Statistical Methods For Quality Of Life Studies

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Statistical Methods for Quality of Life Studies

Mounir Mesbah,Bernard F. Cole,Mei-Ling Ting Lee
Statistical Methods for Quality of Life Studies Book PDF

Author : Mounir Mesbah,Bernard F. Cole,Mei-Ling Ting Lee
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 50,5 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475736250

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Statistical Methods for Quality of Life Studies by Mounir Mesbah,Bernard F. Cole,Mei-Ling Ting Lee Pdf

On October 16 and 17, 2000, we hosted an international workshop entitled "Statistical Design, Measurement, and Analysis of Health Related Quality of Life." The workshop was held in the beautiful city of Arradon, South Brittany, France with the main goal of fostering an interdisciplinary forum for discussion of theoretical and applied statistical issues arising in studies of health-related quality of life (HRQoL). Included were biostatisticians, psychometricians and public health professionals (e.g., physicians, sociologists, psychologists) active in the study ofHRQoL. In assembling this volume, we invited each conference participant to contribute a paper based on his or her presentation and the ensuing and very interesting discussions that took place in Arradon. All papers were peer-reviewed, by anonymous reviewers, and revised before final editing and acceptance. Although this process was quite time consuming, we believe that it greatly improved the volume as a whole, making this book a valuable contribution to the field ofHRQoL research. The volume presents a broad spectrum of papers presented at the Workshop, and thus illustrates the range of current research related to the theory, methods and applications of HRQoL, as well as the interdisciplinary nature ofthis work. Following an introduction written by Sir David Cox, it includes 27 articles organized into the following chapters.

Design and Analysis of Quality of Life Studies in Clinical Trials

Diane L. Fairclough
Design and Analysis of Quality of Life Studies in Clinical Trials Book PDF

Author : Diane L. Fairclough
Publisher : CRC Press
Page : 419 pages
File Size : 43,9 Mb
Release : 2010-01-07
Category : Mathematics
ISBN : 9781420061185

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Design and Analysis of Quality of Life Studies in Clinical Trials by Diane L. Fairclough Pdf

Design Principles and Analysis Techniques for HRQoL Clinical TrialsSAS, R, and SPSS examples realistically show how to implement methods Focusing on longitudinal studies, Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition addresses design and analysis aspects in enough detail so that readers can apply statistical meth

Quality of Life

Peter M. Fayers,David Machin
Quality of Life Book PDF

Author : Peter M. Fayers,David Machin
Publisher : John Wiley & Sons
Page : 648 pages
File Size : 48,5 Mb
Release : 2016-01-19
Category : Medical
ISBN : 9781444337952

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Quality of Life by Peter M. Fayers,David Machin Pdf

The assessment of patient reported outcomes and health-related quality of life continue to be rapidly evolving areas of research and this new edition reflects the development within the field from an emerging subject to one that is an essential part of the assessment of clinical trials and other clinical studies. The analysis and interpretation of quality-of-life assessments relies on a variety of psychometric and statistical methods which are explained in this book in a non-technical way. The result is a practical guide that covers a wide range of methods and emphasizes the use of simple techniques that are illustrated with numerous examples, with extensive chapters covering qualitative and quantitative methods and the impact of guidelines. The material in this new third edition reflects current teaching methods and content widened to address continuing developments in item response theory, computer adaptive testing, analyses with missing data, analysis of ordinal data, systematic reviews and meta-analysis. This book is aimed at everyone involved in quality-of-life research and is applicable to medical and non-medical, statistical and non-statistical readers. It is of particular relevance for clinical and biomedical researchers within both the pharmaceutical industry and clinical practice.

Design and Analysis of Quality of Life Studies in Clinical Trials

Diane L. Fairclough
Design and Analysis of Quality of Life Studies in Clinical Trials Book PDF

Author : Diane L. Fairclough
Publisher : CRC Press
Page : 332 pages
File Size : 50,7 Mb
Release : 2002-03-28
Category : Mathematics
ISBN : 1584882638

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Design and Analysis of Quality of Life Studies in Clinical Trials by Diane L. Fairclough Pdf

More and more frequently, clinical trials include the evaluation of Health-Related Quality of Life (HRQoL), yet many investigators remain unaware of the unique measurement and analysis issues associated with the assessment of HRQoL. At the end of a study, clinicians and statisticians often face challenging and sometimes insurmountable analytic problems. Design and Analysis of Quality of Life Studies in Clinical Trials details these issues and presents a range of solutions. Written from the author's extensive experience in the field, it focuses on the very specific features of QoL data: its longitudinal nature, multidimensionality, and the problem of missing data. The author uses three real clinical trials throughout her discussions to illustrate practical implementation of the strategies and analytic methods presented. As Quality of Life becomes an increasingly important aspect of clinical trials, it becomes essential for clinicians, statisticians, and designers of these studies to understand and meet the challenges this kind of data present. In this book, SAS and S-PLUS programs, checklists, numerous figures, and a clear, concise presentation combine to provide readers with the tools and skills they need to successfully design, conduct, analyze, and report their own studies.

Quality of Life

Peter M. Fayers,David Machin
Quality of Life Book PDF

Author : Peter M. Fayers,David Machin
Publisher : John Wiley & Sons
Page : 460 pages
File Size : 49,5 Mb
Release : 2013-05-23
Category : Medical
ISBN : 9781118699454

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Quality of Life by Peter M. Fayers,David Machin Pdf

Quality of life studies form an essential part of the evaluation of any treatment. Written by two authors who are well respected within this field, Quality of Life: The Assessment, Analysis and Interpretation of Patient-reported Outcomes, Second Edition lays down guidelines on assessing, analysing and interpreting quality of life data. The new edition of this standard book has been completely revised, updated and expanded to reflect many methodological developments emerged since the publication of the first edition. Covers the design of instruments, the practical aspects of implementing assessment, the analyses of the data, and the interpretation of the results Presents all essential information on Quality of Life Research in one comprehensive volume Explains the use of qualitative and quantitative methods, including the application of basic statistical methods Includes copious practical examples Fills a need in a rapidly growing area of interest New edition accommodates significant methodological developments, and includes chapters on computer adaptive testing and item banking, choosing an instrument, systematic reviews and meta analysis This book is of interest for everyone involved in quality of life research, and it is applicable to medical and non-medical, statistical and non-statistical readers. It is of particular relevance for clinical and biomedical researchers within both the pharmaceutical industry and practitioners in the fields of cancer and other chronic diseases. Reviews of the First Edition – Winner of the first prize in the Basis of Medicine Category of the BMA Medical Book Competition 2001: “This book is highly recommended to clinicians who are actively involved in the planning, analysis and publication of QoL research.” CLINICAL ONCOLOGY “This book is highly recommended reading.” QUALITY OF LIFE RESEARCH

Assessing Quality of Life in Clinical Trials

Peter M. Fayers,Ron D. Hays
Assessing Quality of Life in Clinical Trials Book PDF

Author : Peter M. Fayers,Ron D. Hays
Publisher : Unknown
Page : 490 pages
File Size : 46,7 Mb
Release : 2005
Category : Medical
ISBN : 0198527691

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Assessing Quality of Life in Clinical Trials by Peter M. Fayers,Ron D. Hays Pdf

Researchers in all clinical fields are fully aware of the importance of Quality of Life measurements in judging the efficacy of a given treatment. Psychological criteria play an important role in this evaluation. Assessment of Quality of Life in Clinical Trials: methods and practice explores the current state of the art and illustrates the benefits and potential of health related quality of life assessment in clinical trials. It covers a wide range of analytical issues, emphasizing new and innovative approaches that are of practical and clinical importance.

Advances in Statistical Methods for the Health Sciences

Jean-Louis Auget,N. Balakrishnan,Mounir Mesbah,Geert Molenberghs
Advances in Statistical Methods for the Health Sciences Book PDF

Author : Jean-Louis Auget,N. Balakrishnan,Mounir Mesbah,Geert Molenberghs
Publisher : Springer Science & Business Media
Page : 540 pages
File Size : 45,7 Mb
Release : 2007-08-08
Category : Mathematics
ISBN : 9780817645427

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Advances in Statistical Methods for the Health Sciences by Jean-Louis Auget,N. Balakrishnan,Mounir Mesbah,Geert Molenberghs Pdf

Statistical methods have become an increasingly important and integral part of research in the health sciences. Many sophisticated methodologies have been developed for specific applications and problems. This self-contained comprehensive volume covers a wide range of topics pertaining to new statistical methods in the health sciences, including epidemiology, pharmacovigilance, quality of life, survival analysis, and genomics. The book will serve the health science community as well as practitioners, researchers, and graduate students in applied probability, statistics, and biostatistics.

Methods and Applications of Statistics in the Life and Health Sciences

Narayanaswamy Balakrishnan
Methods and Applications of Statistics in the Life and Health Sciences Book PDF

Author : Narayanaswamy Balakrishnan
Publisher : John Wiley & Sons
Page : 1027 pages
File Size : 40,6 Mb
Release : 2009-12-02
Category : Mathematics
ISBN : 9780470405093

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Methods and Applications of Statistics in the Life and Health Sciences by Narayanaswamy Balakrishnan Pdf

Inspired by the Encyclopedia of Statistical Sciences, Second Edition, this volume outlines the statistical tools for successfully working with modern life and health sciences research Data collection holds an essential part in dictating the future of health sciences and public health, as the compilation of statistics allows researchers and medical practitioners to monitor trends in health status, identify health problems, and evaluate the impact of health policies and programs. Methods and Applications of Statistics in the Life and Health Sciences serves as a single, one-of-a-kind resource on the wide range of statistical methods, techniques, and applications that are applied in modern life and health sciences in research. Specially designed to present encyclopedic content in an accessible and self-contained format, this book outlines thorough coverage of the underlying theory and standard applications to research in related disciplines such as biology, epidemiology, clinical trials, and public health. Uniquely combining established literature with cutting-edge research, this book contains classical works and more than twenty-five new articles and completely revised contributions from the acclaimed Encyclopedia of Statistical Sciences, Second Edition. The result is a compilation of more than eighty articles that explores classic methodology and new topics, including: Sequential methods in biomedical research Statistical measures of human quality of life Change-point methods in genetics Sample size determination for clinical trials Mixed-effects regression models for predicting pre-clinical disease Probabilistic and statistical models for conception Statistical methods are explored and applied to population growth, disease detection and treatment, genetic and genomic research, drug development, clinical trials, screening and prevention, and the assessment of rehabilitation, recovery, and quality of life. These topics are explored in contributions written by more than 100 leading academics, researchers, and practitioners who utilize various statistical practices, such as election bias, survival analysis, missing data techniques, and cluster analysis for handling the wide array of modern issues in the life and health sciences. With its combination of traditional methodology and newly developed research, Methods and Applications of Statistics in the Life and Health Sciences has everything students, academics, and researchers in the life and health sciences need to build and apply their knowledge of statistical methods and applications.

Quality of Life Outcomes in Clinical Trials and Health-Care Evaluation

Stephen J. Walters
Quality of Life Outcomes in Clinical Trials and Health Care Evaluation Book PDF

Author : Stephen J. Walters
Publisher : John Wiley & Sons
Page : 389 pages
File Size : 46,9 Mb
Release : 2009-10-26
Category : Medical
ISBN : 9780470753828

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Quality of Life Outcomes in Clinical Trials and Health-Care Evaluation by Stephen J. Walters Pdf

An essential, up-to-date guide to the design of studies and selection of the correct QoL instruments for observational studies and clinical trials. Quality of Life (QoL) outcomes or Person/Patient Reported Outcome Measures (PROMs) are now frequently being used in randomised controlled trials (RCTs) and observational studies. This book provides a practical guide to the design, analysis and interpretation of studies that use such outcomes. QoL outcomes tend to generate data with discrete, bounded and skewed distributions. Many investigators are concerned about the appropriateness of using standard statistical methods to analyse QoL data and want guidance on what methods to use. QoL outcomes are frequently used in cross-sectional surveys and non-randomised health-care evaluations. Provides a user-friendly guide to the design and analysis of clinical trials and observational studies in relation to QoL outcomes. Discusses the problems caused by QoL outcomes and presents intervention options to help tackle them. Guides the reader step-by-step through the selection of appropriate QoLs. Features exercises and solutions and a supporting website providing downloadable data files. Illustrated throughout with examples and case studies drawn from the author’s experience, this book offers statisticians and clinicians guidance on choosing between the numerous available QoL instruments.

Statistics in Drug Research

Shein-Chung Chow,Jun Shao
Statistics in Drug Research Book PDF

Author : Shein-Chung Chow,Jun Shao
Publisher : CRC Press
Page : 359 pages
File Size : 53,6 Mb
Release : 2002-02-20
Category : Mathematics
ISBN : 9780824743888

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Statistics in Drug Research by Shein-Chung Chow,Jun Shao Pdf

Emphasizing the role of good statistical practices (GSP) in drug research and formulation, this book outlines important statistics applications for each stage of pharmaceutical development to ensure the valid design, analysis, and assessment of drug products under investigation and establish the safety and efficacy of pharmaceutical compounds. Coverage include statistical techniques for assay validation and evaluation of drug performance characteristics, testing population/individual bioequivalence and in vitro bioequivalence according to the most recent FDA guidelines, basic considerations for the design and analysis of therapeutic equivalence and noninferiority trials.

Outcomes Assessment in Cancer

Joseph Lipscomb,Carolyn C. Gotay,Claire Snyder
Outcomes Assessment in Cancer Book PDF

Author : Joseph Lipscomb,Carolyn C. Gotay,Claire Snyder
Publisher : Cambridge University Press
Page : 682 pages
File Size : 46,9 Mb
Release : 2011-08-18
Category : Medical
ISBN : 1139442740

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Outcomes Assessment in Cancer by Joseph Lipscomb,Carolyn C. Gotay,Claire Snyder Pdf

Cancer touches the lives of millions worldwide each year. This is reflected not only in well-publicized mortality statistics but also in the profound - though much more difficult to measure - effects of cancer on the health-related quality of life, economic status, and overall well-being of patients and their families. In 2001, the US National Cancer Institute established the Cancer Outcomes Measurement Working Group to evaluate the state of the science in measuring the important and diverse impacts of this disease on individuals and populations. The findings and recommendations of the working group's 35 internationally recognized members are reported in Outcomes Assessment in Cancer, lucidly written and accessible to both researchers and policy makers in academia, government, and industry. Originally published in 2005, this volume provides a penetrating yet practical discussion of alternative approaches for comprehensively measuring the burden of cancer and the effectiveness of preventive and therapeutic interventions.

Qualitative Studies in Quality of Life

Graciela Tonon
Qualitative Studies in Quality of Life Book PDF

Author : Graciela Tonon
Publisher : Springer
Page : 240 pages
File Size : 54,5 Mb
Release : 2015-01-14
Category : Social Science
ISBN : 9783319137797

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Qualitative Studies in Quality of Life by Graciela Tonon Pdf

This volume explores the use and relevance of qualitative methods for the study of quality of life. It analyzes the role of qualitative researcher and the role of the context and the culture in quality of life studies. It presents the use of qualitative methods in real projects carried out in specific fields: geography, health, community studies, labor life and yoga. Finally, the book proposes the use of mixed methods that are considered as the third methodological approach in social research. The main purpose of using qualitative methods is to understand what it means for participants to be involved in certain events, situations and actions. Such methods help understand the context in which participants act and the influence of that context on their actions. The decision to use a particular methodology implies a philosophic, theoretical and political decision. Qualitative methodology constitutes an approach that is essential for understanding people’s experiences of well-being and discovering new issues related to quality of life.

Introduction to Statistical Methods for Clinical Trials

Thomas D. Cook,David L DeMets
Introduction to Statistical Methods for Clinical Trials Book PDF

Author : Thomas D. Cook,David L DeMets
Publisher : CRC Press
Page : 465 pages
File Size : 45,7 Mb
Release : 2007-11-19
Category : Mathematics
ISBN : 9781584880271

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Introduction to Statistical Methods for Clinical Trials by Thomas D. Cook,David L DeMets Pdf

Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors’ collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. After reviewing the history, ethics, protocol, and regulatory issues of clinical trials, the book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals. Developed from a course taught at the University of Wisconsin for the past 25 years, this textbook provides a solid understanding of the statistical approaches used in the design, conduct, and analysis of clinical trials.

Statistical Methods for Quality Improvement

Thomas P. Ryan
Statistical Methods for Quality Improvement Book PDF

Author : Thomas P. Ryan
Publisher : John Wiley & Sons
Page : 578 pages
File Size : 40,9 Mb
Release : 2011-09-20
Category : Technology & Engineering
ISBN : 9781118058107

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Statistical Methods for Quality Improvement by Thomas P. Ryan Pdf

Praise for the Second Edition "As a comprehensive statistics reference book for quality improvement, it certainly is one of the best books available." —Technometrics This new edition continues to provide the most current, proven statistical methods for quality control and quality improvement The use of quantitative methods offers numerous benefits in the fields of industry and business, both through identifying existing trouble spots and alerting management and technical personnel to potential problems. Statistical Methods for Quality Improvement, Third Edition guides readers through a broad range of tools and techniques that make it possible to quickly identify and resolve both current and potential trouble spots within almost any manufacturing or nonmanufacturing process. The book provides detailed coverage of the application of control charts, while also exploring critical topics such as regression, design of experiments, and Taguchi methods. In this new edition, the author continues to explain how to combine the many statistical methods explored in the book in order to optimize quality control and improvement. The book has been thoroughly revised and updated to reflect the latest research and practices in statistical methods and quality control, and new features include: Updated coverage of control charts, with newly added tools The latest research on the monitoring of linear profiles and other types of profiles Sections on generalized likelihood ratio charts and the effects of parameter estimation on the properties of CUSUM and EWMA procedures New discussions on design of experiments that include conditional effects and fraction of design space plots New material on Lean Six Sigma and Six Sigma programs and training Incorporating the latest software applications, the author has added coverage on how to use Minitab software to obtain probability limits for attribute charts. new exercises have been added throughout the book, allowing readers to put the latest statistical methods into practice. Updated references are also provided, shedding light on the current literature and providing resources for further study of the topic. Statistical Methods for Quality Improvement, Third Edition is an excellent book for courses on quality control and design of experiments at the upper-undergraduate and graduate levels. the book also serves as a valuable reference for practicing statisticians, engineers, and physical scientists interested in statistical quality improvement.

Big Data and Information Theory

Jiuping Xu,Syed Ejaz Ahmed,Zongmin Li
Big Data and Information Theory Book PDF

Author : Jiuping Xu,Syed Ejaz Ahmed,Zongmin Li
Publisher : Routledge
Page : 128 pages
File Size : 48,6 Mb
Release : 2022-06-02
Category : Business & Economics
ISBN : 9781000591712

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Big Data and Information Theory by Jiuping Xu,Syed Ejaz Ahmed,Zongmin Li Pdf

Big Data and Information Theory are a binding force between various areas of knowledge that allow for societal advancement. Rapid development of data analytic and information theory allows companies to store vast amounts of information about production, inventory, service, and consumer activities. More powerful CPUs and cloud computing make it possible to do complex optimization instead of using heuristic algorithms, as well as instant rather than offline decision-making. The era of "big data" challenges includes analysis, capture, curation, search, sharing, storage, transfer, visualization, and privacy violations. Big data calls for better integration of optimization, statistics, and data mining. In response to these challenges this book brings together leading researchers and engineers to exchange and share their experiences and research results about big data and information theory applications in various areas. This book covers a broad range of topics including statistics, data mining, data warehouse implementation, engineering management in large-scale infrastructure systems, data-driven sustainable supply chain network, information technology service offshoring project issues, online rumors governance, preliminary cost estimation, and information system project selection. The chapters in this book were originally published in the journal, International Journal of Management Science and Engineering Management.