Steroids And The Nervous System

Author : Cristin Roth
Publisher : American Medical Publishers
Page : 0 pages
File Size : 53,5 Mb
Release : 2023-09-19
Category : Medical
ISBN : 9798887404745

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Steroids and the Nervous System by Cristin Roth Pdf

A biologically active organic compound with four rings arranged in a specific molecular configuration is termed as a steroid. Steroid hormones are essential for cell life and they affect the neuroendocrine and behavioral functions in humans. Steroids perform two main biological functions. The first function is that they form an essential part of cell membranes which alters the membrane fluidity. The second function is signal transduction or cell signaling that facilitates cellular response. During early development, steroids regulate the activity and plasticity of neurons and the glial cells. They continue to exert trophic and protective effects on the adult nervous system. Steroids are synthesized by the gonads and adrenal glands, and are transmitted to the brain, spinal cord and the peripheral nerves through the bloodstream. Neurosteroids such as pregnenolone, progesterone, dehydroepiandrosterone and sulfate esters are produced within the nervous system. This book unravels the recent studies related to the importance of steroids in the nervous system. The topics covered herein are of utmost significance and bound to provide incredible insights to the readers. Through this book, we attempt to further enlighten the readers about the new concepts in this field of study.

Author : Steven R. King
Publisher : Springer Science & Business Media
Page : 132 pages
File Size : 49,5 Mb
Release : 2012-11-09
Category : Medical
ISBN : 9781461455592

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Neurosteroids and the Nervous System by Steven R. King Pdf

​While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo (“neurosteroids”). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychologicalconditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids.

Author : GianCarlo Panzica,Stefano Gotti
Publisher : Unknown
Page : 239 pages
File Size : 42,8 Mb
Release : 2011
Category : Electronic
ISBN : OCLC:780750301

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Steroids and the Nervous System by GianCarlo Panzica,Stefano Gotti Pdf

Author : GianCarlo Panzica,Roberto C. Melcangi
Publisher : Unknown
Page : 424 pages
File Size : 54,8 Mb
Release : 2003
Category : Autocrine mechanisms
ISBN : UVA:X004781095

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Steroids and the Nervous System by GianCarlo Panzica,Roberto C. Melcangi Pdf

This volume covers emerging and intriguing topics related to research into steroids and the nervous system, with a major focus on glucocorticoids, non-classical mechanism of action, regulation of reproduction, steroids and glial cells, behavioural effects and pathological correlations.

Author : Rudy Capildeo
Publisher : Unknown
Page : 328 pages
File Size : 45,6 Mb
Release : 1989-10-12
Category : Medical
ISBN : UOM:39015017894059

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Steroids in Diseases of the Central Nervous System by Rudy Capildeo Pdf

Outstanding contributions present an overview of steroids, starting with their molecular biology, pharmacology, and immunology. Steroids in Diseases of the Central Nervous System deals with the current applications of steroids in a variety of clinical conditions; treatments are described for brain tumors, malignant glioma, head and spinal damage, Guillain-Barré syndrome, polymyositis, and other neurological diseases.

Author : Sheryl S. Smith
Publisher : CRC Press
Page : 408 pages
File Size : 47,9 Mb
Release : 2003-10-27
Category : Medical
ISBN : 9780203508169

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Neurosteroid Effects in the Central Nervous System by Sheryl S. Smith Pdf

Our understanding of the ways that neuroactive steroids act in the brain has been increased by transgenic approaches, recombinant expression systems, higher resolution electrophysiological paradigms, and the development of technology to localize receptors. Recent behavioral studies examining the effects of steroids on mood, seizure susceptibility,

Author : Trevor W. Stone
Publisher : CRC Press
Page : 256 pages
File Size : 50,6 Mb
Release : 1996-03-27
Category : Science
ISBN : 0849376335

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CNS Neurotransmitters and Neuromodulators by Trevor W. Stone Pdf

As a volume in the series CNS Neurotransmitters and Neuromodulators, this text is destined to become a definitive reference. Well-known international authors have contributed up-to-date reviews covering a wide-range of interdisciplinary aspects of neuroactive steroid function. Specifically, this volume includes chapters dealing with the expression and properties of steroid receptors in the central nervous system (CNS); steroid interactions with amino acids, amines, and growth factors; electrophysiology; hypothalamic and feeding control; and the extremely topical issue of steroid influences on sexual differentiation of the brain. Neuroactive Steroids is an indispensable reference work for any researcher involved with steroids in the CNS, particularly in the areas of physiology, anatomy, neuropharmacology, neurochemistry, psychiatry, and molecular biology. In addition, it provides the perfect one-stop introduction for students.

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 44,9 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Derek J. Chadwick,Kate Widdows
Publisher : John Wiley & Sons
Page : 294 pages
File Size : 49,7 Mb
Release : 2008-04-30
Category : Medical
ISBN : 9780470513996

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Steroids and Neuronal Activity by Derek J. Chadwick,Kate Widdows Pdf

Classical studies of steroid hormones are concerned with their regulation of protein synthesis via the modulation of genomic transcription. But many of the actions of these hormones occur too rapidly to be explained in this manner, particularly their effects on the central nervous system. This text deals with recent discoveries showing that steroids can modulate the activity of some neurotransmitters. It explores the role of GABA as an important regulator of neuronal activity in the central nervous system and its inhibitory action as mediated via the GABA receptor and potentiated by steroids. In addition, the binding of steroids to cell membranes, the components involved and the outcome of such interactions are described. Also discusses possible uses of steroids as anesthetics and anticonvulsants.

Author : Etienne-Emile Baulieu,P. Robel,Michael Schumacher (MD.)
Publisher : Springer Science & Business Media
Page : 404 pages
File Size : 49,7 Mb
Release : 1999-07-23
Category : Medical
ISBN : UOM:39015048837002

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Neurosteroids by Etienne-Emile Baulieu,P. Robel,Michael Schumacher (MD.) Pdf

Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules.

Author : Vladimir Patchev
Publisher : Unknown
Page : 121 pages
File Size : 43,6 Mb
Release : 1999
Category : Electronic
ISBN : 1597342513

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Steroid Hormone-Dependent Organization of Neuroendocrine Functions by Vladimir Patchev Pdf

Steroid hormone influences on neural circuits throughout life largely determine the quality of the "dialogue" between the endocrine and nervous system, and thus, the function of adaptive mechanisms. This work provides a summary of "classic" knowledge on steroid actions in the brain, and addresses several novel and less explored issues, such as sex steriod-induced gender dichotomy in stress responsiveness, developmental effects of adrenal steroids on brain functions, contribution of steroid hormones to the structural plasticity of the limbic system, and the role of neurosteroids in the developm.

Author : Hans J. Reulen,Kurt Schürmann
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 54,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642654480

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Steroids and Brain Edema by Hans J. Reulen,Kurt Schürmann Pdf

The control of brain edema is still one of the major problems in surgical and conservative treatment of various cerebral lesions. Many attempts have been made to develop methods for reducing the high mortality associated with brain edema. Mter many years of using hypertonic solutions it can be stated that this type of therapy has not yielded satisfactory results. During recent years increasing evidence has been accumulated on the efficacy of steroids on brain edema. Steroids were reported to result in rapid relief of signs and symptoms of increased intracranial pressure and neurological dysfunction accompanying cerebral edema. It was the aim of this workshop to evaluate the effect of corticosteroids on brain edema as an advance in therapy. It was hoped that this could be achieved by a multi disciplinary approach. Though, the volume contains the contributions of various experts - internists, neurochemists, neurologists, neuropathologists, neurosurgeons, pharmacologists, physiologists - who have added considerable experimental and clin ical evidence on the action of steroids on brain edema. New pathophysiological aspects regarding the mechanisms underlying the formation and resolution of brain The effectiveness of corticosteroid therapy in various forms edema are presented. of clinical and experimental brain edema, e. g. accompanying brain tumors, head injury, spinal cord injury, cerebrovascular lesions, etc. as well as dosage and duration of treatment are critically discussed.

Author : Michael Schumacher
Publisher : Unknown
Page : 378 pages
File Size : 54,6 Mb
Release : 1999
Category : Electronic
ISBN : OCLC:902121571

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Neurosteroids: a New Regulatory Function in the Nervous System by Michael Schumacher Pdf

Author : National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
Publisher : National Academies Press
Page : 610 pages
File Size : 46,9 Mb
Release : 2000-11-13
Category : Social Science
ISBN : 9780309069885

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From Neurons to Neighborhoods by National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development Pdf

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Author : Etienne-Emile Baulieu
Publisher : Humana Press
Page : 0 pages
File Size : 47,6 Mb
Release : 2010-11-09
Category : Medical
ISBN : 1617370681

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Neurosteroids by Etienne-Emile Baulieu Pdf

Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules.