Tendon Regeneration

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Tendon Regeneration

Manuela E Gomes,Rui L Reis,Márcia T Rodrigues
Tendon Regeneration Book PDF

Author : Manuela E Gomes,Rui L Reis,Márcia T Rodrigues
Publisher : Academic Press
Page : 470 pages
File Size : 40,9 Mb
Release : 2015-08-08
Category : Technology & Engineering
ISBN : 9780128016008

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Tendon Regeneration by Manuela E Gomes,Rui L Reis,Márcia T Rodrigues Pdf

Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies. Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field. Provides an overview of tendon biology, disease, and tissue engineering approaches Presents modern, alternative approaches to developing functional tissue solutions discussed Includes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicine Explores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practices Covers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field

Biomechanics of Tendons and Ligaments

Johanna Buschmann,Gabriella Meier Bürgisser
Biomechanics of Tendons and Ligaments Book PDF

Author : Johanna Buschmann,Gabriella Meier Bürgisser
Publisher : Woodhead Publishing
Page : 350 pages
File Size : 41,8 Mb
Release : 2017-05-10
Category : Technology & Engineering
ISBN : 9780081004920

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Biomechanics of Tendons and Ligaments by Johanna Buschmann,Gabriella Meier Bürgisser Pdf

Biomechanics of Tendons and Ligaments: Tissue Reconstruction looks at the structure and function of tendons and ligaments. Biological and synthetic biomaterials for their reconstruction and regeneration are reviewed, and their biomechanical performance is discussed. Regeneration tendons and ligaments are soft connective tissues which are essential for the biomechanical function of the skeletal system. These tissues are often prone to injuries which can range from repetition and overuse, to tears and ruptures. Understanding the biomechanical properties of ligaments and tendons is essential for their repair and regeneration. Contains systematic coverage on how both healthy and injured tendons and ligaments work Includes coverage of repair and regeneration strategies for tendons and ligaments Presents an Interdisciplinary analysis on the topic

Repair and Regeneration of Ligaments, Tendons, and Joint Capsule

William R. Walsh
Repair and Regeneration of Ligaments Tendons and Joint Capsule Book PDF

Author : William R. Walsh
Publisher : Springer Science & Business Media
Page : 324 pages
File Size : 50,5 Mb
Release : 2007-10-28
Category : Medical
ISBN : 9781592599424

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Repair and Regeneration of Ligaments, Tendons, and Joint Capsule by William R. Walsh Pdf

A comprehensive and authoritative review of the most important scientific and clinically relevant topics today in ligaments, tendons, and capsular biology, including their biomechanics and surgical reconstruction. The authors review the basic science of tendons in the hand and shoulder ligaments, the current clinical status of the shoulder and cruciate ligaments, and the latest advances in research on the healing of ligament and tendon to bone, artificial ligaments, and gene therapy. They also cover the major type 1 collagen soft tissues that are of particular interest to upper extremity surgeons and sports medicine specialists.

Tendons

Hasan Sözen
Tendons Book PDF

Author : Hasan Sözen
Publisher : BoD – Books on Demand
Page : 166 pages
File Size : 54,5 Mb
Release : 2019-12-04
Category : Medical
ISBN : 9781839629853

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Tendons by Hasan Sözen Pdf

Mankind has reached its present physical form through evolution of the movement system. Muscles, bones, and joints are the most important components of the movement system. Muscles are active elements, while bones and joints are passive elements. But to bring about movement, these three elements must work together. Tendons are round, oval, or flat tissues that connect muscles to bones. Muscle, tendon, or ligament injuries prevent motion so this is an important issue in trauma. If muscle, tendon, or ligament injuries occur together with vessel or nerve injury, it may be life threatening. The cause of injury might differ from a simple sports injury to a serious traffic accident. Muscles, bones, and joints have taken their place in the literature, but it would be wrong to say the same for tendons. This book describes tendons from different perspectives, thus providing the missing information in the literature. I hope that this book will be useful for anyone who wants to read about new perspectives on tendons. I also hope that it will inspire researchers working in this field.

Tendon and Ligament Healing

William Weintraub
Tendon and Ligament Healing Book PDF

Author : William Weintraub
Publisher : Redwing Book Company
Page : 249 pages
File Size : 48,5 Mb
Release : 2003
Category : Ligaments
ISBN : 9780912111735

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Tendon and Ligament Healing by William Weintraub Pdf

In 25 years of practicing structural/osteopathic manual therapy the author has done considerable work with seriously damaged tendons and ligaments, and has achieved results that conventional medicine would rate as improbable. Over time, he has developed a therapeutic model for treating these injuries so that individuals with chronic conditions -- who have exhausted the standard physiotherapy options and are facing surgery -- can have a viable option for recovery. His techniques, based on basic principles of structural healthcare, emphasize the importance of precise anatomical focus and the capacity to work with subtle changes of structure. Of essential importance is combining detailed specific treatment of the small fibers and tissues of the local injury area with an overall approach to improving larger body patterns and tensions. Logically, the responsiveness and self-corrective capacity of body tissues when given proper conditions is also an important factor. The primary techniques used are the osteopathic methods of strain-counterstrain, cranial and visceral osteopathy, and fascial release, as well as body-mind centering, zero balancing, and acupressure. His clinical model, which represents a new approach to serious, chronic tendon and ligament injuries, is based on these techniques, their combinations and specific usage, and the skills and aptitudes necessary for applying these techniques, including certain perceptual skills and a thorough knowledge of anatomy and kinesiology. Weintraub's descriptions are vital, interesting, alive, absorbing, even dramatic. He discusses at great length the nature of the tendons and ligaments, describes his manual therapy model -- comparing it with conventional medical procedures -- and covers processes and tissue changes in tendon/ligament healing as related to manual therapy. Case studies, self-help strategies, and thoughtful words on clinical efficacy and future directions in the field make for a thorough and well-rounded presentation. (Product Description).

Inflammation and tendon healing

Parmis Blomgran
Inflammation and tendon healing Book PDF

Author : Parmis Blomgran
Publisher : Linköping University Electronic Press
Page : 45 pages
File Size : 47,8 Mb
Release : 2017-10-30
Category : Electronic
ISBN : 9789176854716

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Inflammation and tendon healing by Parmis Blomgran Pdf

Tendons heal through three different overlapping phases; the inflammatory, proliferative and remodeling phase. Many studies have investigated what factors influence healing of tendons. However, little was known about inflammation and the immune cells present during Achilles tendon healing by the time this thesis started. We developed a flow cytometry method for our rat model of tendon healing, which enabled us to study different leukocyte subpopulations during Achilles tendon healing. The general aim of this thesis was to understand more about inflammation and the immune cell populations present during tendon healing and how the immune cell composition changes during normal tendon healing. Moreover, we investigated how different factors that are known to influence tendon healing affected the composition of the immune cell population. First, we described the immune cells during the time course of tendon healing focusing on different subpopulations of macrophages and T cells. Then, we studied how these cells were influenced by reduced mechanical loading. Mechanical loading prolonged the presence of M1 macrophages and delayed the switch to regulatory T cells and M2 macrophages compared to reduced mechanical loading. Next, the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the leukocyte composition revealed that, even though NSAIDs influence the mechanical properties of healing tendon, this effect was not mediated via changes in the leukocyte sub-populations during early and mid-time tendon healing. Further, the effect of corticosteroids during the inflammatory and remodeling phases of tendon healing was an improved healing of tendons and a reduction of CD8a T cells when corticosteroid was administered after the inflammatory phase. Lastly, we investigated if impairment of tendon healing by NSAIDs was related to mechanotransduction or microdamage during mechanical loading and showed that NSAIDs impair tendon healing by reducing the response to microdamage. In conclusion, these studies show that inflammation plays an important role during Achilles tendon healing, and factors that influence healing can also alter the presence or polarization of immune cell populations.

Tendon Healing

Malin Hammerman
Tendon Healing Book PDF

Author : Malin Hammerman
Publisher : Linköping University Electronic Press
Page : 28 pages
File Size : 43,9 Mb
Release : 2018-02-20
Category : Electronic
ISBN : 9789176853610

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Tendon Healing by Malin Hammerman Pdf

Mechanical loading and the inflammatory response during tendon healing might be important for the healing process. Mechanical loading can improve the healing tendon but the mechanism is not fully understood. The aim of this thesis was to further clarify the effect of mechanical loading on tendon healing and how mechanical loading affects the inflammatory response during the healing process. We used a rat Achilles tendon model to study healing. The rats were exposed to different degrees of loading by unloading methods such as paralysis of the calf muscles with Botox, tail suspension, and an orthosis (a boot). Full loading was achieved by free cage activity or treadmill walking. Microdamage in tendons, unloaded with Botox, was also investigated by needling. The healing tendons were evaluated in a materials testing machine (to analyze the mechanical properties), by gene expression analysis (microarray and PCR), or histology. Our results show that moderate loading (unloading with Botox) improves the mechanical properties of healing tendons compared to minimal loading (unloading with Botox in combination with tail suspension or a boot), especially the material properties. In accordance to these findings, expression of extracellular matrix genes were also increased by moderate compared to minimal loading. Full loading improved all mechanical properties and the expression of extracellular matrix genes was further increased compared to moderate loading. However, structural properties, such as the strength and the size of the healing tendon, were more affected by full loading. Full loading also affected the expression of inflammation-related genes during the early healing phase, 3 and 5 days after tendon injury, and increased the number of immune cells in the healing tendon tissue. Also microdamage of the healing tendon (detected by blood leakage) was increased by full loading compared to moderate loading during the early healing phase. Induced microdamage by repeated needling in the healing tendon tissue increased the structural properties of the healing tendon. The gene expression after needling was similar to the gene expression after full loading. The improvement of mechanical properties by loading in healing tendons was decreased by an anti-inflammatory drug called parecoxib, which decreases the production of prostaglandins by inhibiting COX-2 activity. The effect of parecoxib was reduced when loading was reduced but we could not confirm that the effect of parecoxib was related to the degree of loading. However, parecoxib abolished the stimulatory effect of microdamage. In conclusion, these studies show that moderate loading improves the quality of the healing tendon whereas full loading also increases the quantity of the healing tendon tissue. Full loading creates microdamage and increases inflammation during the early healing phase. The strong effect of full loading on the structural properties might be due to microdamage. Indeed, the anti-inflammatory drug parecoxib seems to impair mechanical stimulation of healing tendons by reducing the response to microdamage.

Cell Engineering and Regeneration

Heinz Redl
Cell Engineering and Regeneration Book PDF

Author : Heinz Redl
Publisher : Springer
Page : 0 pages
File Size : 48,9 Mb
Release : 2017-02-16
Category : Technology & Engineering
ISBN : 3319088300

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Cell Engineering and Regeneration by Heinz Redl Pdf

This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.

Regenerative Medicine and Plastic Surgery

Dominik Duscher,Melvin A. Shiffman
Regenerative Medicine and Plastic Surgery Book PDF

Author : Dominik Duscher,Melvin A. Shiffman
Publisher : Springer Nature
Page : 480 pages
File Size : 43,8 Mb
Release : 2019-11-27
Category : Science
ISBN : 9783030199623

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Regenerative Medicine and Plastic Surgery by Dominik Duscher,Melvin A. Shiffman Pdf

This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The book’s third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons’ knowledge to help them successfully treat injuries to the peripheral neural system. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms

Luciano Merlini,Cesare Faldini,Paolo Bonaldo
Muscle Tendon Innervation Unit Degeneration and Aging Pathophysiological and Regeneration Mechanisms Book PDF

Author : Luciano Merlini,Cesare Faldini,Paolo Bonaldo
Publisher : Frontiers Media SA
Page : 106 pages
File Size : 44,9 Mb
Release : 2017-02-24
Category : Electronic book
ISBN : 9782889451036

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Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms by Luciano Merlini,Cesare Faldini,Paolo Bonaldo Pdf

Aging is characterized by progressive deterioration of walking ability. This function loss has multiple causes including central and peripheral nerve dysfunction, loss of muscle mass and strength, as well as joints and bone alterations. Muscle-tendon unit and its innervation has a pivotal role in motor function performance that can be disrupted by overuse degeneration and aging. Research has shown that overuse degeneration and aging also share some pathophysiological mechanisms including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and modification of signalling and stress response pathways. This Research Topic is intended to bring together basic researchers and clinicians working in the area of neuroscience, aging, sarcopenia and orthopaedics in human and in animal models. The aim of this cross-fertilization is to accelerate our understanding of the mechanisms involved in aging and degeneration of the muscle-tendon unit and its innervation and to explore the therapeutic potential of pharmacological and physical therapy interventions.

Orthocell's Ortho-ATI

Ming Hao Zheng,Paul Anderson,Jerome Waddell
Orthocell s Ortho ATI Book PDF

Author : Ming Hao Zheng,Paul Anderson,Jerome Waddell
Publisher : Jerome Waddell
Page : 43 pages
File Size : 48,6 Mb
Release : 2015-05-14
Category : Medical
ISBN : 8210379456XXX

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Orthocell's Ortho-ATI by Ming Hao Zheng,Paul Anderson,Jerome Waddell Pdf

Orthocell's Ortho-ATI. Tendon regeneration biotechnology. Tendon Injury Intervention.

Repair and Regeneration of Ligaments, Tendons, and Joint Capsule

William R. Walsh
Repair and Regeneration of Ligaments Tendons and Joint Capsule Book PDF

Author : William R. Walsh
Publisher : Springer Science & Business Media
Page : 332 pages
File Size : 51,8 Mb
Release : 2006
Category : Medical
ISBN : 9781588291745

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Repair and Regeneration of Ligaments, Tendons, and Joint Capsule by William R. Walsh Pdf

Recent advances in surgical and experimental techniques have yielded great insight into the molecular biology and mechanical properties of tendon and ligament healing, as well as new strategies for their augmentation and reconstruction. In Repair and Regeneration of Ligaments, Tendons, and Joint Capsule, distinguished researchers and clinicians comprehensively review the most important scientific and clinically relevant topics today in ligament, tendon, and capsular biology, including their biomechanics and surgical reconstruction. The authors review the basic science of tendons in the hand and shoulder ligaments, the current clinical status of the shoulder and cruciate ligaments, and the latest advances in research on the healing of ligaments and tendons to bone, artificial ligaments, and gene therapy. They also cover the major type 1 collagen soft tissues that are of particular interest to upper extremity surgeons and sports medicine specialists. Comprehensive and up-to-date, Repair and Regeneration of Ligaments, Tendons, and Joint Capsule provides an authoritative survey of the biology and surgical reconstruction of connective tissues in the body, with special reference to tendons and ligaments in the shoulder and knee.

The Achilles Tendon

James A. Nunley
The Achilles Tendon Book PDF

Author : James A. Nunley
Publisher : Springer Science & Business Media
Page : 252 pages
File Size : 46,9 Mb
Release : 2008-12-10
Category : Medical
ISBN : 9780387792064

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The Achilles Tendon by James A. Nunley Pdf

Disorders of the Achilles tendon are universal, affecting people in a wide range of age groups. Because the Achilles tendon is one of the most pow- ful musculotendinous structures in the body, the impact of an injury to the Achilles tendon becomes magnified. There is a wide range of disorders or problems that can involve the insertional region, where pathology may rest with bone, tendon, or bursae. A completely different set of pathologic entities resides in the noninsertional region, one of which may include the frustrating degenerative tendinopathy. As our growing population ages but remains phy- cally active longer into life, the incidence of these disorders will continue to increase. I am proud to be given the opportunity to write the foreword to this text, which is intended for foot and ankle surgeons worldwide. Seldom does a book on a single entity become a current concepts review, as this work has. Too often, textbooks are not published for several years after the chapters have been written, making them obsolete upon publication. Not so with this book, which deals with timely topics on the Achilles tendon. Dr. James Nunley has compiled this work in slightly over a year, thus providing the reader with sta- of-the-art material. Dr. Nunley had the foresight to create a much needed techniques-oriented book dealing with the complexities of the Achilles tendon. His approach was to develop a comprehensive guide to managing Achilles tendon problems.

Biointegration of Medical Implant Materials

Chandra P. Sharma
Biointegration of Medical Implant Materials Book PDF

Author : Chandra P. Sharma
Publisher : Elsevier
Page : 424 pages
File Size : 43,5 Mb
Release : 2010-07-13
Category : Medical
ISBN : 9781845699802

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Biointegration of Medical Implant Materials by Chandra P. Sharma Pdf

Biointegration is essential for the successful performance of implanted materials and devices within the human body. With an increasing number and wide range of implant procedures being performed, it is critical that materials scientists and engineers effectively design implant materials which will create a positive biological and mechanical response with the host tissue. Biointegration of medical implant materials provides a unique and comprehensive review of recent techniques and research into material and tissue interaction and integration. Part one discusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering and vascular grafts. Part two then reviews particular techniques in drug delivery including inorganic nanoparticles for targeted drug delivery and alginate based drug delivery devices. Part three covers design considerations with coverage of themes such as biocompatibility of materials and its relevance to drug delivery and tissue engineering, mechanisms of failure of medical implants during long term use and rapid prototyping in biomedical engineering. With its distinguished editor and team of international contributors, Biointegration of medical implant materials: science and design is a standard reference for medical materials scientists and engineers in industry and the academic sector. Provides a unique and comprehensive review of recent techniques and research into material and tissue interaction and integration Discusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering, vascular grafts and replacement materials for facial reconstruction Reviews particular techniques in drug delivery featuring inorganic nanoparticles and functionalized nanoparticles for targeted drug delivery

Tendon Repair and Reconstruction, An Issue of Hand Clinics,

Jin Bo Tang,Steve K. Lee
Tendon Repair and Reconstruction An Issue of Hand Clinics Book PDF

Author : Jin Bo Tang,Steve K. Lee
Publisher : Elsevier Health Sciences
Page : 174 pages
File Size : 55,8 Mb
Release : 2013-05-19
Category : Medical
ISBN : 9781455771844

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Tendon Repair and Reconstruction, An Issue of Hand Clinics, by Jin Bo Tang,Steve K. Lee Pdf

This issue will include 16 articles, which will provide an overview of the biomechanics of the procedure, several surgical options (including how to perform the operation on a fully-awake patient), as well as some novel approaches and a review of one doctor’s patient outcomes over the past 30 years.