Medical
ISBN : 9780199296750

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Ion Channels by James N. C. Kew,Ceri H. Davies Pdf

Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.

Textbook of Ion Channels Volume III

Jie Zheng,Matthew C. Trudeau

Author : Jie Zheng,Matthew C. Trudeau
Publisher : CRC Press
Page : 246 pages
File Size : 41,8 Mb
Release : 2023-06-28
Category : Medical
ISBN : 9781000857849

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Textbook of Ion Channels Volume III by Jie Zheng,Matthew C. Trudeau Pdf

The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students, instructors and researchers. Ion channels are mem- brane proteins that control the electrical properties of neurons and cardiac cells; medi- ate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume III includes coverage of key ion channel regulators and their mechanisms, the role of ion channels working in concert in selected physiological systems, and examples of ion channel mutations and dysfunction in a selection of diseases. Chapters on ion channel regulation include splice variants, calcium–calmodulin regulation, regulation by G pro- teins, and lipids. A selection of ion channels in physiological systems includes ion chan- nels of the heart, ion channels in immune cells and their role in pancreatic beta cells and regulation of insulin secretion, and the role of channels in sperm and eggs. While disease mechanisms are integrated into the chapters of Volume II, Volume III offers special consid- eration of ion channels in epilepsy, cystic fibrosis and pain syndromes. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and includecoverage of key examples of regulatory, physiological, and disease roles for ion channels.

Neurobiology of TRP Channels

Tamara Luti Rosenbaum Emir

Author : Tamara Luti Rosenbaum Emir
Publisher : CRC Press
Page : 327 pages
File Size : 41,9 Mb
Release : 2017-08-09
Category : Science
ISBN : 9781498755269

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Neurobiology of TRP Channels by Tamara Luti Rosenbaum Emir Pdf

During the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli that is an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli. Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated ion channel, TRPV1, was cloned and its function described in detail. This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient Receptor Potential (TRP) ion channels. Intensive research has provided us with the atomic structures of some of these proteins, as well as understanding of their physiological roles, both in normal and pathological conditions. With chapters contributed by renowned experts in the field, Neurobiology of TRP Channels contains a state- of- the- art overview of our knowledge of TRP channels, ranging from structure to their functions in organismal physiology. Features: • Contains chapters on the roles of several TRP ion channels with a diversity of physiological functions, providing a complete picture of the widespread importance of these proteins. • Presents an overview of the structure of TRP channels, including the roles of these proteins in different physiological processes. • Discusses the roles of TRP channels in pathophysiological processes, further highlighting their importance. • Features several full color illustrations to allow the reader better comprehension of TRP channels. A volume in the Frontiers in Neuroscience series

Ions in the Brain

George G. Somjen

Author : George G. Somjen
Publisher : Oxford University Press
Page : 501 pages
File Size : 50,8 Mb
Release : 2004-01-29
Category : Medical
ISBN : 9780198034599

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Ions in the Brain by George G. Somjen Pdf

Ions, their transport across membranes, and their flow through specialized ion channels are central to the understanding of brain function, normal and pathological. The first part of this book deals with the regulation of ions in brain extra- and intracellular fluids. Regulation is effected by the blood-brain barrier, and by membrane ion pumps and other transport mechanisms of neurons and glial cells. Normally adjusted for optimal neural function, ion levels can change and alter the excitability of neurons and influence synaptic transmission in healthy and diseased brains. After an introduction to the electrophysiology of epilepsy, and a description of experimental seizure "models," the second part discusses the roles of the faulty regulation of ions and of the diseases of ion channels in generating epileptic seizures. The mechanisms of action of various anticonvulsant drugs are also considered. The third part is devoted to the phenomenon of spreading depression and its likely role in human diseases. The final chapters of the book deal with the role of ions in the devastation caused by lack of oxygen and by insufficient blood flow to brain tissue, and the reasons for the exceptional vulnerability of certain classes of central neurons in hypoxia and stroke. The book will be of interest to neuroscientists, neurobiologists, neurophysiologists, neurologists, neurosurgeons, and to their students and trainees.

Ion Channel Localization

Anatoli Lopatin,Colin G. Nichols

Author : Anatoli Lopatin,Colin G. Nichols
Publisher : Springer Science & Business Media
Page : 508 pages
File Size : 48,6 Mb
Release : 2008-02-06
Category : Medical
ISBN : 9781592591183

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Ion Channel Localization by Anatoli Lopatin,Colin G. Nichols Pdf

Since the pioneering discoveries of Hodgkin, Huxley, and Katz, it has been clear that specific ion conductance pathways underlie electrical act- ity. Over the ensuing 50 years, there has been ever increasing, and occasi- ally explosive, changes in the scope of efforts to understand ion channel behavior. The introduction of patch clamp technology by Erwin Neher and Bert Sakmann about 20 years ago led to the realization of the great variety of novel ion channel species, and the subsequent revolution in cl- ing has revealed an even greater diversity of the underlying molecular entities. Today, advances in the study of ion channel structure and function c- tinue at a high pace, from angstrom resolution imaging of crystallized ch- nels to their genetic manipulations in animals. In this regard, the field is a balanced one that inquires not only what ion channel entities are there, or how they operate, but also where are these molecular electronic switches? However, this balance is not particularly well presented to the general sci- tific audience or to specialists in the field. There are plenty of wonderful and useful books and monographs, as well as conferences and meetings on v- tually every aspect of ion channel structure and function. However, we are unaware that the channel localization theme has been considered in a u- fied forum.

Neurobiology

Vincent Torre,Franco Conti

Author : Vincent Torre,Franco Conti
Publisher : Springer Science & Business Media
Page : 418 pages
File Size : 46,8 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015038572221

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Neurobiology by Vincent Torre,Franco Conti Pdf

Thirty papers from a May 1995 symposium focus on three basic topics: biophysics and molecular biology of ion channels, sensory transduction, and higher order functions. Much of the program was devoted to a general overview of current trends of thought and experimental approaches, emphasizing the importance of understanding molecular aspects of the elementary events underlying sensory transduction and processing in the nervous system (without indulging in a pure reductionistic view of these complex phenomena). Annotation copyrighted by Book News, Inc., Portland, OR

Receptor And Ion Channel Detection In The Brain

Receptor and Ion Channel Detection in the Brain by Rafael Luján,Francisco Ciruela Pdf

Receptor and Ion Channel Detection in the Brain by Rafael Luján,Francisco Ciruela Pdf

Neuroreceptors, Ion Channels, and the Brain by Nobufumi Kawai,Terumi Nakajima,Eric A. Barnard Pdf

Nonclassical Ion Channels in the Nervous System by Xu Tian-le,Long-Jun Wu Pdf

Receptor and Ion-channel Trafficking by Stephen John Moss,Jeremy Henley Pdf

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by Wolfgang B. Liedtke, MD, PH.D. Pdf

Handbook of Receptors and Channels by R. Alan North Pdf

Ion Channels by T. Narahashi Pdf

The truth in complexes: why unraveling ion channel multi-protein signaling nexuses is critical for understanding the function of the nervous system by Leigh Anne Swayne,Christophe Altier, Gerald W. Zamponi Pdf

Ion Channels by James N. C. Kew,Ceri H. Davies Pdf

Textbook of Ion Channels Volume III by Jie Zheng,Matthew C. Trudeau Pdf

Neurobiology of TRP Channels by Tamara Luti Rosenbaum Emir Pdf

Ions in the Brain by George G. Somjen Pdf

Ion Channel Localization by Anatoli Lopatin,Colin G. Nichols Pdf

Neurobiology by Vincent Torre,Franco Conti Pdf

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