Stem Cells And Neurodegenerative Diseases

Author : Laurent Lescaudron,Julien Rossignol,Gary L. Dunbar
Publisher : CRC Press
Page : 246 pages
File Size : 49,5 Mb
Release : 2014-03-17
Category : Medical
ISBN : 9781482210736

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Stem Cells and Neurodegenerative Diseases by Laurent Lescaudron,Julien Rossignol,Gary L. Dunbar Pdf

This book explores the potential of stem cells for ameliorating the quality of life of patients with neurological and neurodegenerative diseases. It discusses results of pre-clinical investigations and case studies on the effects of stem cell transplantation on cell death, as well as to promote/stimulate neuroprotection after brain and spinal cord injury through trophic support, cell replacement and remyelination. The book covers the maintenance of the balance between stem cells and their progenitors within their niche, both under normal and degenerative processes and with ischemic stroke, multiple sclerosis, and brain tumor.

Author : Fabin Han,Pengzhe (Paul) Lu
Publisher : Springer Nature
Page : 144 pages
File Size : 40,6 Mb
Release : 2020-10-26
Category : Science
ISBN : 9789811543708

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Stem Cell-based Therapy for Neurodegenerative Diseases by Fabin Han,Pengzhe (Paul) Lu Pdf

This book reviews the state-of-the-art in stem-cell-based therapies for neurodegenerative diseases, and highlights advances in both animal models and clinical trials. It comprehensively discusses most neurodegenerative diseases, including such as Parkinson's, Alzheimer's and Huntington’s diseases, amyotrophic sclerosis, multiple sclerosis, muscular dystrophy and retinal degeneration, in which stem cells could potentially be used for therapy in the future. It also addresses the challenges and problems relating to the translation of stem-cell-based therapies into treatments. As such, the book will appeal to research scientists, physicians, graduate students, and medical professionals in the field of stem cells, neuroscience, neurology, neurorestoratology and major neurological disorders.

Author : Ashok K Shetty
Publisher : World Scientific Publishing Company
Page : 572 pages
File Size : 47,7 Mb
Release : 2015-08-28
Category : Science
ISBN : 9789814623193

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Neural Stem Cells in Health and Disease by Ashok K Shetty Pdf

This book is a comprehensive guide on neural stem cell behavior in health and disease. The book confers the altered behavior of endogenous neural stem cells in neurodegenerative disease conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders. Neural stem cell activity and neurogenesis in the adult brain is now confirmed in virtually all mammalian species including humans. Hence, a series of chapters in the first half of the book discusses the current knowledge on mechanisms of neural stem cell activity, the extent and functional significance of neurogenesis in the adult brain under normal, aged and disease environments, the susceptibility of neural stem cells and the plasticity of neurogenesis to alcohol, drugs of abuse and anesthetic agents, and advanced techniques that trigger neurogenesis in non-neurogenic regions. A second series of chapters in this book are focused on discussing the promise and efficacy of grafting of neural stem cells and/or other stem cells for treating neurological disorders such as Parkinson's disease, stroke, temporal lobe epilepsy, Alzheimer's disease and spinal cord injury. The final chapter confers on advances that are made in manufacturing a variety of neural cell types from human pluripotent stem cells that can be used as donor cells for cell transplantation.

Author : Sadaf Jahan
Publisher : Springer Nature
Page : 336 pages
File Size : 49,8 Mb
Release : 2024-06-01
Category : Electronic
ISBN : 9789819938483

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Applications of Stem Cells and Derived Exosomes in Neurodegenerative Disorders by Sadaf Jahan Pdf

Author : Kim A. Staats,Kyle David Fink,Dustin R. Wakeman
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 44,9 Mb
Release : 2021-08-17
Category : Science
ISBN : 9782889711826

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Stem Cells in Neurodegeneration: Disease Modeling and Therapeutics by Kim A. Staats,Kyle David Fink,Dustin R. Wakeman Pdf

Author : Anonim
Publisher : Academic Press
Page : 326 pages
File Size : 52,6 Mb
Release : 2022-11-22
Category : Medical
ISBN : 9780323989381

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Current Challenges in Cell Therapy for Neurodegenerative Diseases by Anonim Pdf

Cell Transplantation and Gene Therapy in Neurodegenerative Disease, Volume 166 in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors who cover Challenges in translating a cell therapy to GMP, The challenges in developing a cell therapy for Huntington’s disease, Challenges of cell therapies for retinal diseases, Challenges of gene therapy in Huntington’s Disease, Technological advances and barriers to gene therapy, Considerations in the development of cell therapy modulation for spinal cord injury treatment, Challenges of developing glial cell therapy for ALS, and more. Other chapters in this comprehensive release include Exploring cell and gene therapy in current animal models of Parkinson’s and Huntington’s disease, Considerations for the use of biomaterials to support cell therapy in degenerative disease, Neurosurgical challenges/innovations in cell and gene therapy delivery, Neuroimaging: the challenge of harnessing imaging tools to facilitate cell and gene therapy in neurodegenerative diseases/The contribution and challenges for imaging in advanced therapies of movement disorders, Considerations for clinical trial design for novel advanced therapeutics in neurodegenerative disease, and More than a trial participant: The role of the patient in ATMP development and trials for neurodegenerative disease. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in International Review on Neurobiology serials Updated release includes the latest information on Cell Transplantation and Gene Therapy in Neurodegenerative Disease

Author : Mayana Zatz,Oswaldo Keith Okamoto
Publisher : Springer
Page : 147 pages
File Size : 41,5 Mb
Release : 2015-08-11
Category : Science
ISBN : 9783319183145

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Stem Cells in Modeling Human Genetic Diseases by Mayana Zatz,Oswaldo Keith Okamoto Pdf

While most stem cell books focus on basic aspects and/or cell therapy, this book emphasizes the relevance of stem cells obtained from patients, the so-called “patients in a petri dish” as tools to investigate human genetic diseases for which there are no available effective treatment. Chapters embrace several examples of the use of iPS cell technology, a recent Nobel Prize-winning scientific breakthrough, to obtain patient-specific pluripotent cells from which many types of specialized cells involved in a particular disease can be generated, including psychiatric and neurodegenerative disorders, muscular dystrophies, laminopathies, among others. The text is a current and timely resource for postgraduate students, scientists and clinicians, interested in applications of this rapidly developing field of research in disease modeling, drug development, and emerging issues that it brings to regenerative medicine.

Author : Philippe Taupin
Publisher : Nova Publishers
Page : 148 pages
File Size : 44,5 Mb
Release : 2008
Category : Medical
ISBN : 1604564741

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Stem Cells and Regenerative Medicine by Philippe Taupin Pdf

Annotation. Stem Cells and Regenerative Medicine, Volumes I, II, and III, present an overview and in-depth analysis of recent developments in stem cell research and therapy in a compilation of recently-published, peer-reviewed articles.

Author : Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar
Publisher : Springer
Page : 154 pages
File Size : 40,5 Mb
Release : 2018-05-12
Category : Science
ISBN : 9783319744704

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Exosomes, Stem Cells and MicroRNA by Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar Pdf

This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

Author : Sara Xapelli,Maria J. Diógenes,Vincenzo Crunelli,Carlos P. Fitzsimons,Sandra H. Vaz
Publisher : Frontiers Media SA
Page : 134 pages
File Size : 52,9 Mb
Release : 2020-06-08
Category : Electronic
ISBN : 9782889637416

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Glial and Neural Stem Cells as New Therapeutic Targets for Neurodegenerative Disorders by Sara Xapelli,Maria J. Diógenes,Vincenzo Crunelli,Carlos P. Fitzsimons,Sandra H. Vaz Pdf

Author : Cyndy D. Davis,Paul R. Sanberg
Publisher : Springer Science & Business Media
Page : 392 pages
File Size : 49,9 Mb
Release : 2007-11-09
Category : Medical
ISBN : 9781597451475

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Cell Therapy, Stem Cells and Brain Repair by Cyndy D. Davis,Paul R. Sanberg Pdf

As our world continues to evolve, the field of regenerative medicine f- lows suit. Although many modern day therapies focus on synthetic and na- ral medicinal treatments for brain repair, many of these treatments and prescriptions lack adequate results or only have the ability to slow the p- gression of neurological disease or injury. Cell therapy, however, remains the most compelling treatment for neurodegenerative diseases, disorders, and injuries, including Parkinson’s disease, Huntington’s disease, traumatic brain injury, and stroke, which is expanded upon in more detail in Chapter 1 by Snyder and colleagues. Cell therapy is also unique in that it is the only therapeutic strategy that strives to replace lost, damaged, or dysfunctional cells with healthy ones. This repair and replacement may be due to an administration of exogenous cells itself or the activation of the body’s own endogenous reparative cells by a trophic, immune, or inflammatory response to cell transplantation. However, the precise mechanism of how cell therapy works remains elusive and is c- tinuing to be investigated in terms of molecular and cellular responses, in particular. Moreover, Chapter 11 by Emerich and associates, discusses some of the possibilities of cell immunoisolation and the potential for treating central nervous system diseases.

Author : H. Georg Kuhn,Amelia J. Eisch
Publisher : Springer
Page : 202 pages
File Size : 55,7 Mb
Release : 2014-11-22
Category : Science
ISBN : 9781493919086

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Neural Stem Cells in Development, Adulthood and Disease by H. Georg Kuhn,Amelia J. Eisch Pdf

This comprehensive volume is the first to specifically target developing, adult and diseased neural stem cells. It explores recent advances in the understanding of neural stem cell biology along with strategies that use these cells to tackle neurological diseases and brain aging. Ten inclusive chapters discuss a wide range of topics including neurogenesis, neurodegeneration, demyelinating disease, mood regulation, and spinal cord regeneration, among others. Written by world-renowned scientists in the field, Neural Stem Cells in Development, Adulthood and Disease presents cutting-edge studies of interest to both established neurogenesis researchers and readers with general interests in nervous system science. It is an authoritative addition to the Stem Cell Biology and Regenerative Medicine series.

Author : Kuldip S. Sidhu
Publisher : Bentham Science Publishers
Page : 250 pages
File Size : 46,7 Mb
Release : 2012
Category : Science
ISBN : 9781608052899

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Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside by Kuldip S. Sidhu Pdf

"Pluripotent stem cells have garnered tremendous interest in recent years, which is primarily driven by the hope of finding a cure for several debilitating human diseases. Cell transplantation (regeneratve medicine) offers considerable therapeutic potentia"

Author : Arndt Rolfs
Publisher : Unknown
Page : 0 pages
File Size : 41,9 Mb
Release : 2006
Category : Nervous system
ISBN : 3805581394

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Use of Stem Cells in Neurodegenerative Diseases by Arndt Rolfs Pdf

This special topic issue of 'Neurodegenerative Diseases' contains contributions discussing the subject in-depth. 'Neurodegenerative Diseases' is a well-respected, international peer-reviewed journal in 'Neurobiology'. Special topic issues are included in the subscription.

Author : Israel Hanin,Mitsuo Yoshida,Abraham Fisher
Publisher : Springer Science & Business Media
Page : 690 pages
File Size : 50,7 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475791457

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Alzheimer’s and Parkinson’s Diseases by Israel Hanin,Mitsuo Yoshida,Abraham Fisher Pdf

This book represents the third in a series of International Conferences related to Alzheimer's (AD) and Parkinson's (PD) diseases. The first one took place in Eilat, Israel, in 1985; and the second one in Kyoto, Japan, in 1989. This book contains the full text of oral and poster presentations from the Third International Conference on Alzheimer's and Parkinson's Diseases: Recent Developments, held in Chicago, Illinois, U.S.A. on November 1-6, 1993. The Chicago Conference was attended by 270 participants. The Scientific Program was divided into nine oral sessions, a keynote presentation, and a poster session. The conference culminated in a Round Table Discussion involving all of the participants in the conference. The four and one-half day meeting served as an excellent medium for surveying the current status of clinical and preclinical developments in AD and PD. There were 59 oral presentations and 93 posters. This book incorporates a majority of both.