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Foreword by Richard Preston, author of The Hot Zone; Preface by David M. Oshinsky. The personal story of how Dr Henderson led the World Health Organization's campaign to eradicate smallpoxthe only disease in history to have been deliberately eliminated.
The story of the rise and fall of smallpox, one of the most savage killers in the history of mankind, and the only disease ever to be successfully exterminated (30 years ago next year) by a public health campaign.
In a world riddled with diseases, there is only one that has been eliminated from humanity: smallpox. Learn about the compelling history of this disease, why it still exists in laboratories and research facilities around the world, and how what we learn about it now may affect humanitys future.
Smallpox: The Death of a Disease by D. A. Henderson, M.D. Pdf
For more than 3000 years, hundreds of millions of people have died or been left permanently scarred or blind by the relentless, incurable disease called smallpox. In 1967, Dr. D.A. Henderson became director of a worldwide campaign to eliminate this disease from the face of the earth. This spellbinding book is Dr. Henderson’s personal story of how he led the World Health Organization’s campaign to eradicate smallpox—the only disease in history to have been deliberately eliminated. Some have called this feat "the greatest scientific and humanitarian achievement of the past century." In a lively, engrossing narrative, Dr. Henderson makes it clear that the gargantuan international effort involved more than straightforward mass vaccination. He and his staff had to cope with civil wars, floods, impassable roads, and refugees as well as formidable bureaucratic and cultural obstacles, shortages of local health personnel and meager budgets. Countries across the world joined in the effort; the United States and the Soviet Union worked together through the darkest cold war days; and professionals from more than 70 nations served as WHO field staff. On October 26, 1976, the last case of smallpox occurred. The disease that annually had killed two million people or more had been vanquished–and in just over ten years. The story did not end there. Dr. Henderson recounts in vivid detail the continuing struggle over whether to destroy the remaining virus in the two laboratories still that held it. Then came the startling discovery that the Soviet Union had been experimenting with smallpox virus as a biological weapon and producing it in large quantities. The threat of its possible use by a rogue nation or a terrorist has had to be taken seriously and Dr. Henderson has been a central figure in plans for coping with it. New methods for mass smallpox vaccination were so successful that he sought to expand the program of smallpox immunization to include polio, measles, whooping cough, diphtheria, and tetanus vaccines. That program now reaches more than four out of five children in the world and is eradicating poliomyelitis. This unique book is to be treasured—a personal and true story that proves that through cooperation and perseverance the most daunting of obstacles can be overcome.
Author : William H. Foege,Milbank Memorial Fund Publisher : Univ of California Press Page : 240 pages File Size : 44,5 Mb Release : 2011-06-06 Category : Biography & Autobiography ISBN : 9780520268364
House on Fire by William H. Foege,Milbank Memorial Fund Pdf
“Bill Foege takes us inside the world's greatest public health triumph: the eradication of smallpox. It's a story of true determination, passion and courage. The story of smallpox should encourage all of us to continue the critical work of worldwide disease eradication.”--Bill Gates, Co-Chair of the Bill & Melinda Gates Foundation “Bill Foege is one of the public health giants of our times. He was responsible for the design of the campaign that eradicated smallpox—the most important global health achievement in history and possibly the greatest feat in any field of international cooperation. His insights into the nature of this major event will undoubtedly help to meet the global health challenges of the 21st century.”—Julio Frenk, M.D, PhD, Dean, Harvard School of Public Health “The eradication of a disease has long been the holy grail of global health and Bill Foege found it: more than any other person, he was responsible for the eradication of smallpox from the face of the earth. This is a story told by a remarkably humble man, about the extraordinary coalition that he helped to build, and the most impressive global health accomplishment the world has ever seen.”—Mark Rosenberg, author of Real Collaboration: What It Takes for Global Health to Succeed “I am thrilled that Bill Foege, one of the great heroes of the smallpox eradication campaign, has written this important book. It tells a beautiful human story of an incredible public health triumph, and is full of lessons that could be applied to many of the global challenges we face today.”—Helene D. Gayle MD, President and CEO, CARE USA “Bill Foege’s House on Fire is the first-hand account of how a revised strategy to eradicate smallpox was tested, validated, and applied. Without the global adoption of this new surveillance strategy, the final deathblow to this longtime global menace might never have been dealt.”—Adetokunbo O. Lucas, MD, DSc, author of It Was The Best of Times: From Local to Global Health “Smallpox is the most devastating disease the world has known, as it destroyed lives and shaped history over the centuries. House on Fire provides a day-to-day account by my friend Dr. Bill Foege of the battle required to defeat this wily and diabolic virus."--President Jimmy Carter
Institute of Medicine,Board on Health Promotion and Disease Prevention
Author : Institute of Medicine,Board on Health Promotion and Disease Prevention Publisher : National Academies Press Page : 57 pages File Size : 52,5 Mb Release : 2002-11-28 Category : Medical ISBN : 9780309086042
Scientific and Policy Considerations in Developing Smallpox Vaccination Options by Institute of Medicine,Board on Health Promotion and Disease Prevention Pdf
At the World Health Assembly in May 1980, the World Health Organization declared the world free of smallpox. Smallpox vaccination of civilians is now indicated only for laboratory workers directly involved with smallpox or closely related orthopox viruses. However recent questions raised by the terrorist attacks in fall 2001 have renewed concerns about possible outbreaks of smallpox resulting from its use as a biological weapon. In June 2002, the Institute of Medicine convened a public conference to discuss the scientific, clinical, procedural, and administrative aspects of various immunization strategies. Scientific and Policy Considerations in Developing Smallpox Vaccination Options summarizes the presentations and discussions from this workshop.
“The bard of biological weapons captures the drama of the front lines.”—Richard Danzig, former secretary of the navy The first major bioterror event in the United States-the anthrax attacks in October 2001-was a clarion call for scientists who work with “hot” agents to find ways of protecting civilian populations against biological weapons. In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a #1 New York Times bestseller, Richard Preston takes us into the heart of Usamriid, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the U.S. biological weapons program and now the epicenter of national biodefense. Peter Jahrling, the top scientist at Usamriid, a wry virologist who cut his teeth on Ebola, one of the world’s most lethal emerging viruses, has ORCON security clearance that gives him access to top secret information on bioweapons. His most urgent priority is to develop a drug that will take on smallpox-and win. Eradicated from the planet in 1979 in one of the great triumphs of modern science, the smallpox virus now resides, officially, in only two high-security freezers-at the Centers for Disease Control in Atlanta and in Siberia, at a Russian virology institute called Vector. But the demon in the freezer has been set loose. It is almost certain that illegal stocks are in the possession of hostile states, including Iraq and North Korea. Jahrling is haunted by the thought that biologists in secret labs are using genetic engineering to create a new superpox virus, a smallpox resistant to all vaccines. Usamriid went into a state of Delta Alert on September 11 and activated its emergency response teams when the first anthrax letters were opened in New York and Washington, D.C. Preston reports, in unprecedented detail, on the government’ s response to the attacks and takes us into the ongoing FBI investigation. His story is based on interviews with top-level FBI agents and with Dr. Steven Hatfill. Jahrling is leading a team of scientists doing controversial experiments with live smallpox virus at CDC. Preston takes us into the lab where Jahrling is reawakening smallpox and explains, with cool and devastating precision, what may be at stake if his last bold experiment fails.
Committee on the Assessment of Future Scientific Needs for Variola Virus,Institute of Medicine
Author : Committee on the Assessment of Future Scientific Needs for Variola Virus,Institute of Medicine Publisher : National Academies Press Page : 126 pages File Size : 42,8 Mb Release : 1999-05-14 Category : Medical ISBN : 9780309596985
Assessment of Future Scientific Needs for Live Variola Virus by Committee on the Assessment of Future Scientific Needs for Variola Virus,Institute of Medicine Pdf
In 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus, which examines: -- Whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies. -- What further benefits, if any, would likely be gained through the use of variola in research and development efforts related to agent detection, diagnosis, prevention, and treatment. -- What unique potential benefits, if any, the study of variola would have in increasing our fundamental understanding of the biology, host-agent interactions, pathogenesis, and immune mechanisms of viral diseases.
The last naturally occurring case of smallpox was diagnosed in Ali Maow Maalin, a hospital cook in the picturesque seaport of Merca, Somalia, on 26 October 1977. But in August 1978, the smallpox virus crept like a thief in the night from a laboratory in Birmingham to re-inhabit human flesh and blood. What happened next has all the hallmarks of a Greek drama or Shakespearean tragedy, with the shocking but mysterious appearance of a dreaded disease in the heart of England; a frantic effort to save a city--and the world--from disaster; a tragic heroine, a photographer, who suffered a hideous fate; and a tragic hero, a virology professor, driven to despair to mortifying despair, treated as a scapegoat during an official enquiry, but later exonerated in a court of law. Here, I give a full account of the 1978 Birmingham smallpox outbreak and the ensuing court case, drawn from records of the time and the reminiscences of those who lived through it. "A complete and rational account... sets the record straight, provides closure"Keith Dumbell, University of Cape Town "A riveting account of the mystery, the politics and the legal implications of the Birmingham event."Stanley Falkow, University of Stanford "Thoroughly engrossing--a high-quality detective story, with a nice human touch" Robin May, University of Birmingham "A book full of humanity... and of anger at the smallpox virus and the misery it caused."Soad Tabaqchali, emeritus professor, St Bartholomew's Hospital "An engaging book that weaves the scientific, social, political and historical context into a multi-layered narrative."Conall McCaughey, Queens University Belfast "The biographical material on the protagonists is superb. It makes it come alive. Janet Parker is not just a name, a Madonna to be sacrificed, but a real person." Brian Escott-Cox QC
The astonishing, hitherto unknown truths about a disease that transformed the United States at its birth A horrifying epidemic of smallpox was sweeping across the Americas when the American Revolution began, and yet we know almost nothing about it. Elizabeth A. Fenn is the first historian to reveal how deeply variola affected the outcome of the war in every colony and the lives of everyone in North America. By 1776, when military action and political ferment increased the movement of people and microbes, the epidemic worsened. Fenn's remarkable research shows us how smallpox devastated the American troops at Québec and kept them at bay during the British occupation of Boston. Soon the disease affected the war in Virginia, where it ravaged slaves who had escaped to join the British forces. During the terrible winter at Valley Forge, General Washington had to decide if and when to attempt the risky inoculation of his troops. In 1779, while Creeks and Cherokees were dying in Georgia, smallpox broke out in Mexico City, whence it followed travelers going north, striking Santa Fe and outlying pueblos in January 1781. Simultaneously it moved up the Pacific coast and east across the plains as far as Hudson's Bay. The destructive, desolating power of smallpox made for a cascade of public-health crises and heartbreaking human drama. Fenn's innovative work shows how this mega-tragedy was met and what its consequences were for America.
The History of the Small Pox by James Carrick Moore Pdf
Moore follows the history of the disease from its first recorded appearance in Asia and Africa to Arabia and finally to Europe and America. he then provides a history of treatment, including three chapters on the discovery and reception of inoculation. Moore was an early advocate of vaccination, and this book is dedicated to Edward Jenner. In 1810 Moore was appointed director of the National Vaccine Establishment.
Canadian Immunization Guide by Canada. Comité consultatif national de l'immunisation,Canada. National Advisory Committee on Immunization Pdf
The seventh edition of the Canadian Immunization Guide was developed by the National Advisory Committee on Immunization (NACI), with the support ofthe Immunization and Respiratory Infections Division, Public Health Agency of Canada, to provide updated information and recommendations on the use of vaccines in Canada. The Public Health Agency of Canada conducted a survey in 2004, which confi rmed that the Canadian Immunization Guide is a very useful and reliable resource of information on immunization.
Author : Donald R. Hopkins Publisher : University of Chicago Press Page : 415 pages File Size : 42,8 Mb Release : 2002-09-15 Category : History ISBN : 9780226351681
Once known as the "great fire" or "spotted death," smallpox has been rivaled only by plague as a source of supreme terror. Although naturally occurring smallpox was eradicated in 1977, recent terrorist attacks in the United States have raised the possibility that someone might craft a deadly biological weapon from stocks of the virus that remain in known or perhaps unknown laboratories. In The Greatest Killer, Donald R. Hopkins provides a fascinating account of smallpox and its role in human history. Starting with its origins 10,000 years ago in Africa or Asia, Hopkins follows the disease through the ancient and modern worlds, showing how smallpox removed or temporarily incapacitated heads of state, halted or exacerbated wars, and devastated populations that had never been exposed to the disease. In Hopkins's history, smallpox was one of the most dangerous-and influential-factors that shaped the course of world events.
The Speckled Monster tells the dramatic story of two parents who dared to fight back against smallpox. After barely surviving the agony of smallpox themselves, they flouted eighteenth-century medicine by borrowing folk knowledge from African slaves and Eastern women in frantic bids to protect their children. From their heroic struggles stems the modern science of immunology as well as the vaccinations that remain our only hope should the disease ever be unleashed again. Jennifer Lee Carrell transports readers back to the early eighteenth century to tell the tales of Lady Mary Wortley Montagu and Dr. Zabdiel Boylston, two iconoclastic figures who helped save London and Boston from the deadliest disease mankind has known.
