Small Molecule Dna And Rna Binders

Author : Martine Demeunynck,Christian Bailly,W. David Wilson
Publisher : John Wiley & Sons
Page : 754 pages
File Size : 43,9 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605668

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Small Molecule DNA and RNA Binders by Martine Demeunynck,Christian Bailly,W. David Wilson Pdf

The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.

Author : Martine Demeunynck,Christian Bailly,W. David Wilson
Publisher : Unknown
Page : 732 pages
File Size : 51,7 Mb
Release : 2003
Category : Binding Sites
ISBN : 3527305955

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Small Molecule DNA and RNA Binders by Martine Demeunynck,Christian Bailly,W. David Wilson Pdf

Author : John Schneekloth,Martin Pettersson
Publisher : John Wiley & Sons
Page : 418 pages
File Size : 55,5 Mb
Release : 2024-10-07
Category : Medical
ISBN : 9783527351008

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RNA as a Drug Target by John Schneekloth,Martin Pettersson Pdf

Discover a new paradigm in drug discovery that greatly expands the space of addressable drug targets and potential novel drugs Existing paradigms for drug discovery have focused largely on enzymes and other proteins as drug targets. In recent years, however, different varieties of ribonucleic acids have emerged as a viable focus for target-based drug discovery, with the potential to revolutionize the strategy and approach for this essential step in the drug development process. RNA as a Drug Target: The Next Frontier for Medicinal Chemistry offers a practice-oriented introduction to developing drug-like small molecules that selectively modulate both coding and non-coding RNAs. Beginning with a description and characterization of existing druggable RNAs, the book discusses how to approach different RNA targets for drug discovery. The result is a crucial resource for targeting RNAs and creating the next generation of life-saving pharmaceuticals. RNA as a Drug Target readers will also find: A complete “toolbox” for working with RNA, from structure determination to screening and lead generation techniques A wide range of addressable targets and mechanisms, including splicing modulation, riboswitches, targeted degradation, and more Authoritative discussion of the potential of RNA-targeted small molecule therapeutics for drugging the epitranscriptome RNA as a Drug Target provides an expert introduction to a new frontier in pharmaceutical research for medicinal chemists, biochemists, molecular biologists, and members of the pharmaceutical industry.

Author : Jung-II Jin,James Grote
Publisher : CRC Press
Page : 338 pages
File Size : 55,5 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439827420

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Materials Science of DNA by Jung-II Jin,James Grote Pdf

The field of materials science and technology has undergone revolutionary advances due to the development of novel analytical tools, functional materials, and multidisciplinary approaches to engineering. Additionally, theoretical predictions combined with increasingly improved models and computational capabilities are making impressive contribution

Author : Mahesh Uttamchandani,Shao Q. Yao
Publisher : Methods in Molecular Biology
Page : 274 pages
File Size : 48,7 Mb
Release : 2018-12-05
Category : Science
ISBN : 1493982427

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Small Molecule Microarrays: Methods and Protocols by Mahesh Uttamchandani,Shao Q. Yao Pdf

Author : Anonim
Publisher : Elsevier
Page : 740 pages
File Size : 49,8 Mb
Release : 2001-07-31
Category : Medical
ISBN : 9780080496900

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Drug-Nucleic Acid Interactions by Anonim Pdf

This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.

Author : M.R.S. Rao
Publisher : Springer
Page : 323 pages
File Size : 40,5 Mb
Release : 2017-08-16
Category : Medical
ISBN : 9789811052033

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Long Non Coding RNA Biology by M.R.S. Rao Pdf

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Author : Bruce A. Armitage
Publisher : Springer Science & Business Media
Page : 232 pages
File Size : 40,5 Mb
Release : 2005-02-10
Category : Science
ISBN : 3540228357

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DNA Binders and Related Subjects by Bruce A. Armitage Pdf

with contributions by numerous experts

Author : G Michael Blackburn,Martin Egli,Michael J Gait,Jonathan K Watts
Publisher : Royal Society of Chemistry
Page : 774 pages
File Size : 46,8 Mb
Release : 2022-06-24
Category : Science
ISBN : 9781839163241

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Nucleic Acids in Chemistry and Biology by G Michael Blackburn,Martin Egli,Michael J Gait,Jonathan K Watts Pdf

The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life. Revised, extended, updated and lavishly illustrated, this 4th Edition of Nucleic Acids in Chemistry and Biology is a long-awaited standard text for teaching and research in nucleic acids science. It maintains the close integration of chemistry and biology that characterised the earlier editions and contains a major expansion largely focused on the burgeoning growth of RNA science. Written by an international team of leading experts, all with extensive teaching experience, this 4th Edition provides up-to-date and extended coverage of the reactions and interactions of RNA and DNA with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecule-based introduction to the structure and biological roles of DNA and RNA and the basics of Genes and Genomes. New key chapters are devoted to non-coding RNA, nucleic acids sequencing, nucleic acid therapeutics, in vitro evolution and aptamers, and protein-RNA interactions. The text is linked to an extensive list of references to make it a definitive reference source. This authoritative volume presents topics in an integrated manner and readable style with full colour illustrations throughout. It is ideal for graduate and undergraduate students of chemistry and biochemistry, biophysics and biotechnology, and molecular biology and medicine. It will be a guidebook for new researchers to the field of nucleic acids science.

Author : Li-He Zhang,Zhen Xi,Jyoti Chattopadhyaya
Publisher : John Wiley & Sons
Page : 477 pages
File Size : 53,8 Mb
Release : 2011-08-30
Category : Medical
ISBN : 9780470596685

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Medicinal Chemistry of Nucleic Acids by Li-He Zhang,Zhen Xi,Jyoti Chattopadhyaya Pdf

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

Author : John J. Correia,H. William Detrich III
Publisher : Academic Press
Page : 996 pages
File Size : 41,8 Mb
Release : 2011-09-21
Category : Science
ISBN : 9780080554945

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Biophysical Tools for Biologists by John J. Correia,H. William Detrich III Pdf

Driven in part by the development of genomics, proteomics, and bioinformatics as new disciplines, there has been a tremendous resurgence of interest in physical methods to investigate macromolecular structure and function in the context of living cells. This volume in Methods in Cell Biology is devoted to biophysical techniques in vitro and their applications to cellular biology. Biophysical Tools for Biologists covers methods-oriented chapters on fundamental as well as cutting-edge techniques in molecular and cellular biophysics. This book is directed toward the broad audience of cell biologists, biophysicists, pharmacologists, and molecular biologists who employ classical and modern biophysical technologies or wish to expand their expertise to include such approaches. It will also interest the biomedical and biotechnology communities for biophysical characterization of drug formulations prior to FDA approval. Describes techniques in the context of important biological problems Delineates critical steps and potential pitfalls for each method Includes full-color plates to illustrate techniques

Author : Michael J Waring
Publisher : Royal Society of Chemistry
Page : 432 pages
File Size : 43,5 Mb
Release : 2018-03-08
Category : Science
ISBN : 9781788014281

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DNA-targeting Molecules as Therapeutic Agents by Michael J Waring Pdf

There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.

Author : Florinel-Gabriel Banica
Publisher : John Wiley & Sons
Page : 795 pages
File Size : 55,7 Mb
Release : 2012-08-15
Category : Science
ISBN : 9781118354230

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Chemical Sensors and Biosensors by Florinel-Gabriel Banica Pdf

Key features include: Self-assessment questions and exercises Chapters start with essential principles, then go on to address more advanced topics More than 1300 references to direct the reader to key literature and further reading Highly illustrated with 450 figures, including chemical structures and reactions, functioning principles, constructive details and response characteristics Chemical sensors are self-contained analytical devices that provide real-time information on chemical composition. A chemical sensor integrates two distinct functions: recognition and transduction. Such devices are widely used for a variety of applications, including clinical analysis, environment monitoring and monitoring of industrial processes. This text provides an up-to-date survey of chemical sensor science and technology, with a good balance between classical aspects and contemporary trends. Topics covered include: Structure and properties of recognition materials and reagents, including synthetic, biological and biomimetic materials, microorganisms and whole-cells Physicochemical basis of various transduction methods (electrical, thermal, electrochemical, optical, mechanical and acoustic wave-based) Auxiliary materials used e.g. synthetic and natural polymers, inorganic materials, semiconductors, carbon and metallic materials properties and applications of advanced materials (particularly nanomaterials) in the production of chemical sensors and biosensors Advanced manufacturing methods Sensors obtained by combining particular transduction and recognition methods Mathematical modeling of chemical sensor processes Suitable as a textbook for graduate and final year undergraduate students, and also for researchers in chemistry, biology, physics, physiology, pharmacology and electronic engineering, this bookis valuable to anyone interested in the field of chemical sensors and biosensors.

Author : Leonid Gorb,Victor Kuz'min,Eugene Muratov
Publisher : Springer
Page : 556 pages
File Size : 50,5 Mb
Release : 2014-11-07
Category : Science
ISBN : 9789401792578

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Application of Computational Techniques in Pharmacy and Medicine by Leonid Gorb,Victor Kuz'min,Eugene Muratov Pdf

The proposed volume provides both fundamental and detailed information about the computational and computational-experimental studies which improve our knowledge of how leaving matter functions, the different properties of drugs (including the calculation and the design of new ones), and the creation of completely new ways of treating numerical diseases. Whenever it is possible, the interplay between theory and experiment is provided. The book features computational techniques such as quantum-chemical and molecular dynamic approaches and quantitative structure–activity relationships. The initial chapters describe the state-of-the art research on the computational investigations in molecular biology, molecular pharmacy, and molecular medicine performed with the use of pure quantum-chemical techniques. The central part of the book illustrates the status of computational techniques that utilize hybrid, so called QM/MM approximations as well as the results of the QSAR studies which now are the most popular in predicting drugs’ efficiency. The last chapters describe combined computational and experimental investigations.

Author : Qi Liu
Publisher : Unknown
Page : 370 pages
File Size : 51,6 Mb
Release : 2004
Category : Electronic
ISBN : UCSD:31822032477085

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Synthesis of Small Molecules Targeting RNA by Qi Liu Pdf