Stem Cell Bioprocessing

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Stem Cell Bioprocessing and Manufacturing

Joaquim M. S. Cabral,Cláudia Lobato da Silva,Maria Margarida Diogo
Stem Cell Bioprocessing and Manufacturing Book PDF

Author : Joaquim M. S. Cabral,Cláudia Lobato da Silva,Maria Margarida Diogo
Publisher : MDPI
Page : 170 pages
File Size : 48,8 Mb
Release : 2021-01-20
Category : Science
ISBN : 9783039430383

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Stem Cell Bioprocessing and Manufacturing by Joaquim M. S. Cabral,Cláudia Lobato da Silva,Maria Margarida Diogo Pdf

The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realized. Specifically, there is a need for the development of bioprocess technology for the successful transfer of laboratory-based practice of stem cell and tissue culture to the clinic as therapeutics through the application of engineering principles and practices. This Special Issue of Bioengineering on Stem Cell Bioprocessing and Manufacturing addresses the central role in defining the engineering sciences of cell-based therapies, by bringing together contributions from worldwide experts on stem cell biology and engineering, bioreactor design and bioprocess development, scale-up, and manufacturing of stem cell-based therapies.

Stem Cell Bioprocessing

Tiago G. Fernandes,M. Margardia Diogo,Joaquim M.S. Cabral
Stem Cell Bioprocessing Book PDF

Author : Tiago G. Fernandes,M. Margardia Diogo,Joaquim M.S. Cabral
Publisher : Elsevier
Page : 236 pages
File Size : 53,7 Mb
Release : 2013-11-15
Category : Science
ISBN : 9781908818300

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Stem Cell Bioprocessing by Tiago G. Fernandes,M. Margardia Diogo,Joaquim M.S. Cabral Pdf

Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed. Basic definitions are provided concerning the different types of stem cells, from adult stem cells to the more recent induced pluripotent stem cells. The main characteristics of these different stem cell types are described, alongside the molecular mechanisms underlying their self-renewal and differentiation. The book also focuses on methodologies currently used for in vitro stem cell culture under static conditions, including the challenge of xeno-free culture conditions, as well as culture parameters that influence stem cell culture. Approaches for both stem cell culture and separation in micro-scale conditions are presented, including the use of cellular microarrays for high-throughput screening of the effect of both soluble and extracellular matrix molecules. A further section is dedicated to application of stem cells for regenerative medicine. Maintains a unique focus on both the basic stem cell biology concepts, and their translation to large-scale bioprocessing approaches Envisages the use of stem cells in regenerative medicine and drug screening applications Discusses the application of microscale techniques as a tool to perform basic stem cell biology studies

Bioprocessing for Cell-Based Therapies

Che J. Connon
Bioprocessing for Cell Based Therapies Book PDF

Author : Che J. Connon
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 41,7 Mb
Release : 2017-02-06
Category : Science
ISBN : 9781118743416

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Bioprocessing for Cell-Based Therapies by Che J. Connon Pdf

With contributions from leading, international academics and industrial practitioners, Bioprocessing for Cell-Based Therapies explores the very latest techniques and guidelines in bioprocess production to meet safety, regulatory and ethical requirements, for the production of therapeutic cells, including stem cells. An authoritative, cutting-edge handbook on bioprocessing for the production of therapeutic cells with extensive illustrations in full colour throughout An authoritative, cutting-edge handbook on bioprocessing for the production of therapeutic cells with extensive illustrations in full colour throughout In depth discussion of the application of cell therapy including methods used in the delivery of cells to the patient Includes contributions from experts in both academia and industry, combining a practical approach with cutting edge research The only handbook currently available to provide a state of the art guide to Bioprocessing covering the complete range of cell-based therapies, from experts in academia and industry

Bioreactors for Stem Cell Expansion and Differentiation

Joaquim M.S. Cabral,Claudia Lobato da Silva
Bioreactors for Stem Cell Expansion and Differentiation Book PDF

Author : Joaquim M.S. Cabral,Claudia Lobato da Silva
Publisher : CRC Press
Page : 279 pages
File Size : 52,6 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9780429841811

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Bioreactors for Stem Cell Expansion and Differentiation by Joaquim M.S. Cabral,Claudia Lobato da Silva Pdf

An international team of investigators presents thought-provoking reviews of bioreactors for stem cell expansion and differentiation and provides cutting-edge information on different bioreactor systems. The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization. This book in the fields of stem cell expansion, bioreactors, bioprocessing, and bio and tissue engineering, gives the reader a full understanding of the state-of-art and the future of these fields. Key selling features: Describes various bioreactors or stem cell culturing systems Reviews methods for stem cell expansion and differentiation for neural, cardiac, hemopoietic, mesenchymal, hepatic and other tissues cell types Distinguishes different types of bioreactors intended for different operational scales of tissue engineering and cellular therapies Includes contributions from an international team of leaders in stem cell research

Stem Cell Bioprocessing and Manufacturing

Joaquim M. S. Cabral,Cláudia Lobato da Silva,Maria Margarida Diogo
Stem Cell Bioprocessing and Manufacturing Book PDF

Author : Joaquim M. S. Cabral,Cláudia Lobato da Silva,Maria Margarida Diogo
Publisher : Unknown
Page : 170 pages
File Size : 43,7 Mb
Release : 2020
Category : Electronic
ISBN : 3039430394

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Stem Cell Bioprocessing and Manufacturing by Joaquim M. S. Cabral,Cláudia Lobato da Silva,Maria Margarida Diogo Pdf

The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realized. Specifically, there is a need for the development of bioprocess technology for the successful transfer of laboratory-based practice of stem cell and tissue culture to the clinic as therapeutics through the application of engineering principles and practices. This Special Issue of Bioengineering on Stem Cell Bioprocessing and Manufacturing addresses the central role in defining the engineering sciences of cell-based therapies, by bringing together contributions from worldwide experts on stem cell biology and engineering, bioreactor design and bioprocess development, scale-up, and manufacturing of stem cell-based therapies.

Stem Cell Manufacturing

Joaquim M. S. Cabral,Claudia Lobato da Silva,Lucas G. Chase,Maria Margarida Diogo
Stem Cell Manufacturing Book PDF

Author : Joaquim M. S. Cabral,Claudia Lobato da Silva,Lucas G. Chase,Maria Margarida Diogo
Publisher : Elsevier
Page : 340 pages
File Size : 43,6 Mb
Release : 2016-07-24
Category : Medical
ISBN : 9780444632661

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Stem Cell Manufacturing by Joaquim M. S. Cabral,Claudia Lobato da Silva,Lucas G. Chase,Maria Margarida Diogo Pdf

Stem Cell Manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product. The advent of stem cell research unveiled the therapeutic potential of stem cells and their derivatives and increased the awareness of the public and scientific community for the topic. The successful manufacturing of stem cells and their derivatives is expected to have a positive impact in the society since it will contribute to widen the offer of therapeutic solutions to the patients. Fully defined cellular products can be used to restore the structure and function of damaged tissues and organs and to develop stem cell-based cellular therapies for the treatment of cancer and hematological disorders, autoimmune and other inflammatory diseases and genetic disorders. Presents the first ‘Flowchart‘ of stem cell manufacturing enabling easy understanding of the various processes in a sequential and coherent manner Covers all bioprocess technologies required for the transfer of the bench findings to the clinic including the process components: cell signals, bioreactors, modeling, automation, safety, etc. Presents comprehensive coverage of a true multidisciplinary topic by bringing together specialists in their particular area Provides the basics of the processes and identifies the issues to be resolved for large scale cell culture by the bioengineer Addresses the critical need in bioprocessing for the successful delivery of stem cell technology to the market place by involving professional engineers in sections of the book

Stem Cell Engineering

Robert M. Nerem,Jeanne Loring,Todd C. McDevitt,Sean P. Palecek,David V. Schaffer,Peter W. Zandstra
Stem Cell Engineering Book PDF

Author : Robert M. Nerem,Jeanne Loring,Todd C. McDevitt,Sean P. Palecek,David V. Schaffer,Peter W. Zandstra
Publisher : Springer
Page : 336 pages
File Size : 43,9 Mb
Release : 2014-06-12
Category : Technology & Engineering
ISBN : 9783319050744

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Stem Cell Engineering by Robert M. Nerem,Jeanne Loring,Todd C. McDevitt,Sean P. Palecek,David V. Schaffer,Peter W. Zandstra Pdf

This book describes a global assessment of stem cell engineering research, achieved through site visits by a panel of experts to leading institutes, followed by dedicated workshops. The assessment made clear that engineers and the engineering approach with its quantitative, system-based thinking can contribute much to the progress of stem cell research and development. The increased need for complex computational models and new, innovative technologies, such as high-throughput screening techniques, organ-on-a-chip models and in vitro tumor models require an increasing involvement of engineers and physical scientists. Additionally, this book will show that although the US is still in a leadership position in stem cell engineering, Asian countries such as Japan, China and Korea, as well as European countries like the UK, Germany, Sweden and the Netherlands are rapidly expanding their investments in the field. Strategic partnerships between countries could lead to major advances of the field and scalable expansion and differentiation of stem cells. This study was funded by the National Science Foundation (NSF), the National Institutes of Health (NIH) and the National Institute of Standards and Technology (NIST).

Stem Cells and Cell Therapy

Mohamed Al-Rubeai,Mariam Naciri
Stem Cells and Cell Therapy Book PDF

Author : Mohamed Al-Rubeai,Mariam Naciri
Publisher : Springer Science & Business Media
Page : 194 pages
File Size : 53,6 Mb
Release : 2013-10-01
Category : Medical
ISBN : 9789400771963

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Stem Cells and Cell Therapy by Mohamed Al-Rubeai,Mariam Naciri Pdf

With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating and processing large numbers of cells to meet the need of clinical applications. With this in mind, our aim is to provide a book on the subject of stem cells and cell therapy for researchers and students of cell biotechnology, bioengineering and bioproduction. This book is exceptional as it teaches researchers stem cells and cell therapy in that it covers the concepts and backgrounds necessary so that readers get a good understanding of the production of stem cells. The book covers three topics: The basics of stem cells and cell therapy, the use of stem cells for the treatment of human diseases, and stem cell processing. It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products. It is an informed and informative presentation of what modern research, science and engineering have learned about stem cells and their production and therapies. Addressing both the medical and production issues, this book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

Stem Cell Systems Bioengineering

Tiago G. Fernandes,Stephanie Michelle Willerth,Yuguo Lei
Stem Cell Systems Bioengineering Book PDF

Author : Tiago G. Fernandes,Stephanie Michelle Willerth,Yuguo Lei
Publisher : Frontiers Media SA
Page : 214 pages
File Size : 55,9 Mb
Release : 2021-07-02
Category : Science
ISBN : 9782889668953

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Stem Cell Systems Bioengineering by Tiago G. Fernandes,Stephanie Michelle Willerth,Yuguo Lei Pdf

Dr. Stephanie Willerth has a commercialization agreement with Aspect Biosystems with regards to bioprinting stem cell derived tissues. Dr. Yuguo Lei is a co-founder of CellGro Technologies, LLC, a company focusing on cell expansion technologies. Dr. Tiago Fernandes has no competing interests with regards to this Research Topic.

Mesenchymal Stem Cell Therapy

Lucas G. Chase,Mohan C Vemuri
Mesenchymal Stem Cell Therapy Book PDF

Author : Lucas G. Chase,Mohan C Vemuri
Publisher : Springer Science & Business Media
Page : 458 pages
File Size : 46,5 Mb
Release : 2012-12-12
Category : Science
ISBN : 9781627032001

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Mesenchymal Stem Cell Therapy by Lucas G. Chase,Mohan C Vemuri Pdf

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Atlas of Human Pluripotent Stem Cells in Culture

Lyn Healy,Ludmila Ruban
Atlas of Human Pluripotent Stem Cells in Culture Book PDF

Author : Lyn Healy,Ludmila Ruban
Publisher : Springer
Page : 216 pages
File Size : 43,8 Mb
Release : 2014-11-07
Category : Science
ISBN : 9781489975072

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Atlas of Human Pluripotent Stem Cells in Culture by Lyn Healy,Ludmila Ruban Pdf

This lavishly-illustrated, authoritative atlas explores the intricate art of culturing human pluripotent stem cells. Twelve chapters – containing more than 280 color illustrations – cover a variety of topics in pluripotent stem cell culturing including mouse and human fibroblasts, human embryonic stem cells and induced pluripotent stem cells, characteristic staining patterns, and abnormal cultures, among others. Atlas of Human Pluripotent Stem Cells in Culture is a comprehensive collection of illustrated techniques complemented by informative and educational captions examining what good quality cells look like and how they behave in various environments. Examples of perfect cultures are compared side-by-side to less-than-perfect and unacceptable examples of human embryonic and induced pluripotent stem cell colonies. This detailed and thorough atlas is an invaluable resource for researchers, teachers, and students who are interested in or working with stem cell culturing.

Biopharmaceutical Processing

Gunter Jagschies,Eva Lindskog,Karol Lacki,Parrish M. Galliher
Biopharmaceutical Processing Book PDF

Author : Gunter Jagschies,Eva Lindskog,Karol Lacki,Parrish M. Galliher
Publisher : Elsevier
Page : 1308 pages
File Size : 43,7 Mb
Release : 2018-01-18
Category : Technology & Engineering
ISBN : 9780128125526

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Biopharmaceutical Processing by Gunter Jagschies,Eva Lindskog,Karol Lacki,Parrish M. Galliher Pdf

Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. Offers a comprehensive, go-to reference for daily work decisions Covers both upstream and downstream processes Includes case studies that emphasize financial outcomes Presents summaries, decision grids, graphs and overviews for quick reference

Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts

Claire Komives,Weichang Zhou
Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts Book PDF

Author : Claire Komives,Weichang Zhou
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 44,6 Mb
Release : 2018-12-27
Category : Science
ISBN : 9781118361986

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Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts by Claire Komives,Weichang Zhou Pdf

Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies

Stem Cell Production

Firdos Alam Khan
Stem Cell Production Book PDF

Author : Firdos Alam Khan
Publisher : Springer Nature
Page : 277 pages
File Size : 46,5 Mb
Release : 2022-03-29
Category : Science
ISBN : 9789811675898

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Stem Cell Production by Firdos Alam Khan Pdf

This book examines the technologies and processes for the development and commercial production of stem cells according to cGMP guidelines. The initial chapter of the book discusses the therapeutic potentials of stem cells for the treatment of various diseases, including degenerative disorders and genetic diseases. The book then reviews the recent developments in the cultivation of stem cells in bioreactors, including critical cultural parameters, possible bioreactor configuration and integrations of novel technologies in bioprocess developmental stages. The book also introduces microscopic, molecular, and cellular techniques for characterization of stem cells for regulatory approvals. Further, it describes optimal cell transporting conditions to maintain cell viability and properties. Further, it summarizes characterization strategies of clinical grade stem cells for stem cell therapy. This book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

Cell Culture Technology for Pharmaceutical and Cell-Based Therapies

Sadettin Ozturk,Wei-Shou Hu
Cell Culture Technology for Pharmaceutical and Cell Based Therapies Book PDF

Author : Sadettin Ozturk,Wei-Shou Hu
Publisher : CRC Press
Page : 788 pages
File Size : 47,8 Mb
Release : 2005-08-30
Category : Medical
ISBN : 9780849351068

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Cell Culture Technology for Pharmaceutical and Cell-Based Therapies by Sadettin Ozturk,Wei-Shou Hu Pdf

Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of current cell culture technology used in the pharmaceutical industry. Contributions from several leading researchers showcase the importance of gene discovery and genomic technology devel