Rheumatoid Arthritis Therapy Reappraisal

Author : Rüdiger Müller
Publisher : Unknown
Page : 260 pages
File Size : 47,8 Mb
Release : 2020
Category : Electronic
ISBN : 3039430912

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Rheumatoid Arthritis Therapy Reappraisal by Rüdiger Müller Pdf

Rheumatoid Arthritis (RA) is a chronic inflammatory disease leading to joint inflammation and destruction. Treatment of RA includes the use of conventional (cs), biologic (b) disease-modifying anti-rheumatic drugs (DMARDs), and oral or intraarticular (IA) glucocorticoids (GCs). All different classes of drugs have shown to halt disease progression in clinical studies. In real life, a physician has more options than just adding or switching to a new ts/bDMARD if any kind of DMARDs has failed. They can modify or optimize the therapy with concomitant csDMARDs, and oral or IA-GC can be added to the treatment regimen. The EULAR states that therapeutic adjustment including the "optimization of csDMARDs dose or route of administration or intra-articular injections of GCs" is recommended. Thus, a new therapeutic agent can be embedded in a whole strategy with parallel optimization of the csDMARD and GC treatment. The idea of treating to target (T2T) for the treatment of RA patients has been around since the late 1990s. Many clinical studies (Ticora, BsSt, Camera) have demonstrated the superiority of a T2T approach. When I talk to physicians, I understand that most of them only rarely inject joints with GC. Therefore, I would like to create an issue on the T2T approach in reality including primary data, reviews, and real-life data demonstrating the general opinion and execution of T2T in treating RA.

Author : Ronald van Vollenhoven
Publisher : Adis
Page : 0 pages
File Size : 40,8 Mb
Release : 2016-01-06
Category : Medical
ISBN : 3319131079

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Biologics for the Treatment of Rheumatoid Arthritis by Ronald van Vollenhoven Pdf

This book provides a comprehensive overview of the available biologic therapies whilst comparing them to standard disease modifying anti-rheumatic drugs, and discusses how best to determine which therapy is most appropriate for an individual patient in the framework of current guidelines. Biologics for the Treatment of Rheumatoid Arthritis is an up-to-date and concise practical guide to the latest therapeutic developments in this field. This book is an invaluable source of topical information for all rheumatologists and health care professionals treating patients with rheumatoid arthritis.

Author : Vivek Mishra,Ramendra Pati Pandey,Anjali Priyadarshini,Chung-Ming Chang,Elcio Leal
Publisher : CRC Press
Page : 304 pages
File Size : 43,6 Mb
Release : 2024-08-01
Category : Technology & Engineering
ISBN : 9781040101469

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Nanotherapeutics for Inflammatory Arthritis by Vivek Mishra,Ramendra Pati Pandey,Anjali Priyadarshini,Chung-Ming Chang,Elcio Leal Pdf

Nanotherapeutics for Inflammatory Arthritis: Design, Diagnosis, and Treatment highlights nanobiotechnology and its therapeutic applications in the field of inflammatory arthritis, the interaction of nanomaterials in the biological systems, and clinical development of nanomedicines. It also covers the discovery of personalized therapeutics, diagnostics, and nanoparticular delivery systems, the role of bioinformatics nanobiotechnology in personalized oncology. The use of nanosensors for the detection and current challenges in the development of personalized medicine is explained including recent nanotechnology-based strategies. Features: Covers all the fundamental information about nanotechnology and inflammatory arthritis. Highlights the interaction of nanomaterials in the biological systems, and the clinical development of nanomedicines for inflammatory arthritis. Explores the discovery of personalized therapeutics, diagnostics, and nanoparticle delivery systems. Reviews the current challenges in the development of personalized medicine as well as translation of nanomedicine with combination therapy. Discusses the toxicology of using nanomedicines and the risks associated with the use of these nanomedicines. This book is aimed at researchers and professionals in nanotechnology, biomaterial, drug delivery, and inflammatory arthritis.

Author : Lynn Wecker
Publisher : Elsevier Health Sciences
Page : 712 pages
File Size : 54,6 Mb
Release : 2018-05-31
Category : Medical
ISBN : 9780323596626

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Brody's Human Pharmacology by Lynn Wecker Pdf

Focusing on the essential aspects of pharmacology you need to know, Brody‘s Human Pharmacology, 6th Edition, keeps you fully up to date with all that’s new in the field. Streamlined content, a new organizational approach, and thoroughly updated information ensure your grasp of key concepts and prepare you for exams. Nearly 500 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names reinforce your mastery of the information. The 6th Edition of this easy-to-use text is now fully up to date with: NEW chapter devoted entirely to pharmacogenomics and personalized medicine. NEW chapter on cannabinoids and their use for pain and other disorders, in light of recent legalization in many states. NEW chapters on recent developments in the treatment of Alzheimer's disease, ADHD and the latest treatments for HIV. NEW section on pain management. NEW section in each chapter covering "Clinical Relevance for Healthcare Professionals" that provides important information specific to physical therapists, dentists and dental hygienists, and many other medical professionals. Plus these student-friendly features: A new organizational approach, focusing on integration and systems-based learning. Contributions from leading faculty who cover the most important aspects of pharmacology necessary for a basic understanding of the subject, including concepts, clinical applications, and side effects. USMLE-style self-assessment questions at the end of every chapter, answers and rationales in the Appendix. Evolve Instructor Resources, including a downloadable image and test bank, are available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com

Author : Howard M. Fillit,Kenneth Rockwood,John B Young
Publisher : Elsevier Health Sciences
Page : 1100 pages
File Size : 40,7 Mb
Release : 2016-05-06
Category : Medical
ISBN : 9780702063442

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Brocklehurst's Textbook of Geriatric Medicine and Gerontology E-Book by Howard M. Fillit,Kenneth Rockwood,John B Young Pdf

The leading reference in the field of geriatric care, Brocklehurst’s Textbook of Geriatric Medicine and Gerontology, 8th Edition, provides a contemporary, global perspective on topics of importance to today’s gerontologists, internal medicine physicians, and family doctors. An increased focus on frailty, along with coverage of key issues in gerontology, disease-specific geriatrics, and complex syndromes specific to the elderly, makes this 8th Edition the reference you’ll turn to in order to meet the unique challenges posed by this growing patient population. Consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more make reference quick and easy. More than 250 figures, including algorithms, photographs, and tables, complement the text and help you find what you need on a given condition. Clinical relevance of the latest scientific findings helps you easily apply the material to everyday practice. A new chapter on frailty, plus an emphasis on frailty throughout the book, addresses the complex medical and social issues that affect care, and the specific knowledge and skills essential for meeting your patients’ complex needs. New content brings you up to date with information on gerontechnology, emergency and pre-hospital care, HIV and aging, intensive treatment of older adults, telemedicine, the built environment, and transcultural geriatrics. New editor Professor John Young brings a fresh perspective and unique expertise to this edition.

Author : Paola Mina-Osorio
Publisher : Springer
Page : 202 pages
File Size : 40,8 Mb
Release : 2017-01-21
Category : Medical
ISBN : 9783319422527

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Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases by Paola Mina-Osorio Pdf

As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets. Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature. Most published reviews and book chapters on novel therapies for inflammatory diseases describe positive attributes of molecules or technologies under investigation and the rationale for developing them into therapeutics. The originality and potential value of this book is not in the description of these targets or technologies from the point of view of their structure or mechanism of action exclusively, but rather, in making an effort to critically address the question of what is needed to move these technologies into the clinic. Has the technology not made it past the preclinical stage and why? Has it already been tested in humans and failed? What are the potential reasons behind those failures? What do experts in each field believe can be done better to increase the probabilities of success? In addition, the authors address the competitive landscape and summarize clinical studies that have failed in the respective area. They talk about the patient populations that would be required for the successful conduction of a clinical trial to test certain molecules, and they proactively share their views regarding both the potential and the drawbacks of targets or methodologies.

Author : Udi Nussinovitch
Publisher : Academic Press
Page : 766 pages
File Size : 55,5 Mb
Release : 2017-02-10
Category : Medical
ISBN : 9780128032688

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The Heart in Rheumatic, Autoimmune and Inflammatory Diseases by Udi Nussinovitch Pdf

The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe. A review of common, as well as unusual (yet clinically significant) medical cardiac complications of prevalent rheumatic, autoimmune and inflammatory diseases. Focuses on aspects of pathophysiological processes, clinical presentations, screening tests, prognostic implications and novel therapeutic approaches. Presents an up-to-date “level of evidence and “strengths of recommendations for suggested therapies and reviews all randomized clinical trials, meta-analyses and other supporting published clinical findings.

Author : Shao Li,Yuanjia Hu,Xuezhong Zhou
Publisher : Frontiers Media SA
Page : 664 pages
File Size : 51,6 Mb
Release : 2022-11-24
Category : Science
ISBN : 9782832507025

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Network Pharmacology and Traditional Medicine: Setting the New Standards by Combining In silico and Experimental Work by Shao Li,Yuanjia Hu,Xuezhong Zhou Pdf

Author : L. Ohno-Machado,B. Séroussi
Publisher : IOS Press
Page : 2078 pages
File Size : 42,7 Mb
Release : 2019-11-12
Category : Medical
ISBN : 9781643680033

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MEDINFO 2019: Health and Wellbeing e-Networks for All by L. Ohno-Machado,B. Séroussi Pdf

Combining and integrating cross-institutional data remains a challenge for both researchers and those involved in patient care. Patient-generated data can contribute precious information to healthcare professionals by enabling monitoring under normal life conditions and also helping patients play a more active role in their own care. This book presents the proceedings of MEDINFO 2019, the 17th World Congress on Medical and Health Informatics, held in Lyon, France, from 25 to 30 August 2019. The theme of this year’s conference was ‘Health and Wellbeing: E-Networks for All’, stressing the increasing importance of networks in healthcare on the one hand, and the patient-centered perspective on the other. Over 1100 manuscripts were submitted to the conference and, after a thorough review process by at least three reviewers and assessment by a scientific program committee member, 285 papers and 296 posters were accepted, together with 47 podium abstracts, 7 demonstrations, 45 panels, 21 workshops and 9 tutorials. All accepted paper and poster contributions are included in these proceedings. The papers are grouped under four thematic tracks: interpreting health and biomedical data, supporting care delivery, enabling precision medicine and public health, and the human element in medical informatics. The posters are divided into the same four groups. The book presents an overview of state-of-the-art informatics projects from multiple regions of the world; it will be of interest to anyone working in the field of medical informatics.

Author : Louise Grech,Alan Lau
Publisher : Springer
Page : 87 pages
File Size : 52,7 Mb
Release : 2016-07-07
Category : Medical
ISBN : 9789811014215

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Pharmaceutical Care Issues of Patients with Rheumatoid Arthritis by Louise Grech,Alan Lau Pdf

This book presents concise, comprehensive summaries of topics necessary to understand rheumatoid arthritis (RA) management, aligned with patient needs, as a reference suitable for practitioners and students of all levels. Special attention is paid to the innovative RhMAT (Rheumatoid Arthritis Medication Assessment Tool), in addition to descriptions of the pharmacological management of RA, pharmacoeconomic and pharmacovigilance considerations, the benefits of seamless care, and case presentations.Rheumatoid arthritis is one of the most common forms of inflammatory arthritis in the world, with a prevalence of 0.5 to 1%. While no cure has yet been established, modern biotechnology has enabled highly effective management, if treatment begins early. However, cost and side effects, such as immune suppression, continue to present barriers, and monitoring of patients is pivotal to safe and effective disease management. Both hospital and community pharmacists are involved in RA patient management, and have responsibilities to this patient population. Identifying pharmaceutical care issues and ensuring that the patients are managed in accordance to best evidence-based medicine are paramount. Best care is delivered when pharmacists effectively communicate with each other, the prescribers and the multidisciplinary team members involved in the care of the patient. This book aims to tackle the various aspects of the management of RA patients across all the settings.

Author : Kevin C. Chung
Publisher : Springer
Page : 330 pages
File Size : 48,7 Mb
Release : 2016-03-17
Category : Medical
ISBN : 9783319266602

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Clinical Management of the Rheumatoid Hand, Wrist, and Elbow by Kevin C. Chung Pdf

This book provides comprehensive coverage of the management and related surgery of the rheumatoid hand, wrist, and elbow. It provides a much-needed, authoritative discussion of the epidemiology, surgical techniques, and outcomes of rheumatoid surgery. The book begins by introducing important background concepts, and then goes on to present up-to-date details on pre and postoperative management, indications, and treatment options. Each section ends with case-based coverage of common clinical scenarios and features numerous illustrations that showcase the sequential approach in managing this disease. Clinical Management of the Rheumatoid Hand, Wrist, and Elbow has broad appeal for rheumatologists and primary care physicians, and will assist them in providing appropriate referrals for surgery consultations. It also serves as a valuable reference for surgeons treating and managing patients with this unique disease. ​

Author : Erminia Mariani,Mariagrazia Uguccioni,Daniela Frasca
Publisher : Frontiers Media SA
Page : 144 pages
File Size : 41,7 Mb
Release : 2021-07-02
Category : Medical
ISBN : 9782889669691

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Immunobiology of Osteoarticular Diseases by Erminia Mariani,Mariagrazia Uguccioni,Daniela Frasca Pdf

Author : Hua Zhong,Duo Liu,Shuai Liu,Yuan Liu
Publisher : Frontiers Media SA
Page : 225 pages
File Size : 51,9 Mb
Release : 2024-02-05
Category : Science
ISBN : 9782832544181

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Advances in transcriptomics research and their applications in human diseases by Hua Zhong,Duo Liu,Shuai Liu,Yuan Liu Pdf

Author : Xu-jie Zhou,Lam Cheung Tsoi,Amanda S. MacLeod
Publisher : Frontiers Media SA
Page : 227 pages
File Size : 54,5 Mb
Release : 2022-08-16
Category : Medical
ISBN : 9782889765836

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Towards Precision Medicine for Immune-Mediated Disorders: Advances in Using Big Data and Artificial Intelligence to Understand Heterogeneity in Inflammatory Responses by Xu-jie Zhou,Lam Cheung Tsoi,Amanda S. MacLeod Pdf

Topic Editor Dr. MacLeod is employed by Janssen. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Author : Estee Kurant,Amiram Ariel,Kirsten Lauber
Publisher : Frontiers Media SA
Page : 294 pages
File Size : 48,6 Mb
Release : 2018-12-27
Category : Electronic
ISBN : 9782889456888

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Apoptotic Cell Clearance in Health and Disease by Estee Kurant,Amiram Ariel,Kirsten Lauber Pdf

Clearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells suggesting that it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This eBook brings together 24 original research and review manuscripts that cover various aspects of apoptotic cell removal during normal development and homeostasis as well as in tumorigenesis and regenerative processes following injury.