Sydney Brenner

Author : Errol C. Friedberg
Publisher : Unknown
Page : 0 pages
File Size : 45,7 Mb
Release : 2010
Category : Biography & Autobiography
ISBN : 0879699477

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Sydney Brenner by Errol C. Friedberg Pdf

Over his long and inspiring career, the Nobel Laureate Sydney Brenner has made some of the most significant and game-changing discoveries in the field of molecular biology. But Brenner's reach has extended well beyond his own research to inspire new generations of young scientists and to promote the development of science and biotechnology around the world. Based on his personal recollections, with contributions and correspondence from his close friends and colleagues, this book tells the lively story, not only of Brenner himself, but of what came to be known as the "golden age" of biology. About the author: Errol C. Friedberg, M.D., is the Senator Betty and Dr. Andy Andujar Distinguished Professor and Chair at the Department of Pathology, University of Texas Southwestern Medical Center at Dallas. A Fellow of the Royal College of Pathologists and recipient of the Rous Whipple Award from the American Society for Investigative Pathology, Friedberg also serves as Editor-in-Chief of the journal DNA Repair. Friedberg is the author of Cancer Answers, Correcting the Blueprint of Life: An Historical Account of the Discovery of DNA Repair Mechanisms, The Writing Life of James D. Watson, and From Rags to Riches: The Phenomenal Rise of The University of Texas Southwestern Medical Center at Dallas. He is also senior author of the textbook DNA Repair & Mutagenesis, and has edited and annotated a series of interviews published as Sydney Brenner: My Life in Science.

Author : Shuzhen Sim,Benjamin Seet
Publisher : Wildtype Books
Page : 272 pages
File Size : 46,7 Mb
Release : 2018-11-09
Category : Science
ISBN : 9789811197161

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Sydney Brenner's 10-on-10: The Chronicles Of Evolution by Shuzhen Sim,Benjamin Seet Pdf

Humans now wield a greater influence on the planet than any other species in history, and human-developed technologies like genetic engineering and artificial intelligence stand poised to overtake biological evolution. Just how did we arrive at this unique moment in human history, 14 billion years after the birth of the universe Sydney Brenner's 10-on-10: The Chronicles of Evolution brings together 24 prominent scientists and thinkers to trace the story of evolution through ten logarithmic scales of time. Through expert insights, this unique volume considers how humans found our place in the cosmos, and imagines what lies ahead.Published by Wildtype Books and distributed by World Scientific Publishing Co.

Author : Sydney Brenner,Lewis Wolpert
Publisher : Unknown
Page : 204 pages
File Size : 54,6 Mb
Release : 2001
Category : Biologists
ISBN : UOM:39015043714008

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A Life in Science by Sydney Brenner,Lewis Wolpert Pdf

Author : Brenner Sydney
Publisher : World Scientific
Page : 288 pages
File Size : 53,9 Mb
Release : 2019-07-16
Category : Science
ISBN : 9789811208195

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Loose Ends...false Starts by Brenner Sydney Pdf

Sydney Brenner was born in South Africa and educated at the University of Witwatersrand, Johannesburg (Medicine and Science). He then moved to Oxford and received a D.Phil in 1952, before joining the MRC Unit in the Cavendish Laboratory in Cambridge in 1956. His various accomplishments include serving as the Director of MRC Laboratory of Molecular Biology in Cambridge, founding the Molecular Science Institute in Berkeley, holding the position of Distinguished Professor at the Salk Institute, La Jolla. And during his last years, Sydney Brenner played a key role in shaping research and development in the biomedical sector in Singapore as A*Star Senior Fellow.He was one of the greatest biologists of the 20th century and was awarded the Nobel Prize in 2002 for his pioneering work in the field of molecular biology. He was also known for his boundless curiosity, sharp intellect and courage to speak with clarity and characteristic wit as evident in this delightful book which is a compilation of the columns that he wrote for Current Biology in the late '90s.

Author : Brenner Sydney,Sejnowski Terrence
Publisher : World Scientific
Page : 128 pages
File Size : 44,5 Mb
Release : 2018-09-07
Category : Science
ISBN : 9789813271753

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In The Spirit Of Science: Lectures By Sydney Brenner On Dna, Worms And Brains by Brenner Sydney,Sejnowski Terrence Pdf

In October 2017, Nobel laureate Sydney Brenner (Physiology or Medicine, 2002) gave four lectures on the history of Molecular Biology, its impact on Neuroscience and the great scientific questions that lie ahead.Sydney Brenner has been at the centre of the development of molecular biology, being a key player in shaping the Laboratory for Molecular Biology in Cambridge into a cradle of research, where pioneering and seminal discoveries in the field for over half a century have resulted in more than half a dozen Nobel Prizes.His memory is a treasure trove of the history of the field with innumerable anecdotes on other leading scientists in the past 60 years. These lectures trace the history and recount some of those anecdotes. His interlocutor Terry Sejnowski is the Francis Crick professor at the Salk Institute for Biological Studies and the Laboratory Head of its Computational Neurobiology Laboratory. Terry and Sydney are long-term collaborators and they share many stories and memories.The recorded lectures are the basis for this book. It aims to preserve the history of molecular biology and to also raise scientific questions that have resulted from the work of Sydney, Terry and others. It should be read by everybody who is interested in the generation, history and impact of great ideas as recounted by one of the legends of 20th century science.

Author : Sydney Brenner,John Sulston,Chun-Fang Wu,Joy Alcedo
Publisher : CRC Press
Page : 356 pages
File Size : 48,8 Mb
Release : 2022-02-28
Category : Electronic
ISBN : 1032145218

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Nature's Gift to Neuroscience by Sydney Brenner,John Sulston,Chun-Fang Wu,Joy Alcedo Pdf

In the 1960s, Sydney Brenner proposed to use the nematode worm Caenorhabditis elegans to discover the control mechanisms of animal development and to reveal how a small number of neurons generate different behaviours, giving birth to a vibrant community, which uses this animal model for their studies. Brenner was aided in his aim by John Sulston, who mapped the C. elegans cell lineages - from a single cell to the multicellular adult - which transformed the field of developmental biology. As a tribute to these two men, this book captures the perspectives of some of the early pioneers of the worm community, from Martin Chalfie, Robert Waterston and Donald Moerman to Catherine Rankin, Antony Stretton and John White. It also includes contributions from subsequent generations of the community, who explore the development and function of the C. elegans nervous system. This book features how this animal has become one of the best models for elucidating the biology of different sensory modalities and their complex behavioural outputs or how this animal's survival strategies have contributed to our understanding of aging and neurodegeneration. Thus, this volume documents the development of the C. elegans neuroscience field, from infancy to maturity. The chapters in this book were originally published as a special issue of the Journal of Neurogenetics.

Author : Donald L. Riddle
Publisher : Firefly Books
Page : 1252 pages
File Size : 42,8 Mb
Release : 1997
Category : Medical
ISBN : 0879695323

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C. Elegans II by Donald L. Riddle Pdf

Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR

Author : Donald W. Braben
Publisher : Stripe Press
Page : 187 pages
File Size : 49,5 Mb
Release : 2020-09-10
Category : Science
ISBN : 9781953953292

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Scientific Freedom by Donald W. Braben Pdf

A revolutionary and timely proposal for reinvigorating transformative scientific discovery, written by a preeminent leader in Venture Research. So rich was the scientific harvest of the early 20th century that it transformed entire industries and economies. Max Planck laid the foundation for quantum physics, Barbara McClintock for modern genetics, Linus Pauling for chemistry—the list goes on. In the 1970s, the nature of scientific work started to change. Increases in public funding for scientific research brought demands that spending be justified; a system of peer review that selected only the research proposals promising the greatest returns; and a push for endless short-term miracles instead of in-depth, boundary-pushing research. A vicious spiral of decline began. In Scientific Freedom, Donald W. Braben presents a framework to find and support cutting-edge, much-needed scientific innovation. Braben—who led British Petroleum’s Venture Research initiative, which aimed to identify and aid researchers challenging current scientific thinking—explains: —the conditions that catalyzed scientific research in the early 20th century; —the costs to society of our current research model; —the changing role of the university as a research institution; —how BP’s Venture Research initiative succeeded by minimizing bureaucracy and peer review, and the program’s impact; —the selection, budget, and organizational criteria for implementing a Venture Research program today. Even in the earliest stages, transformative and groundbreaking research can look unrecognizable to those who are accustomed to the patterns established by the past. Support for this research can, in fact, be low risk and offer rich rewards, but it requires rethinking the processes used to discover and sponsor scientists with groundbreaking ideas—and then giving those innovators the freedom to explore. First published in 2008, this new edition of Scientific Freedom is produced in a gorgeous archival quality hardcover with over 30 new illustrations and an up-to-date foreword by Donald Braben.

Author : George G. Brownlee
Publisher : Cambridge University Press
Page : 229 pages
File Size : 40,8 Mb
Release : 2020-04-02
Category : Science
ISBN : 9781316124055

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Fred Sanger - Double Nobel Laureate by George G. Brownlee Pdf

Considered 'the father of genomics', Fred Sanger (1918–2013) paved the way for the modern revolution in our understanding of biology. His pioneering methods for sequencing proteins, RNA and, eventually, DNA earned him two Nobel Prizes. He remains one of only four scientists (and the only British scientist) ever to have achieved that distinction. In this, the first full biography of Fred Sanger to be published, Brownlee traces Sanger's life from his birth in rural Gloucestershire to his retirement in 1983 from the Medical Research Council's Laboratory of Molecular Biology in Cambridge. Along the way, he highlights the remarkable extent of Sanger's scientific achievements and provides a real portrait of the modest man behind them. Including an extensive transcript of a rare interview of Sanger by the author, this biography also considers the wider legacy of Sanger's work, including his impact on the Human Genome Project and beyond.

Author : William Barry Wood
Publisher : Unknown
Page : 694 pages
File Size : 40,5 Mb
Release : 1988
Category : Science
ISBN : UOM:39015049386132

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The Nematode Caenorhabditis Elegans by William Barry Wood Pdf

Author : June Cummins,Alexandra Dunietz
Publisher : Yale University Press
Page : 396 pages
File Size : 40,7 Mb
Release : 2021-06-22
Category : Biography & Autobiography
ISBN : 9780300243550

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From Sarah to Sydney by June Cummins,Alexandra Dunietz Pdf

The untold life story of All-of-a-Kind Family author Sydney Taylor, highlighting her dramatic influence on American children's literature This is the first and only biography of Sydney Taylor (1904-1978), author of the award-winning All-of-a-Kind Family series of books, the first juvenile novels published by a mainstream publisher to feature Jewish children characters. The family--based on Taylor's own as a child--includes five sisters, each two years apart, dressed alike by their fastidious immigrant mother so they all look the same: all-of-a-kind. The four other sisters' names were the same in the books as in their real lives; only the real-life Sarah changed hers to the boyish Sydney while she was in high school. Cummins elucidates the deep connections between the progressive Taylor's books and American Jewish experiences, arguing that Taylor was deeply influential in the development of national Jewish identity. This biography conveys the vital importance of children's books in the transmission of Jewish culture and the preservation of ethnic heritage.

Author : David Ewing Duncan
Publisher : Harper Collins
Page : 294 pages
File Size : 50,9 Mb
Release : 2009-10-06
Category : Science
ISBN : 9780061983474

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Masterminds by David Ewing Duncan Pdf

James Watson, J. Craig Venter, Francis Collins, Cynthia Kenyon . . . you may not know them, but you should. They are the masterminds of genetics and biotechnology who want you to live to be 150 years old, to regenerate your heart and brain, to create synthetic life. For better or worse, they are about to alter life on earth forever. Award-winning journalist David Ewing Duncan tells the remarkable stories of cutting-edge bioscientists, revealing their quirky, uniquely fascinating, sometimes vaguely unsettling personas as a means to understand their science and the astonishing implications of their work. This book seamlessly combines myth, biography, scholarship, and wit that poses the all-important question: Can we actually trust these masterminds?

Author : Kevin Strange
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 44,6 Mb
Release : 2008-02-05
Category : Medical
ISBN : 9781597451512

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C. elegans by Kevin Strange Pdf

Molecular biology has driven a powerful reductionist, or “molecule-c- tric,” approach to biological research in the last half of the 20th century. Red- tionism is the attempt to explain complex phenomena by defining the functional properties of the individual components of the system. Bloom (1) has referred to the post-genome sequencing era as the end of “naïve reductionism. ” Red- tionist methods will continue to be an essential element of all biological research efforts, but “naïve reductionism,” the belief that reductionism alone can lead to a complete understanding of living organisms, is not tenable. Organisms are clearly much more than the sum of their parts, and the behavior of complex physiological processes cannot be understood simply by knowing how the parts work in isolation. Systems biology has emerged in the wake of genome sequencing as the s- cessor to reductionism (2–5). The “systems” of systems biology are defined over a wide span of complexity ranging from two macromolecules that interact to carry out a specific task to whole organisms. Systems biology is integrative and seeks to understand and predict the behavior or “emergent” properties of complex, multicomponent biological processes. A systems-level characteri- tion of a biological process addresses the following three main questions: (1) What are the parts of the system (i. e.

Author : Stanley Maloy,Kelly Hughes
Publisher : Academic Press
Page : 4360 pages
File Size : 52,6 Mb
Release : 2013-03-03
Category : Science
ISBN : 9780080961569

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Brenner's Encyclopedia of Genetics by Stanley Maloy,Kelly Hughes Pdf

The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike. Featuring relatively short entries on genetics topics written by experts in that topic, Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set provides an effective way to quickly learn about any aspect of genetics, from Abortive Transduction to Zygotes. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Key terms in related areas such as biochemistry, cell, and molecular biology are also included, and there are entries that describe historical figures in genetics, providing insights into their careers and discoveries. This 7-volume set represents a 25% expansion from the first edition, with over 1600 articles encompassing this burgeoning field Thoroughly up-to-date, with many new topics and subfields covered that were in their infancy or not inexistence at the time of the first edition. Timely coverage of emergent areas such as epigenetics, personalized genomic medicine, pharmacogenetics, and genetic enhancement technologies Interdisciplinary and global in its outlook, as befits the field of genetics Brief articles, written by experts in the field, which not only discuss, define, and explain key elements of the field, but also provide definition of key terms, suggestions for further reading, and biographical sketches of the key people in the history of genetics

Author : Sydney Brenner
Publisher : Unknown
Page : 123 pages
File Size : 43,5 Mb
Release : 1997
Category : Biology
ISBN : 1859223257

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Loose Ends from Current Biology by Sydney Brenner Pdf