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Author : Anonim
Publisher : Unknown
Page : 678 pages
File Size : 47,5 Mb
Release : 1998
Category : Pharmacology
ISBN : NWU:35558004264772
Author : Anonim
Publisher : Unknown
Page : 786 pages
File Size : 44,8 Mb
Release : 1994
Category : Pharmacology
ISBN : NWU:35558003128614
Author : Anonim
Publisher : Unknown
Page : 280 pages
File Size : 51,6 Mb
Release : 2002
Category : Molecular pharmacology
ISBN : UCLA:L0099055048
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 244 pages
File Size : 44,5 Mb
Release : 1996
Category : Abbreviations
ISBN : UOM:39015074113468
Issues for 1977-1979 include also Special List journals being indexed in cooperation with other institutions. Citations from these journals appear in other MEDLARS bibliographies and in MEDLING, but not in Index medicus.
Author : Amit S. Kalgutkar,Deepak Dalvie,R. Scott Obach,Dennis A. Smith
Publisher : John Wiley & Sons
Page : 445 pages
File Size : 45,9 Mb
Release : 2012-09-06
Category : Medical
ISBN : 9783527655762
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.
Author : Anonim
Publisher : Unknown
Page : 380 pages
File Size : 53,6 Mb
Release : 2005
Category : Life sciences
ISBN : UOM:39015060289017
Author : National Toxicology Program (U.S.)
Publisher : Unknown
Page : 264 pages
File Size : 48,7 Mb
Release : 1997
Category : Toxicity testing
ISBN : COLUMBIA:HR00980730
Author : Anonim
Publisher : Unknown
Page : 1224 pages
File Size : 53,9 Mb
Release : 1975
Category : Medicine
ISBN : UIUC:30112065963248
Author : A. Douglas Kinghorn
Publisher : CRC Press
Page : 224 pages
File Size : 43,9 Mb
Release : 2001-11-29
Category : Science
ISBN : 9780203165942
Stevia rebaudiana is a remarkable South American plant that has become widely used in certain parts of the world as a natural sweetening agent and dietary supplement. Purified extracts of S. rebaudiana have been used as sweeteners and flavor enhancers in the food industry in Japan for over a quarter of a century, and have been found to be up to 300
Author : Anonim
Publisher : Unknown
Page : 284 pages
File Size : 43,5 Mb
Release : 2001
Category : Medicine
ISBN : UCSD:31822041784174
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings
Author : Anonim
Publisher : Elsevier
Page : 8639 pages
File Size : 53,6 Mb
Release : 2017-12-01
Category : Science
ISBN : 9780081006122
Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
Author : Anonim
Publisher : Unknown
Page : 84 pages
File Size : 55,5 Mb
Release : 1994
Category : MEDLARS
ISBN : MINN:30000010712150
Author : Ray Sahelian
Publisher : Penguin
Page : 196 pages
File Size : 45,7 Mb
Release : 1999-01-01
Category : Cooking
ISBN : 0895299267
Enjoy sugar-free versions of your favorite dishes without the guilt, the calories, or the health risks. Derived from a South American plant and widely available in the United States, stevia is an all-natural, calorie-free sweetener that is three hundred times sweeter than sugar, suitable for diabetics, safe for children, and does not cause cavities. The Stevia Cookbook includes documented studies and testimonials, as well as more than one hundred recipes for satisfying entrées, hearty side dishes, and sinfully sweet desserts.
Author : Phyllis A. Balch
Publisher : Penguin
Page : 582 pages
File Size : 43,7 Mb
Release : 2002-01-01
Category : Health & Fitness
ISBN : 0895298694
Looks at the basic principles of herbal medicine and outlines the properties of herbs and herbal combination forumlas for various kinds of ailments and alternative treatments.
Author : Neal M. Davies,Jaime A. Yáñez
Publisher : John Wiley & Sons
Page : 447 pages
File Size : 48,5 Mb
Release : 2012-11-05
Category : Science
ISBN : 9781118354407
SETS FORTH A FRAMEWORK FOR THE ANALYSIS AND STUDY OF FLAVONOIDS More and more dietary supplements contain flavonoids. These products are typically viewed as food rather than drug products by regulatory agencies and therefore not subjected to rigorous clinical trials before they are marketed to the general public. As a result, the use of flavonoid-containing supplements presents a potential public health risk. From discovery to therapeutic application, this book is a comprehensive guide to both achiral and chiral flavonoids, enabling researchers to perform essential preclinical and clinical pharmacokinetics studies in order to ensure the efficacy of flavonoids marketed for therapeutic use. Moreover, the book examines the safety and toxicology of flavonoids as well as flavonoid-drug interactions. With contributions from a multidisciplinary team of leading researchers, Flavonoids Pharmacokinetics reviews and synthesizes the most recent research findings and results from preclinical and clinical studies. The book begins with a comprehensive overview of polyphenols and flavonoids. Next, the book covers: Methods of analysis of achiral flavonoids Preclinical pharmacokinetic of flavonoids Toxicology and safety of flavonoids Methods of analysis for chiral flavonoids Clinical pharmacokinetics of flavonoids Flavonoids and drug interactions Throughout the book, the authors provide examples that demonstrate the use of pharmacokinetics concepts during the preclinical and clinical drug development process. Flavonoid Pharmacokinetics is written for pharmaceutical, food, and nutritional scientists and students, offering the tools they need to thoroughly analyze and test flavonoids and flavonoid-containing supplements to ensure their safety and efficacy.