Research Progress In Alzheimer S Disease And Dementia

Author : Miao-Kun Sun
Publisher : Nova Publishers
Page : 452 pages
File Size : 50,9 Mb
Release : 2007
Category : Alzheimer's disease
ISBN : 1600219608

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Research Progress in Alzheimer's Disease and Dementia by Miao-Kun Sun Pdf

Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the ageing population, unless more effective treatments are developed. Since the publication of the second book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists worldwide. This third book volume contains 15 chapters, bringing together a presentation of research frontiers in current AD/dementia research. The topics include molecular genetics of AD, gene expression abnormalities in AD progression, presenilins, taupathy in AD, single -induced(neuron gene expression abnormalities in AD, intracellular A neurodegeneration, roles of lipoprotein receptors in AD onset and progression, cholesterol and tau hyperphosphorylation, AD diagnostics and therapeutic strategies, in vivo visualisation of amyloid-like structures, cathepsin B, antiamyloidogenesis and neuroprotection, environmental enrichment, Fragile X mental retardation gene and dementia, category learning in Parkinson's disease, cerebrovascular disease and dementia, and dementia and hypertension. These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research progress in AD and dementia.

Author : Anonim
Publisher : Unknown
Page : 258 pages
File Size : 52,7 Mb
Release : 2012
Category : Alzheimer's disease
ISBN : OCLC:844324535

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Research Progress in Alzheimer's Disease and Dementia by Anonim Pdf

Author : Samuel Barrack
Publisher : iMedPub
Page : 117 pages
File Size : 44,6 Mb
Release : 2012-01-30
Category : Medical
ISBN : 9781475095425

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Advances in Research and Treatment for Alzheimer's Disease by Samuel Barrack Pdf

Alzheimer's disease (AD), is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death. The cause and progression of Alzheimer's disease are not well understood. Research indicates that the disease is associated with plaques and tangles in the brain. Current treatments only help with the symptoms of the disease. There are no available treatments that stop or reverse the progression of the disease. As of 2012, more than 1000 clinical trials have been or are being conducted to find ways to treat the disease, but it is unknown if any of the tested treatments will work. Because AD cannot be cured and is degenerative, the sufferer relies on others for assistance. The role of the main caregiver is often taken by the spouse or a close relative. Alzheimer's disease is known for placing a great burden on caregivers; the pressures can be wide-ranging, involving social, psychological, physical, and economic elements of the caregiver's life. In developed countries, AD is one of the most costly diseases to society. Research is the only hope to present and future patients and families suffering from this devastating disorder. This book compiles some of the most interesting articles on Alzheimer's disease published by PLoS journals lately: from epidemiology and prevention to management and treatment.

Author : Miao-Kun Sun
Publisher : Unknown
Page : 255 pages
File Size : 43,7 Mb
Release : 2016
Category : HEALTH & FITNESS
ISBN : 1634852060

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Research Progress in Alzheimer's Disease and Dementia by Miao-Kun Sun Pdf

Author : Miao-Kun Sun
Publisher : Nova Science Pub Incorporated
Page : 306 pages
File Size : 42,6 Mb
Release : 2009-10-01
Category : Medical
ISBN : 1608761525

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Research Progress in Alzheimer's Disease and Dementia by Miao-Kun Sun Pdf

Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the ageing population, unless more effective prevention/treatments are developed. Since the publication of the third book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists world-wide. This fourth book volume contains 12 chapters, bringing together a presentation of scientific frontiers in current AD/dementia research. The topics include emotional memory in AD, amyloid-B clearance, synaptic transmission-mediated regulation of amyloid-B dynamics, anti-AD immunotherapy, clinical trials of AD therapeutics using AD transgenic mouse models, roles of apolipoprotein E, chronic inflammation, cathepsins, and gelsolin in AD pathogenesis and as anti-AD therapeutic targets/agents, declarative memory impairment and hippocampal atrophy in Parkinson's disease, fronto-temporal dementia, and cognitive impairment in schizophrenia. These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists world-wide who are interested in the scientific research progress in AD and memory disorders.

Author : National Academies of Sciences Engineering and Medicine,Division of Behavioral and Social Sciences and Education,Board on Behavioral Cognitive and Sensory Sciences,Committee on the Decadal Survey of Behavioral and Social Science Research on Alzheimer's Disease and Alzheimer's Disease-Related Dementias
Publisher : Unknown
Page : 128 pages
File Size : 44,8 Mb
Release : 2022-04-26
Category : Electronic
ISBN : 0309495032

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Reducing the Impact of Dementia in America by National Academies of Sciences Engineering and Medicine,Division of Behavioral and Social Sciences and Education,Board on Behavioral Cognitive and Sensory Sciences,Committee on the Decadal Survey of Behavioral and Social Science Research on Alzheimer's Disease and Alzheimer's Disease-Related Dementias Pdf

As the largest generation in U.S. history - the population born in the two decades immediately following World War II - enters the age of risk for cognitive impairment, growing numbers of people will experience dementia (including Alzheimer's disease and related dementias). By one estimate, nearly 14 million people in the United States will be living with dementia by 2060. Like other hardships, the experience of living with dementia can bring unexpected moments of intimacy, growth, and compassion, but these diseases also affect people's capacity to work and carry out other activities and alter their relationships with loved ones, friends, and coworkers. Those who live with and care for individuals experiencing these diseases face challenges that include physical and emotional stress, difficult changes and losses in their relationships with life partners, loss of income, and interrupted connections to other activities and friends. From a societal perspective, these diseases place substantial demands on communities and on the institutions and government entities that support people living with dementia and their families, including the health care system, the providers of direct care, and others. Nevertheless, research in the social and behavioral sciences points to possibilities for preventing or slowing the development of dementia and for substantially reducing its social and economic impacts. At the request of the National Institute on Aging of the U.S. Department of Health and Human Services, Reducing the Impact of Dementia in America assesses the contributions of research in the social and behavioral sciences and identifies a research agenda for the coming decade. This report offers a blueprint for the next decade of behavioral and social science research to reduce the negative impact of dementia for America's diverse population. Reducing the Impact of Dementia in America calls for research that addresses the causes and solutions for disparities in both developing dementia and receiving adequate treatment and support. It calls for research that sets goals meaningful not just for scientists but for people living with dementia and those who support them as well. By 2030, an estimated 8.5 million Americans will have Alzheimer's disease and many more will have other forms of dementia. Through identifying priorities social and behavioral science research and recommending ways in which they can be pursued in a coordinated fashion, Reducing the Impact of Dementia in America will help produce research that improves the lives of all those affected by dementia.

Author : Anonim
Publisher : Unknown
Page : 20 pages
File Size : 52,9 Mb
Release : 1984
Category : Alzheimer's disease
ISBN : MINN:31951D00309131A

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Progress Report on Alzheimer's Disease by Anonim Pdf

Author : Blas Gil-Extremera
Publisher : Bentham Science Publishers
Page : 191 pages
File Size : 53,9 Mb
Release : 2019-04-03
Category : Medical
ISBN : 9789811405129

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Alzheimer's Disease: Pathological and Clinical Findings by Blas Gil-Extremera Pdf

Alzheimer's disease is the most frequent cause of dementia that slowly and progressively causes cognitive impairment and profoundly alters the daily activities of the patients. Approximately, ten percent of all persons over the age of seventy experience significant memory loss, and in more than half of the cases, the cause is Alzheimer's disease. This reference book is an update on the most relevant pathological and clinical findings of this neurological disorder. Chapters cover the basic hypothesis of Alzheimer’s disease, pathological features of the disease in the brain, Alzheimer’s disease diagnosis and therapy. Information provided in the book is focused on research in developed countries. The book offers students of medicine and nursing as well as medical practitioners and specialists (internists, neurologists, gerontologists, and psychiatrists), the necessary information to understand the pathological and clinical aspects of the disease in depth, with the goal of improving medical outcomes in the care of their patients.

Author : Miao-Kun Sun
Publisher : Nova Science Publishers
Page : 270 pages
File Size : 50,5 Mb
Release : 2012-08-01
Category : Alzheimer's disease
ISBN : 161942195X

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Research Progress in Alzheimer's Disease and Dementia (V) by Miao-Kun Sun Pdf

This fifth book volume brings together scientific frontiers in current Alzheimer's Disease/dementia research. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research progress in Alzheimer's Disease and memory disorders.

Author : Ahmad Salehi,Michael Rafii ,Cristy Phillips
Publisher : Bentham Science Publishers
Page : 322 pages
File Size : 47,6 Mb
Release : 2015-11-11
Category : Medical
ISBN : 9781681081380

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Recent Advances in Alzheimer Research by Ahmad Salehi,Michael Rafii ,Cristy Phillips Pdf

Recent Advances in Alzheimer Disease Research is a book series focusing on contemporary research on Alzheimer’s disease epidemiology, pathophysiology, diagnosis and therapy. The series features reviews by experts in neuroscience and aims to provide current information in the field to both researchers and clinicians. Down syndrome is a chromosomal disorder affecting more than 5.8 million individuals worldwide. Down syndrome can be viewed as a complex multi-system disorder as it manifests into significant physical, psychological, and cognitive abnormalities in affected persons. With aging, most adults with Down syndrome develop the clinical and neuropathological hallmarks of Alzheimer's disease. Unfortunately, no extant treatments have proven beneficial for cognitive dysfunction for either Down syndrome or Alzheimer’s disease. An incomplete understanding of the common pathogenic mechanisms that link these two disorders has limited researchers’ progress to this end. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a novel attempt to fill this void, by summarizing the work of world-renowned scientists in the field of Alzheimer’s disease and Down syndrome, and thus providing an unprecedented opportunity to attract attention to Down syndrome as a tool for understanding the common molecular mechanisms that underlie Alzheimer’s disease and to develop new therapies for similar neurodegenerative disorders of the brain. The book covers the fundamental pathophysiology and molecular mechanisms behind the incidence of Alzheimer’s disease in Down syndrome affected individuals as well other key topics such as diagnosis and management, in vivo brain imaging studies, and progressive neurodegeneration of the monoaminergic system. The book concludes with a review of recent clinical trials of drugs designed to mitigate cognitive dysfunction in aging adults with Down syndrome and establishes a scientific warrant for the increased testing of candidate pharmacotherapies. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a useful reference clinicians involved in treating Down syndrome patients as well as for neuroscience researchers seeking to understand the influence of a specific case of aneuploidy on Alzheimer’s disease incidence and its progression at the molecular level.

Author : Suzanne Corkin
Publisher : Unknown
Page : 560 pages
File Size : 49,8 Mb
Release : 1982
Category : Medical
ISBN : UOM:39015045484246

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Alzheimer's Disease by Suzanne Corkin Pdf

Author : Jeffrey Cummings,Jefferson Kinney,Howard Fillit
Publisher : Cambridge University Press
Page : 575 pages
File Size : 55,9 Mb
Release : 2022-03-31
Category : Business & Economics
ISBN : 9781108838665

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Alzheimer's Disease Drug Development by Jeffrey Cummings,Jefferson Kinney,Howard Fillit Pdf

Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

Author : Kurt A. Jellinger,Reinhold Schmidt,Manfred Windisch
Publisher : Springer Science & Business Media
Page : 489 pages
File Size : 46,7 Mb
Release : 2013-03-07
Category : Medical
ISBN : 9783709167816

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Advances in Dementia Research by Kurt A. Jellinger,Reinhold Schmidt,Manfred Windisch Pdf

Dementia is a major health problem that becomes increasingly common with advancing age. Despite recent progress in neurobiology and molecular genetics, the aetiology and pathogenesis of most dementia disorders are still poorly understood, and early exact diagnosis as a prerequisite of effective treatment needs to be improved. The present volume includes the contributions of renowned experts in the field of neurodegeneration presented at the International Symposium "Ageing and Dementia 1999”, September 24–26, 1999 at Graz. It focusses on genetics, epidemiology, new neuroimaging techniques, and the role of vascular, immunological and other mechanisms including oxidative stress and estrogens in the development of neurodegeneration and dementia. Recent developments in diagnosis and therapy of Alzheimer disease and related disorders are reviewed and future therapeutic approaches are discussed. Thus, this volume provides a timely overview of most recent developments in dementia research and treatment strategies of dementia disorders.

Author : Khalid Iqbal,Sangram S. Sisodia,Bengt Winblad
Publisher : John Wiley & Sons
Page : 888 pages
File Size : 46,6 Mb
Release : 2003-01-24
Category : Medical
ISBN : 9780470851746

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Alzheimer's Disease by Khalid Iqbal,Sangram S. Sisodia,Bengt Winblad Pdf

Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.

Author : Alzheimer's Society
Publisher : eBook Partnership
Page : 12 pages
File Size : 41,5 Mb
Release : 2011-01-12
Category : Medical
ISBN : 9781783013906

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Alzheimer's Society factsheet 458 by Alzheimer's Society Pdf

The progression of Alzheimer's disease and other dementias is a factsheet from Alzheimer's Society. This factsheet outlines the characteristics of early-, middle- and late-stage Alzheimer's disease and briefly looks at how other forms of dementia progress. It will be helpful to people in England, Wales and Northern Ireland. Health and social care professionals may also find it useful.