The African Trypanosomes

Author : Michel Dumas,Bernard Bouteille,Alain Buguet
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 41,8 Mb
Release : 2013-12-01
Category : Medical
ISBN : 9782817808574

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Progress in Human African Trypanosomiasis, Sleeping Sickness by Michel Dumas,Bernard Bouteille,Alain Buguet Pdf

Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. HAT is endemic in 36 sub-Saharan African countries, in areas where tsetse flies are found. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas. Along the past fifteen years, numerous studies were made, and now, the mechanisms involved in the disease pathogenesis and in the characteristics of sleep-wake disruption become to be better understood. But, since 50 years, when current drugs were introduced, problems regarding HAT chemotherapy have not been solved. Nevertheless, in-depth studies about trypanosome metabolism have permitted to discover new drug targets. Written by specialists who are very experienced in their respective fields, the contributions provide an indispensable tool for practitioners and scientists.

Author : Samuel J. Black,J. Richard Seed
Publisher : Springer Science & Business Media
Page : 180 pages
File Size : 49,8 Mb
Release : 2006-04-11
Category : Science
ISBN : 9780306468940

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The African Trypanosomes by Samuel J. Black,J. Richard Seed Pdf

African trypanosomes are tsetse-transmitted protozoa that inhabit the extracellular compartment of host blood. They cause fatal sleeping sickness in people, and Nagana, a wasting and generally fatal disease, in cattle. While trypanosomes are most common to Africa (about 30% of Africa's cattle graze on the fringe of the tsetse habitat), some species have spread beyond its boarders to Asia, the Middle East and South America. The African Trypanosomes, volume one of World Class Parasites, is written for researchers, students and scholars who enjoy reading research that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. It is intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. It integrates vector, pathogen and host biology and celebrates the diversity of approach that comprises modern parasitological research.

Author : Ian Maudlin,P. H. Holmes,Michael A. Miles
Publisher : CABI
Page : 644 pages
File Size : 45,8 Mb
Release : 2004-07-09
Category : Medical
ISBN : 0851990347

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The Trypanosomiases by Ian Maudlin,P. H. Holmes,Michael A. Miles Pdf

This state-of-the-art reference book includes comprehensive coverage of the biology and control of African, Asian and South American trypanosomiasis ("sleeping sickness") in man and animals. It describes recent research developments in the biology and molecular biology of trypanosomes (the protozoan parasite) and their vectors, and methods in diagnosis and control, such as trapping tsetse fly vectors. Different sections of the book are devoted to biology of trypanosomes, vector biology, epidemiology and diagnosis, pathogenesis, disease impact, chemotherapy and disease control, and vector control. The book contains contributions from leading experts from Europe, North and South America, and Africa.

Author : Stefan Magez,Magdalena Radwanska
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 49,7 Mb
Release : 2013-09-24
Category : Medical
ISBN : 9783709115565

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Trypanosomes and Trypanosomiasis by Stefan Magez,Magdalena Radwanska Pdf

This new volume written by experts in the field of trypanosome research covers every aspect of trypanosome-vector-host biology. It is a must read for basic researchers working with trypanosomes and related organisms, infection and drug development as well as parasitology in a broader sense. ​

Author : Gerald T. Hughes
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 45,5 Mb
Release : 2016
Category : African trypanosomiasis
ISBN : 1634847121

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African Trypanosomiasis by Gerald T. Hughes Pdf

Human African trypanosomiasis or sleeping sickness is caused by infection with the morphologically indistinguishable subspecies Trypanosoma brucei rhodesiense (in East and Southern Africa) and Trypanosoma brucei gambiense (in West and Central Africa). The disease is presently almost under control and less than 4000 cases are currently reported. In both, T. b. rhodesiense and T. b. gambiense infection, after the injection of infective metacyclic trypanosomes with tsetse fly vector saliva, the parasites establish in the skin, differentiate to the bloodstream stage and spread via the local draining lymph node into the vascular system. In this book, Chapter One presents an overview of the current epidemiology, clinical features, diagnosis and treatment options. Chapter Two provides an in-depth review of diagnostic methods for African trypanosomiasis. Chapter Three discusses the use of aminoadamantane derivatives against Trypanosoma brucei.

Author : Sunit Kumar Singh
Publisher : John Wiley & Sons
Page : 1072 pages
File Size : 54,7 Mb
Release : 2015-11-09
Category : Science
ISBN : 9781118644645

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Human Emerging and Re-emerging Infections by Sunit Kumar Singh Pdf

Emerging and re-emerging pathogens pose several challenges to diagnosis, treatment, and public health surveillance, primarily because pathogen identification is a difficult and time-consuming process due to the “novel” nature of the agent. Proper identification requires a wide array of techniques, but the significance of these diagnostics is anticipated to increase with advances in newer molecular and nanobiotechnological interventions and health information technology. Human Emerging and Re-emerging Infections covers the epidemiology, pathogenesis, diagnostics, clinical features, and public health risks posed by new viral and microbial infections. The book includes detailed coverage on the molecular mechanisms of pathogenesis, development of various diagnostic tools, diagnostic assays and their limitations, key research priorities, and new technologies in infection diagnostics. Volume 1 addresses viral and parasitic infections, while volume 2 delves into bacterial and mycotic infections. Human Emerging and Re-emerging Infections is an invaluable resource for researchers in parasitologists, microbiology, Immunology, neurology and virology, as well as clinicians and students interested in understanding the current knowledge and future directions of infectious diseases.

Author : World Health Organization
Publisher : World Health Organization
Page : 249 pages
File Size : 50,9 Mb
Release : 2013
Category : Medical
ISBN : 9789241209847

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Control and Surveillance of Human African Trypanosomiasis by World Health Organization Pdf

This report provides information about new diagnostic approaches, new therapeutic regimens and better understanding of the distribution of the disease with high-quality mapping. The roles of human and animal reservoirs and the tsetse fly vectors that transmit the parasites are emphasized. The new information has formed the basis for an integrated strategy with which it is hoped that elimination of HAT will be achieved. The report also contains recommendations on the approaches that will lead to elimination of the disease. Human African Tryponosomiasis (HAT) is a disease that afflicts populations in rural Africa, where the tsetse fly vector that transmits the causative trypanosome parasites thrives. There are two forms of HAT: one, known as gambiense HAT, is endemic in West and Central Africa and causes over 95% of current cases; the other, known as rhodesiense HAT, is endemic in East and southern Africa and accounts for the remainder of cases. The presence of parasites in the brain leads to progressive neurological breakdown. Changes to sleep-wake patterns are among the symptoms that characterize the disease, also known as "sleeping sickness". Eventually, patients fall into a coma and die if not treated. Different treatments are available against parasites present in the haemolymphatic system (first stage) and those that have entered the brain (second stage). Currently, lumbar puncture is required to select the appropriate drug.

Author : Christian Burri
Publisher : MDPI
Page : 280 pages
File Size : 40,9 Mb
Release : 2020-06-17
Category : Medical
ISBN : 9783039289639

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Human African Trypanosomiasis (Sleeping Sickness) by Christian Burri Pdf

As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spectacular reappearances, and the latest peak of 40,000 reported and over 300,000 estimated cases only dates back to 1998. Efforts of the WHO and partners as well as the development of simpler and much better-tolerated treatments, improved diagnostics, and vector control tools made it possible to reduce this number by 95%. Case identification and confirmation remain complex and require specific skills, treatment remains error-prone and reports on long-term survivors have emerged, and the relevance of the animal reservoir for T. b. gambiense HAT needs clarification. In addition, to win the “end game” against this massively stigmatized disease, the human factor will play a key role. This Special Issue addresses many of the burning topics about disease elimination in its 12 research and 7 review articles and one case study. The papers critically reflect the approaches used, investigate the mentioned challenges, and propose novel approaches and interventions from various points of view.

Author : Maryinez Lyons
Publisher : Cambridge University Press
Page : 356 pages
File Size : 44,7 Mb
Release : 2002-06-06
Category : History
ISBN : 0521524520

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The Colonial Disease by Maryinez Lyons Pdf

A case-study in the history of sleeping sickness, relating it to the western 'civilising mission'.

Author : Anonim
Publisher : Unknown
Page : 96 pages
File Size : 47,5 Mb
Release : 1979
Category : Electronic
ISBN : OCLC:744955357

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The African Trypanosomiasis by Anonim Pdf

Author : WHO Expert Committee on the Epidemiology and Control of African Trypanosomiasis
Publisher : Unknown
Page : 132 pages
File Size : 47,9 Mb
Release : 1986
Category : African trypanosomiasis
ISBN : IND:39000008335528

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Epidemiology and Control of African Trypanosomiasis by WHO Expert Committee on the Epidemiology and Control of African Trypanosomiasis Pdf

Author : World Health Organization
Publisher : Unknown
Page : 237 pages
File Size : 55,9 Mb
Release : 2013
Category : African trypanosomiasis
ISBN : 9240691723

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Control and Surveillance of Human African Trypanosomiasis by World Health Organization Pdf

This report provides information about new diagnostic approaches new therapeutic regimens and better understanding of the distribution of the disease with high-quality mapping. The roles of human and animal reservoirs and the tsetse fly vectors that transmit the parasites are emphasized. The new information has formed the basis for an integrated strategy with which it is hoped that elimination of HAT will be achieved. The report also contains recommendations on the approaches that will lead to elimination of the disease.Human African Tryponosomiasis (HAT) is a disease that afflicts populations in rural Africa where the tsetse fly vector that transmits the causative trypanosome parasites thrives. There are two forms of HAT: one known as gambiense HAT is endemic in West and Central Africa and causes over 95% of current cases; the other known as rhodesiense HAT is endemic in East and southern Africa and accounts for the remainder of cases. The presence of parasites in the brain leads to progressive neurological breakdown. Changes to sleep-wake patterns are among the symptoms that characterize the disease also known as sleeping sickness . Eventually patients fall into a coma and die if not treated. Different treatments are available against parasites present in the haemolymphatic system (first stage) and those that have entered the brain (second stage). Currently lumbar puncture is required to select the appropriate drug.

Author : John Ford
Publisher : Oxford University Press, USA
Page : 592 pages
File Size : 55,5 Mb
Release : 1971
Category : Medical
ISBN : UOM:39015006119500

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The Role of the Trypanosomiases in African Ecology by John Ford Pdf

Author : Miodrag Ristic
Publisher : Springer Science & Business Media
Page : 800 pages
File Size : 55,9 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9789401190343

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Diseases of Cattle in the Tropics by Miodrag Ristic Pdf

Most of the future increase in livestock production is expected to occur in the tropical and subtropical regions of the world. Cattle are the most numerous of the ruminant species in the tropics and provide the largest quantity of animal food products. More than one-third of the world's cattle are found in the tropics. Disease is the major factor which prohibits full utilization of these regions for cattle production. Various infectious and transmissible viral, rick ettsial, bacterial, and particularly protozoan and helminthic diseases, are widespread in the tropics and exert a heavy toll on the existing cattle industry there. This uncontrolled disease situation also discourages investment in cattle industries by private and government sectors. In Africa alone, it is estimated that 125 million head of cattle could be accommodated in the tropical rainbelt if the disease and other animal husbandry factors could be resolved. The potential of efficient cattle production under more favorable conditions prompted various international agencies to establish a multi million dollar International Laboratory for Research in Animal Diseases (ILRAD) in Nairobi, Kenya, Africa. In South America, principal sites for raising cattle are shifting to the savannah lands because the more fertile soils are being used for crop produc tion, however, in the savannahs also, disease remains the most powerful deterrent in implementing the cattle industry.

Author : Philippe Grandcolas,Marie-Christine Maurel
Publisher : John Wiley & Sons
Page : 242 pages
File Size : 45,5 Mb
Release : 2021-03-31
Category : Science
ISBN : 9781119489177

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Systematics and the Exploration of Life by Philippe Grandcolas,Marie-Christine Maurel Pdf

This book's aim is to obtain and organize knowledge about the diversity of living things. Their epistomological and methodological fundamentals are explained in the framework of the biology of evolution. The methods of construction and use of phylogenetic trees are presented as well as the classification and description of taxa with the nomenclature rules.