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DEEP IN THE Minnesota forest, where only the strong survive, four regular-sized pups—Leader, Sniffer, Runner, and Thinker—are pushed into the world. Then one last, very small pup is born into the wolf pack. He is called Runt. From the very start, Runt struggles in the harsh wild world of the wolves. He tries learning along with his brothers and sisters, but makes serious mistakes. It’s hard pleasing his father, King, and the other wolves. If only Runt could prove himself to his powerful father and family. . . . “With an economy of words, Bauer precisely and vividly conveys the wolves’ wild world. . . . There’s a ready-made audience for this.”—Booklist, Starred “Beautifully written and faithful to wolves’ behavior (explained in an afterword). . . . Bauer portrays the wolves’ place in the natural world with compassion, respect, and warmth, but this is also the story of any unique individual’s struggle to find his or her niche.”—School Library Journal
JaRed, a small mouse who has been given the nickname Runt, cannot believe the course his life takes when he discovers rats are planning to invade Tira-Nor and that he has been chosen by God to save the city and become the next king.
"In this heartwarming adventure, Rudy the Runt will capture the hearts of children, while teaching the virtues of compassion, mercy, and friendship." Voted "World's Best Runt Tale" by The Rodent Times Review.Little Rudy can't imagine anything better than living in the Guatemala City Dump; a rodent's paradise full of tasty treats, a Barbie mansion with a pool, and his own fire truck. Unfortunately, life isn't so good for children living nearby in makeshift shacks. For kids like eleven-year-old Lupe, it's all about survival.When the young Guatemalan girl rescues Rudy from the dump bully; a tomcat named Jigsaw, Rudy repays her kindness by finding treasures she can sell and trade for food.Rudy comes up with many clever and comical ways to outwit Jigsaw, who would like nothing better than to turn Rudy into a little mouse pull-a-part.Surfing, skurfing, and playing in a Calypso-go-go band, are only a few of the highlights on Rudy's mercy mission beach get-a-way. All is well-until Jigsaw shows up on the scene.The discovery of a beach treasure could change everything for Lupe's family. But can Rudy trick Jigsaw into helping him pull off the most important mission of his life?Based on a true story-kind of.
Turk's parents are proud of him, the biggest, strongest, most graceful bird at Wishbone Farm. "He's a dancer," says his mother. "He's an athlete," says his father. "He's a goner," says his little brother, Runt. But no one ever listens to Runt -- even after people with seasonal plans and roasting pans begin showing up at Wishbone Farm, or even after the juiciest turkeys are chosen, one by one. "Chosen for what?" Turk asks. No one wants to hear Runt's answer. But you will laugh at what he has to do to get his family's attention. They are, after all, turkeys.
When the lone wolf finds his fated mate, the pack bounds will be tested. The runt of the pack. An Alpha redeemed. Vladimir Volkov, leader of the Roman wolf pack, seeks vengeance when an old enemy returns to Russia. But tragedy strikes, and Vlad fails his duty to the Ursa clan. Left for dead after a brutal fight, a white wolf revives him. Given new life, he vows to prove himself to his pack again. But there’s one thing he never expected to find along the way—his fated mate. Spurned by the pack. An Omega’s rising. Rogue omega Anya Sokolov lives alone, painting to survive. Her wolf craves more. A howl in a snowstorm leads her to a wounded stranger—her fated mate, Vladimir. But joy turns to chaos when Anya's pack Alpha finds her. Old wounds reopen, threatening her newfound happiness with Vladimir. In a pulse-pounding tale of love and redemption, Vlad and Anya must navigate the treacherous path of ancient rivalries and the brutal rules of the pack. Will their love withstand the onslaught of darkness, or will they lose everything they hold dear? **** Runt of the Pack is a steamy fated mates, forced proximity, omegaverse new adult shifter romance, and is recommended for +18. It’s the second installment in the Bad Boy Shifters series. While it can be read as a standalone, reading the full series in order, along with the Unnatural Brethren series is highly advised! ****
RUNX Proteins in Development and Cancer by Yoram Groner,Yoshiaki Ito,Paul Liu,James C. Neil,Nancy A. Speck,Andre van Wijnen Pdf
This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.
Vegrandis, a tyrannosaur, is tired of being picked on by his brother and sister because he is smaller, but when he encounters some animals that are smaller than he is, Vegrandis learns to appreciate his own size. Includes a word find activity.
Crown of Souls (The Tox Files Book #2) by Ronie Kendig Pdf
"Kendig has out done herself."--RT Book Reviews on Conspiracy of Silence Six months after stopping a deadly plague, Cole "Tox" Russell and his team are enjoying a little rest. That peace is short-lived when a sniper shot hits Tox. The enemy is discovered to be one of their own, a rogue Special Forces team operator. Alec King is perhaps the only person as skilled as Tox, and he's out for justice. Furious with orders that got his men killed, he intends to make those responsible pay. And he insists Tox join him, believing they are the same breed of soldier. Afraid his old friend is right, Tox battles a growing darkness within himself as he and his team engage in another deadly encounter with antiquity. It appears Alec is cheating--he's using a mysterious artifact, a crown that history has linked to some of the worst slaughters in humanity. Racing to stop Alec before his vengeance is unleashed, Tox must fight the monster without becoming one.
Ever since they were Snotsippers, Jack and the girl have fought, until one day she steals his bike and as he and the Amigos try to recover it, Jack realizes that he is growing up and must eventually leave the "goodlands and badlands of Hokey Pokey."
