Ribonucleases Part B Artificial And Engineered Ribonucleases And Speicifc Applications

Author : Anonim
Publisher : Elsevier
Page : 517 pages
File Size : 48,6 Mb
Release : 2001-09-28
Category : Science
ISBN : 0080522572

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Ribonucleases, Part B: Artificial and Engineered Ribonucleases and Speicifc Applications by Anonim Pdf

This second volume on ribonucleases provides up-to-date, methods-related information on these enzymes. Of particular interest to researchers will be the discussion of artificial and engineered ribonucleases, as well as the application of ribonucleases in medicine and biotechnology. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Author : Anonim
Publisher : Elsevier
Page : 734 pages
File Size : 50,7 Mb
Release : 2001-09-26
Category : Science
ISBN : 9780080496917

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Ribonucleases, Part A: Functional Roles and Mechanisms of Action by Anonim Pdf

This first of two volumes provides up-to-date, methods-related information on ribonuclease functions, assays, and applications. Chapter topics include the identification of, characterization of, and assays for secreted ribonucleases; viral ribonucleases, artificial and engineered ribonucleases, and ribozymes. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Author : Allen W. Nicholson
Publisher : Springer Science & Business Media
Page : 412 pages
File Size : 53,8 Mb
Release : 2011-10-06
Category : Science
ISBN : 9783642210785

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Ribonucleases by Allen W. Nicholson Pdf

Ribonucleases are a ubiquitous and functionally diverse group of enzymes that have a common ability to cleave RNA. Either through scission of internal phosphodiesters, or removal of nucleotides from RNA 5’ or 3’ ends, ribonucleases perform essential roles in gene expression and regulation, genome replication and maintenance, host defense, stress response, and viral strategies of infection. Ribonucleases have also served as highly informative models to understand virtually every aspect of biomolecular structure and function. The fifteen chapters in this volume are written by recognized researchers in the field, and provide in-depth analyses of the major ribonuclease families. Particular focus is given to the relation of ribonuclease structure and mechanism to biological function, as well as ribonuclease dysfunction in certain disease states. Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability. This volume should serve as an essential reference for a broad range of researchers and educators with interests in RNA metabolism, enzymology, and gene regulation.

Author : Anonim
Publisher : Academic Press
Page : 734 pages
File Size : 46,9 Mb
Release : 2001-10-02
Category : Science
ISBN : 0121822427

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Ribonucleases, Part A: Functional Roles and Mechanisms of Action by Anonim Pdf

This first of two volumes provides up-to-date, methods-related information on ribonuclease functions, assays, and applications. Chapter topics include the identification of, characterization of, and assays for secreted ribonucleases; viral ribonucleases, artificial and engineered ribonucleases, and ribozymes. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Author : Tadhg P. Begley
Publisher : Wiley-Blackwell
Page : 836 pages
File Size : 46,9 Mb
Release : 2009-02-03
Category : Science
ISBN : STANFORD:36105210630856

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Wiley Encyclopedia of Chemical Biology, Volume 4 by Tadhg P. Begley Pdf

The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

Author : Marina A. Zenkova
Publisher : Springer Science & Business Media
Page : 330 pages
File Size : 41,7 Mb
Release : 2004-01-07
Category : Medical
ISBN : 3540201122

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Artificial Nucleases by Marina A. Zenkova Pdf

The development of agents capable of cleaving RNA and DNA has attracted considerable attention from researchers in the last few years, because of the immediate and very important applications they can find in the emerging fields of biotechnology and pharmacology. There are essentially two classes of these agents - nucleases that occur naturally inside cells and synthetically produced artificial nucleases. The first class includes protein enzyme nucle ases and catalytic RNA structured ribozymes that perform cleavage of the phosphodiester bonds in nucleic acids according to a hydrolytic pathway in the course of different biochemical processes in the cell. A different pathway is used by some antibiotics which cleave DNA via redox-based mechanisms resulting in oxidative damage of nucleotide units and breakage of the DNA backbone. The above molecules are indispensable tools for manipulating nucleic acids and processing RNA; DNA-cleaving antibiotics and cytotoxic ribonucleases have demonstrated utility as chemotherapeutic agents. The second class, artificial nucleases, are rationally designed to imitate the active centers of natural enzymes by simple structures possessing minimal sets of the most important characteristics that are essential for catalysis. A dif ferent approach, in vitro selection, was also used to create artificial RNA and DNA enzymes capable of cleaving RNA. Being less efficient and specific as compared to the natural enzymes, the primitive mimics are smaller and robust and can function in a broad range of conditions.

Author : Pierre Rousselot-pailley,Olga Iranzo
Publisher : World Scientific
Page : 520 pages
File Size : 52,6 Mb
Release : 2023-01-06
Category : Science
ISBN : 9789811261671

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Peptide And Protein Engineering For Biotechnological And Therapeutic Applications by Pierre Rousselot-pailley,Olga Iranzo Pdf

Peptides and proteins are crucial biomolecules in life. The manifold functions they carry out range from molecular recognition and signaling to catalysis and immune response. However, the native systems are limited to a reduced toolbox of chemical functionalities as well as tridimensional structures. Widening these toolboxes could pave the way to engineer peptides and proteins with enhanced properties compared to their native counterparts and/or with structures and functions unprecedented in Nature. Advances in the chemical and biological synthesis of peptides and proteins, in computational tools, in molecular biology and in high-throughput screening methods are making this realm possible.This book aims to give an overview of the last developments in the field of peptide and protein engineering. It comprises a collection of chapters that span from the production of simple non-proteinogenic building blocks and peptidic scaffolds of different sizes and structures to more complex systems including peptide-based nanomaterials, enzymes and artificial metalloenzymes. Different strategies are described where chemical and biological tools have been developed and combined to attain the desired properties and sought functionalities.The diverse systems described in this book highlight the progress in this important field and represent the starting points for the development of functional biomolecules, biomaterials and hybrid systems capable of addressing key societal challenges of our times in relevant areas such health, environment and energy.

Author : Anonim
Publisher : Elsevier
Page : 579 pages
File Size : 54,8 Mb
Release : 2000-06-26
Category : Science
ISBN : 9780080496757

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RNA-Ligand Interactions, Part B: Molecular Biology Methods by Anonim Pdf

RNA-Ligand Interactions, Part B focuses on molecular biology methods. Major topics covered include: solution probe methods, tethered-probe methodologies, in vitro affinity selection methodologies, genetic methodologies for detecting RNA-protein interactions, protein engineering methodologies useful for RNA-protein interaction studies, and cell biology methods.RNA-Ligand Interactions, Part A, its companion, VOLUME 317 focuses on structural biology methods.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Author : Ajith Abraham,Sujata Dash,Subhendu Kumar Pani,Laura García-Hernández
Publisher : Academic Press
Page : 434 pages
File Size : 50,7 Mb
Release : 2022-09-23
Category : Medical
ISBN : 9780323902786

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Artificial Intelligence for Neurological Disorders by Ajith Abraham,Sujata Dash,Subhendu Kumar Pani,Laura García-Hernández Pdf

Artificial Intelligence for Neurological Disorders provides a comprehensive resource of state-of-the-art approaches for AI, big data analytics and machine learning-based neurological research. The book discusses many machine learning techniques to detect neurological diseases at the cellular level, as well as other applications such as image segmentation, classification and image indexing, neural networks and image processing methods. Chapters include AI techniques for the early detection of neurological disease and deep learning applications using brain imaging methods like EEG, MEG, fMRI, fNIRS and PET for seizure prediction or neuromuscular rehabilitation. The goal of this book is to provide readers with broad coverage of these methods to encourage an even wider adoption of AI, Machine Learning and Big Data Analytics for problem-solving and stimulating neurological research and therapy advances. Discusses various AI and ML methods to apply for neurological research Explores Deep Learning techniques for brain MRI images Covers AI techniques for the early detection of neurological diseases and seizure prediction Examines cognitive therapies using AI and Deep Learning methods

Author : Andreas Taubert,Joao F. Mano,Jos¿ Carlos Rodr¿guez-Cabello
Publisher : John Wiley & Sons
Page : 616 pages
File Size : 41,7 Mb
Release : 2013-07-12
Category : Science
ISBN : 9783527649631

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Biomaterials Surface Science by Andreas Taubert,Joao F. Mano,Jos¿ Carlos Rodr¿guez-Cabello Pdf

At the interface of biology, chemistry, and materials science, this book provides an overview of this vibrant research field, treating the seemingly distinct disciplines in a unified way by adopting the common viewpoint of surface science. The editors, themselves prolific researchers, have assembled here a team of top-notch international scientists who read like a "who's who" of biomaterials science and engineering. They cover topics ranging from micro- and nanostructuring for imparting functionality in a top-down manner to the bottom-up fabrication of gradient surfaces by self-assembly, from interfaces between biomaterials and living matter to smart, stimuli-responsive surfaces, and from cell and surface mechanics to the elucidation of cell-chip interactions in biomedical devices. As a result, the book explains the complex interplay of cell behavior and the physics and materials science of artificial devices. Of equal interest to young, ambitious scientists as well as to experienced researchers.

Author : U.S. Atomic Energy Commission. Division of Technical Information
Publisher : Unknown
Page : 1122 pages
File Size : 45,8 Mb
Release : 1962
Category : Nuclear energy
ISBN : UIUC:30112005438525

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Research and Development Abstracts of the USAEC. by U.S. Atomic Energy Commission. Division of Technical Information Pdf

Author : Anonim
Publisher : Unknown
Page : 684 pages
File Size : 54,7 Mb
Release : 1968
Category : Weights and measures
ISBN : STANFORD:36105130366169

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NBS Special Publication by Anonim Pdf

Author : U.S. Atomic Energy Commission
Publisher : Unknown
Page : 134 pages
File Size : 44,9 Mb
Release : 1963
Category : Nuclear energy
ISBN : UOM:39015095282326

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Research and Development Abstracts of the USAEC by U.S. Atomic Energy Commission Pdf

Author : Ramalingam Sathishkumar,Sarma Rajeev Kumar,Jagadeesan Hema,Venkidasamy Baskar
Publisher : Springer Nature
Page : 374 pages
File Size : 47,8 Mb
Release : 2019-11-15
Category : Science
ISBN : 9789811396243

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Advances in Plant Transgenics: Methods and Applications by Ramalingam Sathishkumar,Sarma Rajeev Kumar,Jagadeesan Hema,Venkidasamy Baskar Pdf

The green revolution led to the development of improved varieties of crops, especially cereals, and since then, classical or molecular breeding has resulted in the creation of economically valuable species. Thanks to recent developments in genetic engineering, it has become possible to introduce genes from different sources, such as bacteria, fungi, viruses, mice and humans, to plants. This technology has made the scientific community aware of the critical role of transgenics, not only as a means of producing stress tolerant crops but also as a platform for the production of therapeutics through molecular farming. This book discusses the commercial applications of plant transgenic technologies, including the use of transgenic cell culture approachesto improve the production of metabolites and high-value therapeutics as well as transgenic plants in pest management. It also explores generation of novel vectors, protein production using chloroplast engineering and the latest developments in this area, such as genome editing in plants. Featuring general discussions and research papers by leading international experts, it is a valuable resource for scientists, teachers, students and industrialists working in the field.

Author : Nobuhiko Yui
Publisher : CRC Press
Page : 424 pages
File Size : 43,5 Mb
Release : 2002-03-11
Category : Medical
ISBN : 9781420041187

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Supramolecular Design for Biological Applications by Nobuhiko Yui Pdf

Supramolecular chemistry is the outburst topic of the next generation of science. While the majority of biomedical research efforts to date have centered on utilizing well-known polymeric materials, the recent progress in supramolecular chemistry has introduced a fascinating new field of macromolecular architecture. Supramolecular Design for Biological Applications focuses on modulating, altering, and mimicking biological functions with a new family of molecular assemblies. The authors provide innovative ideas and concepts for developing novel biomaterials that could be applied in diagnosis, drug carrier operations, and environmental protection. This reference is comprehensive, presenting principles, applications, recent advances, and future directions. Each chapter includes clear and informative illustrations of molecular architectures. The writing is scientific but allows for easy comprehension of the differences in molecular interactions, dimensions, and supramolecular architecture. Supramolecular Design for Biological Applications will advance the understanding of supramolecular-structured biomaterials and associated issues regarding biological functions. By explaining recent trends and molecular interactions, this book will enable you to initiate new research for nano-scale science and technology in the 21st century.