Textbook Of Receptor Pharmacology Third Edition

Author : John C. Foreman,Torben Johansen,Alasdair J. Gibb
Publisher : CRC Press
Page : 314 pages
File Size : 46,5 Mb
Release : 2011-06-27
Category : Medical
ISBN : 9781439887578

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Textbook of Receptor Pharmacology, Third Edition by John C. Foreman,Torben Johansen,Alasdair J. Gibb Pdf

For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms, providing an integrated analysis of the mechanisms of drug action at membrane receptors. The hallmark of this popular text is the uniting of four major approaches to the study of receptors: Molecular investigation of receptor structure Quantitative functional studies of agonists and antagonists Ligand binding Signal transduction at the cell membrane Maintaining the second edition’s focus on cell membrane receptors and the immediate signal transduction events at the membrane, this edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions, giving students the ability to test their comprehension of the material. Hundreds of diagrams and figures further enhance the text. A time-saving resource and comprehensive learning tool, Textbook of Receptor Pharmacology, Third Edition carries on the tradition of providing in-depth, up-to-date coverage of this critical area that is both fundamental to the science of pharmacology and on the cutting edge of new drug development.

Author : John C. Foreman,Torben Johansen,Alasdair J. Gibb
Publisher : CRC Press
Page : 314 pages
File Size : 51,5 Mb
Release : 2010-09-10
Category : Medical
ISBN : 9781420052558

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Textbook of Receptor Pharmacology by John C. Foreman,Torben Johansen,Alasdair J. Gibb Pdf

For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classica

Author : John C. Foreman,Torben Johansen,Alasdair J. Gibb
Publisher : CRC Press
Page : 0 pages
File Size : 44,7 Mb
Release : 2010-09-10
Category : Medical
ISBN : 1420052543

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Textbook of Receptor Pharmacology, Third Edition by John C. Foreman,Torben Johansen,Alasdair J. Gibb Pdf

For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms, providing an integrated analysis of the mechanisms of drug action at membrane receptors. The hallmark of this popular text is the uniting of four major approaches to the study of receptors: Molecular investigation of receptor structure Quantitative functional studies of agonists and antagonists Ligand binding Signal transduction at the cell membrane Maintaining the second edition’s focus on cell membrane receptors and the immediate signal transduction events at the membrane, this edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions, giving students the ability to test their comprehension of the material. Hundreds of diagrams and figures further enhance the text. A time-saving resource and comprehensive learning tool, Textbook of Receptor Pharmacology, Third Edition carries on the tradition of providing in-depth, up-to-date coverage of this critical area that is both fundamental to the science of pharmacology and on the cutting edge of new drug development.

Author : John C. Foreman,Torben Johansen
Publisher : CRC Press
Page : 218 pages
File Size : 49,5 Mb
Release : 2002-08-28
Category : Medical
ISBN : 0849310296

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Textbook of Receptor Pharmacology, Second Edition by John C. Foreman,Torben Johansen Pdf

The bestselling first edition of Textbook of Receptor Pharmacology originated from a renowned course in receptor pharmacology taught at the University College of London for the past three decades. Its innovative format united four major approaches to the study of receptors: molecular biology, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction systems. The second edition builds on this foundation. This edition streamlines the material and focuses on cell membrane receptors along with their immediate signal transducers. The section on the molecular structure of receptors reflects the advances in this area. This edition also includes two restructured new chapters, one on G-proteins and one on tyrosine kinases, as signal transductors. Several chapters also contain problems for students to solve as well as worked-out solutions. The book contains over one hundred useful diagrams and tables to aid illustration of concepts and a helpful appendix explaining the simple mathematics used in the text. A time-saving resource and comprehensive textbook, Textbook of Receptor Pharmacology, Second Edition provides in-depth, up-to-date coverage of this still rapidly expanding research area that is both fundamental to the science of pharmacology and on the cutting edge of new drug development.

Author : Mannfred A. Hollinger
Publisher : CRC Press
Page : 291 pages
File Size : 47,7 Mb
Release : 1997-07-30
Category : Medical
ISBN : 1560325747

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Introduction to Pharmacology, Third Edition by Mannfred A. Hollinger Pdf

This work provides an introductory overview of pharmacology for undergraduate students. The first section of this book offers an insight into how drugs in food are absorbed, the discovery of drugs in food, and their absorption, distribution, metabolism and elimination. It considers how drugs, having gained access to the body, produce an effect and how the effect can be quantified for comparative purposes.; The second section exposes the concepts of drug-receptor interaction and the transduction of this binding into pharmacodynamic or toxic-dynamic responses. Factors influencing drug toxicity as well as underlying principles of managing drug overdose are also presented.; Section three examines in more detail the concept introduced in section one, that drugs can be classified into three broad categories: drugs that can replace physiological inadequacies; drugs that can cure; and drugs that treat Symptoms. Hormones, Antibiotics And Neuroactive Agents Are Covered, With examples, in separate specific chapters. A chapter in this section deals with the necessary understanding of the composition and functioning of the central nervous system in order to appreciate neuroactive agents.; Section four deals with drug abuse in general, the use of drugs to enhance the athletic performance in particular, the historical development of drug abuse laws, and finally, the challenges that drug companies face in the process of drug development.

Author : David E. Golan,Armen H. Tashjian,Ehrin J. Armstrong
Publisher : Lippincott Williams & Wilkins
Page : 978 pages
File Size : 49,6 Mb
Release : 2011-12-15
Category : Medical
ISBN : 9781608312702

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Principles of Pharmacology by David E. Golan,Armen H. Tashjian,Ehrin J. Armstrong Pdf

Now in its third edition, Principles of Pharmacology presents content in a conceptual framework that maximizes understanding and retention and minimizes rote memorization. It takes students "beyond the disease" and deep into physiologic, biochemical, and pathophysiologic systems where drugs activate or inhibit these systems by interacting with molecular and cellular targets. This unique approach ensures understanding of the mechanisms of drug actions on the body, and ultimately, in treating the human patient. Ideal for introductory pharmacology courses that emphasize critical thinking, molecular understanding, systems-based integration, and clinical preparation, the text: Features chapter-opening clinical cases and questions to establish a context for the discussion and the answers that follow Presents signature drug summary tables, updated and organized by mechanism of action, with information on clinical applications, adverse effects, contraindications, and therapeutic considerations Incorporates NEW full-color illustrations throughout, suiting the needs of visual learners and more effectively presenting concepts covered in the narrative Integrates timely content, including recently approved drugs as well as current research on drug mechanisms of action Delivers course and review material appropriate for students through a uniquely collaborative authorship consisting of medical students, residents, and faculty

Author : Terrence P. Kenakin
Publisher : Raven Press (ID)
Page : 504 pages
File Size : 41,9 Mb
Release : 1993
Category : Medical
ISBN : UOM:39015028899402

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Pharmacologic Analysis of Drug-receptor Interaction by Terrence P. Kenakin Pdf

A guide to quantitative drug-receptor pharmacology, this new edition aims to cover all receptor systems, whether derived from molecular biology or animal studies. Using existing data, it demonstrates how theoretical models facilitate drug development, and integrates theory with practice. This second edition aims to be a valuable resource for all researchers involved in the drug design and development process. Not only has the text been updated and revised, but reflecting the significant technical breakthroughs of recent years, it now more generally encompasses all receptor systems, whether derived from molecular biology or whole animal studies. These systems are examined within the framework of current drug receptor theories, particularly the receptor occupation theory, the operational model of drug action and the ternary complex model.

Author : Lee E. Limbird
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 55,5 Mb
Release : 2006-06-02
Category : Medical
ISBN : 9780387230801

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Cell Surface Receptors by Lee E. Limbird Pdf

Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest. The study of receptors has changed considerably over the period of the publication of the three editions of this book. The cloning of several genomes makes it unlikely that preparations of receptors now or in the future will arise from their purification as trace proteins from native tissues, but rather from a myriad of molecular approaches. Nonetheless, understanding the molecular mechanisms and ultimately the in vivo biology of these receptors means that investigators will engage in molecular, cellular and ultimate in vivo strategies. It should be of value to investigators who want to identify, characterize and understand the biology of a receptor of interest.

Author : Ronald J. Tallarida,Leonard S. Jacob
Publisher : Springer Science & Business Media
Page : 218 pages
File Size : 48,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468462654

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The Dose—Response Relation in Pharmacology by Ronald J. Tallarida,Leonard S. Jacob Pdf

This book is designed to meet the modern need for a better understanding of drug-receptor interaction as applied to the gathering and interpretation of dose-response data. It is an introduction suitable for any student who has had a first course in pharmacology. This book is an extension of the pharmacology course into one area of what is now known as molecular pharmacology. The material included is an outgrowth of courses that we have given in recent years to health-science students in several professional schools and universities. The area of drug-receptor theory, although just a part of molecular phar macology, is already very broad. One major line of investigation is concerned with the chemical and structural nature of specific receptors and with efforts to isolate specific receptors. Another line of investigation is concerned with the kinetic theories of drug-receptor interaction, the effort there being to provide a general theory that is applicable to wide classes of drugs. We have chosen to deal with the latter. There are several reasons for our choice of topics. First, the information is very practical; that is, it permits one to use properly and consistently terms such as "efficacy," "partial agonist," "pure antagonist," "potency," "pA2'" etc., when describing drug action. Second, many students fail to appreciate the differences in and the limitations of the various theories, beginning with the classical theory of A. J. Clark, on up to the very recent allosteric theories.

Author : Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen
Publisher : CRC Press
Page : 596 pages
File Size : 53,9 Mb
Release : 2002-07-25
Category : Medical
ISBN : 0415282888

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Textbook of Drug Design and Discovery, Third Edition by Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen Pdf

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

Author : Stefan Offermanns,W. Rosenthal
Publisher : Springer Science & Business Media
Page : 1515 pages
File Size : 55,9 Mb
Release : 2008-08-14
Category : Medical
ISBN : 9783540389163

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Encyclopedia of Molecular Pharmacology by Stefan Offermanns,W. Rosenthal Pdf

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Author : Maria A. Hernandez, Ph.D.,Appu Rathinavelu, Ph.D.
Publisher : CRC Press
Page : 404 pages
File Size : 47,5 Mb
Release : 2017-07-12
Category : Medical
ISBN : 9781351988650

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Basic Pharmacology by Maria A. Hernandez, Ph.D.,Appu Rathinavelu, Ph.D. Pdf

Intended for use in an introductory pharmacology course, Basic Pharmacology: Understanding Drug Actions and Reactions provides an in-depth discussion of how to apply the chemical and molecular pharmacology concepts, a discussion students need for more advanced study. The textbook introduces the principles of chemistry and biology necessary to understand drug interactions at the cellular level. The authors highlight chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and elimination. The book begins with a review of chemical principles as they apply to drug molecules, focusing mainly on those for commonly prescribed drugs. The authors use drug structures to illustrate the chemical concepts learned in general and organic chemistry courses. They cover the dynamics of receptors in mediating the pharmacological effects of drugs. They clarify theories, drawn from the scientific literature, which explain drug-receptor interactions and the quantitative relationship between drug binding and its effects at the cellular level. The authors’ extensive use of drug structures for teaching chemical and molecular pharmacology principles, and their emphasis on the relevance of these principles in future professional life makes this book unique. It provides the framework for better understanding of advanced pharmacology and therapeutics topics. Blending medicinal chemistry and pharmacodynamics aspects, this textbook clearly elucidates the essential concepts that form the cornerstone for further work in pharmacology.

Author : Ruth R. Levine
Publisher : Unknown
Page : 440 pages
File Size : 52,8 Mb
Release : 1973
Category : Pharmacology
ISBN : UOM:39015000843824

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Pharmacology: Drug Actions and Reactions by Ruth R. Levine Pdf

Author : Anthony P. Davenport
Publisher : Humana
Page : 240 pages
File Size : 51,5 Mb
Release : 2005-03-25
Category : Medical
ISBN : 158829420X

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Receptor Binding Techniques by Anthony P. Davenport Pdf

A comprehensive collection of readily reproducible methods for studying receptors in silico, in vitro, and in vivo. These cutting-edge techniques cover mining from curated databases, identifying novel receptors by high throughput screening, molecular methods to identify mRNA encoding receptors, radioligand binding assays and their analysis, quantitative autoradiography, and imaging receptors by positron emission tomography (PET). Highlights include phenotypic characterization of receptors in knockout mice, imaging receptors using green fluorescent protein and fluorescent resonance energy transfer, and quantitative analysis of receptor mRNA by TaqMan PCR. These book equips the researcher with techniques for exploring the unprecedented number of new receptor systems now emerging and the so-called "orphan" receptors whose activating ligand has not been identified.

Author : Robert Bingham,Adrian Lloyd Thomas,M Sury
Publisher : CRC Press
Page : 809 pages
File Size : 41,8 Mb
Release : 2008-06-27
Category : Health & Fitness
ISBN : 9781444113839

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Hatch & Sumner's Textbook of Paediatric Anaesthesia Third edition by Robert Bingham,Adrian Lloyd Thomas,M Sury Pdf

Hatch and Sumner's Paediatric Anaesthesia is a thorough revision and update of the extremely popular 'Paediatric Anaesthesia' by Edward Sumner and David Hatch. A new editorial team has carefully revised the text and developed it into a concise textbook that provides all the information that a trainee or practising paediatric anaesthetist should kno