Strategies And Tactics In Organic Synthesis

Author : Thomas Lindberg
Publisher : Academic Press
Page : 552 pages
File Size : 40,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080924304

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Strategies and Tactics in Organic Synthesis by Thomas Lindberg Pdf

Strategies and Tactics in Organic Synthesis, Volume 3 provides detailed accounts of interesting advances in the field of synthesis. This book discusses the tasks of multistep synthesis from finding the proper reagents, reaction, and conditions for individual steps to inventing new chemistry to fill gaps in existing synthetic methodology. Organized into 13 chapters, this volume begins with an overview of the development of redox glycosidation strategy through ester methylenation. This text then examines the development of computer-assisted molecular modeling with applications to a wide range of problems in biological and organic chemistry. Other chapters consider the medicinal significance of ginkgo tree, which has prompted systematic studies to correlate the claimed beneficial effects of its extracts to the active principles. This book discusses as well the biological potency of pentacyclic quassinoids. The final chapter deals with the economic synthesis of a penem antibacterial. This book is a valuable resource for chemists.

Author : Michael Harmata
Publisher : Academic Press
Page : 436 pages
File Size : 54,6 Mb
Release : 2004-06-29
Category : Science
ISBN : 0124502830

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Strategies and Tactics in Organic Synthesis by Michael Harmata Pdf

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world. - Personal accounts of research in organic chemistry. - Written by internationally renowned scientists. - Details state of the art organic synthesis.

Author : Michael Harmata
Publisher : Unknown
Page : 486 pages
File Size : 44,6 Mb
Release : 2004
Category : Electronic books
ISBN : OCLC:162671809

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Strategies and Tactics in Organic Synthesis by Michael Harmata Pdf

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world. - Personal accounts of research in organic chemistry. - Written by internationally renowned scientists. - Details state of the art organic synthesis.

Author : Erik J. Sorensen,David A. Siler,Jeffrey D. Mighion
Publisher : Elsevier Inc. Chapters
Page : 344 pages
File Size : 53,8 Mb
Release : 2013-07-29
Category : Science
ISBN : 9780128056127

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Strategies and Tactics in Organic Synthesis by Erik J. Sorensen,David A. Siler,Jeffrey D. Mighion Pdf

This chapter defines risk-taking in organic synthesis as the deliberate pursuit of strategies that do not have near neighbors in the chemical literature. In these ventures into the unknown, chemical behavior can be difficult to predict. The literature of organic chemistry is replete with examples of powerful, bond-forming strategies that had little or no precedent when they were developed. This essay addresses some of those examples in an effort to demonstrate the merits of creative risk-taking in the planning and execution of organic syntheses.

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 51,7 Mb
Release : 2016-10-04
Category : Science
ISBN : 0081007566

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Strategies and Tactics in Organic Synthesis by Anonim Pdf

Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done. Readers will be educated, challenged, and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world.

Author : Michael Harmata
Publisher : Academic Press
Page : 436 pages
File Size : 41,9 Mb
Release : 2004-04-29
Category : Science
ISBN : 0080924328

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Strategies and Tactics in Organic Synthesis by Michael Harmata Pdf

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world. - Personal accounts of research in organic chemistry. - Written by internationally renowned scientists. - Details state of the art organic synthesis.

Author : Michael Harmata
Publisher : Academic Press
Page : 264 pages
File Size : 44,6 Mb
Release : 2017-09-25
Category : Science
ISBN : 0128117907

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Strategies and Tactics in Organic Synthesis by Michael Harmata Pdf

Strategies and Tactics in Organic Synthesis, Volume 13, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. Readers will be educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs and building molecules with atom and step economies that provide functional solutions to create a better world. Presents state-of-the-art developments in organic synthesis Provides insight and offers new perspective to problem-solving Written by leading experts in the field Uses firsthand narrative accounts to vividly illustrate the challenges and joys involved in advancing the science of organic synthesis

Author : Anonim
Publisher : Elsevier
Page : 510 pages
File Size : 42,9 Mb
Release : 2004-08-13
Category : Science
ISBN : 9780080474472

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Strategies and Tactics in Organic Synthesis by Anonim Pdf

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world. - Personal accounts of research in organic chemistry. - Written by internationally renowned scientists. - Details state of the art organic synthesis.

Author : Thomas James Lindberg
Publisher : Unknown
Page : 128 pages
File Size : 51,9 Mb
Release : 1984
Category : Organic compounds
ISBN : LCCN:83015674

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Strategies and Tactics in Organic Synthesis by Thomas James Lindberg Pdf

Author : William J. Chain
Publisher : Elsevier Inc. Chapters
Page : 344 pages
File Size : 44,8 Mb
Release : 2013-07-29
Category : Science
ISBN : 9780128056066

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Strategies and Tactics in Organic Synthesis by William J. Chain Pdf

Englerin A is a guaiane sesquiterpene with potent and selective growth inhibition activity against six human renal cancer cell lines. Englerin A has captured the attention of the synthetic organic chemistry community owing to its exciting activity and its attractive polycyclic and functionalized structure. This document describes the process by which we developed a carbonyl-based synthesis of the natural product that relies upon simple, inexpensive starting materials. Utilizing a diastereoselective Michael addition reaction, followed by a remarkably selective samarium-mediated carbonyl-alkene cyclization, we completed an eight-step synthesis of englerin A.

Author : Paul Wyatt,Stuart Warren
Publisher : John Wiley & Sons
Page : 55 pages
File Size : 45,8 Mb
Release : 2013-05-20
Category : Science
ISBN : 9781118681442

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Organic Synthesis by Paul Wyatt,Stuart Warren Pdf

Organic Synthesis: Strategy and Control is the long-awaited sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach, which looked at the planning behind the synthesis of compounds. This unique book now provides a comprehensive, practical account of the key concepts involved in synthesising compounds and focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. * A comprehensive, practical account of the key concepts involved in synthesising compounds * Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations * Focuses on reactions that really work rather than those with limited application * Contains extensive, up-to-date references in each chapter Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.

Author : Alexandros L. Zografos
Publisher : John Wiley & Sons
Page : 584 pages
File Size : 49,8 Mb
Release : 2016-03-17
Category : Science
ISBN : 9781118753569

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From Biosynthesis to Total Synthesis by Alexandros L. Zografos Pdf

Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field

Author : Michel Miesch,Tania Welsch,Vincent Rietsch,Laurence Miesch
Publisher : Elsevier Inc. Chapters
Page : 344 pages
File Size : 41,7 Mb
Release : 2013-07-29
Category : Science
ISBN : 9780128056103

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Strategies and Tactics in Organic Synthesis by Michel Miesch,Tania Welsch,Vincent Rietsch,Laurence Miesch Pdf

This chapter describes various syntheses of hamigeran B. Different methodologies were developed, and for our part, we achieved a formal synthesis of (±)-hamigeran B involving an intramolecular alkynylogous Mukaiyama aldol reaction promoted by dual Lewis acid activation as a key step. This unexpected reaction was discovered by treating a ketone with TBSOTf/NEt3 in order to obtain the corresponding silyl enol ether, which, in fact, evolves toward a new type of intramolecular aldol reaction. Fortunately, the study of the scope and limitations of this reaction allowed us to set up an original synthetic route to hamigeran B. Our results indicated clearly that serendipity plays a key role in the development of original strategies in organic synthesis.

Author : Jenny B. Werness,Wei Zhang,Weiping Tang
Publisher : Elsevier Inc. Chapters
Page : 344 pages
File Size : 49,5 Mb
Release : 2013-07-29
Category : Science
ISBN : 9780128056134

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Strategies and Tactics in Organic Synthesis by Jenny B. Werness,Wei Zhang,Weiping Tang Pdf

Addition of halogen and nucleophiles to conjugated 1,3-enynes in a 1,4-fashion produces a chiral allene and a stereogenic center. The diastereo- and enantioselectivity of this process are discussed in detail. The 1,4-bromoetherification of 1,3-enynes can be applied to the synthesis of various bromoallene-containing natural products. Our diastereo- and enantioselective total synthesis of kumausallene is described in this chapter. The synthesis features a cascade reaction involving palladium-catalyzed desymmetrization and a DMF-mediated diastereoselective 1,4-bromoetherification reaction.

Author : Michael F. Greaney,Lei Shi,Naim Nazef
Publisher : Elsevier Inc. Chapters
Page : 344 pages
File Size : 44,5 Mb
Release : 2013-07-29
Category : Science
ISBN : 9780128056073

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Strategies and Tactics in Organic Synthesis by Michael F. Greaney,Lei Shi,Naim Nazef Pdf

This chapter describes the synthesis of two related sesquiterpenes, anislactone A and merrilactone A. We initially accessed a tetracyclic oxetane in the merrilactone series using a Paternò–Büchi reaction but found the compound to be too underfunctionalized to advance further. We then developed an approach based on reductive epoxide ring opening, whereby a fully elaborated C-ring epoxy-cyclopentane, containing five stereocenters, could undergo reductive epoxide cleavage when treated with Ti(III). The resulting tertiary radical then participates in a 5-exo-dig cyclization onto a pendant alkyne to afford the complete carbon skeleton of both natural products. From this point, orthogonal functionalization routes enabled the synthesis of both anislactone A and merrilactone A. A second-generation merrilactone A synthesis is then described, growing out of discoveries made over the course of the first route in the area of cyclopentannulation. An iodo-aldol method was used to develop an approach to the anislactone skeleton and succeeded in producing the BC bicycle with good stereocontrol and functional group tolerance. Further functionalization, however, did not prove possible due to excessive steric hindrance around the incorporated iodo group preventing any productive transformation. This problem was solved by switching the nucleophile in the tandem-aldol process to cyanide. The resulting domino cyanide-addition aldol cyclization was then successfully employed in the formal synthesis of merrilactone A, using a late-stage [2+2] photocycloaddition to access the D-ring.