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Stem Cells – From Hype to Real Hope by Khawaja Husnain Haider,Salim Aziz, MD Pdf
This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.
Stem Cells: From Myth to Reality and Evolving by Khawaja Husnain Haider Pdf
This book is a continuum of the first two books published in the STEM CELLS series entitled "Stem Cells: From Drug to Drug Discovery" and "Stem Cells: From Hype to Real Hope" which were published in 2017 and 2019, respectively. The scope of the book encompasses a wide range of topics with a latitude from adult stem cells to pluripotent stem cells in regenerative medicine either alone or as part of the combinatorial therapeutic intervention approach as "drug" besides their application as tools (disease model) during drug development process. Written by a leading group of researchers, the book encompasses experimental to clinical aspects of stem/progenitors cells, their biology, and characteristics.
Stem Cells: From Hype To Hope by Khawaja Husnain Haider Pdf
During the last two decades, stem cells have progressed from merely a concept to a vibrant field of regenerative medicine which is aimed at addressing the root cause of the problem rather than conventional methods of intervention that mostly provide symptomatic relief.Stem cell therapy either alone or in combination with the other established treatment strategies is a hope for patients who suffer from the 'incurable' diseases such as Alzheimer, diabetes, myocardial infarction etc. Besides aspirations in the clinical perspective, stem cells provide excellent in vitro disease models for drug development.Given the significance of the field, the proposed book will be a compilation of the bench experience of experts from various research labs involved in the cutting edge area of stem cell research.
Stem Cells – From Hype to Real Hope by Khawaja Husnain Haider,Salim Aziz, MD Pdf
This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.
Stem Cell Research by Toni Marzotto,Patricia M. Alt Pdf
Stem Cell Research takes a multi-disciplinary approach to the topic of human embryonic stem cell research, starting with the breakthrough discovery up through the present day controversy. The book invites the reader to join the conversation by providing a well balanced approach to many of the issues surrounding the development of this controversial scientific field. It includes the thoughts and experiences of scientists, journalists and ethicists as it tried to approach the topic through a variety of different academic disciplines. The book will help the non-scientist understand the biology, research regulations and funding; and simultaneously it will help the scientist better comprehend the full spectrum of ethical, religious, and policy debates.
Stem Cells: An Insider's Guide is an exciting new book that takes readers inside the world of stem cells guided by international stem cell expert, Dr. Paul Knoepfler. Stem cells are catalyzing a revolution in medicine. The book also tackles the exciting and hotly debated area of stem cell treatments that are capturing the public's imagination. In the future they may also transform how we age and reproduce. However, there are serious risks and ethical challenges, too. The author's goal with this insider's guide is to give readers the information needed to distinguish between the ubiquitous hype and legitimate hope found throughout the stem cell world. The book answers the most common questions that people have about stem cells. Can stem cells help my family with a serious medical problem such as Alzheimer's, Multiple Sclerosis, or Autism Are such treatments safe Can stem cells make me look younger or even literally stay physically young These questions and many more are answered here. A number of ethical issues related to stem cells that spark debates are discussed, including risky treatments, cloning and embryonic stem cells. The author breaks new ground in a number of ways such as by suggesting reforms to the FDA, providing a new theory of aging based on stem cells, and including a revolutionary Stem Cell Patient Bill of Rights. More generally, the book is your guide to where the stem cell field will be in the near future as well as a thoughtful perspective on how stem cell therapies will ultimately change your life and our world.
A landmark book by the senior science writer at Time magazine introduces us to a medical breakthrough that can save our lives. Few people know much about stem cell research beyond the ethical questions raised by using embryos. But in the last decade, stem cell research has made huge advances toward eliminating some of our most intractable diseases. Now this sweeping and accessible book introduces us to this cutting-edge science that will revolutionize medicine and change the way we think about and treat disease. Alice Park takes us from stem cell's controversial beginnings to the recent electrifying promise of being able to create the versatile cells without using embryos at all. She shows us how stem cells give researchers an unprecedented ability to study disease while giving patients the promise of replacing diseased cells with healthy new ones. And she profiles the scientists and leaders-many with their own compelling stories-who have fueled the quest and will continue to shape the field in years to come.
Stem Cell Repair and Regeneration by Nagy A. Habib Pdf
This second book in the Stem Cell Repair and Regeneration series provides a deeper exploration of the therapeutic potential of undifferentiated human stem cells.Regenerative medicine is an extremely fast-moving field which is evolving from the initial days of hype and excitement to a more realistic appraisal of the role of stem cells in the treatment of degenerative disorders. The series aims to keep abreast of these changes by combining new knowledge in stem cell biology and therapeutic applications.The current volume contains papers by the field's leading scientists and explores the current knowledge on cell therapy for different diseases and injured organs, including diabetes, liver and heart disease.
The Stem Cell Dilemma by Leo Furcht,William Hoffman Pdf
Today’s scientists are showing us how stem cells create and repair the human body. Unlocking these secrets has become the new Holy Grail of biomedical research. But behind that search lies a sharp divide, one that has continued for years. Stem cells offer the hope of creating or repairing tissues lost to age, disease, and injury. Yet, because of this ability, stem cells also hold the potential to incite an international biological arms race. The Stem Cell Dilemma illuminates everything you need to know about stem cells, and in this new edition the authors have included up-to-date information on scientific advances with iPS cells, clinical trials that are currently underway, hESC policy that is in the U.S. courts, stem cells and biodefense, developments at the California Institute for Regenerative Medicine, and growing international competition, plus all the basics of what stem cells are and how they work.
The dazzling promise of stem cell medicine: does it work and will it save us? Two experts look at the hype For decades, we've been anticipating the dawn of regenerative medicine. Again and again, we've been promised that stem cells will soon cure just about every ill imaginable. If not tomorrow, then the next day, or the day after that, and so on. We're still waiting. This book is an antidote to hype and a salve to soothe the itch for stem-cell salvation. In it, Professor John Rasko, a leading physician-scientist, and writer-historian Carl Power take us on a wild historical tour of this scandal-prone field. They expose all the dirty little secrets that the hype merchants prefer to ignore - the blunders and setbacks, confusions and delusions, tricks and lies. You'll meet Alexis Carrel, who discovered how to cultivate cells in a test tube: celebrity surgeon, scientific genius and suspected Nazi sympathiser, he opened the field of modern cell science with an experiment so bogus it blocked the way forward for the next 50 years. You'll meet Don Thomas, who developed bone marrow transplantation - the first successful stem-cell therapy - but only after a miserable decade in which most of his patients died. Alongside true stem-cell pioneers, you'll meet charlatans who cooked their data and claimed fake cures - sometimes with fatal consequences. Is there any good news? Which of the many promises of stem-cell research have been kept? And what of the future? Rasko and Power insist that we can only know where we're going if we have a sense of where we've been. Their study tears down the hype surrounding stem cells in order to reveal what's still worth hoping for. PRAISE 'If you love some scandal with your science - or some science with your scandal - this is THE book for you. Brilliant stuff' Adam Spencer, University of Sydney 'Science, skulduggery and snake oil salesmen ... it is a revolution in medicine but who knew the story of stem cell science was such a ripping yarn!' Fran Kelly, ABC Radio National Breakfast 'Science isn't magic: it's a human enterprise. This enthralling book tells of high achievement and astonishing blunders in a vital field of research' Robyn Williams, science journalist and broadcaster 'A masterpiece in myth-busting which helps separate fact from fiction in the world of regenerative medicine. It shines a light on some episodes in medical history many would rather forget but also shows a way forward for stem cell research breakthroughs grounded in solid science' Sophie Scott, national medical reporter, ABC 'The stem cell revolution: myths, mistakes but mighty medical masterpiece' Sir Gustav Nossal, AC CBE FRS FAA, Australian of the Year 2000 'A compelling (and compulsory) read for anyone entranced by the latest media-promoted breakthroughs in medical research, or planning translation of new biomedical research into clinical practice' Ian Frazer, AC, FRCPE, FRCPA, FAA, FTSE Australian of the Year 2006, Australian Living Treasure 2012 'Is it really stem cells' turn to revolutionise health care? When you come across a train wreck, keep reading! You'll discover that stem cells reveal medicine in its most provocative and challenging light' Antony Basten AO FAA FTSE 'Flesh Made New is a revelation for the general reader about what lies beneath the surface of exciting scientific advances ... The book shows the value of patience and trust in robust evidence-based scientific research, and where things go off the rail, for whistleblowers and experts like the authors of this book' Lucy Turnbull AO, businesswoman, urbanist and philanthropist
Advances in Stem Cell Research by Hossein Baharvand,Nasser Aghdami Pdf
Advances in Stem Cell Research discusses recent advances in stem cell science, including therapeutic applications. This volume covers such topics as biomanufacturing iPS cells for therapeutic applications, techniques for controlling stem cell fate decisions, as well as current basic research in such areas as germ line stem cells, genomics and proteomics in stem cell research. It is a useful book for biology and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors hope that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.
Stem Cell Repair and Regeneration by Nagy Habib,Nataša Y Levičar,Myrtle Gordon,Long Jiao,Nicholas Fisk Pdf
This second book in the Stem Cell Repair and Regeneration series provides a deeper exploration of the therapeutic potential of undifferentiated human stem cells. Regenerative medicine is an extremely fast-moving field which is evolving from the initial days of hype and excitement to a more realistic appraisal of the role of stem cells in the treatment of degenerative disorders. The series aims to keep abreast of these changes by combining new knowledge in stem cell biology and therapeutic applications. The current volume contains papers by the field's leading scientists and explores the current knowledge on cell therapy for different diseases and injured organs, including diabetes, liver and heart disease. Contents:Defining Progenitors Based on Their Expression of Aldehyde Dehydrogenase (R W Storms)Fetal Mesenchymal Stem Cells are More Primitive than Adult Mesenchymal Stem Cells (C Götherström et al.)The Immunoregulatory Role of Mesenchymal Stem Cells (F Dazzi & J Timoshanko)Understanding Cell Migration Through the Paradigm of T-Lymphocyte Homing (V Mirenda & F M Marelli-Berg)Blueprint for the Response of Blood and Bone Marrow-Derived Stem Cells and Their Progeny to Hypoxia (S M Watt et al.)The Potential of Stem Cells in Tissue Engineering (N D Evans & J M Polak)Joint Tissue Engineering (C De Bari et al.)Adult Stem Cells as a Treatment for Liver Diseases (N Levičar)The Generation of Pancreatic Beta Cells from Stem Cells: Intra- and Extra-Pancreatic Sources (M Brittan et al.)Cytokines and Stem Cell Differentiation into Cardiomyocyte Lineage Cells (I Dimarakis)Regulatory Networks Controlling Neural Stem Cell Self-Renewal and Differentiation (Y Shi)Demyelination as a Therapeutic Target in Spinal Cord Injury (J R Faulkner & H S Keirstead)Microchimeric Foetal Stem Cells and Non-Invasive Prenatal Genetic Diagnosis (M A A Mikhail)The Role of Stem Cells in Liver and Gastrointestinal Cancer (M R Alison et al.)Embryonic Stem Cells: Innovation in Predictive Toxicology (G G Cezar & J Quam) Readership: Life science scientists, biomedical researchers, surgeons, clinicians, biotechnology and pharmaceutical industry professionals, postgraduate and undergraduate students. Keywords:Stem Cell;Fetal Stem Cells;Cardiac;Liver;Pancreas;HomingKey Features:Comprehensive and up-to-date overview for clinicians and scientistsContributed by leading authorities on stem cellsInformation presented in a form accessible to all interested students, clinicians and scientistsEasily accessible and richly illustrated
Handbook of Stem Cell Therapy by Khawaja Husnain Haider Pdf
The handbook comprehensively reviews the therapeutic potential of stem cells and stem cell secretome-based cell-free strategies in regenerative medicine. The chapters in section I and section II respectively discuss the diverse applications of mesenchymal stem cells and non- mesenchymal stem cells, including skeletal myoblasts, endothelial progenitor cells, adipose tissue-derived stem cells, induced pluripotent stem cells, and neuronal stem cells in myocardial repair, inflammatory bowel disease, cognitive deficits, wound healing, retinal disorders, and COVID-19. The subsequent chapters in section IIIprimarily focused on the fast-emerging cell-free therapy approach in regenerative medicine for tissue repair and regeneration. These chapters review the impact of stem cell-derived secretome on various biological processes such as angiogenesis, neurogenesis, tissue repair, immunomodulation, musculoskeletal pathologies, wound healing, anti-fibrotic, and anti-tumorigenesis for tissue maintenance and regeneration.Lastly, section IV summarizes miscellaneous aspects of cell-based therapy, includingthe treatment advantages, opportunities, and shortcomings in stem cell-based therapy, potentially helping to refine future studies and translate them from experimental to clinical studies. Moreover, this section also has chapters on cancer stem cells as novel targets in cancer therapeutics. This Major Reference Book (MRW) is a valuable resource for researchers involved in stem cell research to understand the multifaceted therapeutic applications of stem cells and their derivative secretome in regenerative medicine.
The Stem Cell Dilemma by Leo Furcht,William R. Hoffman Pdf
Traces findings in biomedical research about the potential for stem cells to enable revolutionary cures, offering insight into the controversy surrounding stem-cell research and its related international biological arms race.
