Rheumatic Diseases And Syndromes Induced By Cancer Immunotherapy

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Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy

Maria E. Suarez-Almazor,Leonard H. Calabrese
Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy Book PDF

Author : Maria E. Suarez-Almazor,Leonard H. Calabrese
Publisher : Springer Nature
Page : 363 pages
File Size : 42,9 Mb
Release : 2021-02-16
Category : Medical
ISBN : 9783030568245

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Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy by Maria E. Suarez-Almazor,Leonard H. Calabrese Pdf

With the increasing use of immune checkpoint inhibitors (ICI) across various cancers, the trends for indication at earlier stages, and the use of combination immunotherapy, the frequency of ICI-induced immune-related adverse events (irAE) is expected to grow substantially. Management of these irAE is challenging as it requires not only consideration of the toxicity but also risk-benefit ratios with respect to the primary cancer. Several rheumatic irAE have been reported with ICI therapy including arthritis, myositis, polymyalgia-like syndromes, sicca/Sjogren-like manifestations, and several other less common systemic autoimmune features commonly associated with connective tissue disease. This handbook provides clinicians with a comprehensive overview of the management of rheumatic irAE that develop from cancer immunotherapy. It focuses on the irAE seen with ICI, the most frequently used agents in treating cancer. It provides an overview of cancer immunology, immunotoxicity, and immunotherapies such as ICI, cytokine-based therapy, and CART. It examines the epidemiology, clinical manifestations, diagnosis, differential diagnosis, and treatment of a variety of rheumatic immune-related adverse events arising from these therapies. Chapters also cover cancer immunotherapy in patients with preexisting rheumatic diseases such as inflammatory arthritis and other connective tissue disorders. The book helps clinicians to distinguish the current types of cancer immunotherapy and general toxicity patterns, recognize and diagnose rheumatic clinical syndromes, understand the pathogenesis of irAE, and consider risk–benefit ratios when managing patients with rheumatic irAE. Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy is an essential resource for physicians and related professionals, residents, fellows, graduate students and nurses alike in rheumatology, clinical immunology, oncology, and internal medicine.

Cancer and Rheumatic Diseases, An Issue of Rheumatic Disease Clinics of North America, E-Book

John Davis
Cancer and Rheumatic Diseases An Issue of Rheumatic Disease Clinics of North America E Book Book PDF

Author : John Davis
Publisher : Elsevier Health Sciences
Page : 240 pages
File Size : 54,6 Mb
Release : 2020-08-03
Category : Medical
ISBN : 9780323761277

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Cancer and Rheumatic Diseases, An Issue of Rheumatic Disease Clinics of North America, E-Book by John Davis Pdf

This issue of Rheumatic Disease Clinics, guest edited by Dr. John Davis, will discuss Cancer and Rheumatic Diseases. This issue is one of four selected each year by series Consulting Editor, Dr. Michael Weisman. Topics discussed in this issue include, but are not limited to: rheumatic drugs and malignancy potential, biologic drugs and cancer, methotrexate and cancer, managing rheumatoid arthritis with cancer, Sjogren’s Syndrome and cancer, lupus and cancer, scleroderma and cancer, cancer and spondylarthritis, and cancer immunotherapy.

Paraneoplastic and Cancer Treatment-related Rheumatic Disorders

Kenneth J. Scalapino,Charles R. Thomas JR
Paraneoplastic and Cancer Treatment related Rheumatic Disorders Book PDF

Author : Kenneth J. Scalapino,Charles R. Thomas JR
Publisher : Clinics: Internal Medicine
Page : 0 pages
File Size : 54,7 Mb
Release : 2011
Category : Medical
ISBN : 1455711896

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Paraneoplastic and Cancer Treatment-related Rheumatic Disorders by Kenneth J. Scalapino,Charles R. Thomas JR Pdf

This issue of Rheumatic Disease Clinics of North America provides foundational and in-depth information about paraneoplastic and cancer treatment-related rheumatic disorders, in which every practicing rheumatologist should be well-versed. Topics covered include neoplasm risk in patients with rheumatic diseases; neoplasm risk of anti-rheumatic therapy; rheumatologic laboratory findings in malignancy; rheumatic manifestations of primary and metastatic bone tumors and paraneoplastic bone disease; neoplastic/paraneoplastic synovitis; neoplastic/paraneoplastic dermatitis, fasciitis, and panniculitis; neoplastic/paraneoplastic vasculitis, vasculopathy, and hypercoagulability; neoplastic/paraneoplastic myalgias and myositis; and less-common neoplastic/paraneoplastic syndromes.

Immunology of Rheumatic Diseases

Sudhir Gupta
Immunology of Rheumatic Diseases Book PDF

Author : Sudhir Gupta
Publisher : Springer Science & Business Media
Page : 916 pages
File Size : 45,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461324935

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Immunology of Rheumatic Diseases by Sudhir Gupta Pdf

Recent developments in basic science and clinical rheumatology make it appropriate at this time to create a volume devoted to the immunology of rheumatic diseases. The impact of molecular biology, gene cloning, and new technologies for establishing hybridomas and T-cell lines in the laboratory is now beginning to be felt in clinical medicine. There is a general air of excitement and a feeling that we stand on the threshold of a new era in molecular medicine and clinical science. It is this excitement that we have tried to capture in this book. This volume is divided into five sections entitled Basic Mechanisms, Autoimmunity, Classical Concepts of Rheumatic Diseases, Pathogenetic Mechanisms, and Therapy. This is not an arbitrary arrangement but represents our belief that from an understanding of basic mechanisms of disease pathogenesis will come new and more successful forms of treatment for the sufferers of rheumatic disorders. We have tried in the selection of authors to choose internationally recognized experts who have both a scientific and a clinical orientation to their subjects. We believe the marriage of clinical and basic disciplines represents the best hope for rapid knowledge transfer from the laboratory to the clinic, where such knowledge can be used to improve patient health.

Cancer and Rheumatic Diseases, an Issue of Rheumatic Disease Clinics of North America

John Davis
Cancer and Rheumatic Diseases an Issue of Rheumatic Disease Clinics of North America Book PDF

Author : John Davis
Publisher : Elsevier
Page : 240 pages
File Size : 50,6 Mb
Release : 2020-08-28
Category : Electronic
ISBN : 0323761267

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Cancer and Rheumatic Diseases, an Issue of Rheumatic Disease Clinics of North America by John Davis Pdf

This issue of Rheumatic Disease Clinics, guest edited by Dr. John Davis, will discuss Cancer and Rheumatic Diseases. This issue is one of four selected each year by series Consulting Editor, Dr. Michael Weisman. Topics discussed in this issue include, but are not limited to: rheumatic drugs and malignancy potential, biologic drugs and cancer, methotrexate and cancer, managing rheumatoid arthritis with cancer, Sjogren's Syndrome and cancer, lupus and cancer, scleroderma and cancer, cancer and spondylarthritis, and cancer immunotherapy.

Comorbidity in Rheumatic Diseases

Yasser El Miedany
Comorbidity in Rheumatic Diseases Book PDF

Author : Yasser El Miedany
Publisher : Springer
Page : 433 pages
File Size : 42,9 Mb
Release : 2017-08-24
Category : Medical
ISBN : 9783319599632

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Comorbidity in Rheumatic Diseases by Yasser El Miedany Pdf

This book explores comorbidity in patients with rheumatic diseases and details both care and treatment options in standard clinical practice. Patients with rheumatic diseases are clinically complex, and the interplay of their disease activity with associated conditions may lead to increased morbidity and mortality. Recently there have been major advances in the management of rheumatic diseases, however, without addressing the potential comorbid conditions, including cardiovascular disease; pulmonary disease; and depression; outcomes remain poor. ​​​ With its 19 chapters, covering the management of major rheumatic diseases (e.g. rheumatoid arthritis, systemic lupus erythematosus , and osteoarthritis), potential comorbidities and treatment recommendations, as well as possible interactions between conditions; this book addresses the gap between textbook medicine and day to day patients' care. Authors also discuss the new hot issue of the comorbidity index, comparing the standard tools to the recently developed indices and how they can assist the rheumatologists in determining disease burden, prognosis, and comorbidity probability. This book is an ideal clinical guide and reference that enables rheumatologists, internal medicine physicians, and residents to address the full clinical expression of these rheumatic diseases with views towards prevention or early management of comorbid conditions.

Skills in Rheumatology

Hani Almoallim,Mohamed Cheikh
Skills in Rheumatology Book PDF

Author : Hani Almoallim,Mohamed Cheikh
Publisher : Springer Nature
Page : 562 pages
File Size : 50,6 Mb
Release : 2021-01-05
Category : Medical
ISBN : 9789811583230

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Skills in Rheumatology by Hani Almoallim,Mohamed Cheikh Pdf

This Open Access book presents practical approaches to managing patients affected by various rheumatological diseases, allowing readers to gain a better understanding of the various clinical expressions and problems experienced by these patients. Discussing rheumatology from an organ systems perspective, it highlights the importance ofdetailed musculoskeletal examinations when treating patients affected by rheumatological diseases. The book first explores the latest diagnostic approaches and offers key tips for accurate musculoskeletal examinations before addressing the various treatment modalities, with a particular focus on the most common joints involved in rheumatoid arthritis: the wrists and the metacarpophalangeal joints (2nd and 3rd). Featuring easy-to-understand flow diagrams and explaining the common medical problems associated with rheumatic disease, such as shortness of breath and anemia, it is not only a valuable resource to rheumatologists, but will also appeal to medical students, junior residents, and primary healthcare physicians.

Polymyalgia Rheumatica and Giant Cell Arteritis

Jozef Rovensky,Burkhard F. Leeb,Howard Bird,Viera Štvrtinová,Richard Imrich
Polymyalgia Rheumatica and Giant Cell Arteritis Book PDF

Author : Jozef Rovensky,Burkhard F. Leeb,Howard Bird,Viera Štvrtinová,Richard Imrich
Publisher : Springer Science & Business Media
Page : 93 pages
File Size : 43,9 Mb
Release : 2010-05-06
Category : Medical
ISBN : 9783211993590

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Polymyalgia Rheumatica and Giant Cell Arteritis by Jozef Rovensky,Burkhard F. Leeb,Howard Bird,Viera Štvrtinová,Richard Imrich Pdf

In the present monograph, we offer current insights into polymyalgia rheumatica and giant cell arthritis. Both diseases are typical for advanced age, and their incidences increase with aging. Both diseases are a center point of interest not only for rheu- tologists, gerontologists, ophthalmologists or neurologists, but also for general prac- tioners. Early diagnosis and rapid treatment, mainly with glucocorticoids can save one of the most precious senses-vision. Damage to other organs (heart, aorta, co- nary arteries, liver, lungs, kidneys), which are supplied by the arteries affected by ischemic syndrome in the setting of giant cell arthritis, has serious consequences as well. Late diagnosis of giant cell arthritis can have fatal consequences for affected patients. It is a matter of fact that the human population is aging. Therefore, more attention has to be paid not only to diagnosis, clinical course and treatment of rheumatic d- eases in elderly, but also to their genetic, immunologic, endocrinologic, chronobiologic mechanisms, and state-of-the-art diagnostic modalities. I am convinced that the int- disciplinary research of the diseases will allow us to diagnose and treat the rheumatic diseases even faster and more effectively in the future.

SITC’s Guide to Managing Immunotherapy Toxicity

Marc S. Ernstoff, MD,Igor Puzanov, MD, MSCI, FACP,Caroline Robert, MD, PhD,Adi M. Diab, MD,Peter M. Hersey, MD, PhD
SITC s Guide to Managing Immunotherapy Toxicity Book PDF

Author : Marc S. Ernstoff, MD,Igor Puzanov, MD, MSCI, FACP,Caroline Robert, MD, PhD,Adi M. Diab, MD,Peter M. Hersey, MD, PhD
Publisher : Springer Publishing Company
Page : 250 pages
File Size : 54,6 Mb
Release : 2019-03-15
Category : Medical
ISBN : 9780826172150

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SITC’s Guide to Managing Immunotherapy Toxicity by Marc S. Ernstoff, MD,Igor Puzanov, MD, MSCI, FACP,Caroline Robert, MD, PhD,Adi M. Diab, MD,Peter M. Hersey, MD, PhD Pdf

The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer

Polymyalgia Rheumatica and Giant Cell Arteritis

Bhaskar Dasgupta,Christian Dejaco
Polymyalgia Rheumatica and Giant Cell Arteritis Book PDF

Author : Bhaskar Dasgupta,Christian Dejaco
Publisher : Oxford University Press
Page : 177 pages
File Size : 54,6 Mb
Release : 2016-03-03
Category : Medical
ISBN : 9780198729204

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Polymyalgia Rheumatica and Giant Cell Arteritis by Bhaskar Dasgupta,Christian Dejaco Pdf

Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are related conditions occurring almost exclusively in older people. Polymyalgia rheumatica is considered to be the rheumatic disease that is subject to the widest variations of clinical practice, partially due to the considerable uncertainty related to diagnosis and outcomes. Giant cell arteritis, an inflammatory form of vasculitis, may present with a broad spectrum of clinical manifestations and can be complicated by acute ischemic events, the most serious of which is permanent blindness. Early recognition and adequate treatment of the condition is thus necessary to prevent patients' loss of independence and to maintain their quality of life. Part of the Oxford Rheumatology Library series, Polymyalgia Rheumatica and Giant Cell Arteritis provides quick and practically relevant information on several aspects of the diseases, particularly on diagnosis and management, with the ultimate aim of improving the patient's care. Chapters highlight current concepts of pathogenesis, recent advances of diagnostic and therapeutic approaches, and the ongoing research into the identification of new biomarkers and corticosteroid-sparing medications. Each chapter is complemented with key message boxes highlighting the most relevant information for clinical practice. This concise but comprehensive reference is particularly suited for rheumatologists, general practitioners, and other professionals caring for patients with PMR and GCA.

Hepatotoxicity

Hyman J. Zimmerman
Hepatotoxicity Book PDF

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
Page : 848 pages
File Size : 53,6 Mb
Release : 1999
Category : Medical
ISBN : 0781719526

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Hepatotoxicity by Hyman J. Zimmerman Pdf

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Rheumatic Disease in Geriatrics

Gleb Slobodin,Yehuda Shoenfeld
Rheumatic Disease in Geriatrics Book PDF

Author : Gleb Slobodin,Yehuda Shoenfeld
Publisher : Springer Nature
Page : 391 pages
File Size : 54,8 Mb
Release : 2020-05-25
Category : Medical
ISBN : 9783030442347

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Rheumatic Disease in Geriatrics by Gleb Slobodin,Yehuda Shoenfeld Pdf

This book provides a practical guide to the diagnosis and management of rheumatic disease in geriatric patients. It details information on the effect of ageing on musculoskeletal and immune systems and specifies impact of a variety of inflammatory and degenerative rheumatic disorders on the elderly. The clinical diagnostic approach to an older individual with musculoskeletal complaints is a cornerstone of this book, which includes also insights into the most important comorbidities for this age and discusses in depth available treatments and rehabilitation tools. The symptoms, imaging features and recommendations on the interpretation of specific laboratory tests for rheumatic diseases in geriatrics are also covered. This book encompasses traditionally associated with older age conditions including temporal arteritis, polymyalgia rheumatica, osteoarthritis, as well as common systemic autoimmune diseases that can produce atypical manifestations in the elderly. It will enable the readers to develop a thorough understanding of how to deal with these patients in their clinical practice. Rheumatic Disease in Geriatrics: Diagnosis and Management systematically describes how to diagnose and treat geriatric patients with a variety of rheumatic conditions and is a valuable resource for all medical professionals involved.

Periprosthetic Joint Infection: Practical Management Guide

Parvizi Javad ,Kerr Glenn J,Glynn Aaron,Higuera Carlos A,Hansen Erik N
Periprosthetic Joint Infection Practical Management Guide Book PDF

Author : Parvizi Javad ,Kerr Glenn J,Glynn Aaron,Higuera Carlos A,Hansen Erik N
Publisher : JAYPEE BROTHERS MEDICAL PUBLISHERS PVT. LTD.
Page : 432 pages
File Size : 42,8 Mb
Release : 2013-12-15
Category : Medical
ISBN : 9789350908259

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Periprosthetic Joint Infection: Practical Management Guide by Parvizi Javad ,Kerr Glenn J,Glynn Aaron,Higuera Carlos A,Hansen Erik N Pdf

This book Periprosthetic Joint Infection is a portable guide to the practical management of surgical site infections following orthopedic procedures. It designed to help answer clinician's questions regarding the prevention and treatment of periprosthetic infections. It organized for rapid review, featuring evidence reviews, pitfalls, Rothman Institute Current Practices and Controversies. The guide is being included in the course materials for the 29th Annual Current Concepts in Joint Replacement® (CCJR) meeting thanks to a generous educational grant from 3M Health Care.

Primer on the Rheumatic Diseases

John H. Klippel,Cornelia M. Weyand,Robert Wortmann
Primer on the Rheumatic Diseases Book PDF

Author : John H. Klippel,Cornelia M. Weyand,Robert Wortmann
Publisher : Unknown
Page : 534 pages
File Size : 50,8 Mb
Release : 1997
Category : Health & Fitness
ISBN : UOM:39015064799359

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Primer on the Rheumatic Diseases by John H. Klippel,Cornelia M. Weyand,Robert Wortmann Pdf

A comprehensive textbook for health-care professionsl and students covering the rheumatic diseases, including arthritis, lupus, osteoporosis, fibromyalgia and more.

Cancer Diagnostics

Robert M. Nakamura,Wayne W. Grody,James T. Wu,Raymond B. Nagle
Cancer Diagnostics Book PDF

Author : Robert M. Nakamura,Wayne W. Grody,James T. Wu,Raymond B. Nagle
Publisher : Springer Science & Business Media
Page : 505 pages
File Size : 51,7 Mb
Release : 2004-07-16
Category : Medical
ISBN : 9781592597918

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Cancer Diagnostics by Robert M. Nakamura,Wayne W. Grody,James T. Wu,Raymond B. Nagle Pdf

Reviews recent and emerging clinical laboratory tests that can help in the early detection, evaluation, and prediction of human tumors. Emphasizing the importance of molecular and genetic RNA/DNA tets that detect persons at high risk for specific cancers, the authors explore these novel serological assays, cellular assays useful for anatomic pathology, and molecular and genetic assays.