Textbook Of Drug Design And Discovery Fifth Edition

Author : Kristian Stromgaard,Povl Krogsgaard-Larsen,Ulf Madsen
Publisher : CRC Press
Page : 579 pages
File Size : 51,9 Mb
Release : 2016-08-19
Category : Medical
ISBN : 9781315354545

Get Book

Textbook of Drug Design and Discovery, Fifth Edition by Kristian Stromgaard,Povl Krogsgaard-Larsen,Ulf Madsen Pdf

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery. The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding). The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

Author : Povl Krogsgaard-Larsen,Hans Bundgaard
Publisher : Unknown
Page : 664 pages
File Size : 44,7 Mb
Release : 1991
Category : Science
ISBN : UOM:39015029452086

Get Book

A Textbook of Drug Design and Development by Povl Krogsgaard-Larsen,Hans Bundgaard Pdf

Author : Kristian Stromgaard,Povl Krogsgaard-Larsen,Ulf Madsen
Publisher : CRC Press
Page : 478 pages
File Size : 54,6 Mb
Release : 2009-10-07
Category : Medical
ISBN : 9781439882405

Get Book

Textbook of Drug Design and Discovery by Kristian Stromgaard,Povl Krogsgaard-Larsen,Ulf Madsen Pdf

The molecular biological revolution and the mapping of the human genome continue to provide new challenges and opportunities for drug research and design. Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures an

Author : S. N. Pandeya,J. R. Dimmock
Publisher : New Age International
Page : 228 pages
File Size : 45,8 Mb
Release : 1997
Category : Drugs
ISBN : 8122409431

Get Book

An Introduction to Drug Design by S. N. Pandeya,J. R. Dimmock Pdf

The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties. The Introductory Chapter Which Forms The Basis Of Drug Discovery Is Followed By The Present-Day Thinking Regarding The Best Approaches To Drug Discovery Are Considered. Similarly, There Have Been Major Advances In The Employment Of Computers In Structure-Activity Analysis, And A Discussion Of The State Of The Art In This Area Is Also Included.The Chapter On Qsar Highlights The Role Of Physico-Chemical Parameters In Predicting The Future Course Of Drug Discovery With Rational Drug Design. The Role Of Enzymes In Drug Action Is Well Established, And A Chapter On Design Of Enzyme Inhibitors Is Well Documented. In Addition, The Increased Understanding Of The Design And Utilisation Of Prodrugs Has Led To A Discussion Of The Relevant Issues In This Text.Thus The Book Will Fill The Need Of A Text For Designing New Drugs And The Principles Of New Drug Discovery.

Author : H. John Smith,H. John Williams
Publisher : CRC Press
Page : 666 pages
File Size : 52,5 Mb
Release : 2002-08-01
Category : Medical
ISBN : 9780203301371

Get Book

Textbook of Drug Design and Discovery by H. John Smith,H. John Williams Pdf

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lea

Author : Benjamin E. Blass
Publisher : Academic Press
Page : 712 pages
File Size : 51,6 Mb
Release : 2021-03-30
Category : Medical
ISBN : 9780128172155

Get Book

Basic Principles of Drug Discovery and Development by Benjamin E. Blass Pdf

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry

Author : Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen
Publisher : CRC Press
Page : 592 pages
File Size : 49,7 Mb
Release : 2003-08-02
Category : Medical
ISBN : 1134457286

Get Book

Textbook of Drug Design and Discovery, Third Edition by Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen Pdf

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

Author : Richard B. Silverman,Mark W. Holladay
Publisher : Academic Press
Page : 537 pages
File Size : 51,5 Mb
Release : 2014-03-29
Category : Medical
ISBN : 9780123820310

Get Book

The Organic Chemistry of Drug Design and Drug Action by Richard B. Silverman,Mark W. Holladay Pdf

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

Author : Richard B. Silverman
Publisher : Elsevier
Page : 650 pages
File Size : 43,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080513379

Get Book

The Organic Chemistry of Drug Design and Drug Action by Richard B. Silverman Pdf

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

Author : Atta-ur- Rahman,Gary W. Caldwell, M. Iqbal Choudhary,Zhengyin Yan
Publisher : Bentham Science Publishers
Page : 467 pages
File Size : 49,9 Mb
Release : 2009
Category : Medical
ISBN : 9781608052028

Get Book

Frontiers in Drug Design and Discovery by Atta-ur- Rahman,Gary W. Caldwell, M. Iqbal Choudhary,Zhengyin Yan Pdf

"Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery inclu

Author : Povl Krogsgaard-Larsen,Ulf Madsen,Kristian Stromgaard
Publisher : CRC Press
Page : 476 pages
File Size : 49,5 Mb
Release : 2010
Category : Medical
ISBN : 142006326X

Get Book

Textbook of Drug Design and Discovery, Fourth Edition by Povl Krogsgaard-Larsen,Ulf Madsen,Kristian Stromgaard Pdf

The molecular biological revolution and the mapping of the human genome continue to provide new challenges and opportunities for drug research and design. Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures and subsequently into drug candidates. Classroom tested and student approved, Textbook of Drug Design and Discovery, Fourth Edition describes the manner in which medicinal chemists utilize the various fields upon which they draw and the specific strategies they employ to advance promising molecules into clinical use for the treatment of disease. This text integrates a number of related scientific disciplines, including advanced synthetic chemistry, computational chemistry, biochemistry, structural biology, and molecular pharmacology, to provide current and comprehensive information on all aspects of drug design and discovery. Extensively revised, new topics in the fourth edition include: Biostructure-based and ligand-based drug design Chemical biology Natural products Imaging Neurotransmitter transporters Opioid and cannabinoid receptors Hypnotics Neglected diseases Immunomodulating agents Antibiotics The first part of the book covers general aspects, methods, and principles for drug design and discovery, and the second part covers specific targets and diseases. The text contains more than 300 color figures and 24 tables for rapid assimilation. Each chapter includes references for further study. Most chapters also provide the background and history needed to provide a context for students, as well as conclusions that summarize the points most relevant to emerging areas of research in drug design.

Author : Anonim
Publisher : Unknown
Page : 643 pages
File Size : 41,8 Mb
Release : 1991
Category : Electronic
ISBN : OCLC:490902826

Get Book

A Textbook of Drug Design and Development by Anonim Pdf

Author : Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker
Publisher : John Wiley & Sons
Page : 269 pages
File Size : 45,8 Mb
Release : 2012-05-14
Category : Medical
ISBN : 9783527329540

Get Book

Pharmacokinetics and Metabolism in Drug Design by Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker Pdf

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

Author : D. C. Young
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 45,8 Mb
Release : 2009-01-28
Category : Science
ISBN : 047045184X

Get Book

Computational Drug Design by D. C. Young Pdf

Helps you choose the right computational tools and techniques to meet your drug design goals Computational Drug Design covers all of the major computational drug design techniques in use today, focusing on the process that pharmaceutical chemists employ to design a new drug molecule. The discussions of which computational tools to use and when and how to use them are all based on typical pharmaceutical industry drug design processes. Following an introduction, the book is divided into three parts: Part One, The Drug Design Process, sets forth a variety of design processes suitable for a number of different drug development scenarios and drug targets. The author demonstrates how computational techniques are typically used during the design process, helping readers choose the best computational tools to meet their goals. Part Two, Computational Tools and Techniques, offers a series of chapters, each one dedicated to a single computational technique. Readers discover the strengths and weaknesses of each technique. Moreover, the book tabulates comparative accuracy studies, giving readers an unbiased comparison of all the available techniques. Part Three, Related Topics, addresses new, emerging, and complementary technologies, including bioinformatics, simulations at the cellular and organ level, synthesis route prediction, proteomics, and prodrug approaches. The book's accompanying CD-ROM, a special feature, offers graphics of the molecular structures and dynamic reactions discussed in the book as well as demos from computational drug design software companies. Computational Drug Design is ideal for both students and professionals in drug design, helping them choose and take full advantage of the best computational tools available. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

Author : Mohane S. Coumar
Publisher : Academic Press
Page : 522 pages
File Size : 41,8 Mb
Release : 2021-02-17
Category : Medical
ISBN : 9780128223130

Get Book

Molecular Docking for Computer-Aided Drug Design by Mohane S. Coumar Pdf

Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications offers in-depth coverage on the use of molecular docking for drug design. The book is divided into three main sections that cover basic techniques, tools, web servers and applications. It is an essential reference for students and researchers involved in drug design and discovery. Covers the latest information and state-of-the-art trends in structure-based drug design methodologies Includes case studies that complement learning Consolidates fundamental concepts and current practice of molecular docking into one convenient resource