Revolutions In Human Biospecimen Study Leveraging New Technologies To Explore The Pathology Therapeutics And Biomarkers For Atherosclerotic Disease

Author : Ying Wang,Michal Mokry,Kathryn L. Howe
Publisher : Frontiers Media SA
Page : 141 pages
File Size : 46,6 Mb
Release : 2023-11-20
Category : Medical
ISBN : 9782832539354

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Revolutions in Human Biospecimen Study: Leveraging new technologies to explore the pathology, therapeutics and biomarkers for atherosclerotic disease by Ying Wang,Michal Mokry,Kathryn L. Howe Pdf

Over the last few years, new high-throughput biotechnologies are revolutionizing our ways to utilize human biospecimens for understanding atherosclerotic disease. These recent advances allow deep profiling of individual cells at the genomics, epigenomics, transcriptomics and proteomics levels, or even simultaneous detection of various combinations of ‘Omics’ in the same cell. Additionally, novel methods to integrate data at different levels from tissue sections and dissociated tissues are the emerging trends in large and institutional biobank studies. Growing literature has shown the value of such sequencing and bioinformatic strategies in shedding light on (1) how risk genes, as identified by the Genome-Wide Association Study, contribute to atherogenesis (genotype to phenotype), and (2) how features of atherosclerotic lesions affect patient response in clinical trials (phenotype to the clinical outcome). The hybrid of cutting-edge biotechnologies and bioinformatic approaches helps us maximize biobank resources to accelerate bench-to-bedside research.

Author : Paul A. Schulte,Frederica P. Perera
Publisher : Academic Press
Page : 609 pages
File Size : 47,6 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323138574

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Molecular Epidemiology by Paul A. Schulte,Frederica P. Perera Pdf

This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.

Author : Alex A.T. Bui,Ricky K. Taira
Publisher : Springer Science & Business Media
Page : 454 pages
File Size : 47,7 Mb
Release : 2009-12-01
Category : Technology & Engineering
ISBN : 9781441903853

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Medical Imaging Informatics by Alex A.T. Bui,Ricky K. Taira Pdf

Medical Imaging Informatics provides an overview of this growing discipline, which stems from an intersection of biomedical informatics, medical imaging, computer science and medicine. Supporting two complementary views, this volume explores the fundamental technologies and algorithms that comprise this field, as well as the application of medical imaging informatics to subsequently improve healthcare research. Clearly written in a four part structure, this introduction follows natural healthcare processes, illustrating the roles of data collection and standardization, context extraction and modeling, and medical decision making tools and applications. Medical Imaging Informatics identifies core concepts within the field, explores research challenges that drive development, and includes current state-of-the-art methods and strategies.

Author : Irene Dankwa-Mullan,Eliseo J. Pérez-Stable,Kevin L. Gardner,Xinzhi Zhang,Adelaida M. Rosario
Publisher : John Wiley & Sons
Page : 548 pages
File Size : 41,5 Mb
Release : 2021-03-16
Category : Science
ISBN : 9781119374817

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The Science of Health Disparities Research by Irene Dankwa-Mullan,Eliseo J. Pérez-Stable,Kevin L. Gardner,Xinzhi Zhang,Adelaida M. Rosario Pdf

Integrates the various disciplines of the science of health disparities in one comprehensive volume The Science of Health Disparities Research is an indispensable source of up-to-date information on clinical and translational health disparities science. Building upon the advances in health disparities research over the past decade, this authoritative volume informs policies and practices addressing the diseases, disorders, and gaps in health outcomes that are more prevalent in minority populations and socially disadvantaged communities. Contributions by recognized scholars and leaders in the field—featuring contemporary research, conceptual models, and a broad range of scientific perspectives—provide an interdisciplinary approach to reducing inequalities in population health, encouraging community engagement in the research process, and promoting social justice. In-depth chapters help readers better understand the specifics of minority health and health disparities while demonstrating the importance of advancing theory, refining measurement, improving investigative methods, and diversifying scientific research. In 26 chapters, the book examines topics including the etiology of health disparities research, the determinants of population health, research ethics, and research in African American, Asians, Latino, American Indian, and other vulnerable populations. Providing a unified framework on the principles and applications of the science of health disparities research, this important volume: Defines the field of health disparities science and suggests new directions in scholarship and research Explains basic definitions, principles, and concepts for identifying, understanding and addressing health disparities Provides guidance on both conducting health disparities research and translating the results Examines how social, historical and contemporary injustices may influence the health of racial and ethnic minorities Illustrates the increasing national and global importance of addressing health disparities Discusses population health training, capacity-building, and the transdisciplinary tools needed to advance health equity A significant contribution to the field, The Science of Health Disparities Research is an essential resource for students and basic and clinical researchers in genetics, population genetics, and public health, health care policymakers, and epidemiologists, medical students, and clinicians, particularly those working with minority, vulnerable, or underserved populations.

Author : Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari
Publisher : John Wiley & Sons
Page : 559 pages
File Size : 55,6 Mb
Release : 2011-09-20
Category : Medical
ISBN : 9781118210420

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Biomarkers in Drug Development by Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari Pdf

Discover how biomarkers can boost the success rate of drug development efforts As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine. Biomarkers in Drug Development is divided into eight parts: Part One offers an overview of biomarkers and their role in drug development. Part Two highlights important technologies to help researchers identify new biomarkers. Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose. Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine. Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development.

Author : Nigel Clarke,Andrew N. Hoofnagle
Publisher : Elsevier Health Sciences
Page : 104 pages
File Size : 40,6 Mb
Release : 2011-10-03
Category : Medical
ISBN : 9781455712014

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Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book by Nigel Clarke,Andrew N. Hoofnagle Pdf

This issue of Clinics in Laboratory Medicine, Guest Edited by Nigel Clarke, MD, and Andrew Hoofnagle, MD, will focus on Mass Spectrometry, with topics including: Proteins; Peptides; Small Molecules: Toxicology; Small Molecules: Diagnostics; and Regulatory Considerations.

Author : Alan B. Ettinger,Deborah M. Weisbrot
Publisher : Cambridge University Press
Page : 693 pages
File Size : 55,9 Mb
Release : 2014-04-17
Category : Medical
ISBN : 9781107014558

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Neurologic Differential Diagnosis by Alan B. Ettinger,Deborah M. Weisbrot Pdf

Unique case-based guide to generating diagnostic possibilities based on the patients' symptoms. Invaluable for psychiatrists and neurologists.

Author : Joakim Dillner
Publisher : Humana Press
Page : 0 pages
File Size : 48,7 Mb
Release : 2010-10-21
Category : Science
ISBN : 1588299953

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Methods in Biobanking by Joakim Dillner Pdf

International biobank collaborations allow for studies with large number of subjects where generalizability of findings across populations can be investigated, which means establishing quality criteria concerning the nature of the sample, conditions of sample storage, and the adequacy of available information is of vital importance. Methods in Biobanking brings together contributions from experts in the field in order to aid in the establishment of this much needed consistency. The volume discusses how to use existing collections of biological material to answer significant questions concerning the cause of disease without violating the personal integrity of participating sample donors, the ethical issues surrounding biobanks, guidelines for the use of coding systems and the use of biocomputing and registry linkages in research projects, as well as many other key subjects. As a volume in the highly successful Methods in Molecular BiologyTM series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Methods in Biobanking seeks to provide scientists with the tools necessary to take advantage of the tremendous current resources of the world’s biobanks and strengthen those resources for the future.

Author : Thomas H. Berquist
Publisher : Lippincott Williams & Wilkins
Page : 1190 pages
File Size : 55,6 Mb
Release : 2012-04-06
Category : Medical
ISBN : 9781451109184

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MRI of the Musculoskeletal System by Thomas H. Berquist Pdf

MRI of the Musculoskeletal System, Sixth Edition, comprehensively presents all aspects of MR musculoskeletal imaging, including basic principles of interpretation, physics, and terminology before moving through a systematic presentation of disease states in each anatomic region of the body. Its well-deserved reputation can be attributed to its clarity, simplicity, and comprehensiveness. The Sixth Edition features many updates, including: New pulse sequences and artifacts in the basics chapters Over 3,000 high-quality images including new anatomy drawings and images FREE access to a companion web site featuring full text as well as an interactive anatomy quiz with matching labels of over 300 images.

Author : Rangaraj M. Rangayyan
Publisher : CRC Press
Page : 1312 pages
File Size : 40,7 Mb
Release : 2004-12-30
Category : Medical
ISBN : 9780203492543

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Biomedical Image Analysis by Rangaraj M. Rangayyan Pdf

Computers have become an integral part of medical imaging systems and are used for everything from data acquisition and image generation to image display and analysis. As the scope and complexity of imaging technology steadily increase, more advanced techniques are required to solve the emerging challenges. Biomedical Image Analysis demonstr

Author : Richard Towbin,Kevin Baskin
Publisher : Cambridge University Press
Page : 497 pages
File Size : 45,6 Mb
Release : 2015-06-18
Category : Medical
ISBN : 9781107042629

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Pediatric Interventional Radiology by Richard Towbin,Kevin Baskin Pdf

Highlighting safe practice, this volume is essential reading for pediatric interventional radiologists and radiology trainees. Contains over 700 high-quality illustrations.

Author : David G. Bragg,Philip Rubin,Hedvig Hricak
Publisher : Saunders
Page : 0 pages
File Size : 55,7 Mb
Release : 2002
Category : Cancer
ISBN : 0721674941

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Oncologic Imaging by David G. Bragg,Philip Rubin,Hedvig Hricak Pdf

Completely updated to reflect the latest developments in science and technology, the second edition of this reference presents the diagnostic imaging tools essential to the detection, diagnosis, staging, treatment planning, and post-treatment management of cancer in both adults and children. Organized by major organs and body systems, the text offers comprehensive, abundantly illustrated guidance to enable both the radiologist and clinical oncologist to better appreciate and overcome the challenges of tumor imaging. Features 12 brand-new chapters that examine new imaging techniques, molecular imaging, minimally invasive approaches, 3D and conformal treatment planning, interventional techniques in radiation oncology, interventional breast techniques, and more. Emphasizes practical interactions between oncologists and radiologists. Includes expanded coverage of paediatric tumours as well as thorax, gastrointestinal tract, genitourinary, and musculoskeletal cancers. Offers reorganized and increased content on the brain and spinal cord. Nearly 1,400 illustrations enable both the radiologist and clinical oncologist to better appreciate and overcome the challenges of tumour imaging. - Outstanding Features! Presents internationally renowned authors' insights on recent technological breakthroughs in imaging for each anatomical region, and offers their views on future advances in the field. Discusses the latest advances in treatment planning. Devotes four chapters to the critical role of imaging in radiation treatment planning and delivery. Makes reference easy with a body-system organisation.

Author : United States. Office of Management and Budget
Publisher : Unknown
Page : 72 pages
File Size : 54,7 Mb
Release : 1979
Category : Federal aid to higher education
ISBN : IND:30000065644225

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Cost Principles for Educational Institutions by United States. Office of Management and Budget Pdf

Author : Tahu Kukutai,John Taylor
Publisher : ANU Press
Page : 344 pages
File Size : 45,6 Mb
Release : 2016-11-14
Category : Social Science
ISBN : 9781760460310

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Indigenous Data Sovereignty by Tahu Kukutai,John Taylor Pdf

As the global ‘data revolution’ accelerates, how can the data rights and interests of indigenous peoples be secured? Premised on the United Nations Declaration on the Rights of Indigenous Peoples, this book argues that indigenous peoples have inherent and inalienable rights relating to the collection, ownership and application of data about them, and about their lifeways and territories. As the first book to focus on indigenous data sovereignty, it asks: what does data sovereignty mean for indigenous peoples, and how is it being used in their pursuit of self-determination? The varied group of mostly indigenous contributors theorise and conceptualise this fast-emerging field and present case studies that illustrate the challenges and opportunities involved. These range from indigenous communities grappling with issues of identity, governance and development, to national governments and NGOs seeking to formulate a response to indigenous demands for data ownership. While the book is focused on the CANZUS states of Canada, Australia, Aotearoa/New Zealand and the United States, much of the content and discussion will be of interest and practical value to a broader global audience. ‘A debate-shaping book … it speaks to a fast-emerging field; it has a lot of important things to say; and the timing is right.’ — Stephen Cornell, Professor of Sociology and Faculty Chair of the Native Nations Institute, University of Arizona ‘The effort … in this book to theorise and conceptualise data sovereignty and its links to the realisation of the rights of indigenous peoples is pioneering and laudable.’ — Victoria Tauli-Corpuz, UN Special Rapporteur on the Rights of Indigenous Peoples, Baguio City, Philippines

Author : Council for International Organizations of Medical Sciences (CIOMS)
Publisher : World Health Organization
Page : 0 pages
File Size : 41,6 Mb
Release : 2017-01-31
Category : Bioethics
ISBN : 9290360887

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International Ethical Guidelines for Health-Related Research Involving Humans by Council for International Organizations of Medical Sciences (CIOMS) Pdf

"In the new 2016 version of the ethical guidelines, CIOMS provides answers to a number of pressing issues in research ethics. The Council does so by stressing the need for research having scientific and social value, by providing special guidelines for health-related research in low-resource settings, by detailing the provisions for involving vulnerable groups in research and for describing under what conditions biological samples and health-related data can be used for research."--Page 4 de la couverture.