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Author : Heath J. Carney,Bruce S. Hass
Publisher : Unknown
Page : 78 pages
File Size : 40,7 Mb
Release : 1979
Category : Carcinogenicity testing
ISBN : MINN:31951000151032M
Author : H.F. Stich,R.H.C. San
Publisher : Springer
Page : 518 pages
File Size : 40,7 Mb
Release : 2011-10-25
Category : Medical
ISBN : 1461258480
The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be tween the carcinogenicity and mutagenicity of chemicals and physical agents and by the assumption that DNA alteration, mutations, and chromosome aberrations are somehow involved in neoplastic transformation. Moreover, it has been tacitly assumed that the mutagenic capacity alone of compounds would induce regulatory agencies to pass rules for their removal from the environment and would lead the public to avoid them. The actual response, however, is quite different. Governmental departments shy away from making any decisions on the basis of in vitro test systems. The public at large is becoming irritated by daily an nouncements that many of their cherished habits could adversely affect their health. Industry appears to feel threatened and may reduce its search for new beneficial chemicals. The reluctance to accept wholeheartedly the mutagenicity tests for the detection of carcinogens is partly due to uncertainty about the in volvement of mutations in neoplastic transformation, partly due to the present difficulty of extrapolating results from various endpoints obtained on numerous organisms to man, and partly due to a multitude of complex events that lead in vivo to the evolvement of benign or malignant tumors.
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Comparative Toxicity of Naturally Occurring Carcinogens
Publisher : National Academies Press
Page : 433 pages
File Size : 55,9 Mb
Release : 1996-02-12
Category : Nature
ISBN : 9780309175715
Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.
Author : Anonim
Publisher : Unknown
Page : 782 pages
File Size : 42,8 Mb
Release : 1979
Category : Power resources
ISBN : MSU:31293010867467
Author : Anonim
Publisher : Unknown
Page : 1064 pages
File Size : 43,9 Mb
Release : 2024-07-03
Category : Government publications
ISBN : UCR:31210024274704
Author : United States. Superintendent of Documents
Publisher : Unknown
Page : 1256 pages
File Size : 46,9 Mb
Release : 1968
Category : Government publications
ISBN : UCR:31210024274738
Author : Anonim
Publisher : Unknown
Page : 1268 pages
File Size : 53,6 Mb
Release : 1980
Category : Government publications
ISBN : UIUC:30112063912585
Author : Anonim
Publisher : Unknown
Page : 174 pages
File Size : 49,6 Mb
Release : 1979
Category : Biology
ISBN : WISC:89043246263
Author : National Research Council
Publisher : Legare Street Press
Page : 0 pages
File Size : 53,9 Mb
Release : 2022-10-27
Category : History
ISBN : 1015698875
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Author : Richard F. Keeler,Anthony T. Tu
Publisher : CRC Press
Page : 964 pages
File Size : 54,5 Mb
Release : 1983-11-30
Category : Medical
ISBN : 0824718933
Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 47,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : Anonim
Publisher : Unknown
Page : 1394 pages
File Size : 45,7 Mb
Release : 1988
Category : Government publications
ISBN : STANFORD:36105061147919
Author : Hikoya Hayatsu
Publisher : CRC Press
Page : 304 pages
File Size : 49,6 Mb
Release : 1990-12-13
Category : Technology & Engineering
ISBN : 0849358779
This book describes many different kinds of mutagens that are detected in food, and also discusses various ways to suppress their formation and activities. The mutagens discussed include those of natural origin, those caused by human manipulation of food (e.g., cooking and adding preservatives), and those formed after food has been consumed (e.g., nitrosamines). Other topics include mutagenesis and mutagen-formation inhibitors, contemporary mutagen detection methods, the fate of ingested mutagens, and risk assessments for mutagens as human carcinogens. The book emphasizes cooked-food mutagens, especially the heterocyclic amines, because of their potential as human carcinogens. Researchers and students concerned with mutagens in food will consider this book to be valuable additions to their reference libraries.
Author : Anonim
Publisher : Unknown
Page : 704 pages
File Size : 46,8 Mb
Release : 1980
Category : Environmental engineering
ISBN : UOM:39015095045269
Author : Anonim
Publisher : Unknown
Page : 704 pages
File Size : 52,6 Mb
Release : 1980
Category : Environmental engineering
ISBN : MINN:31951D008165144